DK1239952T3 - Syntetiseringsindretning til oligonukleotider ved anvendelse af en centrifugalkraft - Google Patents

Syntetiseringsindretning til oligonukleotider ved anvendelse af en centrifugalkraft

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Publication number
DK1239952T3
DK1239952T3 DK00988097.2T DK00988097T DK1239952T3 DK 1239952 T3 DK1239952 T3 DK 1239952T3 DK 00988097 T DK00988097 T DK 00988097T DK 1239952 T3 DK1239952 T3 DK 1239952T3
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DK
Denmark
Prior art keywords
liquid
vessel
aperture
combinatorial
centrifugal force
Prior art date
Application number
DK00988097.2T
Other languages
English (en)
Inventor
Michal Lebl
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of DK1239952T3 publication Critical patent/DK1239952T3/da

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    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00281Individual reactor vessels
    • B01J2219/00283Reactor vessels with top opening
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00281Individual reactor vessels
    • B01J2219/00295Individual reactor vessels the reactor vessels having pervious side walls
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/111666Utilizing a centrifuge or compartmented rotor
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/00Chemistry: analytical and immunological testing
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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
DK00988097.2T 1999-12-13 2000-12-13 Syntetiseringsindretning til oligonukleotider ved anvendelse af en centrifugalkraft DK1239952T3 (da)

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Application Number Priority Date Filing Date Title
US17031499P 1999-12-13 1999-12-13
PCT/US2000/034127 WO2001041918A2 (en) 1999-12-13 2000-12-13 Oligonucleotide synthesizer using centrifugal force

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DK1239952T3 true DK1239952T3 (da) 2012-01-02

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US (1) US6663832B2 (da)
EP (1) EP1239952B1 (da)
JP (1) JP2004507337A (da)
AT (1) ATE527053T1 (da)
AU (1) AU779983B2 (da)
CA (1) CA2394374A1 (da)
DK (1) DK1239952T3 (da)
HK (1) HK1049804B (da)
WO (1) WO2001041918A2 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060431B2 (en) 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
US7612020B2 (en) 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
ATE341003T1 (de) * 1999-02-16 2006-10-15 Applera Corp Vorrichtung zur handhabung von kügelchen
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6975924B2 (en) * 1999-12-03 2005-12-13 Baxter International Inc. Method and apparatus for controlling the strategy of compounding pharmaceutical admixtures
US7390459B2 (en) * 1999-12-13 2008-06-24 Illumina, Inc. Oligonucleotide synthesizer
US7708946B1 (en) * 2001-07-19 2010-05-04 Michael Sherman Device for protein detecting tests
US7282183B2 (en) * 2001-12-24 2007-10-16 Agilent Technologies, Inc. Atmospheric control in reaction chambers
WO2003067231A1 (en) * 2002-02-07 2003-08-14 The Regents Of The University Of California Optically encoded particles
MXPA05000047A (es) * 2002-07-05 2005-04-08 Aventis Pharma Inc Aparato y metodo para uso en sintesis quimica en fase solida.
AU2002319970A1 (en) * 2002-08-02 2004-02-23 Avantium International B.V. An assembly and method for performing parallel chemical experiments, in particular crystallisation experiments
JP4016811B2 (ja) * 2002-11-15 2007-12-05 日立工機株式会社 自動分注装置
CA2513985C (en) 2003-01-21 2012-05-29 Illumina Inc. Chemical reaction monitor
US20050058577A1 (en) * 2003-04-08 2005-03-17 Irm, Llc Material removal and dispensing devices, systems, and methods
US9518899B2 (en) 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
WO2005058471A2 (en) * 2003-12-15 2005-06-30 Applera Corporation Automated oligomer synthesis
EP1713595A2 (en) * 2003-12-22 2006-10-25 The Regents of The University of California Optically encoded particles, system and high-throughput screening
WO2005062865A2 (en) * 2003-12-22 2005-07-14 The Regents Of The University Of California Optically encoded particles with grey scale spectra
DE602004000441T2 (de) * 2004-01-15 2006-08-10 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Positionierung für eine Flüssigkeitsübertragung
WO2005082110A2 (en) * 2004-02-26 2005-09-09 Illumina Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
US20070108465A1 (en) * 2005-03-10 2007-05-17 The Regents Of The University Of California Porous microstructure multi layer spectroscopy and biosensing
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
EP1937400A4 (en) * 2005-09-14 2011-02-23 Illumina Inc DEVICE FOR THE CONTINUOUS SYNTHESIS OF POLYMERS
US20070092410A1 (en) * 2005-10-26 2007-04-26 Ricker Robert D Device for pipetting solution from one plate format to a different plate platform using movable position pipette tips
US7803751B2 (en) 2005-12-09 2010-09-28 Illumina, Inc. Compositions and methods for detecting phosphomonoester
WO2007130434A2 (en) * 2006-05-02 2007-11-15 Applera Corporation Variable volume dispenser and method
US8459509B2 (en) 2006-05-25 2013-06-11 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
EP2548972A1 (en) 2006-06-14 2013-01-23 Verinata Health, Inc Methods for the diagnosis of fetal abnormalities
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
CA2655272C (en) 2006-06-14 2017-04-18 Living Microsystems, Inc. Rare cell analysis using sample splitting and dna tags
JP2010504516A (ja) * 2006-09-21 2010-02-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 複数の物質を基板(substrate)上に放出することによって生物学的分析基板を生産するためのインクジェットデバイス及び方法
CA2676570C (en) * 2007-01-26 2016-05-03 Illumina, Inc. Nucleic acid sequencing system and method
US8315817B2 (en) * 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
WO2008140742A1 (en) 2007-05-08 2008-11-20 Idexx Laboratories, Inc. Chemical analyzer
WO2008138337A2 (en) * 2007-05-09 2008-11-20 Alcorlab A/S An oligo peptide synthesis and a cleavage and evaporation apparatus
GB0717452D0 (en) * 2007-09-07 2007-10-17 Mole Genetics As Separation apparatus
US8211370B2 (en) 2007-12-07 2012-07-03 Thomas Downing Polymer synthesizer
US20090181390A1 (en) * 2008-01-11 2009-07-16 Signosis, Inc. A California Corporation High throughput detection of micrornas and use for disease diagnosis
GB2472252A (en) * 2009-07-31 2011-02-02 Simon Stafford Microplate holder for inclining a microplate
US8703652B2 (en) 2009-11-06 2014-04-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of graft rejection in organ transplant patients
CN202823394U (zh) * 2010-01-19 2013-03-27 伊鲁米那股份有限公司 用于处理化学反应的设备和***
US8752732B2 (en) 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
US8580568B2 (en) 2011-09-21 2013-11-12 Sakura Finetek U.S.A., Inc. Traceability for automated staining system
US8932543B2 (en) 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
DK3327123T3 (da) 2013-03-15 2019-11-25 Lineage Biosciences Inc Fremgangsmåder til sekvensering af immunrepertoiret
US9797916B2 (en) 2014-01-10 2017-10-24 Idexx Laboratories, Inc. Chemical analyzer
EP3825697A1 (en) * 2014-06-11 2021-05-26 F. Hoffmann-La Roche AG In-vitro diagnostic analysis method and system
US10040048B1 (en) 2014-09-25 2018-08-07 Synthego Corporation Automated modular system and method for production of biopolymers
WO2016196358A1 (en) 2015-05-29 2016-12-08 Epicentre Technologies Corporation Methods of analyzing nucleic acids
EP3559271A1 (en) * 2016-12-22 2019-10-30 Ventana Medical Systems, Inc. Fully automated nucleic acid extraction method for tissue samples
US11982611B2 (en) 2017-03-20 2024-05-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
WO2019006391A1 (en) 2017-06-30 2019-01-03 Sri International REACTION SCREENING AND OPTIMIZATION APPARATUSES, AND ASSOCIATED METHODS
EP3681637A4 (en) * 2017-09-11 2021-06-02 Synthego Corporation SYSTEM AND PROCEDURE FOR BIOPOLYMER SYNTHESIS
AU2021306343A1 (en) 2020-07-10 2023-03-02 Idexx Laboratories Inc. Point-of-care medical diagnostic analyzer and devices, systems, and methods for medical diagnostic analysis of samples

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3586484A (en) 1969-05-23 1971-06-22 Atomic Energy Commission Multistation analytical photometer and method of use
GB1241539A (en) 1969-10-27 1971-08-04 American Hospital Supply Corp Cell-washing centrifuge and method
US3605829A (en) * 1970-04-29 1971-09-20 Becton Dickinson Co Blood handling machine
AT308712B (de) 1971-10-08 1973-07-25 Immuno Ag Tischzentrifuge
US4244694A (en) * 1978-03-31 1981-01-13 Union Carbide Corporation Reactor/separator device for use in automated solid phase immunoassay
US4287154A (en) * 1980-05-07 1981-09-01 Sommers Philip B Specimen transfer rack
FR2496268A1 (fr) * 1980-12-15 1982-06-18 Guigan Jean Dispositif autonome d'analyse simultanee et procede de mise en oeuvre
JPS61139756A (ja) * 1984-12-12 1986-06-27 Hitachi Koki Co Ltd 遠心式自動反応装置
JPH0786509B2 (ja) * 1985-06-18 1995-09-20 株式会社東芝 自動化学分析装置
JPH0690212B2 (ja) * 1986-02-21 1994-11-14 株式会社東芝 自動化学分析装置
JPH0754326B2 (ja) * 1986-06-24 1995-06-07 株式会社東芝 自動化学分析装置
US5089417A (en) 1987-07-01 1992-02-18 Miles Inc. Fluid separation and processing device
JPH06103315B2 (ja) * 1987-08-14 1994-12-14 株式会社東芝 自動化学分析装置の分注ノズル装置
US4862932A (en) * 1988-04-20 1989-09-05 Bio-Rad Laboratories, Inc. Fraction collector
SU1704838A1 (ru) 1988-11-14 1992-01-15 Институт молекулярной биологии АН СССР Устройство дл разделени проб суспензии
JP2539512B2 (ja) * 1989-07-17 1996-10-02 株式会社日立製作所 複数項目分析装置およびその分析装置を動作させる方法
DE3923833C2 (de) * 1989-07-19 1998-07-02 Boehringer Mannheim Gmbh Analysegerät für heterogene immunologische Tests
CZ280777B6 (cs) 1990-02-02 1996-04-17 Ústav Organické Chemie A Biochemie Avčr Mnohonásobná automatizovaná syntéza peptidů na planárních nosičích
US5585068A (en) * 1990-02-20 1996-12-17 Biochemical Diagnostics, Inc. Apparatus for automatically separating a compound from a plurality of discrete liquid specimens
WO1993010455A1 (en) 1991-11-21 1993-05-27 Cirrus Diagnostics, Inc. Improved centrifuge vessel for automated solid-phase immunoassay
EP0569115A3 (en) 1992-05-05 1994-01-05 General Atomics High throughput DNA preparation system
DE59410037D1 (de) * 1993-09-17 2002-03-14 Hoffmann La Roche Analysengerät mit einer Vorrichtung zum Abtrennen magnetischer Mikropartikel
AU8102694A (en) 1993-11-17 1995-06-06 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
US6045755A (en) 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
CA2301095A1 (en) * 1997-08-15 1999-02-25 Alexion Pharmaceuticals, Inc. Apparatus for performing assays at reaction sites
US6121054A (en) 1997-11-19 2000-09-19 Trega Biosciences, Inc. Method for separation of liquid and solid phases for solid phase organic syntheses
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
ID23862A (id) * 1998-02-20 2000-05-25 Scil Diagnotics Gmbh Sistem analisis
CA2361223A1 (en) 1999-01-29 2000-08-03 Illumina, Inc. Centrifuging apparatus and method for separation of liquid phases and organic synthesis
US6357907B1 (en) * 1999-06-15 2002-03-19 V & P Scientific, Inc. Magnetic levitation stirring devices and machines for mixing in vessels

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