FR2436781A1 - Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique - Google Patents

Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique

Info

Publication number
FR2436781A1
FR2436781A1 FR7826809A FR7826809A FR2436781A1 FR 2436781 A1 FR2436781 A1 FR 2436781A1 FR 7826809 A FR7826809 A FR 7826809A FR 7826809 A FR7826809 A FR 7826809A FR 2436781 A1 FR2436781 A1 FR 2436781A1
Authority
FR
France
Prior art keywords
amino
anxiolytics
quinazoline
cpds
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826809A
Other languages
English (en)
Other versions
FR2436781B1 (fr
Inventor
Rene Baronnet
Raymond Callendret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BERRI BALZAC
Original Assignee
BERRI BALZAC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BERRI BALZAC filed Critical BERRI BALZAC
Priority to FR7826809A priority Critical patent/FR2436781A1/fr
Publication of FR2436781A1 publication Critical patent/FR2436781A1/fr
Application granted granted Critical
Publication of FR2436781B1 publication Critical patent/FR2436781B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues

Abstract

L'INVENTION A POUR OBJET DES COMPOSES DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R ET R REPRESENTENT CHACUN, INDEPENDAMMENT L'UN DE L'AUTRE, UN ATOME D'HYDROGENE, UN GROUPE ALKYLE EN C A C OU UN GROUPE ACYLE ALIPHATIQUE OU AROMATIQUE, OU BIEN R ET R FORMENT ENSEMBLE ET AVEC L'ATOME D'AZOTE AUQUEL ILS SONT FIXES UN HETEROCYCLE A 5OU 6CHAINONS POUVANT PORTER UN AUTRE HETERO-ATOME; R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE ALKYLE EN C A C; ET R ET R REPRESENTENT CHACUN UN ATOME D'HYDROGENE OU D'HALOGENE, UN GROUPE ALKYLE EN C A C OU UN GROUPE ALCOXY EN C A C; LA FORME TAUTOMERE DE TYPE AMINO-3 HYDROXY-2 3H-QUINAZOLINONE-4 DES COMPOSES DE FORMULE I DANS LESQUELS R EST L'HYDROGENE; ET LES SELS D'ADDITION AVEC DES ACIDES DES COMPOSES CI-DESSUS. CES NOUVEAUX COMPOSES ONT UNE ACTIVITE ANXIOLYTIQUE ET DIURETIQUE.
FR7826809A 1978-09-19 1978-09-19 Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique Granted FR2436781A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7826809A FR2436781A1 (fr) 1978-09-19 1978-09-19 Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7826809A FR2436781A1 (fr) 1978-09-19 1978-09-19 Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique

Publications (2)

Publication Number Publication Date
FR2436781A1 true FR2436781A1 (fr) 1980-04-18
FR2436781B1 FR2436781B1 (fr) 1981-12-18

Family

ID=9212765

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826809A Granted FR2436781A1 (fr) 1978-09-19 1978-09-19 Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique

Country Status (1)

Country Link
FR (1) FR2436781A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370686A2 (fr) * 1988-11-23 1990-05-30 Pfizer Inc. Procédé pour la préparation d'intermédiares d'acide quinolone carboxylique
EP0781767A1 (fr) * 1995-12-26 1997-07-02 Sumitomo Chemical Company, Limited Procédé de préparation d'anhydrides isatoiques
US20100113774A1 (en) * 2007-03-06 2010-05-06 Roger John Taylor Bicyclic organic compounds suitable for the treatment of inflammatory or allergic conditions
US8080557B2 (en) * 2004-06-30 2011-12-20 Janssen Pharmaceutica, Nv Quinazolinedione derivatives as PARP inhibitors
US8168644B2 (en) 2008-03-27 2012-05-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
US8450486B2 (en) 2003-11-20 2013-05-28 Janssen Pharmaceutica, Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US8524714B2 (en) 2003-11-20 2013-09-03 Janssen Pharmaceutica, Nv 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US8623872B2 (en) 2004-06-30 2014-01-07 Janssen Pharmaceutica, Nv Quinazolinone derivatives as PARP inhibitors
US8889866B2 (en) 2008-03-27 2014-11-18 Janssen Pharmaceutica, Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
US8946221B2 (en) 2004-06-30 2015-02-03 Janssen Pharmaceutica, Nv Phthalazine derivatives as PARP inhibitors

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370686A2 (fr) * 1988-11-23 1990-05-30 Pfizer Inc. Procédé pour la préparation d'intermédiares d'acide quinolone carboxylique
EP0370686A3 (en) * 1988-11-23 1990-12-12 Pfizer Inc. A process for preparing quinolone carboxylic acid intermediates
EP0781767A1 (fr) * 1995-12-26 1997-07-02 Sumitomo Chemical Company, Limited Procédé de préparation d'anhydrides isatoiques
US5795984A (en) * 1995-12-26 1998-08-18 Sumitomo Chemical Company Limited Process for producing isatoic anhydrides
US5973145A (en) * 1995-12-26 1999-10-26 Sumitomo Chemical Company, Limited Process for producing isatoic anhydrides
US5981749A (en) * 1995-12-26 1999-11-09 Sumitomo Chemical Company Limited Process for producing isatoic anhydrides
US8524714B2 (en) 2003-11-20 2013-09-03 Janssen Pharmaceutica, Nv 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US8450486B2 (en) 2003-11-20 2013-05-28 Janssen Pharmaceutica, Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US8080557B2 (en) * 2004-06-30 2011-12-20 Janssen Pharmaceutica, Nv Quinazolinedione derivatives as PARP inhibitors
US10150757B2 (en) 2004-06-30 2018-12-11 Janssen Pharmaceutica Nv Quinazolinone derivatives as PARP inhibitors
US9522905B2 (en) 2004-06-30 2016-12-20 Janssen Pharmaceutica Nv Quinazolinone derivatives as PARP inhibitors
US9255080B2 (en) 2004-06-30 2016-02-09 Janssen Pharmaceutica Nv Quinazolinedione derivatives as PARP inhibitors
US8946221B2 (en) 2004-06-30 2015-02-03 Janssen Pharmaceutica, Nv Phthalazine derivatives as PARP inhibitors
US8623872B2 (en) 2004-06-30 2014-01-07 Janssen Pharmaceutica, Nv Quinazolinone derivatives as PARP inhibitors
US8633211B2 (en) * 2007-03-06 2014-01-21 Novartis Ag Bicyclic organic compounds suitable for the treatment of inflammatory or allergic conditions
US20100113774A1 (en) * 2007-03-06 2010-05-06 Roger John Taylor Bicyclic organic compounds suitable for the treatment of inflammatory or allergic conditions
US8778966B2 (en) 2007-03-08 2014-07-15 Janssen Pharmaceutica, Nv Quinolinone derivatives as PARP and tank inhibitors
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
US8889866B2 (en) 2008-03-27 2014-11-18 Janssen Pharmaceutica, Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
US9150540B2 (en) 2008-03-27 2015-10-06 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
US9598396B2 (en) 2008-03-27 2017-03-21 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
US8168644B2 (en) 2008-03-27 2012-05-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors

Also Published As

Publication number Publication date
FR2436781B1 (fr) 1981-12-18

Similar Documents

Publication Publication Date Title
FR2436781A1 (fr) Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique
ES8700252A1 (es) Procedimiento para preparar nuevos compuestos indolicos
ES8305334A1 (es) Derivados de carbostirilo y sus sales.
ES517331A0 (es) Procedimiento para preparar derivados de piridazinona.
ES476658A1 (es) Procedimiento para preparar derivados de sulfonamido-piridi-na
ES347430A1 (es) Procedimiento para la obtencion de derivados de benzoxazi- na.
GB1492528A (en) Pyrazinyl piperazine derivatives
IT1133066B (it) Derivati di & ammino 1h 3h chinazolin 2 4 dione procedimenti per la loro preparazione e loro applicazioni terapeutiche
GB1176672A (en) Piperazine Derivatives
ES8407058A1 (es) Procedimiento para la preparacion de un nuevo derivado del 1h, 3h-pirrolo(1,2-c)tiazol
ES488901A1 (es) Procedimiento de preparacion de nuevos derivados de benzoil-2 glicilanilidas substituidas
ES335648A1 (es) Procedimiento para la obtencion de compuestos bencimidazolicos.
ES439181A1 (es) Un procedimiento para la preparacion de nuevas xantonas.
ES419019A1 (es) Procedimiento para la preparacion de compuestos polici- clicos.
ES421092A1 (es) Procedimiento para la preparacion de nuevas 6-azabenzo-1,5-diazepinas.
ZA8312B (en) Substituted 1-benzoyl-2-phenyliminiomidazolidine derivatives
GB1552163A (en) 5 -2(-imidazolin -2- ylamino) -213- benzothladiazole derivatives
GB1226896A (fr)
SE7502790L (fr)
JPS5528997A (en) Pyrano heterocyclic compound
JPS6421439A (en) Dimechincyanine pigment containing 1-aryl- 2-heteroaryl indole nucleus for direct positive
NL7602374A (en) Benzodiazepine prepn - by condensn of 1-haloacetamido benzoyl cpds with hexamine and derivs in presence of ammonium carbonate or acids
ES255920A2 (es) Procedimiento para la obtenciën de colorantes
JPS5283780A (en) 7-heterocyclic thioalkaneamide-3-methyl-3-cephem-4-carboxylic acid der ivative
FR2278338A1 (fr) Derives de la dihydro-1-2 trimethyl-2-2-4 quinoleine et application comme medicaments