JP2013068612A - 自動染色システムおよび反応チャンバ - Google Patents
自動染色システムおよび反応チャンバ Download PDFInfo
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Abstract
【解決手段】試薬カートリッジおよび反応チャンバを含み、試薬カートリッジが試薬を反応チャンバに分注するための着脱可能に配置されている試薬カプセルを有している装置であり、少なくとも1つの液体分注カートリッジを受け取るように寸法合わせをした複数の搭載ステーションを有する直線的に平行移動可能な搭載アセンブリ、複数のバルク試薬分注ノズルと連結した直線的に平行移動可能なバルク試薬分注アセンブリ、および搭載アセンブリならびにバルク試薬分注アセンブリの下方に配置され、複数の反応ステーションを含む受容アセンブリを含む。
【選択図】図1
Description
Claims (57)
- 試薬保持収納部ならびに試薬誘導流路を有し、該試薬保持収納部および該試薬誘導流路の両方が該試薬カートリッジの底部から伸長している出口流路と液体連通している試薬カートリッジ;および
スライドを受け取るように寸法合わせをした圧盤を有し、該圧盤が試薬カートリッジから分注された試薬を受け取るための試薬滴下面を画定する反応チャンバ:
を含む装置。 - 前記試薬保持収納部が試薬を含む試薬カプセルを受け取るように寸法合わせをされている請求項1に記載の装置。
- 前記試薬カプセルが、つぶせる容器および、該容器がつぶされたときに該容器のシールを破るように寸法合わせをしたプランジャとを含む請求項2に記載の装置。
- 前記試薬カートリッジに接続した第1識別子および第2識別子をさらに含み、該第1識別子および該第2識別子が該試薬カートリッジ内に含まれる試薬を識別する情報を含み、該第1識別子および該第2識別子のうち1つが着脱可能である請求項1に記載の装置。
- 前記圧盤が親水性材料から成る請求項1に記載の装置
- 前記圧盤が抗菌特性または耐腐食特性のうち少なくとも1つを有する金属製材料から成る請求項1に記載の装置。
- 水平面に対する水平角度が5度〜15度で前記圧盤が配置されている請求項1に記載の装置。
- 水平面に対する垂直角度が15度〜45度で前記圧盤が配置されている請求項1に記載の装置。
- 前記圧盤の表面から伸長し、該圧盤と該圧盤に配置されたスライドとの間に不均一な間隙を作る少なくとも1つのスペーサ部材をさらに含む請求項1に記載の装置。
- 前記反応チャンバに接続したバルク試薬貯槽をさらに含み、該バルク試薬貯槽が該反応チャンバと液体連通している請求項1に記載の装置。
- 前記反応チャンバが、前記圧盤を貫通して伸長する第1液体出口、第2液体出口および液体入口をさらに含み、該液体入口が第1液体出口と第2液体出口との間に配置されている請求項1に記載の装置。
- 前記圧盤に接続した温度修正アセンブリをさらに含み、前記反応チャンバの温度を修正する請求項1に記載の装置。
- 前記温度修正アセンブリが熱電冷却器(TEC)を含む請求項12に記載の装置。
- 前記温度修正アセンブリが放熱板および送風機を含み、該温度修正アセンブリの温度を制御する請求項12に記載の装置。
- 前記温度修正アセンブリが前記反応チャンバの温度を監視するためのサーミスタを含む請求項12に記載の装置。
- 試薬保持収納部を含む試薬カートリッジ;および
該試薬保持収納部内に着脱可能に配置された試薬カプセル:
を含む装置。 - 前記試薬カートリッジが試薬誘導流路をさらに含み、前記試薬保持収納部および該試薬誘導流路が、該試薬カートリッジから試薬を導くための出口流路と液体連通している請求項16に記載の装置。
- 前記試薬カプセルが、つぶせる容器、および該容器がつぶされたときに該容器のシールを破るように寸法合わせをしたプランジャを含む請求項16に記載の装置。
- 前記カプセルに接続したブラケットアセンブリをさらに含み、該ブラケットアセンブリは該カプセルを前記試薬カートリッジに固定するように寸法合わせをした請求項16に記載の装置。
- 前記ブラケットアセンブリが前記カプセル内に含まれた試薬を識別する識別子を含む請求項19に記載の装置。
- 前記カプセルが前記ブラケットアセンブリに着脱可能に連結している請求項19に記載の装置。
- スライドを受け取るように寸法合わせをした圧盤;
該圧盤の表面から伸長し、該圧盤とそこに配置したスライドとの間に不均一な間隙を作る少なくとも1つのスペーサ部材;および
該圧盤を貫通して伸長する少なくとも1つの出口ならびに少なくとも1つの入口:
を含む装置。 - 前記圧盤が、上方から該圧盤へと分注された液体を受け取るための一端にある液体滴下面を画定する請求項22に記載の装置。
- 少なくとも1つのスペーサ部材が前記圧盤の幅寸法にわたって伸長するスペーサバーであり、該スペーサバーは、液体が該スペーサバー上を移動するのを防止するのに十分な幅寸法を有する請求項22に記載の装置。
- 少なくとも1つのスペーサ部材が前記圧盤の一端に配置された第1スペーサ部材であり、第2スペーサ部材が該圧盤の一端で該第1スペーサ部材から距離をとって配置されており、第3スペーサ部材が該圧盤の反対側の端部に配置されており、該圧盤とそこに配置したスライドとの間に不均一な間隙を作るように該第1スペーサ部材および該第2スペーサ部材が該第三スペーサ部材とは異なる高さを有している、請求項22に記載の装置。
- 前記圧盤の一部の周囲に配置された壁をさらに含み、該壁は該圧盤に分注された液体を保持するのに十分な高さを有している請求項22に記載の装置。
- 前記圧盤が親水性の表面を含む請求項22に記載の装置。
- 前記圧盤が金属またはプラスチック材料から成る請求項22に記載の装置。
- 前記少なくとも1つの出口が前記圧盤の一端に配置された第1出口であり、第2出口が該圧盤の反対側の端部に配置され、前記少なくとも1つの入口が該第1出口と該第2出口との間に配置されている請求項22に記載の装置。
- 少なくとも1つの液体分注カートリッジを受け取るように寸法合わせをした複数の搭載ステーションを有する直線的に平行移動可能な搭載アセンブリ;
複数のバルク試薬分注ノズルに連結した直線的に平行移動可能なバルク試薬分注アセンブリ;および
該搭載アセンブリならびに該バルク試薬分注アセンブリの下方に配置され、複数の反応ステーションを含む受容アセンブリ:
を含むシステム。 - 前記複数の搭載ステーションのうち少なくとも1つが試薬カプセル押圧機構を受け取るように寸法を合わせてある請求項30に記載のシステム。
- 前記平行移動可能な搭載アセンブリが、直線的に平行移動可能な回転軸の周囲を回転することも可能である請求項30に記載のシステム。
- 前記複数のバルク試薬分注ノズルの各々がバルク試薬容器と流体的に連結している請求項30に記載のシステム。
- 前記複数の反応ステーションの各々に配置された試薬カートリッジおよび反応チャンバをさらに含み、該試薬カートリッジは分注液を受け取り、分注液を前記液体分注カートリッジから該反応チャンバへと導くように寸法合わせをした請求項30に記載のシステム。
- 前記反応チャンバが顕微鏡スライドを搭載した圧盤を含む請求項34に記載のシステム。
- 前記複数の反応ステーションに1つずつ設置した複数の温度修正アセンブリをさらに含む請求項30に記載のシステム。
- 前記温度修正アセンブリが前記複数の反応ステーションを加熱および冷却するように選択的に制御される請求項36に記載のシステム。
- 前記複数の温度修正アセンブリが熱電冷却器(TEC)である請求項36に記載のシステム。
- バルク容器、および該バルク容器の液体レベルを判断するために該バルク容器に連結したセンサーをさらに含む請求項30に記載のシステム。
- 前記センサーが重量センサーである請求項39に記載のシステム。
- 前記反応ステーションを定位置に係止するために該反応ステーションの各々に連結した係止アセンブリをさらに含む請求項30に記載のシステム。
- 前記係止アセンブリが、停電の場合に係止されたままとなる電気機械的係止システムである請求項41に記載のシステム。
- 前記複数の反応ステーションに流体的に連結した廃液排出アセンブリをさらに含み、該廃液排出アセンブリは、廃液が前記複数の反応ステーション内に逆流しないように寸法合わせをした変更可能液体導管を有している請求項30に記載のシステム。
- 自動試料処理システムの備品確認を判断する工程であって、該自動試料処理システム内の少なくとも1つの反応ステーションと接続した識別子および該自動試料処理システム内の少なくとも1つのバルク容器と接続した少なくとも1つのセンサーから情報を回収する工程を含む備品確認判断工程;
処理プロトコルを中央制御装置から該自動試料処理システムへダウンロードする工程;
該処理プロトコルに基づいて、該中央制御装置とは無関係に該自動試料処理システムを操作する工程;ならびに
該自動試料処理システムから試薬を分注する工程:
を含む方法。 - 備品確認判断工程が、前記少なくとも1つの反応ステーションと接続した試薬カートリッジ上に含まれる識別子を走査する工程を含む請求項44に記載の方法。
- 備品確認判断工程が、前記自動試料処理システムに使用した液体分注カートリッジ上に含まれる識別子を走査する工程をさらに含む請求項44に記載の方法。
- 前記センサーから回収した情報が前記バルク容器内の液体体積に関連した情報を含む請求項44に記載の方法。
- 前記自動試料処理システムを操作する工程が、第1バルク容器から第2バルク容器に切り替える工程を含み、この工程では該第1バルク容器が空であることが前記センサーから判断される請求項44に記載の方法。
- 試薬を分注する工程が、前記少なくとも1つのバルク容器に流体的に接続された直線的に平行移動可能バルク液分注アセンブリから試薬を分注する工程を含む請求項44に記載の方法。
- 試薬を分注する工程が、試薬カプセルから該試薬を分注する工程を含み、該試薬カプセルから試薬を分注する工程が:
該カプセル上に形成したシールを介して該カプセルに連結したプランジャを前進させることにより該カプセル内に含まれる初期量の試薬を分注する工程;ならびに
該カプセルをつぶすことにより該カプセル内に含まれる残存量の試薬を分注する工程を含む請求項44に記載の方法。 - ダウンロードする工程が、前記処理プロトコルを前記少なくとも1つの反応ステーションにダウンロードする工程を含む請求項44に記載の方法。
- 前記少なくとも1つの反応ステーションが前記中央制御装置から独立した前記処理プロトコルを実行する請求項51に記載の方法。
- 前記少なくとも1つの反応ステーションで行った処理プロトコルの状態を監視する工程;および
該反応ステーションで該処理プロトコルにしたがって行った前記プロセスの各々の運用記録を作成する工程:
をさらに含む請求項44に記載の方法。 - スキャナに向けてスライド上に設置した識別子の像を反射させる工程;および
該スキャナで該識別子を走査する工程:
を含む方法。 - 識別子が第1識別子を含む方法であって、さらに:
前記スライドと接続した試薬カートリッジに設置した第2識別子を走査する工程;
該スライドならびに該試薬カートリッジと接続した反応ステーションに設置した第3識別子を走査する工程;および
該第1識別子、該第2識別子ならびに該第3識別子から得た情報を比較し、該スライド上で行った処理プロトコルを決定する工程:
を含む請求項54に記載の方法。 - 反射させる工程がミラー上の前記像を反射させる工程を含む請求項54に記載の方法。
- 前記スライドを支持する反応ステーションに前記ミラーを着脱可能に搭載した請求項56に記載の方法。
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US8932543B2 (en) | 2015-01-13 |
CA2774503A1 (en) | 2013-03-21 |
JP2019002935A (ja) | 2019-01-10 |
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US20150111202A1 (en) | 2015-04-23 |
JP6599929B2 (ja) | 2019-10-30 |
US11193859B2 (en) | 2021-12-07 |
AU2012202090B2 (en) | 2014-06-26 |
JP6753575B2 (ja) | 2020-09-09 |
JP2017198687A (ja) | 2017-11-02 |
CN105865880A (zh) | 2016-08-17 |
DK2573542T3 (da) | 2021-02-01 |
ES2846756T3 (es) | 2021-07-29 |
EP2573542B1 (en) | 2020-11-04 |
BR102012021902A2 (pt) | 2014-07-01 |
US20190271618A1 (en) | 2019-09-05 |
CN103018081A (zh) | 2013-04-03 |
EP2573542A3 (en) | 2017-12-20 |
CA2774503C (en) | 2021-06-29 |
CN103018081B (zh) | 2017-11-03 |
AU2012202090A1 (en) | 2013-04-04 |
CN105865880B (zh) | 2019-07-26 |
EP2573542A2 (en) | 2013-03-27 |
BR102012021902B1 (pt) | 2020-12-15 |
US10295444B2 (en) | 2019-05-21 |
US20130071858A1 (en) | 2013-03-21 |
US20220090994A1 (en) | 2022-03-24 |
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