KR920021522A - 피페라진 유도체 - Google Patents

피페라진 유도체 Download PDF

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KR920021522A
KR920021522A KR1019920007528A KR920007528A KR920021522A KR 920021522 A KR920021522 A KR 920021522A KR 1019920007528 A KR1019920007528 A KR 1019920007528A KR 920007528 A KR920007528 A KR 920007528A KR 920021522 A KR920021522 A KR 920021522A
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ethyl
cyclohexanecarboxamide
methoxyphenyl
pyridyl
aryl
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KR1019920007528A
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KR100203254B1 (ko
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안토니 클리프 아이언
랭햄 만셀 하워드
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폴 에이. 리쳐
존 와이어스 앤드 브라드 리미티드
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Priority claimed from GB919109475A external-priority patent/GB9109475D0/en
Priority claimed from GB919127189A external-priority patent/GB9127189D0/en
Application filed by 폴 에이. 리쳐, 존 와이어스 앤드 브라드 리미티드 filed Critical 폴 에이. 리쳐
Publication of KR920021522A publication Critical patent/KR920021522A/ko
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

내용 없음

Description

피페라진 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 다음 일반식(Ⅰ)의 화합물 또는 약제학적으로 허용되는 이의 산 부가염.
    상기 식에서, A는 하나 이상의 저급 알킬 그룹에 의해 임의로 치환되는 탄소수 2 내지 4의 알킬렌쇄이고, Z는 산소 또는 황이며, R은 수소 또는 저급 알킬이고, R1은 모노 또는 비사이클릭 아릴 또는 헤테로아릴 라디탈이며, R2는 모노 또는 비사이클릭 헤테로아릴 라디칼이고, R3은 수소 저급 알킬, 사이클로알킬, 사이클로알케닐, 사이클로알킬(저급)알킬, 아릴, 아릴(저급)알킬, 헤테로아릴, 헤테로아릴(저급)알킬, 일반식 -NR4R5의 그룹[여기서, R4는 수소, 저급 알킬, 아릴 또는 아릴(저급)알킬이고. R5는 수소, 저급 알킬, -CO(저급)알킬, 아릴, CO아릴, 아릴(저급)알킬, 사이클로알킬 또는 사이클로알킬-(저급)알킬이거나, 또는 R4및 R5는 이들이 결합하고 있는 질소원자와 함께 추가의 헤테로 원자를 함유할 수도 있는 포화 헤테로사이클릭 환을 형성한다]또는 일반식 OR6의 그룹[여기서, R6은 저급 알킬, 사아클로알킬, 사이클로알킬(저급)알킬, 아릴, 아릴(저급)알킬, 헤테로아릴 또는 헤테로아릴(저급)알킬이다.]이다.
  2. 제1항에 있어서, N-(2-(1-(4-(2-메톡시페닐)-피페라지닐))에틸)-N-(2-피리디닐)사이클로헥산카복스아미드 또는 N-사이클로헥실-N′-(2-(1-(4-(2-메톡시페닐)-피페라지닐))에틸)-N-(2-피리디닐)우레아 또는 N-(2-(1-(4-(2-메톡시페닐)-피페라지닐))에틸)-N-(2-피리디닐)벤즈아미드 또는 N-(2-(1-(4-(2-메톡시페닐)-피페라지닐))에틸)-N-(2-티아졸릴)트리메틸아세트아미드 또는 N-(2-(1-(4-(2-메톡시페닐)-피페라지닐))에틸)-N-(2-티아졸릴)사이클로헥산카복스아미드 또는 N-(2-(4-(4-플로오로-2-메톡시페닐)-피페라지닐))에틸)-N-(2-피리디닐)사이클로헥산카복스 아미드 또는 N-(2-(1-(4-(2,3-디하이드로-1,4-벤조디옥신-5-일)-피페라지닐))에틸)-N-(2-피리디닐)사이클로헥산카복스 아미드 또는 N-[2-[1-[4-[3-(1,2-벤즈이소티아졸일)]]피페라지닐))에틸)-N-(2-피리디닐)사이클로헥산카복스아미스 또는 N-(2-(1-(4-(2-메톡시페닐)피페리지닐))에틸)-N-(1-피페리디닐카보닐)-2-피리딘 또는 N-(2-(1-(4-(2-메톡시페닐)피페리지닐))에틸)-N-(피리딘-2-일)-N′-사이클로헥실티오우레아 또는 N-(2-(1-(4-(2-하이드록시페닐)-1-피레라지닐))에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 N-(2-(1-(4-(1-나프틸))피레라지닐)에틸)-N-(2피리딜)사이클로헥산카복스아미드 또는 N-(2-(1-(4-(2-메틸페닐))피페라지닐)에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 N-[2[1-[4-(2-플우오르페닐))피페라지닐)에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 N-[2[1-[4-(1-이소퀴놀리닐)]피페라지닐))에틸)-N-(2-피리디닐)사이클로헥산카복스아미드 또는 N-[2-[1-[4-1(7-메톡시)나프틸]]피레라지닐))에틸)-N-(2-피리디닐)사이클로헥산카복스아미드 또는 N-(2-(1-(4-(2-메톡시페닐)피페리지닐))에틸)-N-(2-피리딜)아다만탄-1-카복시아미드 또는 N-[2[1-[4-(1-(7-메톡시)나프틸]]피레라지닐))에틸)-N-(2-피리디닐)사이클로헥산카복스아미드 또는 N-[2[1-[4-(1-(5,6,7,8-테트라하이드로)나트틸]]-페라지닐]에틸0-N-[(2-피리디닐)사이클로헥산카복스아미드 또는 (S)-N-(1-메틸-2-(4-(2-메톡시페닐)-1-피레라지닐)에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 (R)-N-(1-메틸-2-(4-(2-메톡시페닐)-1-피레라지닐)에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 N-[3-[4-(2-메톡시페닐)-1-페리지닐]프로필)-N-[(2-피리딜)사이클로헥산카복스아미드 또는 N-[2-[4-(2-메톡시페닐)-1-페라지닐]에틸)-N-(2-퀴놀리닐)사이클로헥산카복스아미드 또는 (Rac)-N-(2-(4-(2-메톡시페닐)-1-페라지닐)프로필)-N-(2-피리딜)사이클로헥산카복스아미드 또는 (S)-N-(2-(4-(2-메톡시페닐)-1-피레라지닐)에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 (R)-N-(2-(4-(2-메톡시페닐)-1-피레라지닐)에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 N-(2-(4-페닐-1-피페리지닐)에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 N-2-(4-(2-이소프로필페닐)-1-(피레라지닐)에틸)-N-(2-피리딜)사이클로헥산카복스아미드 또는 N-(2-(4-(2-메톡시페닐)-1-피페라지닐)에틸)-N-(4-피리딜)사이클로헥산카복스아미드 또는 N-(2-(4-(2-메톡시페닐)-1-(피페라지닐)에틸)-N-(3-피리딜)사이클로헥산카복스아미드 또는 N-(2-(4-(2-메톡시페닐)피레라진-1-일)에틸)-N-(2-피리디닐)사이클로헥스-1-엔카복스아미드 또는 N-(2-(4-(2-메톡시페닐)-1-(피페라지닐)에틸)-N-(2-피리디닐)사이클로헥산카복스아미드인 화합물 또는 약제학적으로 허용되는 의의 염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019920007528A 1991-05-02 1992-05-02 피페라진 유도체 KR100203254B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB919109475A GB9109475D0 (en) 1991-05-02 1991-05-02 Piperazine derivatives
GB9109475.5 1991-05-02
GB9127189 1991-12-21
GB919127189A GB9127189D0 (en) 1991-12-21 1991-12-21 Piperazine derivatives
GB9127189.0 1991-12-21

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KR920021522A true KR920021522A (ko) 1992-12-18
KR100203254B1 KR100203254B1 (ko) 1999-06-15

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ATE115566T1 (de) 1994-12-15
EP0512755A2 (en) 1992-11-11
IE64634B1 (en) 1995-08-23
RU2193561C2 (ru) 2002-11-27
IE921409A1 (en) 1992-11-04
HU211148A9 (en) 1995-10-30
FI921942A (fi) 1992-11-03
CN1040106C (zh) 1998-10-07
CA2067929C (en) 2002-06-04
HK1003001A1 (en) 1998-09-30
AU1524192A (en) 1992-11-05
US6127357A (en) 2000-10-03
AU645681B2 (en) 1994-01-20
HUT61012A (en) 1992-11-30
FI108720B (fi) 2002-03-15
MY107756A (en) 1996-06-15
CZ286778B6 (cs) 2000-07-12
SK280133B6 (sk) 1999-08-06
BR9201624A (pt) 1992-12-15
EP0512755A3 (en) 1993-03-03
KR100203254B1 (ko) 1999-06-15
JP3095521B2 (ja) 2000-10-03
EP0512755B1 (en) 1994-12-14
IL101722A (en) 1996-05-14
ES2065133T3 (es) 1995-02-01
DE69200893T2 (de) 1995-04-13
MX9201991A (es) 1992-11-01
UA39917C2 (uk) 2001-07-16
IL101722A0 (en) 1992-12-30
GB2255337B (en) 1994-12-14
DE69200893D1 (de) 1995-01-26
CN1098098A (zh) 1995-02-01
GB2255337A (en) 1992-11-04
CA2067929A1 (en) 1992-11-03
JPH05170743A (ja) 1993-07-09
DK0512755T3 (da) 1995-01-30
CN1206589A (zh) 1999-02-03
FI921942A0 (fi) 1992-04-30
HU9201462D0 (en) 1992-07-28
CN1084619C (zh) 2002-05-15
CS134492A3 (en) 1992-10-14
GB9209340D0 (en) 1992-06-17
HU223527B1 (hu) 2004-08-30

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