JP4852540B2 - Parp阻害剤としてのフタラジン誘導体 - Google Patents
Parp阻害剤としてのフタラジン誘導体 Download PDFInfo
- Publication number
- JP4852540B2 JP4852540B2 JP2007518607A JP2007518607A JP4852540B2 JP 4852540 B2 JP4852540 B2 JP 4852540B2 JP 2007518607 A JP2007518607 A JP 2007518607A JP 2007518607 A JP2007518607 A JP 2007518607A JP 4852540 B2 JP4852540 B2 JP 4852540B2
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- JP
- Japan
- Prior art keywords
- compound
- alkyl
- hydrogen
- alkanediyl
- parp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 CCOC(N(CCC1(CC1)C1)[C@@]1(C1)[C@]1c1ccccc1)=* Chemical compound CCOC(N(CCC1(CC1)C1)[C@@]1(C1)[C@]1c1ccccc1)=* 0.000 description 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04076886.3 | 2004-06-30 | ||
EP04076886 | 2004-06-30 | ||
PCT/EP2005/053030 WO2006003147A1 (en) | 2004-06-30 | 2005-06-28 | Phthalazine derivatives as parp inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008504348A JP2008504348A (ja) | 2008-02-14 |
JP4852540B2 true JP4852540B2 (ja) | 2012-01-11 |
Family
ID=34977026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007518607A Expired - Fee Related JP4852540B2 (ja) | 2004-06-30 | 2005-06-28 | Parp阻害剤としてのフタラジン誘導体 |
Country Status (22)
Country | Link |
---|---|
US (3) | US7803795B2 (no) |
EP (1) | EP1771175B1 (no) |
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