JP2010521275A - ロックナットを備えた注射装置 - Google Patents
ロックナットを備えた注射装置 Download PDFInfo
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- JP2010521275A JP2010521275A JP2010500195A JP2010500195A JP2010521275A JP 2010521275 A JP2010521275 A JP 2010521275A JP 2010500195 A JP2010500195 A JP 2010500195A JP 2010500195 A JP2010500195 A JP 2010500195A JP 2010521275 A JP2010521275 A JP 2010521275A
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- 239000007924 injection Substances 0.000 title claims abstract description 215
- 230000033001 locomotion Effects 0.000 claims abstract description 52
- 239000003814 drug Substances 0.000 claims abstract description 16
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 230000006835 compression Effects 0.000 claims description 15
- 238000007906 compression Methods 0.000 claims description 15
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 102000018997 Growth Hormone Human genes 0.000 description 2
- 108010051696 Growth Hormone Proteins 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000000122 growth hormone Substances 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
【選択図】11a
Description
−ハウジングと、
−所望の投与量を設定するために操作可能な投与量設定機構であって、回転可能な投与量ノブを備え、操作することによりがばね部材にエネルギーを蓄える投与量設定機構と、
−ピストンロッドを備える注射機構であって、このピストンロッドが、送達される薬剤を収容するカートリッジ内に配置されたピストンと協働することにより、設定された投与量がカートリッジから注射装置を介して送達されるもので、投与量設定中にばね部材に前もって蓄えられたエネルギーを解放することによって駆動される注射機構と、
−投与量設定中にハウジングに対して軸方向に沿って近位方向に移動可能であり、且つ設定された投与量を注射する間にハウジングに対して軸方向に沿って遠位方向に移動可能な投薬管と、
−投与量設定中に、投薬管がハウジングに対して遠位方向へ軸方向運動することを防止する保持手段と
を具備している。
−ハウジングと、
−所望の投与量を設定するために操作可能な投与量設定機構であって、回転可能な投与量ノブを備え、操作することによりがばね部材にエネルギーを蓄える投与量設定機構と、
−ピストンロッドを備える注射機構であって、このピストンロッドが、送達される薬剤を収容するカートリッジ内に配置されたピストンと協働することにより、設定された投与量がカートリッジから注射装置を介して送達されるもので、投与量設定中にばね部材に前もって蓄えられたエネルギーを解放することによって駆動される注射機構と、
−ハウジングに対して軸方向に固定されたロックナットであって、投与量設定中にハウジングに対して回転しないようにロックされ、設定された投与量を注射する間にハウジングに対して回転運動を行うことができ、且つ第1ねじ接続を介してピストンロッドにねじ係合するロックナットと、
−第1ねじ接続を介してピストンロッドにねじ接続された投薬管であって、投与量を設定する間及び設定された投与量を注射する間に、ハウジングに対して軸方向に移動可能な投薬管と、
−投与量設定中にピストンロッドの回転運動を防止する手段と
を具備する。
Claims (15)
- 一定の投与量を注射するための注射装置であって、
−ハウジングと、
−所望の投与量を設定するために操作可能な投与量設定機構であって、回転可能な投与量ノブを備え、操作することによりばね部材にエネルギーを蓄える投与量設定機構と、
−ピストンロッドを備える注射機構であって、このピストンロッドが、送達される薬剤を収容するカートリッジ内に配置されたピストンと協働することにより、設定された投与量がカートリッジから注射装置を介して送達されるもので、投与量設定中にばね部材に前もって蓄えられたエネルギーを解放することによって駆動される注射機構と、
−投与量設定中にハウジングに対して軸方向に沿って近位方向に移動可能であり、且つ設定された投与量を注射する間にハウジングに対して軸方向に沿って遠位方向に移動可能な投薬管と、
−投与量設定中に、投薬管がハウジングに対して軸方向に沿って遠位方向へ運動することを防止するように構成された保持手段と
を具備する注射装置。 - 保持手段が、ハウジングに対して軸方向に固定されたロックナットであり、このロックナットが投与量設定中にハウジングに対して回転しないようにロックされ、且つ設定された投与量を注射する間にハウジングに対する回転運動を行うことができる、請求項1記載の注射装置。
- ロックナットと投薬管が、投薬管とロックナットのそれぞれに形成された互いに噛み合うねじ山を介して接続される、請求項2記載の注射装置。
- 更にロック要素を具備し、このロック要素が、ロックナットがハウジングに対して回転することが防止されるロック位置と、ロックナットがハウジングに対して回転することが許容されるロック解除位置との間で移動可能である、請求項2又は3記載の注射装置。
- ロック要素がロック位置にあるとき、ロックナットとロック要素に形成された互いに噛み合う歯が噛み合う、請求項4記載の注射装置。
- 注射機構の動作に応じてロック要素がロック位置からロック解除位置に移動する、請求項4又は5記載の注射装置。
- 設定された投与量を注射する間、投薬管がハウジングに対して回転運動を行なうことが防止される、請求項1〜6のいずれか一項に記載の注射装置。
- 投薬管とピストンロッドが、投薬管とピストンロッドのそれぞれに形成された互いに噛み合うねじ山を介して接続される、請求項1〜7のいずれか一項に記載の注射装置。
- 更に、投与量設定中にピストンロッドの回転運動を防止する手段を備えている、請求項1〜8のいずれか一項に記載の注射装置。
- ピストンロッドの回転運動を防止する手段が、ピストンロッドと、ハウジングに対して固定された部材とのキー及びキー溝式の接続を含む、請求項9記載の注射装置。
- ピストンロッドの回転運動を防止する手段が、ピストンロッドとハウジングに対して固定された部材との第の3ねじ接続を含む、請求項9記載の注射装置。
- 第3ねじ接続が、投薬管のめねじに係合するピストンロッドのおねじの方向と反対方向に向いたピッチを有する、請求項11記載の注射装置。
- ばね部材が圧縮ばねであるか又は圧縮ばねを含む、請求項1〜12のいずれか一項に記載の注射装置。
- 更に、ばね部材に蓄積されたエネルギーを解放する解放機構を具備し、この解放によって、設定された投与量が注射される、請求項1〜13のいずれか一項に記載の注射装置。
- 解放機構が軸方向に移動可能である、請求項14記載の注射装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07104819 | 2007-03-23 | ||
EP07104819.3 | 2007-03-23 | ||
PCT/EP2008/053103 WO2008116766A1 (en) | 2007-03-23 | 2008-03-14 | An injection device comprising a locking nut |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010521275A true JP2010521275A (ja) | 2010-06-24 |
JP5230722B2 JP5230722B2 (ja) | 2013-07-10 |
Family
ID=38147058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010500195A Active JP5230722B2 (ja) | 2007-03-23 | 2008-03-14 | ロックナットを備えた注射装置 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8353878B2 (ja) |
EP (1) | EP2125081B1 (ja) |
JP (1) | JP5230722B2 (ja) |
CN (1) | CN101641126B (ja) |
AU (1) | AU2008231897B2 (ja) |
BR (1) | BRPI0809265A2 (ja) |
CA (1) | CA2681023C (ja) |
RU (1) | RU2468829C2 (ja) |
WO (1) | WO2008116766A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2016518951A (ja) * | 2013-05-27 | 2016-06-30 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイス用のアセンブリ、および薬物送達デバイス |
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Also Published As
Publication number | Publication date |
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AU2008231897A1 (en) | 2008-10-02 |
CN101641126A (zh) | 2010-02-03 |
RU2468829C2 (ru) | 2012-12-10 |
JP5230722B2 (ja) | 2013-07-10 |
US20100114025A1 (en) | 2010-05-06 |
BRPI0809265A2 (pt) | 2014-10-07 |
RU2009137484A (ru) | 2011-04-27 |
AU2008231897B2 (en) | 2012-11-29 |
EP2125081B1 (en) | 2017-12-20 |
CA2681023A1 (en) | 2008-10-02 |
CA2681023C (en) | 2015-11-03 |
EP2125081A1 (en) | 2009-12-02 |
CN101641126B (zh) | 2014-06-04 |
WO2008116766A1 (en) | 2008-10-02 |
US8353878B2 (en) | 2013-01-15 |
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