KR870004033A - 헤테로사이클릭 퀴나졸린 화합물의 제조방법 - Google Patents

헤테로사이클릭 퀴나졸린 화합물의 제조방법 Download PDF

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Publication number
KR870004033A
KR870004033A KR860008729A KR860008729A KR870004033A KR 870004033 A KR870004033 A KR 870004033A KR 860008729 A KR860008729 A KR 860008729A KR 860008729 A KR860008729 A KR 860008729A KR 870004033 A KR870004033 A KR 870004033A
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South Korea
Prior art keywords
compound
formula
general formula
reacting
vii
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KR860008729A
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KR940010035B1 (ko
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와트젠 프랑크
엔겔스토프트 모겐스
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외르겐 부스 라센
에이/에스 페로산
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Priority claimed from DK476885A external-priority patent/DK476885D0/da
Priority claimed from DK476985A external-priority patent/DK476985D0/da
Application filed by 외르겐 부스 라센, 에이/에스 페로산 filed Critical 외르겐 부스 라센
Publication of KR870004033A publication Critical patent/KR870004033A/ko
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Publication of KR940010035B1 publication Critical patent/KR940010035B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

헤테로사이클릭 퀴나졸린 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. a) 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키거나 ; b) 일반식(Ⅳ)의 화합물의 반응성 유도체를 일반식(Ⅴ)의 화합물과 반응시켜 X가인 일반식(Ⅰ)의 화합물을 생성시키거나 ; c) 일반식(Ⅵ)의 화합물을 일반식(Ⅶ)의 화합물과 반응시켜 일반식(Ⅷ)의 화합물을 생성시키고, 이렇게 하여 생성된 화합물을 NH2OH 또는 다른 아미노화제(aminating agent)와 반응시켜 X가인 일반식(Ⅰ)의 화합물을 생성시키거나 ; d) 일반식(Ⅸ)의 화합물을 NH2OH와 반응시켜 일반식(Ⅹ)의 화합물을 생성시키고, 이렇게 하여 생성된 화합물을 일반식 R′-COCl 의 화합물과 반응시켜 X가인 일반식(Ⅰ)의 화합물을 생성시킴을 특징으로 하여, 일반식(Ⅰ)의 헤테로사이클릭 퀴나졸린 화합물을 제조하는 방법.
    CN-CH2-X (Ⅲ)
    R′-C(OCH3)2N(CH3)2(Ⅶ)
    상기 식에서,또는 CO2R′이고, 여기에서 R′은 C1~6-알킬, C3~7-사이클로알킬 또는 C3~7-사이클로알킬메틸이며, R6및 R7은 각각 수소, 할로겐, 알콕시 또는 트리플루오로메틸이고, R″은 수소, C1~6-알킬 또는 C3~7-사이크로알킬이며, Y는 이탈기이다.
  2. 제 1 항에 있어서, 반응 a)를 알칼리성 조건하에서 수행하는 방법.
  3. 제 1 항에 있어서, 3-(5-사이클로프로필-1,2,4-옥사디아졸-5-일)-4,5-디하이드로-4-메틸-5-옥소-6-클로로이미다조(1,5-a) 퀴나졸린을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008729A 1985-10-17 1986-10-17 헤테로사이클릭 퀴나졸린 화합물의 제조방법 KR940010035B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK4769/1985 1985-10-17
DK476885A DK476885D0 (da) 1985-10-17 1985-10-17 Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DK4768/1985 1985-10-17
DK4769 1985-10-17
DK4768 1985-10-17
DK476985A DK476985D0 (da) 1985-10-17 1985-10-17 Fremgangsmaade til fremstilling af oxadiazolylderivater af imidazobenzodiazepiner og mellemprodukt til brug ved fremgangsmaaden

Publications (2)

Publication Number Publication Date
KR870004033A true KR870004033A (ko) 1987-05-07
KR940010035B1 KR940010035B1 (ko) 1994-10-21

Family

ID=26067609

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860008729A KR940010035B1 (ko) 1985-10-17 1986-10-17 헤테로사이클릭 퀴나졸린 화합물의 제조방법

Country Status (17)

Country Link
EP (2) EP0226282B1 (ko)
JP (2) JPH0751577B2 (ko)
KR (1) KR940010035B1 (ko)
AT (2) ATE80392T1 (ko)
AU (1) AU586043B2 (ko)
CA (1) CA1297099C (ko)
DE (2) DE3686723T2 (ko)
DK (1) DK155007C (ko)
ES (1) ES2011448B3 (ko)
FI (1) FI83871C (ko)
GR (2) GR3000177T3 (ko)
IE (2) IE59830B1 (ko)
IL (1) IL80320A (ko)
NO (1) NO165840C (ko)
NZ (1) NZ217959A (ko)
PH (2) PH24902A (ko)
PT (1) PT83573B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
ATE80392T1 (de) 1985-10-17 1992-09-15 Novo Nordisk As Oxadiazolylacetonitrile, ihre herstellung und anwendung.
DK155524C (da) * 1987-03-18 1989-09-11 Ferrosan As Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
DK522187D0 (da) * 1987-10-06 1987-10-06 Ferrosan As Imidozothienopyrimidiner, deres fremstilling og anvendelse
DK626288D0 (da) * 1988-11-10 1988-11-10 Ferrosan As Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
DK443589D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK204291D0 (da) * 1991-12-20 1991-12-20 Novo Nordisk As Heterocykliske forbindelser deres fremstilling og anvendelse
US5371080A (en) * 1990-06-22 1994-12-06 Novo Nordisk A/S Imidazoquinazoline compounds and their use
US5276028A (en) * 1990-06-22 1994-01-04 Nordisk A/S Imidazoquinoxaline compounds
DK151890D0 (da) * 1990-06-22 1990-06-22 Ferrosan As Heterocykliske forbindelser deres fremstilling og brug
AU8396491A (en) * 1990-09-04 1992-03-30 Upjohn Company, The Oxygenated quinoxalines
WO1993012113A1 (en) * 1991-12-17 1993-06-24 The Upjohn Company 3-SUBSTITUTED IMIDAZO (1,5-a) AND IMIDAZO (1,5-a)-TRIAZOLO (1,5-c) QUINOXALINES AND QUINAZOLINES WITH CNS ACTIVITY
FI101305B1 (fi) * 1996-03-18 1998-05-29 Map Medical Technologies Oy Radiofarmaseuttisena aineena käyttökelpoiset radiojodatut bentsodiatsepiini-johdannaiset ja niiden käyttö diagnostiikassa

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374988A (en) * 1981-11-05 1983-02-22 American Cyanamid Company 4-Heteroarylimidazo-[1,5-A]pyrimidines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4622320A (en) 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
ATE80392T1 (de) 1985-10-17 1992-09-15 Novo Nordisk As Oxadiazolylacetonitrile, ihre herstellung und anwendung.

Also Published As

Publication number Publication date
NZ217959A (en) 1989-02-24
IE59830B1 (en) 1994-04-20
IL80320A (en) 1990-02-09
DE3686723T2 (de) 1993-04-01
PT83573B (pt) 1988-10-14
PH25034A (en) 1991-01-28
IE63631B1 (en) 1995-05-17
FI83871C (fi) 1991-09-10
DK499586D0 (da) 1986-10-17
ATE80392T1 (de) 1992-09-15
DK155007C (da) 1989-06-05
NO864063D0 (no) 1986-10-13
ATE44381T1 (de) 1989-07-15
NO165840C (no) 1991-04-17
JPH06192242A (ja) 1994-07-12
DE3664211D1 (en) 1989-08-10
DK499586A (da) 1987-04-18
GR3006440T3 (ko) 1993-06-21
FI864126A (fi) 1987-04-18
EP0274009A1 (en) 1988-07-13
JPH072727B2 (ja) 1995-01-18
DE3686723D1 (de) 1992-10-15
NO864063L (no) 1987-04-21
NO165840B (no) 1991-01-07
PH24902A (en) 1990-12-26
KR940010035B1 (ko) 1994-10-21
DK155007B (da) 1989-01-23
EP0226282A2 (en) 1987-06-24
JPS62167782A (ja) 1987-07-24
EP0226282B1 (en) 1989-07-05
FI83871B (fi) 1991-05-31
PT83573A (en) 1986-11-01
EP0274009B1 (en) 1992-09-09
FI864126A0 (fi) 1986-10-13
EP0226282A3 (en) 1987-09-16
JPH0751577B2 (ja) 1995-06-05
ES2011448B3 (es) 1990-01-16
GR3000177T3 (en) 1990-12-31
IE862734L (en) 1987-04-17
AU586043B2 (en) 1989-06-29
AU6418086A (en) 1987-04-30
CA1297099C (en) 1992-03-10

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