JP2009297025A - 撹拌タンクバイオリアクタ - Google Patents
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- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
Abstract
【解決手段】本発明は、成形プラスチックから形成される使い捨て可能なバイオリアクタである。バイオリアクタは、予め滅菌されるとともに、互いにシールされる上端部と本体とを有する。上端部およびハウジングの側面には1つ以上のポートが形成される。少なくとも1つのポートは、ハウジングにおける液体/空気の高さよりも下側にあることが好ましい。液体/空気界面高さよりも下側にある1つ以上のポートは、サンプリングポート、または、プローブ或いはドレインのためのアクセスポート、または、液体或いは気体のための供給ポートとして使用されてもよい。バイオリアクタは、既存の支持構造および制御を利用する既存のガラスアセンブリまたはスチールアセンブリのための直接的な改良を提供する。
【選択図】図1
Description
本出願は、全体の内容が参照により本明細書に組み込まれる2008年6月11日に出願された米国仮特許出願第61/131,640号の利益を主張する。
4 スタンド
6 脚部
8 支持リム
10 支持片
12 駆動機構
16 上端部
20 シャフト
22 バイオリアクタ本体
24 クリップ
30、32 ポート
Claims (23)
- バイオマスを培養し、発酵させ、あるいは、処理するためのバイオリアクタであって、半硬質プラスチックおよび硬質プラスチックからなるグループから選択されるプラスチックから形成される予め滅菌された使い捨て可能なハウジングを備え、前記ハウジングが互いにシールされる上端部と本体とを有し、本体が内部空間を有し、ハウジングの上端部および本体のそれぞれにはハウジングの内部と流体連通する1つ以上のポートが形成され、本体の内部空間を環境から分離するために1つ以上のポートがキャップを有する、バイオリアクタ。
- 1つ以上のポートが上端部および本体に成形される、請求項1に記載のバイオリアクタ。
- 1つ以上のポートが上端部および本体に成形され、本体の少なくとも1つのポートがハウジングの液体/空気界面よりも下側の高さにある、請求項1に記載のバイオリアクタ。
- 2つ以上のポートが存在し、少なくとも1つのポートがハウジングの液体/空気界面よりも下側の高さで本体に成形される、請求項1に記載のバイオリアクタ。
- 上端部が一連の第1のポートを有し、本体が一連の第2のポートを有する、請求項1に記載のバイオリアクタ。
- 1つ以上のパドルを有してハウジングの本体内に装着される撹拌シャフトを更に備える、請求項1に記載のバイオリアクタ。
- 1つ以上のパドルを有してハウジングの本体内に装着され且つ磁気要素を含む撹拌シャフトを更に備え、磁気要素が、撹拌シャフトの磁気要素と略平行な位置で本体の外部であるが本体に隣接して位置する磁気ドライブと相互作用する、請求項1に記載のバイオリアクタ。
- 1つ以上のパドルを有してハウジングの本体内に装着される撹拌シャフトを更に備え、シャフトが、ポートを介してハウジングの上端部を貫通して延びるとともに、1つ以上のガスケットによってポートで液密シールされる、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが散気装置を含む、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが、プラスチック、セラミック、および、金属フリットからなるグループから選択されるフリットにより形成される散気装置を含む、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが、本体の内部に散気装置を含み、散気装置が、プラスチック、セラミック、および、金属フリットからなるグループから選択されるフリットにより形成され、ポートが、本体の外部部分のガスラインに対して接続される、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが、本体の内部に成形される散気装置を含み、散気装置が、プラスチック、セラミック、および、金属フリットからなるグループから選択されるフリットにより形成され、ポートが、本体の外部部分のガスラインに対して接続される、請求項1に記載のバイオリアクタ。
- 本体が、上端部から最も離れた本体の部分に隣接するポートを含み、上端部から最も離れたポートが、本体の内部に対して選択的に保持される散気装置を含み、散気装置が、プラスチック、セラミック、および、金属フリットからなるグループから選択されるフリットにより形成され、ポートが、本体の外部部分のガスラインに対して接続される、請求項1に記載のバイオリアクタ。
- 本体の1つ以上のポートがそれぞれ、ルアー管継手およびホースバーブからなるグループから選択される管継手に接続される、請求項1に記載のバイオリアクタ。
- 本体の1つ以上のポートがそれぞれ、管継手に接続されるとともに、逆止弁およびサンプリングデバイスからなるグループから選択されるデバイスを含む、請求項1に記載のバイオリアクタ。
- 本体の1つ以上のポートがそれぞれ、管継手に接続されるとともに、サンプリング用のセプタムと、セプタムを穿刺するためのニードルとを有し、ニードルが前穿刺部と後部とを有し、ニードルが前穿刺部から後部へと延びる中空ルーメンを有し、後部がチューブに接続され、チューブがサンプル容器に接続される、請求項1に記載のバイオリアクタ。
- 本体の1つ以上のポートがそれぞれ、管継手に接続されるとともに、サンプリング用のセプタムと、セプタムを穿刺するためのニードルとを有し、ニードルが前穿刺部と後部とを有し、ニードルが前穿刺部から後部へと延びる中空ルーメンを有し、後部がチューブに接続され、チューブがサンプル容器に接続され、容器がバッグおよびシリンジからなるグループから選択される、請求項1に記載のバイオリアクタ。
- 複数のポートが存在し、少なくとも1つのポートがパラメータプローブを含む、請求項1に記載のバイオリアクタ。
- 複数のポートが存在し、少なくとも1つのポートがパラメータプローブを含み、プローブが、pH、温度、溶存酸素、乳糖濃度、および、圧力からなるグループから選択される、請求項1に記載のバイオリアクタ。
- 1つ以上のパドルを有してハウジングの本体内に装着される撹拌シャフトと、撹拌シャフトの下端を保持するために本体の内部空間の底面に位置する保持ハブとを更に備える、請求項1に記載のバイオリアクタ。
- ハウジングの本体内に装着される磁気結合要素を有するインペラと、本体内でインペラを遠隔的に駆動させるためにインペラに隣接する本体の外面上に位置する磁気駆動要素とを更に備える、請求項1に記載のバイオリアクタ。
- 上端部が、バイオリアクタの上端部に取り付けられる1つ以上のチューブクリップを有する、請求項1に記載のバイオリアクタ。
- ハウジングの底部の外壁が2つ以上のロッキングタブを有し、2つ以上のロッキング特徴形態を有するスタンドを更に備え、ロッキング特徴形態が、スタンド内にハウジングを直立に安定した態様で保持するためにハウジングのロッキングタブと相互作用する、請求項1に記載のバイオリアクタ。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13164008P | 2008-06-11 | 2008-06-11 | |
US61/131,640 | 2008-06-11 |
Publications (2)
Publication Number | Publication Date |
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JP2009297025A true JP2009297025A (ja) | 2009-12-24 |
JP5281483B2 JP5281483B2 (ja) | 2013-09-04 |
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JP2009128573A Active JP5281483B2 (ja) | 2008-06-11 | 2009-05-28 | 撹拌タンクバイオリアクタ |
Country Status (9)
Country | Link |
---|---|
US (2) | US8999702B2 (ja) |
EP (1) | EP2141224B1 (ja) |
JP (1) | JP5281483B2 (ja) |
KR (1) | KR101386026B1 (ja) |
CN (1) | CN101724548B (ja) |
AU (1) | AU2009201890B2 (ja) |
ES (1) | ES2808600T3 (ja) |
SG (1) | SG158007A1 (ja) |
WO (1) | WO2009151514A1 (ja) |
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Also Published As
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KR101386026B1 (ko) | 2014-04-29 |
AU2009201890A1 (en) | 2010-01-07 |
AU2009201890B2 (en) | 2013-11-07 |
EP2141224A1 (en) | 2010-01-06 |
SG158007A1 (en) | 2010-01-29 |
EP2141224B1 (en) | 2020-06-03 |
ES2808600T3 (es) | 2021-03-01 |
CN101724548A (zh) | 2010-06-09 |
US20090311776A1 (en) | 2009-12-17 |
US20150210973A1 (en) | 2015-07-30 |
WO2009151514A1 (en) | 2009-12-17 |
JP5281483B2 (ja) | 2013-09-04 |
KR20090129330A (ko) | 2009-12-16 |
US8999702B2 (en) | 2015-04-07 |
CN101724548B (zh) | 2013-03-27 |
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