PE20030269A1 - Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas - Google Patents

Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas

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Publication number
PE20030269A1
PE20030269A1 PE2002000595A PE2002000595A PE20030269A1 PE 20030269 A1 PE20030269 A1 PE 20030269A1 PE 2002000595 A PE2002000595 A PE 2002000595A PE 2002000595 A PE2002000595 A PE 2002000595A PE 20030269 A1 PE20030269 A1 PE 20030269A1
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PE
Peru
Prior art keywords
alkyl
benzamide
ilamine
heteroalkyl
haloalkyl
Prior art date
Application number
PE2002000595A
Other languages
English (en)
Inventor
Larry Andrew Alegria
Ted Michael Bleckman
Wesley Kwan Mung Chong
Shao Song Chu
Michelle Yi Yang
Lin Li
Siegfried Heinz Reich
William Henry Romines Iii
Michael B Wallace
Rohit K Duvadie
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of PE20030269A1 publication Critical patent/PE20030269A1/es

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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D491/10—Spiro-condensed systems

Abstract

SE REFIERE A COMPUESTOS CON NUCLEO (4-AMINOTIAZOL-2-ILAMINA)-BENZAMIDA DE FORMULA (I) DONDE R1 Y R2 SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS O JUNTOS CON N-C=O Y DOS ATOMOS DE C ADYACENTES AL FENILO FORMAN UN ANILLO DE 5 O 6 MIEMBROS FUSIONADA CON FENILO Y PUEDE O NO SUSTITUIRSE CON ALQUILO, HETEROALQUILO, HALOALQUILO, HALOARILO, ENTRE OTROS; O R1 Y R2 JUNTO CON EL ATOMO DE N FORMAN UN MONOCICLICO O POLICICLICO QUE PUEDE CONTENER DE UNO A TRES HETEROATOMOS ADICIONALES, SIENDO NO SUSTITUIDO O SUSTITUIDO CON UNO O MAS ALQUILO, HETEROALQUILO, HALOALQUILO, HALOARILO, ENTRE OTROS; R3 ES UN ARILO HETEROARILO, ALQUILO O CICLOALQUILO, NO SUSTITUIDO O SUSTITUIDO CON UNO O MAS ALQUILO, HETEROALQUILO, HALOALQUILO, HALOARILO, ENTRE OTROS; Y ES H, ALQUILO, HETEROALQUILO, HALOALQUILO, HALOCICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 4-(4-AMINA-5-(2,6-DIFLUORO-BENZOIL)-TIAZOL-2-ILAMINA)-N-(2-DIMETILPROPIL)-BENZAMIDA, 4-(4-AMINA-5-(2,6-DIFLUORO-BENZOIL)-TIAZOL-2-ILAMINA)-N-(2-DIMETILAMINA-METIL-ETIL)-BENZAMIDA, 4-(4-AMINA-5-(2,6-DIFLUORO-BENZOIL)-2-ILAMINA)-N-(1-ETIL-PIRROLIDIN-2-ILMETIL)-BENZAMIDA, ENTRE OTROS. LOS COMPUESTOS SON INHIBIDORES DE PROTEINAQUINASA, MODULANDO LA PROLIFERACION CELULAR Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE CRECIMIENTO DE TUMOR, ANGIOGENESIS, INFECCION VIRAL, ENFERMEDAD AUTOINMUNE O DESORDEN NEURODEGENERATIVO
PE2002000595A 2001-07-06 2002-07-02 Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas PE20030269A1 (es)

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US30367901P 2001-07-06 2001-07-06
US30527401P 2001-07-13 2001-07-13

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US (1) US6720346B2 (es)
EP (1) EP1438046A4 (es)
JP (1) JP2005521631A (es)
AU (1) AU2002354801A1 (es)
BR (1) BR0210874A (es)
CA (1) CA2452609A1 (es)
HN (1) HN2002000156A (es)
MX (1) MXPA04000069A (es)
PA (1) PA8550101A1 (es)
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SV (1) SV2003001148A (es)
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EP1438046A4 (en) 2004-10-20
HN2002000156A (es) 2003-11-27
WO2003004467A3 (en) 2004-05-06
MXPA04000069A (es) 2004-05-21
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BR0210874A (pt) 2006-10-24
UY27370A1 (es) 2003-04-30
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US6720346B2 (en) 2004-04-13
CA2452609A1 (en) 2003-01-16

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