KR100763728B1 - 5알파 리덕타아제 활성을 억제하도록 디자인된 조성물을제조하기 위한 약리학, 특히 피부 의학, 화장품에있어서의 하나 이상의 지방 에스테르의 용도 및 식품첨가제로서의 이의 용도 - Google Patents
5알파 리덕타아제 활성을 억제하도록 디자인된 조성물을제조하기 위한 약리학, 특히 피부 의학, 화장품에있어서의 하나 이상의 지방 에스테르의 용도 및 식품첨가제로서의 이의 용도 Download PDFInfo
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Abstract
Description
상당히 놀랍고도 의외로, 특정 화합물, 지방 에스테르의 사용으로 현저한 5알파 리덕타아제 활성 억제 효과를 얻을 수 있어서, 특히 피부 의학 병리 및/또는 상술한 질환의 치료에 신규 반응을 제공할 수 있다.
또한, 본 발명의 사용에 의해 제조된 조성물은 약제, 피부 의학 또는 미용상 허용가능한 부형제를 포함할 수 있다. 국소용, 경구용, 직장용 또는 비경구용, 특히 직장용 경로에 의한 투여를 위해 당해 기술분야의 숙련가에게 공지된 생약 형태(galenic form)에 적합한 부형제를 사용할 수 있다.
(표 2)
지방산 함유량 잔류 불비누화성 성분 지방산의 분포: 미리스트산 C14:0 팔미트산 C16:0 팔미톨레산 C16:1 스테아르산 C18:0 올레산 C18:1 리놀레산 C18:2 리놀렌산 C18:3 | 96.2% 3.8% 0.08% 22.7% 9.9% 0.6% 50.3% 11.8% 0.9% |
(표 3)
지방산의 메틸에스테르 잔류 불비누화성 성분 미확인 성분 지방산의 분포: 팔미트산 C16:0 팔미톨레산 C16:1 스테아르산 C18:0 올레산 C18:1 리놀레산 C18:2 리놀렌산 C18:3 | 86.0 2.1 11.9 25.1% 8.4% 0.6% 55.8% 9.1% 0.4% |
(표 4)
지방산의 메틸에스테르 잔류 불비누화성 성분 미확인 성분 지방산의 분포: 팔미트산 C16:0 팔미톨레산 C16:1 스테아르산 C18:0 올레산 C18:1 리놀레산 C18:2 리놀렌산 C18:3 | 97.8 - 2.2 20.4% 0.2% 2.9% 20.9% 49.8% 2.8% |
테스트한 생성물 | IC 50 (㎍/㎖) |
아보카도유의 지방산 (1) | 510 |
아보카도유의 메틸에스테르 (1) | 13 |
대두유의 메틸에스테르 (1) | 304 |
메틸올레이트 (2) | 386 |
세레노아 레펜스 | 60 |
각 실험 조건은 세번 테스트 하였다.
제품 | DMSO 1% (v/v) | 농도 (㎍/㎖) | |
10 | 100 | ||
아보카도 메틸에스테르 | 8.00 8.92 8.68 8.53 +/- 0.48 100 | 5.80 6.36 6.08 6.08* +/- 0.28 71 | 4.28 2.72 4.48 3.83* +/- 0.96 45 |
제품 | DMSO 1% (v/v) | 농도(㎍/㎖) | ||
1 | 10 | 100 | ||
메틸 올레이트 | 8.00 8.92 8.68 8.53 +/- 0.48 100 | 7.12 6.24 6.08 6.48* +/- 0.56 76 | 3.00 7.04 5.92 5.32* +/- 2.09 62 | 5.44 5.12 4.60 5.05* +/- 0.42 59 |
세레노아 레펜스 추출물 | 8.00 8.92 8.68 8.53 +/- 0.48 100 | 7.72 9.20 8.08 8.33 +/- 0.77 98 | 6.84 7.48 7.52 7.28* +/- 0.38 85 | 5.48 5.68 5.44 5.53* +/- 0.13 65 |
제품 | DMSO 0.1% (v/v) | 농도(㎍/㎖) | ||
1 | 10 | 100 | ||
메틸 올레이트 | 10.56 12.00 11.64 11.40 +/- 0.75 100 | 8.24 8.28 7.84 8.12*+/-0.24 71 | 6.28 6.44 7.12 6.61*+/-0.45 58 | 7.52 7.00 7.20 7.24*+/-0.26 64 |
올레일 올레이트 | 10.56 12.00 11.64 11.40 +/- 0.75 100 | 9.00 7.32 8.20 8.17*+/-0.84 72 | 6.12 6.44 6.20 6.25*+/-0.17 55 | 6.28 8.60 7.48 7.45*+/-1.16 65 |
부틸 올레이트 | 10.56 12.00 11.64 11.40 +/- 0.75 100 | 10.64 8.28 8.08 9.00*+/-1.42 79 | 6.24 5.04 7.36 6.21*+/-1.16 55 | 5.20 6.72 5.40 5.77*+/-0.83 51 |
메틸 운데실레네이트 | 10.56 12.00 11.64 11.40 +/- 0.75 100 | 6.56 7.44 6.68 6.89*+/-0.48 60 | 7.68 7.84 7.60 7.71*+/-0.12 68 | 8.68 7.76 9.00 8.48*+/-0.64 74 |
메틸 스테아레이트 | 10.56 12.00 11.64 11.40 +/- 0.75 100 | 6.92 6.08 7.08 6.69*+/-0.54 59 | 8.80 6.72 6.76 7.43*+/-1.19 65 | 6.88 5.92 6.76 6.52*+/-0.52 57 |
메틸 리놀레이트 | 10.56 12.00 11.64 11.40 +/- 0.75 100 | 7.04 6.40 6.36 6.60*+/-0.38 58 | 6.00 6.60 8.00 6.87*+/-1.03 60 | 8.56 8.04 7.56 8.05*+/-0.50 64 |
메틸 리시놀레이트 | 10.56 12.00 11.64 11.40 +/- 0.75 100 | 6.52 8.36 6.68 7.19*+/-1.02 63 | 7.84 7.40 5.88 7.04*+/-1.03 62 | 3.68 4.52 4.80 4.33*+/-0.58 38 |
메틸 라우레이트 | 10.56 12.00 11.64 11.40 +/- 0.75 100 | 5.76 6.88 6.84 6.49*+/-0.64 57 | 6.84 9.88 9.52 8.75+/-1.66 77 | 8.48 11.96 8.96 9.80*+/-1.89 86 |
중량%
Claims (34)
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- 아보카도유의 메틸에스테르, 대두유의 메틸에스테르, 아보카도유의 부틸에스테르, 대두유의 부틸에스테르, 메틸올레이트, 메틸리놀레이트, 메틸스테아레이트, 메틸라우레이트, 메틸운데실레네이트, 부틸올레이트, 올레일올레이트, 메틸리시놀레이트, 메틸팔미테이트, 메틸팔미톨레이트 또는 이들의 혼합물로부터 선택되는 하나 이상의 지방 에스테르를 함유하는 미용 조성물로서, 지성 피부에 사용되고, 피부에 도포하는 것을 특징으로 하는 미용 조성물.
- 아보카도유의 메틸에스테르, 대두유의 메틸에스테르, 아보카도유의 부틸에스테르, 대두유의 부틸에스테르, 메틸올레이트, 메틸리놀레이트, 메틸스테아레이트, 메틸라우레이트, 메틸운데실레네이트, 부틸올레이트, 올레일올레이트, 메틸리시놀레이트, 메틸팔미테이트, 메틸팔미톨레이트 또는 이들의 혼합물로부터 선택되는 하나 이상의 지방 에스테르를 함유하는 미용 조성물로서, 모발 손실에 사용되고, 두피에 도포되는 것을 특징으로 하는 미용 조성물.
- 아보카도유의 메틸에스테르, 대두유의 메틸에스테르, 아보카도유의 부틸에스테르, 대두유의 부틸에스테르, 메틸올레이트, 메틸리놀레이트, 메틸스테아레이트, 메틸라우레이트, 메틸운데실레네이트, 부틸올레이트, 올레일올레이트, 메틸리시놀레이트, 메틸팔미테이트, 메틸팔미톨레이트 또는 이들의 혼합물로부터 선택되는 하나 이상의 지방 에스테르를 함유하는 미용 조성물로서, 과다 다모성에 사용되고, 과다 다모성을 나타내는 피부 부위에 도포되는 것을 특징으로 하는 미용 조성물.
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- 제 24 항 내지 제 26 항 중 어느 한 항에 있어서, 지방 에스테르는 상기 미용 조성물의 전체 중량에 대하여, 0.001중량% 이상 100중량% 미만의 비율로 상기 미용 조성물 중에 존재하는 것을 특징으로 하는 미용 조성물.
- 제 24 항 내지 제 26 항 중 어느 한 항에 있어서, 상기 미용 조성물은 또한 하나 이상의 미용상 허용가능한 부형제를 함유하는 것을 특징으로 하는 미용 조성물.
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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FR0000577A FR2803749B1 (fr) | 2000-01-18 | 2000-01-18 | Utilisation d'au moins un ester gras pour la preparation d'une composition destinee a inhiber l'activite de la 5 alpha-reductase, en pharmacie notamment en dermatologie, en cosmetique et en tant qu'additif alimentaire |
FR00/00577 | 2000-01-18 |
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KR20020087394A KR20020087394A (ko) | 2002-11-22 |
KR100763728B1 true KR100763728B1 (ko) | 2007-10-04 |
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KR1020027009245A KR100763728B1 (ko) | 2000-01-18 | 2001-01-18 | 5알파 리덕타아제 활성을 억제하도록 디자인된 조성물을제조하기 위한 약리학, 특히 피부 의학, 화장품에있어서의 하나 이상의 지방 에스테르의 용도 및 식품첨가제로서의 이의 용도 |
Country Status (12)
Country | Link |
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US (1) | US8318186B2 (ko) |
EP (1) | EP1248610B1 (ko) |
JP (1) | JP4948732B2 (ko) |
KR (1) | KR100763728B1 (ko) |
AT (1) | ATE297725T1 (ko) |
AU (1) | AU782758B2 (ko) |
CA (1) | CA2397987C (ko) |
DE (1) | DE60111489T2 (ko) |
ES (1) | ES2240414T3 (ko) |
FR (1) | FR2803749B1 (ko) |
MX (1) | MXPA02006986A (ko) |
WO (1) | WO2001052837A2 (ko) |
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FR2839516B1 (fr) * | 2002-05-13 | 2006-08-04 | Pierre Bruno Grascha | Formulation de detergent d'atelier |
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ITMI20030210A1 (it) * | 2003-02-07 | 2004-08-08 | Res & Innovation Soc Coop A R L | Composti endocannabinoido-simili e loro impiego |
AU2003298241A1 (en) * | 2003-02-19 | 2004-09-09 | Unilever Plc | Topical composition containing alkyl gallate or alkyl hydroxybenzoate or phenol alkyloxy as agent against acne |
EP1604639B1 (en) * | 2004-04-30 | 2012-05-09 | Kao Germany GmbH | Anti-fat composition for hair and scalp |
EP1604640B1 (en) * | 2004-04-30 | 2012-03-07 | KPSS-Kao Professional Salon Services GmbH | Treatment composition for hair and scalp |
US7686803B2 (en) * | 2004-05-14 | 2010-03-30 | Cardima, Inc. | Ablation probe with stabilizing member |
DE102004036237A1 (de) * | 2004-07-26 | 2006-03-23 | Dako Ag | Holzschutzmittel mit Fettsäureestern |
US7776033B2 (en) * | 2005-01-08 | 2010-08-17 | Boston Scientific Scimed, Inc. | Wettable structures including conductive fibers and apparatus including the same |
US7862561B2 (en) * | 2005-01-08 | 2011-01-04 | Boston Scientific Scimed, Inc. | Clamp based lesion formation apparatus with variable spacing structures |
ITMI20060392A1 (it) * | 2006-03-03 | 2007-09-04 | Schiapparelli Pikenz S P A | Composizione cosmetica |
WO2007101357A2 (de) * | 2006-03-07 | 2007-09-13 | Pelloni, Claudio | Haarwuchsmittel zur behandlung von menschlichen keratinfasern und verfahren zu dessen herstellung |
US20090285876A1 (en) * | 2008-05-14 | 2009-11-19 | Hein Arthur J | Natural butters reconstituted by transesterification with glycerin and its use in cosmetics applications |
EP2158906A1 (en) | 2008-08-28 | 2010-03-03 | ProxiPHARM GmbH | Composition for the treatment of alopecia |
IT1391663B1 (it) | 2008-11-10 | 2012-01-17 | Giuliani Spa | Uso di composti atti ad inibire l' attivita' dell'enzima 5alfa-reduttasi e composizioni farmaceutiche e cosmetiche che li contengono |
EP2215913A1 (en) | 2009-01-23 | 2010-08-11 | Nutreco Nederland B.V. | Animal feed additive and animal feed comprising alkyl esters of medium chain fatty acids, and their use in animal feed |
FR2948566B1 (fr) | 2009-07-30 | 2012-08-10 | Expanscience Lab | Extrait du fruit de schizandra sphenanthera et compositions cosmetiques, dermatologiques et nutraceutiques le comprenant |
FR2953136B1 (fr) | 2009-11-30 | 2012-05-11 | Expanscience Lab | Extrait de graines de vigna unguiculata et compositions cosmetiques, pharmaceutiques, dermatologiques, nutraceutiques ou alimentaires le comprenant |
FR2953135B1 (fr) | 2009-11-30 | 2012-05-11 | Expanscience Lab | Extrait de graines d'acacia macrostachya et compositions cosmetiques, pharmaceutiques, dermatologiques, nutraceutiques ou alimentaires le comprenant |
FR2953722B1 (fr) * | 2009-12-16 | 2012-03-09 | Expanscience Lab | Composition comprenant au moins un sucre en c7 pour le traitement de l'alopecie, pour le traitement cosmetique des phaneres, et pour le soin des cheveux, cils ou ongles |
FR2969496B1 (fr) | 2010-12-22 | 2013-11-08 | Expanscience Lab | Extrait de pulpe et/ou de peau d'avocat riche en polyphenols et compositions cosmetiques, dermatologiques et nutraceutiques le comprenant |
FR2969495B1 (fr) | 2010-12-22 | 2013-10-11 | Expanscience Lab | Extrait de parties aeriennes de maca riche en polyphenols et composition le comprenant |
FR2975004B1 (fr) | 2011-05-13 | 2013-06-28 | Expanscience Lab | Nouvel actif anti-rougeurs et compositions cosmetiques le comprenant |
FR2999429B1 (fr) | 2012-12-18 | 2015-01-02 | Expanscience Lab | Extrait de graines de passiflore et compositions cosmetiques, pharmaceutiques, dermatologiques ou nutraceutiques le comprenant |
FR3001889B1 (fr) | 2013-02-11 | 2021-02-12 | Expanscience Lab | Utilisation d'une composition comprenant un perseose d'avocat dans la protection des cellules souches epidermiques . |
EP2962732A4 (en) * | 2013-02-28 | 2016-07-27 | Martínez Leonardo Jimeno | TOPICAL USE PRODUCT FOR SCALP, AND METHOD OF MAKING SAME |
FR3010906B1 (fr) | 2013-09-25 | 2016-12-23 | Expanscience Lab | Extrait lipidique de graines de passiflores |
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DE4134137A1 (de) * | 1991-10-16 | 1993-04-22 | Scharfe Peter Michael | Haarboden-bioaktivlotion und verfahren zu ihrer herstellung |
WO1999022728A1 (en) * | 1997-10-31 | 1999-05-14 | Arch Development Corporation | Methods and compositions for regulation of 5-alpha reductase activity |
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JPH01110610A (ja) * | 1987-10-22 | 1989-04-27 | Lion Corp | ニキビ予防剤 |
JPH0266516A (ja) | 1988-09-01 | 1990-03-06 | Sumitomo Bakelite Co Ltd | 液晶表示素子 |
US5059443A (en) * | 1989-08-30 | 1991-10-22 | The Procter & Gamble Co. | Esterified ethoxylated alkyl glycosides useful in low calorie fat-containing food compositions |
JPH04228050A (ja) * | 1990-06-29 | 1992-08-18 | Nippon Oil & Fats Co Ltd | 高級脂肪アルコール含有水溶性組成物及びその製造方法 |
JP2894805B2 (ja) * | 1990-07-02 | 1999-05-24 | ライオン株式会社 | 液体頭髪化粧料 |
JP2932642B2 (ja) * | 1990-08-28 | 1999-08-09 | ライオン株式会社 | 細胞賦活剤組成物 |
JP3253982B2 (ja) * | 1991-03-13 | 2002-02-04 | ピアス株式会社 | にきび用化粧料 |
US5605929A (en) * | 1992-05-27 | 1997-02-25 | Arch Development Corp. | Methods and compositions for inhibiting 5α-reductase activity |
US5422371A (en) * | 1992-05-27 | 1995-06-06 | Arch Development Corp. | Methods and compositions for inhibiting 5α-reductase activity |
US6365558B2 (en) * | 1995-06-07 | 2002-04-02 | The Lubrizol Corporation | Vegetable oils containing styrene/butadiene copolymers in combination with additional commercial polymers that have good low temperature and high temperature viscometrics |
GB9620248D0 (en) * | 1996-09-26 | 1996-11-13 | Scotia Holdings Plc | Esters of unsaturated fatty acids |
AUPO690297A0 (en) * | 1997-05-20 | 1997-06-12 | Kahale, Laura | Prevention/retardation of hair growth |
DE19735518C1 (de) * | 1997-08-16 | 1999-03-11 | Friedrun Geier | Abspülbare Emulsionen zur Verwendung als talglösende Zubereitungen |
PT979605E (pt) * | 1998-08-07 | 2003-06-30 | Pfizer Prod Inc | Coleira contendo uma nova formulacao de gel para controlar a infestacao artropode de animais |
US6127560A (en) * | 1998-12-29 | 2000-10-03 | West Central Cooperative | Method for preparing a lower alkyl ester product from vegetable oil |
US5972345A (en) * | 1999-05-03 | 1999-10-26 | Chizick; Stephen | Natural preparation for treatment of male pattern hair loss |
US6642274B1 (en) * | 1999-09-09 | 2003-11-04 | Gary W. Neal | Methods and compositions for preventing and treating prostate disorders |
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2000
- 2000-01-18 FR FR0000577A patent/FR2803749B1/fr not_active Expired - Lifetime
-
2001
- 2001-01-18 WO PCT/FR2001/000168 patent/WO2001052837A2/fr not_active Application Discontinuation
- 2001-01-18 ES ES01907633T patent/ES2240414T3/es not_active Expired - Lifetime
- 2001-01-18 AT AT01907633T patent/ATE297725T1/de not_active IP Right Cessation
- 2001-01-18 JP JP2001552885A patent/JP4948732B2/ja not_active Expired - Lifetime
- 2001-01-18 KR KR1020027009245A patent/KR100763728B1/ko active IP Right Grant
- 2001-01-18 EP EP01907633A patent/EP1248610B1/fr not_active Expired - Lifetime
- 2001-01-18 US US10/181,370 patent/US8318186B2/en not_active Expired - Lifetime
- 2001-01-18 DE DE60111489T patent/DE60111489T2/de not_active Expired - Lifetime
- 2001-01-18 MX MXPA02006986A patent/MXPA02006986A/es active IP Right Grant
- 2001-01-18 AU AU35549/01A patent/AU782758B2/en not_active Ceased
- 2001-01-18 CA CA2397987A patent/CA2397987C/fr not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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DE4134137A1 (de) * | 1991-10-16 | 1993-04-22 | Scharfe Peter Michael | Haarboden-bioaktivlotion und verfahren zu ihrer herstellung |
WO1999022728A1 (en) * | 1997-10-31 | 1999-05-14 | Arch Development Corporation | Methods and compositions for regulation of 5-alpha reductase activity |
Also Published As
Publication number | Publication date |
---|---|
WO2001052837A3 (fr) | 2002-06-20 |
JP4948732B2 (ja) | 2012-06-06 |
MXPA02006986A (es) | 2002-12-13 |
DE60111489D1 (de) | 2005-07-21 |
DE60111489T2 (de) | 2006-05-11 |
CA2397987C (fr) | 2013-05-21 |
US8318186B2 (en) | 2012-11-27 |
JP2003520229A (ja) | 2003-07-02 |
FR2803749B1 (fr) | 2006-09-22 |
ES2240414T3 (es) | 2005-10-16 |
EP1248610A2 (fr) | 2002-10-16 |
EP1248610B1 (fr) | 2005-06-15 |
AU782758B2 (en) | 2005-08-25 |
ATE297725T1 (de) | 2005-07-15 |
CA2397987A1 (fr) | 2001-07-26 |
AU3554901A (en) | 2001-07-31 |
FR2803749A1 (fr) | 2001-07-20 |
WO2001052837A2 (fr) | 2001-07-26 |
US20030129268A1 (en) | 2003-07-10 |
KR20020087394A (ko) | 2002-11-22 |
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