JP4979686B2 - 注入デバイス - Google Patents
注入デバイス Download PDFInfo
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- JP4979686B2 JP4979686B2 JP2008508200A JP2008508200A JP4979686B2 JP 4979686 B2 JP4979686 B2 JP 4979686B2 JP 2008508200 A JP2008508200 A JP 2008508200A JP 2008508200 A JP2008508200 A JP 2008508200A JP 4979686 B2 JP4979686 B2 JP 4979686B2
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- piston rod
- housing
- dose
- screw
- dose setting
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- Expired - Fee Related
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31556—Accuracy improving means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31556—Accuracy improving means
- A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
欧州特許第327910号には、上述のような投与量設定及び注入の仕組みを用いたほぼ標準的なペン型注射器が開示されている。
米国特許第6663602号明細書に開示されている注入デバイスは、投与量送出時にナットの回転が固定される投与量設定及び注入機構を備える。しかし、本発明によれば、ナットは投与量送出時にもハウジングに対して回転することができる。
a.近位端と遠位端とを備える投与量設定及び注入機構のためのハウジングと、
b.回転自在の投与量設定部材と、
c.第1ねじを備える、軸方向に移動可能なピストンロッドと追加の縦方向に延びるトラックと、
d.前記ピストンロッドの追加の縦方向に延びるトラックと係合し、よってピストンロッドが軸方向に平行移動するときにピストンロッドの角度方向の動きを誘導するハウジング内の中央開口部と、
e.投与量設定時に回転自在に投与量設定部材に固定される、前記ピストンロッドの第1ねじと係合するねじ込みナットと、
f.第1位置から第2位置へ軸方向に移動可能な結合部材を備える回転結合機構であって、投与量設定時には、前記結合部材に対する前記ナットの回転運動を可能にし、注入時には同回転運動を防止する回転結合機構と
を備える。前記結合部材がハウジングに回転可能に結合されることにより、少なくとも前記第1位置から前記第2位置への軸方向移動の一部分において、ハウジングに対する結合部材の軸方向移動に応じて、結合部材が強制的に回転させられる。
後述では、図面を参照しながら更に詳細に本発明を説明する。
Claims (10)
- 注入デバイスであって、
a.投与量設定及び注入機構のための、近位端と遠位端を有するハウジング(1、101)と、
b.回転自在の投与量設定部材(17、117)と、
c.第1ねじ(4a、104a)を有する軸方向に移動可能なピストンロッド(4、104)と追加の縦方向に延びるトラック(4b、104b)と、
d.前記ピストンロッド(4、104)の追加の縦方向に延びるトラック(4b、104b)と係合し、よってピストンロッド(4、104)が軸方向に平行移動するときに、ピストンロッド(4、104)の角度方向の動きを誘導する、ハウジング内の中央開口部(2b、102b)と、
e.前記ピストンロッド(4、104)の第1ねじ(4a、104a)と係合する、ねじ山を有するナット(13、113)であって、投与量設定時に回転自在に投与量設定部材(17、117)に固定されるナットと
f.第1位置から第2位置へ軸方向に移動可能な結合部材(25、125)を有する回転結合機構(24、124、25、125、26、126、27、127)であって、投与量設定時には前記結合部材(25)に対する前記ナット(13、113)の角度方向の運動を可能にし、注入時には前記ナット(13、113)と前記結合部材(25、125)の間の角度方向の動きを防止する回転結合機構と
を備え、
前記結合部材(25、125)が、角度を変更可能にハウジング(1、101)に結合されていることにより、前記ハウジング(1、101)に対して軸方向に移動すると、少なくとも前記第1位置から前記第2位置への軸方向移動の一部分において、それに応じて角度方向に強制的に動かされることを特徴とする注入デバイス。 - 前記投与量設定部材(17、117)が、ハウジング(1、101)に対する回転の結果、軸方向に移動可能であること、及び前記結合部材(25、125)が投与量設定部材(17、117)に結合していることにより、投与量設定部材(17、117)の軸方向移動が結合部材(25、125)の軸方向移動にほぼ対応することを特徴とする、請求項1に記載の注入デバイス。
- 前記結合部材(25、125)がねじ(28、128)を有し、前記ハウジング(1、101)に設けられた螺旋ねじ(37、137)と螺合し、前記ハウジングの螺旋ねじ(37、137)が一定のピッチを有することを特徴とする、請求項1又は2に記載の注入デバイス。
- 前記結合部材(25、125)が、前記ハウジング(1、101)に設けられた縦方向に延びるトラック(37、137)と対になり係合する突起(28、128)を有し、縦方向に延びるトラック(37、137)が、トラックの延長部に沿って可変のピッチを有することを特徴とする、請求項1又は2に記載の注入デバイス。
- 前記回転結合機構(24、25、26、27、28)が、投与量設定時に、投与量の容積に応じて増分クリックを提供する増分フィードバック機構を含むことを特徴とする、請求項1ないし4のいずれか1項に記載の注入デバイス。
- 更に、注入ボタン(19、119)、及び注入ボタン(19、119)の軸方向運動とナット(13、113)の軸方向運動を結合させるギアボックスアセンブリ(9、109)を備えることを特徴とする、請求項1ないし5のいずれか1項に記載の注入デバイス。
- 前記ギアボックスアセンブリ(9、109)が、注入時に、注入ボタン(19、119)によって動かされる距離より短い距離だけナット(13、113)を遠位方向に移動させるような伝動を行うことを特徴とする、請求項6に記載の注入デバイス。
- 前記ピストンロッド(4、104)上の追加の縦方向に延びるトラック(4b、104b)がらせん状に設けられて、前記ピストンロッド(4、104)上の第2ねじを形成していることを特徴とする、請求項1ないし7のいずれか1項に記載の注入デバイス。
- 前記ピストンロッド(4、104)上の第1ねじ(4a、104a)と縦方向に延びるトラック(4b、104b)とは、前記ピストンロッド(4、104)の互いに反対側の端部に設けられていることを特徴とする、請求項8に記載の注入デバイス。
- 前記結合部材(25)がねじ(28、128)を有し、ハウジング(1)に設けられた螺旋ねじ(37、137)と螺合し、ハウジング(1)の螺旋ねじ(37、137)が、ピストンロッド(4、104)上の追加の縦方向に延びるトラック(4b、104b)のピッチとほぼ対応する一定のピッチを有することを特徴とする、請求項8又は9に記載の注入デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200500589 | 2005-04-24 | ||
DKPA200500589 | 2005-04-24 | ||
PCT/EP2006/061748 WO2006114396A1 (en) | 2005-04-24 | 2006-04-21 | Injection device |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008538719A JP2008538719A (ja) | 2008-11-06 |
JP4979686B2 true JP4979686B2 (ja) | 2012-07-18 |
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ID=36685844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2008508200A Expired - Fee Related JP4979686B2 (ja) | 2005-04-24 | 2006-04-21 | 注入デバイス |
Country Status (5)
Country | Link |
---|---|
US (3) | US20090043264A1 (ja) |
EP (1) | EP1877121B1 (ja) |
JP (1) | JP4979686B2 (ja) |
CN (1) | CN101163514B (ja) |
WO (1) | WO2006114396A1 (ja) |
Cited By (13)
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US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
US9180259B2 (en) | 2005-01-24 | 2015-11-10 | Antares Pharma, Inc. | Prefilled syringe jet injector |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US9333309B2 (en) | 2002-02-11 | 2016-05-10 | Antares Pharma, Inc. | Intradermal injector |
US9364611B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9446195B2 (en) | 2011-07-15 | 2016-09-20 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9486583B2 (en) | 2012-03-06 | 2016-11-08 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
US9561333B2 (en) | 2008-08-05 | 2017-02-07 | Antares Pharma, Inc. | Multiple dosage injector |
US9707354B2 (en) | 2013-03-11 | 2017-07-18 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
US9744302B2 (en) | 2013-02-11 | 2017-08-29 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9808582B2 (en) | 2006-05-03 | 2017-11-07 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9867949B2 (en) | 2008-03-10 | 2018-01-16 | Antares Pharma, Inc. | Injector safety device |
US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6663602B2 (en) * | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
WO2006045526A1 (en) | 2004-10-21 | 2006-05-04 | Novo Nordisk A/S | Dial-down mechanism for wind-up pen |
JP4979686B2 (ja) * | 2005-04-24 | 2012-07-18 | ノボ・ノルデイスク・エー/エス | 注入デバイス |
DE102005023824A1 (de) * | 2005-05-24 | 2006-12-07 | Tecpharma Licensing Ag | Dosiervorrichtung für eine Injektionsvorrichtung |
US8361036B2 (en) * | 2006-03-10 | 2013-01-29 | Novo Nordisk A/S | Injection device having a gearing arrangement |
WO2007104636A1 (en) * | 2006-03-10 | 2007-09-20 | Novo Nordisk A/S | An injection device and a method of changing a cartridge in the device |
EP2019701B1 (en) * | 2006-05-16 | 2010-02-24 | Novo Nordisk A/S | A gearing mechanism for an injection device |
ES2389866T3 (es) * | 2006-05-18 | 2012-11-02 | Novo Nordisk A/S | Dispositivo de inyección con medio de bloqueo de modo |
DE102006038101A1 (de) * | 2006-08-14 | 2008-02-21 | Tecpharma Licensing Ag | Injektionsvorrichtung mit Klauensicherung |
EP2091598B1 (en) * | 2006-12-15 | 2012-07-11 | Novo Nordisk A/S | A medical delivery system comprising a container and a dosing assembly with radially moving fastening means |
CN101600468B (zh) * | 2006-12-21 | 2012-12-12 | 诺沃-诺迪斯克有限公司 | 注射器装置 |
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2006
- 2006-04-21 JP JP2008508200A patent/JP4979686B2/ja not_active Expired - Fee Related
- 2006-04-21 CN CN2006800138180A patent/CN101163514B/zh not_active Expired - Fee Related
- 2006-04-21 US US11/911,871 patent/US20090043264A1/en not_active Abandoned
- 2006-04-21 WO PCT/EP2006/061748 patent/WO2006114396A1/en active Application Filing
- 2006-04-21 EP EP06743375.5A patent/EP1877121B1/en not_active Not-in-force
-
2009
- 2009-10-01 US US12/571,721 patent/US8197450B2/en not_active Expired - Fee Related
-
2012
- 2012-02-28 US US13/407,430 patent/US8641683B2/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
EP1877121A1 (en) | 2008-01-16 |
US20090043264A1 (en) | 2009-02-12 |
US8641683B2 (en) | 2014-02-04 |
CN101163514A (zh) | 2008-04-16 |
EP1877121B1 (en) | 2015-09-23 |
US20100016806A1 (en) | 2010-01-21 |
CN101163514B (zh) | 2012-01-25 |
WO2006114396A1 (en) | 2006-11-02 |
US20120157932A1 (en) | 2012-06-21 |
US8197450B2 (en) | 2012-06-12 |
JP2008538719A (ja) | 2008-11-06 |
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