FR2891828B1 - Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique - Google Patents

Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique

Info

Publication number
FR2891828B1
FR2891828B1 FR0510408A FR0510408A FR2891828B1 FR 2891828 B1 FR2891828 B1 FR 2891828B1 FR 0510408 A FR0510408 A FR 0510408A FR 0510408 A FR0510408 A FR 0510408A FR 2891828 B1 FR2891828 B1 FR 2891828B1
Authority
FR
France
Prior art keywords
phtalazine
derivatives
amino
substituted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0510408A
Other languages
English (en)
Other versions
FR2891828A1 (fr
Inventor
Jean Michel Augereau
Gilles Courtemanche
Michel Geslin
Laurence Serva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0510408A priority Critical patent/FR2891828B1/fr
Priority to PE2006001223A priority patent/PE20070550A1/es
Priority to JP2008535059A priority patent/JP2009511552A/ja
Priority to PCT/FR2006/002271 priority patent/WO2007042660A2/fr
Priority to EP06820177A priority patent/EP1940823A2/fr
Priority to GT200600455A priority patent/GT200600455A/es
Priority to ARP060104456A priority patent/AR057980A1/es
Priority to TW095137577A priority patent/TW200800208A/zh
Priority to DO2006000217A priority patent/DOP2006000217A/es
Publication of FR2891828A1 publication Critical patent/FR2891828A1/fr
Application granted granted Critical
Publication of FR2891828B1 publication Critical patent/FR2891828B1/fr
Priority to US12/098,635 priority patent/US20090124624A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
FR0510408A 2005-10-12 2005-10-12 Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique Expired - Fee Related FR2891828B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR0510408A FR2891828B1 (fr) 2005-10-12 2005-10-12 Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique
PE2006001223A PE20070550A1 (es) 2005-10-12 2006-10-06 Derivados de la 1-amino-ftalazina sustituida afines al receptor mch1 y su preparacion
PCT/FR2006/002271 WO2007042660A2 (fr) 2005-10-12 2006-10-10 Dérivés de la 1-amino-phtalazine substituee, leur préparation et leur application en thérapeutique
EP06820177A EP1940823A2 (fr) 2005-10-12 2006-10-10 Dérivés de la 1-amino-phtalazine substituee, leur préparation et leur application en thérapeutique
JP2008535059A JP2009511552A (ja) 2005-10-12 2006-10-10 置換１−アミノ−フタラジン誘導体、これらの調製およびこれらの治療的使用
ARP060104456A AR057980A1 (es) 2005-10-12 2006-10-11 Derivados de la 1- amino-ftalazina sustituida, su preparacion y composicion farmaceutica
GT200600455A GT200600455A (es) 2005-10-12 2006-10-11 Derivados de la 1-amino-ftalazina sustituida, su preparación y su aplicación en terapéutica
TW095137577A TW200800208A (en) 2005-10-12 2006-10-12 1-Aminophthalazine derivatives, preparation thereof and therapeutic application thereof
DO2006000217A DOP2006000217A (es) 2005-10-12 2006-10-12 Derivados de la 1-amino-ftalazina sustituida, su preparación y su aplicación en terapéutica
US12/098,635 US20090124624A1 (en) 2005-10-12 2008-04-07 Substituted 1-aminophthalazine derivatives, preparation thereof and therapeutic application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0510408A FR2891828B1 (fr) 2005-10-12 2005-10-12 Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2891828A1 FR2891828A1 (fr) 2007-04-13
FR2891828B1 true FR2891828B1 (fr) 2007-12-21

Family

ID=36623451

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0510408A Expired - Fee Related FR2891828B1 (fr) 2005-10-12 2005-10-12 Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique

Country Status (10)

Country Link
US (1) US20090124624A1 (fr)
EP (1) EP1940823A2 (fr)
JP (1) JP2009511552A (fr)
AR (1) AR057980A1 (fr)
DO (1) DOP2006000217A (fr)
FR (1) FR2891828B1 (fr)
GT (1) GT200600455A (fr)
PE (1) PE20070550A1 (fr)
TW (1) TW200800208A (fr)
WO (1) WO2007042660A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090099175A1 (en) * 2006-03-01 2009-04-16 Arrington Mark P Phosphodiesterase 10 inhibitors
CA2666193A1 (fr) 2006-08-08 2008-02-14 Sanofi-Aventis Imidazolidin-2,4-dione arylaminoaryl-alkyl-substituee, son procede de fabrication, medicament contenant ce compose et son utilisation
WO2010003624A2 (fr) 2008-07-09 2010-01-14 Sanofi-Aventis Composés hétérocycliques, leurs procédés de préparation, médicaments comprenant lesdits composés et leur utilisation
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
DK2470552T3 (en) 2009-08-26 2014-02-17 Sanofi Sa NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683705B1 (fr) 2011-03-08 2015-04-22 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
EP2683699B1 (fr) 2011-03-08 2015-06-24 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2016123796A1 (fr) * 2015-02-06 2016-08-11 Abbvie Inc. Phtalazines substituées
CN115433163A (zh) * 2021-06-05 2022-12-06 药捷安康(南京)科技股份有限公司 Nlrp3炎症小体抑制剂及其应用
CN115417856A (zh) * 2021-09-30 2022-12-02 成都奥睿药业有限公司 一类取代杂芳酞嗪衍生物的药学用途及其制备方法
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001226269A (ja) * 2000-02-18 2001-08-21 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
WO2003070244A1 (fr) * 2002-02-22 2003-08-28 Abbott Laboratories Antagoniste des effets d'une hormone de concentration de melanine et son utilisation
WO2003106452A2 (fr) * 2002-06-12 2003-12-24 Millennium Pharmaceuticals, Inc. Antagonistes du recepteur de l'hormone de melano-concentration
US20060111357A1 (en) * 2002-12-11 2006-05-25 Frimurer Thomas M Quinoline compounds for use in mch receptor related disorders
US7605176B2 (en) * 2004-03-06 2009-10-20 Boehringer Ingelheim International Gmbh β-ketoamide compounds with MCH antagonistic activity
FR2868780B1 (fr) * 2004-04-13 2008-10-17 Sanofi Synthelabo Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique
CN1980674B (zh) * 2004-06-30 2011-05-25 詹森药业有限公司 作为parp抑制剂的2,3-二氮杂萘衍生物

Also Published As

Publication number Publication date
US20090124624A1 (en) 2009-05-14
PE20070550A1 (es) 2007-06-19
EP1940823A2 (fr) 2008-07-09
DOP2006000217A (es) 2007-05-15
FR2891828A1 (fr) 2007-04-13
WO2007042660A2 (fr) 2007-04-19
JP2009511552A (ja) 2009-03-19
WO2007042660A3 (fr) 2007-05-31
TW200800208A (en) 2008-01-01
AR057980A1 (es) 2008-01-09
GT200600455A (es) 2007-05-28

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Effective date: 20090630