KR880012633A - C_17 내지 C_20 리아제 억제제로서 유용한 17β-(사이클로프로필아미노)안드로스트-5-엔-3β-올 및 관련 화합물 - Google Patents
C_17 내지 C_20 리아제 억제제로서 유용한 17β-(사이클로프로필아미노)안드로스트-5-엔-3β-올 및 관련 화합물 Download PDFInfo
- Publication number
- KR880012633A KR880012633A KR1019880004512A KR880004512A KR880012633A KR 880012633 A KR880012633 A KR 880012633A KR 1019880004512 A KR1019880004512 A KR 1019880004512A KR 880004512 A KR880004512 A KR 880004512A KR 880012633 A KR880012633 A KR 880012633A
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogen
- compound
- androst
- cyclopropylamino
- ene
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 일반식(Ⅰ)의 화합물.상기식에서, R은 수소 또는 메틸이고; R1는 수소, C1내지 C4알킬 또는 사이클로프로필이며;이다(여기서, Z는 수소, 탄소수 1 내지 10의 알카노일 또는 알카노일 부분이 4개 이하의 탄소원자를 함유하는 사이클로펜탈- 및 벤젤-알카노일이다)
- 제 1항에 있어서, 일반식(Ⅰ')의 화합물.상기식에서, R은 수소 또는 메틸이고; R1는 수소, C1내지 C4알킬 또는 사이클로프로필이다.
- 제 1항에 있어서, 일반식(Ⅰ)의 화합물.상기식에서, R은 수소 또는 메틸이고; R1는 수소, C1내지 C4알킬이다.
- 제 1항에 있어서, 17β-(사이클로프로필아미노)안드로스트-5-엔-3β-올린 화합물.
- 제 1항에 있어서, 17β-[N-메틸(사이클로프로필아미노)]안드로스트-5-엔-3β-올린 화합물.
- 제 1항에 있어서, 17β-(사이클로프로필아미노)안드로스트-4-엔-3-온인 화합물.
- 안드로겐-의존성 질병을 앓고 있는 개개 환자에게 일반식(Ⅰ)의 화합물 유효량을 투여함을 특징으로 하여 안드로겐-의존성 질병을 치료하는 방법.상기식에서, R은 수소 또는 메틸이고; R1는 수소, C1내지 C4알킬 또는 사이클로프로필이며;Q는이다(여기서, Z는 수소, 탄소수 1 내지 10의 알카노일 또는 알카노일 부분이 4개 이하의 탄소원자를 함유하는 사이클로펜탄-및 벤젠-알카노일이다).
- 제 7항에 있어서, 안드로겐-의존성 질병을 앓고 있는 개개 환자에게 일반식(Ⅰ')의 화합물 유효량을 투여함을 특징으로 하여 안드로겐-의존성 질병을 치료하는 방법.상기식에서, R은 수소 또는 메틸이고; R'는 수소, C1내지 C4알킬 또는 사이클로프로필이다.
- 제 7항에 있어서, 17β-(사이클로프로필아미노)안드로스트-5-엔-3β-올 유효량을 투여하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4117287A | 1987-04-22 | 1987-04-22 | |
US041172 | 1987-04-22 | ||
US041,172 | 1987-04-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880012633A true KR880012633A (ko) | 1988-11-28 |
KR960015037B1 KR960015037B1 (ko) | 1996-10-24 |
Family
ID=21915133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880004512A KR960015037B1 (ko) | 1987-04-22 | 1988-04-21 | C_17 내지 C_20 리아제 억제제로서 유용한 17β-(사이클로프로필아미노)안드로스트-5-엔-3β-올 및 관련 화합물 |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0288053B1 (ko) |
JP (1) | JP2711672B2 (ko) |
KR (1) | KR960015037B1 (ko) |
CN (1) | CN88102176A (ko) |
AT (1) | ATE67211T1 (ko) |
AU (1) | AU606677B2 (ko) |
CA (1) | CA1326234C (ko) |
DE (1) | DE3864725D1 (ko) |
DK (1) | DK217588A (ko) |
ES (1) | ES2038712T3 (ko) |
FI (1) | FI88397C (ko) |
GR (1) | GR3002713T3 (ko) |
HU (1) | HU198511B (ko) |
IL (1) | IL86139A (ko) |
NO (1) | NO169346C (ko) |
NZ (1) | NZ224288A (ko) |
PH (1) | PH24090A (ko) |
PT (1) | PT87294B (ko) |
ZA (1) | ZA882717B (ko) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4891367A (en) * | 1987-04-22 | 1990-01-02 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
US4954488A (en) * | 1989-06-14 | 1990-09-04 | Merrell Dow Pharmaceuticals Inc. | Method of treating hyperaldosteronism using 17β-cyclopropylaminoandrostene derivatives |
US4966898A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
US5256408A (en) * | 1990-06-12 | 1993-10-26 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
US5252319A (en) * | 1990-06-12 | 1993-10-12 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
US5209926A (en) * | 1990-06-12 | 1993-05-11 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
US5124154A (en) * | 1990-06-12 | 1992-06-23 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
US5604213A (en) * | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
JP2742331B2 (ja) * | 1992-03-31 | 1998-04-22 | ブリテイツシユ・テクノロジー・グループ・リミテツド | 癌治療に有用な17位置換ステロイド |
US5486511A (en) * | 1993-05-25 | 1996-01-23 | Merrell Dow Pharmaceuticals Inc. | 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase |
MY134929A (en) | 2000-11-17 | 2008-01-31 | Takeda Pharmaceutical | Novel imidazole derivatives, production method thereof and use thereof |
ATE502030T1 (de) | 2000-11-20 | 2011-04-15 | Takeda Pharmaceutical | Imidazolderivate, verfahren zu deren herstellung und deren verwendung |
DE60139639D1 (de) | 2000-12-08 | 2009-10-01 | Takeda Pharmaceutical | Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung |
UA105794C2 (uk) | 2009-06-26 | 2014-06-25 | Новартіс Аг | 1,3-ДИЗАМІЩЕНІ ПОХІДНІ ІМІДАЗОЛІДИН-2-ОНУ ЯК ІНГІБІТОРИ Cyp17 |
WO2012018948A2 (en) | 2010-08-04 | 2012-02-09 | Pellficure Pharmaceuticals, Inc. | Novel treatment of prostate carcinoma |
JP2013537210A (ja) | 2010-09-16 | 2013-09-30 | ノバルティス アーゲー | 17α−ヒドロキシラーゼ/C17,20−リアーゼ阻害剤 |
JP6002210B2 (ja) | 2011-04-28 | 2016-10-05 | ノバルティス アーゲー | 17α−ヒドロキシラーゼ/C17,20−リアーゼ阻害剤 |
EP2968219B1 (en) | 2013-03-14 | 2019-04-24 | Pellficure Pharmaceuticals, Inc. | Novel therapy for prostate carcinoma |
US10093620B2 (en) | 2014-09-12 | 2018-10-09 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
AU2017350690A1 (en) | 2016-10-24 | 2019-06-13 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL302932A (ko) * | 1962-12-31 | |||
US4891367A (en) * | 1987-04-22 | 1990-01-02 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
-
1988
- 1988-04-18 ZA ZA882717A patent/ZA882717B/xx unknown
- 1988-04-18 CA CA000564364A patent/CA1326234C/en not_active Expired - Fee Related
- 1988-04-18 NZ NZ224288A patent/NZ224288A/xx unknown
- 1988-04-18 AU AU14719/88A patent/AU606677B2/en not_active Ceased
- 1988-04-19 PH PH36817A patent/PH24090A/en unknown
- 1988-04-20 IL IL86139A patent/IL86139A/xx unknown
- 1988-04-21 KR KR1019880004512A patent/KR960015037B1/ko not_active IP Right Cessation
- 1988-04-21 AT AT88106397T patent/ATE67211T1/de not_active IP Right Cessation
- 1988-04-21 DE DE8888106397T patent/DE3864725D1/de not_active Expired - Fee Related
- 1988-04-21 PT PT87294A patent/PT87294B/pt not_active IP Right Cessation
- 1988-04-21 CN CN198888102176A patent/CN88102176A/zh active Pending
- 1988-04-21 HU HU882029A patent/HU198511B/hu not_active IP Right Cessation
- 1988-04-21 ES ES198888106397T patent/ES2038712T3/es not_active Expired - Lifetime
- 1988-04-21 JP JP63096969A patent/JP2711672B2/ja not_active Expired - Fee Related
- 1988-04-21 NO NO881746A patent/NO169346C/no unknown
- 1988-04-21 DK DK217588A patent/DK217588A/da not_active Application Discontinuation
- 1988-04-21 EP EP88106397A patent/EP0288053B1/en not_active Expired - Lifetime
- 1988-04-21 FI FI881877A patent/FI88397C/fi not_active IP Right Cessation
-
1991
- 1991-09-12 GR GR91401315T patent/GR3002713T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO881746D0 (no) | 1988-04-21 |
JPS63284195A (ja) | 1988-11-21 |
PT87294A (pt) | 1988-05-01 |
HUT47307A (en) | 1989-02-28 |
AU606677B2 (en) | 1991-02-14 |
FI88397B (fi) | 1993-01-29 |
HU198511B (en) | 1989-10-30 |
CA1326234C (en) | 1994-01-18 |
DK217588D0 (da) | 1988-04-21 |
PT87294B (pt) | 1992-08-31 |
IL86139A0 (en) | 1988-11-15 |
KR960015037B1 (ko) | 1996-10-24 |
ATE67211T1 (de) | 1991-09-15 |
NZ224288A (en) | 1989-12-21 |
NO881746L (no) | 1988-10-24 |
NO169346B (no) | 1992-03-02 |
ES2038712T3 (es) | 1993-08-01 |
FI881877A (fi) | 1988-10-23 |
FI88397C (fi) | 1993-05-10 |
NO169346C (no) | 1992-06-10 |
AU1471988A (en) | 1988-10-27 |
FI881877A0 (fi) | 1988-04-21 |
GR3002713T3 (en) | 1993-01-25 |
JP2711672B2 (ja) | 1998-02-10 |
IL86139A (en) | 1993-02-21 |
EP0288053B1 (en) | 1991-09-11 |
CN88102176A (zh) | 1988-11-23 |
EP0288053A1 (en) | 1988-10-26 |
ZA882717B (en) | 1988-10-17 |
DE3864725D1 (de) | 1991-10-17 |
DK217588A (da) | 1988-10-23 |
PH24090A (en) | 1990-03-05 |
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