JP2009102341A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009102341A5 JP2009102341A5 JP2008309431A JP2008309431A JP2009102341A5 JP 2009102341 A5 JP2009102341 A5 JP 2009102341A5 JP 2008309431 A JP2008309431 A JP 2008309431A JP 2008309431 A JP2008309431 A JP 2008309431A JP 2009102341 A5 JP2009102341 A5 JP 2009102341A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- rapamycin
- hydroxy
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000003826 tablet Substances 0.000 claims 4
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 239000007962 solid dispersion Substances 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000007919 dispersible tablet Substances 0.000 claims 2
- 230000001861 immunosuppresant Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Claims (7)
- ４０−Ｏ−（２−ヒドロキシ）エチル−ラパマイシンの固体分散体、架橋ポリビニルピロリドンを含んでなる崩壊剤およびコロイド状二酸化ケイ素を含む医薬組成物であって、１〜５重量％のコロイド状二酸化ケイ素を含んでなる、分散可能な錠剤の形態である医薬組成物。
- 架橋ポリビニルピロリドンが、医薬組成物の総重量に基づき１０〜３０重量％の量で含まれる、請求項１に記載の医薬組成物。
- 錠剤が３５〜８０Ｎの硬度および３分以下の崩壊時間を有する、請求項１または２に記載の医薬組成物。
- 錠剤が９０秒もしくはそれ未満の崩壊時間を有する、請求項３に記載の医薬組成物。
- 錠剤が、２５０ｍｇの組成物を９ｍｍのダイおよび標準的フラットパンチで８〜１１ｋＮの力を用いて圧縮することにより形成されたものである、請求項１〜４のいずれかに記載の医薬組成物。
- 免疫抑制剤として使用するための、請求項１〜５のいずれかに記載の医薬組成物。
- ４０−Ｏ−（２−ヒドロキシ）エチル−ラパマイシン含有分散可能な錠剤の製造方法であって、４０−Ｏ−（２−ヒドロキシ）エチル−ラパマイシンの固体分散体を調製すること、４０−Ｏ−（２−ヒドロキシ）エチル−ラパマイシンの固体分散体を、架橋ポリビニルピロリドンを含んでなる崩壊剤およびコロイド状二酸化ケイ素と混合して医薬組成物を形成させること、ならびに該医薬組成物を圧縮して分散可能な錠剤を形成させることを含んでなる方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0123400.4 | 2001-09-28 | ||
| GBGB0123400.4A GB0123400D0 (en) | 2001-09-28 | 2001-09-28 | Organic compounds |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532038A Division JP2005507897A (ja) | 2001-09-28 | 2002-09-27 | コロイド状二酸化ケイ素を含んでなる医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009102341A JP2009102341A (ja) | 2009-05-14 |
| JP2009102341A5 true JP2009102341A5 (ja) | 2011-12-08 |
| JP5160386B2 JP5160386B2 (ja) | 2013-03-13 |
Family
ID=9922916
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532038A Withdrawn JP2005507897A (ja) | 2001-09-28 | 2002-09-27 | コロイド状二酸化ケイ素を含んでなる医薬組成物 |
| JP2008309431A Expired - Lifetime JP5160386B2 (ja) | 2001-09-28 | 2008-12-04 | コロイド状二酸化ケイ素を含んでなる医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532038A Withdrawn JP2005507897A (ja) | 2001-09-28 | 2002-09-27 | コロイド状二酸化ケイ素を含んでなる医薬組成物 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US20040254210A1 (ja) |
| EP (2) | EP2193788B1 (ja) |
| JP (2) | JP2005507897A (ja) |
| KR (1) | KR100626785B1 (ja) |
| CN (3) | CN101912392A (ja) |
| AR (2) | AR036643A1 (ja) |
| AT (1) | ATE485813T1 (ja) |
| BR (2) | BR0212922A (ja) |
| CA (1) | CA2458455C (ja) |
| CO (1) | CO5390072A1 (ja) |
| CY (2) | CY1111119T1 (ja) |
| DE (1) | DE60238131D1 (ja) |
| DK (2) | DK1432408T3 (ja) |
| EC (1) | ECSP024323A (ja) |
| ES (2) | ES2560106T3 (ja) |
| GB (1) | GB0123400D0 (ja) |
| HK (2) | HK1067036A1 (ja) |
| HU (1) | HU229991B1 (ja) |
| IL (2) | IL160498A0 (ja) |
| MX (1) | MXPA04002814A (ja) |
| MY (1) | MY150060A (ja) |
| NO (1) | NO333892B1 (ja) |
| NZ (2) | NZ531599A (ja) |
| PE (1) | PE20030602A1 (ja) |
| PL (1) | PL209704B1 (ja) |
| PT (2) | PT2193788E (ja) |
| RU (1) | RU2322970C2 (ja) |
| SI (1) | SI1432408T1 (ja) |
| TW (1) | TWI242449B (ja) |
| WO (1) | WO2003028705A1 (ja) |
| ZA (1) | ZA200401300B (ja) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| IL162734A0 (en) | 2002-02-01 | 2005-11-20 | Ariad Gene Therapeutics Inc | Phosphorus-containing compounds & uses thereof |
| KR20050084559A (ko) * | 2002-09-17 | 2005-08-26 | 와이어쓰 | 경구 제형 |
| WO2004035089A1 (ja) * | 2002-10-09 | 2004-04-29 | Kyowa Hakko Kogyo Co., Ltd. | ホルモン依存性癌の治療剤 |
| DE10351448A1 (de) * | 2003-11-04 | 2005-06-09 | Bayer Healthcare Ag | Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften |
| CN105770871A (zh) * | 2005-06-09 | 2016-07-20 | 汉莎医药有限公司 | IdeS蛋白酶(来自于酿脓链球菌)在自身免疫性疾病和移植排斥的治疗中的用途 |
| CA2669415A1 (en) * | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Solid dosage form comprising ap23573 |
| PL2487161T3 (pl) | 2007-02-23 | 2017-03-31 | Gilead Sciences, Inc. | Modulatory farmakokinetycznych właściwości środków terapeutycznych |
| SG190618A1 (en) * | 2008-05-02 | 2013-06-28 | Gilead Sciences Inc | The use of solid carrier particles to improve the processability of a pharmaceutical agent |
| CN101439025B (zh) * | 2008-12-31 | 2011-05-11 | 江苏大学 | 一种水飞蓟素高效长效制剂及其制法 |
| CN101444503B (zh) * | 2008-12-31 | 2011-02-02 | 江苏大学 | 一种水飞蓟宾高效长效制剂及其制法 |
| CN101444494B (zh) * | 2008-12-31 | 2011-03-30 | 江苏大学 | 难溶性药物高效长效缓释制剂及其制法 |
| ES2433076T3 (es) * | 2009-01-21 | 2013-12-09 | Mylan Inc. | Formulaciones disgregables de carbonato de lantano |
| US8728516B2 (en) | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
| TWI471321B (zh) | 2009-06-08 | 2015-02-01 | Abbott Gmbh & Co Kg | Ｂｃｌ－２族群抑制劑之口服醫藥劑型 |
| TWI532484B (zh) * | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
| SG181916A1 (en) | 2009-12-22 | 2012-08-30 | Abbott Lab | Abt-263 capsule |
| US20170087134A1 (en) * | 2010-07-12 | 2017-03-30 | Salix Pharmaceuticals, Ltd | Formulations of rifaximin and uses thereof |
| US8709419B2 (en) | 2010-08-17 | 2014-04-29 | Hoffmann-La Roche, Inc. | Combination therapy |
| US20120045433A1 (en) * | 2010-08-17 | 2012-02-23 | Kapil Dhingra | Combination therapy |
| KR102095698B1 (ko) | 2010-10-29 | 2020-04-01 | 애브비 인코포레이티드 | 아폽토시스―유도제를 포함하는 고체 분산체 |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| HUE031267T2 (en) | 2010-11-23 | 2017-06-28 | Abbvie Ireland Unlimited Co | Methods of treatment using selective BCL-2 inhibitors |
| EP2643322B1 (en) | 2010-11-23 | 2017-08-30 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| US9295669B2 (en) | 2010-12-14 | 2016-03-29 | Hoffman La-Roche Inc. | Combination therapy for proliferative disorders |
| DE102011052396A1 (de) * | 2011-08-04 | 2013-02-07 | Gelita Ag | Verfahren zur Herstellung einer stabilen Dispersion von Nanopartikeln, hergestellte Dispersion und deren Verwendung |
| KR101151890B1 (ko) * | 2011-08-11 | 2012-05-31 | 동아제약주식회사 | 안정화 및 가용화된 시롤리무스 유도체 조성물의 제조방법 |
| CA2850995A1 (en) | 2011-10-06 | 2013-04-11 | Novartis Ag | Pharmaceutical compositions comprising 40-o-(2-hydroxy) ethyl-rapamycin |
| CN102793673A (zh) * | 2012-09-07 | 2012-11-28 | 中国药科大学 | 一种小檗碱磷脂复合物固体分散体及其制备方法 |
| DK2948134T3 (da) | 2013-01-24 | 2020-06-02 | Palvella Therapeutics Inc | Sammensætninger til transdermal indgivelse af mtor-inhibitorer |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TW201503912A (zh) * | 2013-03-19 | 2015-02-01 | Novartis Ag | 包含癌莫事（ｅｖｅｒｏｌｉｍｕｓ）之醫藥組合物 |
| EA201690987A1 (ru) | 2013-11-13 | 2016-10-31 | Новартис Аг | Низкодозовые иммуностимулирующие ингибиторы mtor и их применения |
| CN103610646B (zh) * | 2013-12-05 | 2015-07-15 | 江苏奥赛康药业股份有限公司 | 一种含依维莫司的组合物及其制备方法和含有这一组合物的药物制剂 |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| WO2016135740A1 (en) | 2015-02-23 | 2016-09-01 | Natco Pharma Limited | Process for preparing stable oral compositions of everolimus |
| US10576076B2 (en) | 2015-05-20 | 2020-03-03 | Novartis Ag | Pharmaceutical combination of everolimus with dactolisib |
| EP3329916A4 (en) | 2015-07-28 | 2019-03-20 | Nippon Kayaku Kabushiki Kaisha | PHARMACEUTICAL COMPOSITION COMPRISING RAPAMYCIN OR A DERIVATIVE THEREOF, AND PROCESS FOR PRODUCING THE SAME |
| WO2017204215A1 (ja) | 2016-05-27 | 2017-11-30 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
| WO2018064472A1 (en) | 2016-09-30 | 2018-04-05 | Salix Pharmaceuticals, Ltd. | Solid dispersion forms of rifaximin |
| KR20190089005A (ko) | 2016-11-23 | 2019-07-29 | 노파르티스 아게 | 에베롤리무스, 닥톨리십 또는 둘 다를 사용하여 면역 반응을 증진시키는 방법 |
| IL267869B2 (en) | 2017-01-06 | 2023-10-01 | Palvella Therapeutics Inc | Non-aqueous preparations of mTOR inhibitors and methods of use |
| US11504333B2 (en) | 2017-07-05 | 2022-11-22 | Novartis Ag | Pharmaceutical composition |
| CN108125918B (zh) * | 2018-01-12 | 2020-06-23 | 杭州中美华东制药有限公司 | 依维莫司药物组合物 |
| US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
| US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| WO2022219652A1 (en) * | 2021-04-17 | 2022-10-20 | Bdr Pharmaceuticals International Private Limited | Novel sublingual pharmaceutical formulations for everolimus |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8608080D0 (en) | 1986-04-02 | 1986-05-08 | Fujisawa Pharmaceutical Co | Solid dispersion composition |
| US5211958A (en) * | 1987-11-30 | 1993-05-18 | Gist-Brocades, N.V. | Pharmaceutical composition and process for its preparation |
| US4920102A (en) | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
| IT1246383B (it) * | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per il mascheramento del sapore di farmaci |
| HU222242B1 (hu) | 1991-07-03 | 2003-05-28 | Pharmacia & Upjohn Co. | Kolesztipol-hidroklorid tabletta és eljárás annak előállítására |
| US5605889A (en) | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
| IL115742A (en) | 1994-10-26 | 2000-06-01 | Novartis Ag | Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant |
| BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
| DE19549852B4 (de) | 1995-11-29 | 2009-06-04 | Novartis Ag | Cyclosporin enthaltende Präparate |
| DK1166651T3 (da) * | 1996-02-29 | 2005-05-30 | Fujisawa Pharmaceutical Co | Hurtigt disintegrerende granulat af et syntetisk södemiddel indeholdende kiselsyre og/eller siliciumdioxid |
| JP4064476B2 (ja) | 1996-03-29 | 2008-03-19 | エラワン ファーマスーティカル リサーチ アンドラボラトリー カンパニー リミテッド | 二酸化珪素を有する球状凝集した澱粉 |
| WO1997040828A1 (fr) * | 1996-04-26 | 1997-11-06 | Shionogi & Co., Ltd. | Comprimes de s1452 a liberation rapide |
| GB2318511A (en) * | 1996-10-23 | 1998-04-29 | Eurand Int | Process for the preparation of a pharmaceutical composition for rapid suspension in water |
| WO1998020858A1 (en) | 1996-11-12 | 1998-05-22 | Pharmacia & Upjohn Ab | COMPACT MEMBER COMPRISING A PLURALITY OF POROUS CELLULOSE MATRICES, (PCMs), METHOD OF MANUFACTURING AND USE THEREOF |
| US5989591A (en) | 1997-03-14 | 1999-11-23 | American Home Products Corporation | Rapamycin formulations for oral administration |
| US6080427A (en) * | 1997-04-17 | 2000-06-27 | Bristol-Myers Squibb Company | Cefadroxil monohydrate tablet formulation |
| CA2293793C (en) | 1997-06-13 | 2006-07-11 | American Home Products Corporation | Rapamycin formulations for oral administration |
| BRPI9909201B8 (pt) | 1998-03-26 | 2021-05-25 | Astellas Pharma Inc | formulação de composto de macrolídeo de liberação controlada |
| FR2785538B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| AU2944700A (en) * | 1999-03-15 | 2000-10-04 | Kaken Pharmaceutical Co., Ltd. | Quickly disintegrating tablets and process for producing the same |
| FR2793690B1 (fr) | 1999-03-30 | 2003-01-03 | Cll Pharma | Formulations pharmaceutiques en macrolides seuls ou associes a d'autres principes actifs et leur utilisation en therapeutique |
| AU782005B2 (en) * | 1999-05-21 | 2005-06-30 | Kissei Pharmaceutical Co. Ltd. | Immediate release medicinal compositions for oral use |
| GB0008785D0 (en) | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| CA2311734C (en) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
| US20020076437A1 (en) | 2000-04-12 | 2002-06-20 | Sanjeev Kothari | Flashmelt oral dosage formulation |
| GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| EP2281556A1 (en) | 2005-02-25 | 2011-02-09 | F. Hoffmann-La Roche AG | Tablets with improved drugs substance dispersibility |
| TWI347942B (en) | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
-
2001
- 2001-09-28 GB GBGB0123400.4A patent/GB0123400D0/en not_active Ceased
-
2002
- 2002-09-26 PE PE2002000948A patent/PE20030602A1/es not_active Application Discontinuation
- 2002-09-26 AR ARP020103642A patent/AR036643A1/es not_active Application Discontinuation
- 2002-09-26 EC EC2002004323A patent/ECSP024323A/es unknown
- 2002-09-27 ES ES09177889.4T patent/ES2560106T3/es not_active Expired - Lifetime
- 2002-09-27 CO CO02087099A patent/CO5390072A1/es not_active Application Discontinuation
- 2002-09-27 EP EP09177889.4A patent/EP2193788B1/en not_active Expired - Lifetime
- 2002-09-27 DK DK02774661.9T patent/DK1432408T3/da active
- 2002-09-27 WO PCT/EP2002/010890 patent/WO2003028705A1/en active Search and Examination
- 2002-09-27 DE DE60238131T patent/DE60238131D1/de not_active Expired - Lifetime
- 2002-09-27 NZ NZ531599A patent/NZ531599A/en not_active IP Right Cessation
- 2002-09-27 CN CN2010101174089A patent/CN101912392A/zh active Pending
- 2002-09-27 US US10/490,089 patent/US20040254210A1/en not_active Abandoned
- 2002-09-27 PT PT91778894T patent/PT2193788E/pt unknown
- 2002-09-27 MX MXPA04002814A patent/MXPA04002814A/es active IP Right Grant
- 2002-09-27 RU RU2004113205/15A patent/RU2322970C2/ru active
- 2002-09-27 ES ES02774661T patent/ES2354687T3/es not_active Expired - Lifetime
- 2002-09-27 EP EP02774661A patent/EP1432408B8/en not_active Expired - Lifetime
- 2002-09-27 CN CN2006101159063A patent/CN1951390B/zh not_active Expired - Lifetime
- 2002-09-27 TW TW091122345A patent/TWI242449B/zh not_active IP Right Cessation
- 2002-09-27 SI SI200230928T patent/SI1432408T1/sl unknown
- 2002-09-27 IL IL16049802A patent/IL160498A0/xx unknown
- 2002-09-27 BR BR0212922-1A patent/BR0212922A/pt not_active IP Right Cessation
- 2002-09-27 DK DK09177889.4T patent/DK2193788T3/en active
- 2002-09-27 MY MYPI20023631A patent/MY150060A/en unknown
- 2002-09-27 CN CNA028190459A patent/CN1561201A/zh active Pending
- 2002-09-27 PT PT02774661T patent/PT1432408E/pt unknown
- 2002-09-27 KR KR1020047004628A patent/KR100626785B1/ko active IP Right Grant
- 2002-09-27 HU HU0402394A patent/HU229991B1/hu unknown
- 2002-09-27 NZ NZ542273A patent/NZ542273A/en not_active IP Right Cessation
- 2002-09-27 JP JP2003532038A patent/JP2005507897A/ja not_active Withdrawn
- 2002-09-27 BR BRPI0212922-1A patent/BRPI0212922B1/pt unknown
- 2002-09-27 CA CA2458455A patent/CA2458455C/en not_active Expired - Lifetime
- 2002-09-27 PL PL367896A patent/PL209704B1/pl not_active IP Right Cessation
- 2002-09-27 AT AT02774661T patent/ATE485813T1/de active
-
2004
- 2004-02-18 ZA ZA200401300A patent/ZA200401300B/en unknown
- 2004-02-19 IL IL160498A patent/IL160498A/en active IP Right Grant
- 2004-03-26 NO NO20041270A patent/NO333892B1/no not_active IP Right Cessation
- 2004-12-15 HK HK04109968.5A patent/HK1067036A1/xx not_active IP Right Cessation
- 2004-12-15 HK HK10107727.3A patent/HK1141239A1/xx not_active IP Right Cessation
-
2008
- 2008-12-04 JP JP2008309431A patent/JP5160386B2/ja not_active Expired - Lifetime
-
2010
- 2010-05-10 US US12/776,711 patent/US20100221331A1/en not_active Abandoned
- 2010-11-30 CY CY20101101091T patent/CY1111119T1/el unknown
-
2011
- 2011-06-13 US US13/158,921 patent/US20110306630A1/en not_active Abandoned
-
2012
- 2012-06-05 US US13/489,396 patent/US8617598B2/en not_active Expired - Lifetime
-
2014
- 2014-08-14 AR ARP140103055A patent/AR097341A2/es unknown
-
2016
- 2016-01-21 CY CY20161100068T patent/CY1117164T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009102341A5 (ja) | ||
| JP2005507897A5 (ja) | ||
| AR097341A2 (es) | Composición farmaceutica que comprende una dispersión de macrólidos sólidos, y un proceso para producir una tableta dispersable que contiene un macrólido | |
| WO2009074351A3 (en) | Solid forms of tenofovir disoproxil | |
| WO2011049706A8 (en) | Orally transformable tablets | |
| WO2009043844A3 (en) | Orodispersible tablets | |
| MY147641A (en) | Fast release paracetamol tablets | |
| JP2009507047A5 (ja) | ||
| NZ610729A (en) | Therapeutic compositions comprising rilpivirine hcl and tenofovir disoproxil fumarate | |
| WO2006128121A3 (en) | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications | |
| TW200621268A (en) | Antimicrobial copolymers and uses thereof | |
| IL192374A0 (en) | Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol | |
| JP2009280621A5 (ja) | ||
| MX343358B (es) | Tabletas de acetato de ulipristal. | |
| JP2011518842A5 (ja) | ||
| TW200637537A (en) | Pharmaceutical composition containing sibutramine free base and manufacturing method thereof | |
| IL207928A (en) | Pharmacotherapeutic agent that contains an active drug (mtx) and helps 2, 2-anhydropyrimidine to reduce and use mtx toxicity | |
| HRP20100120T1 (hr) | Formulacije s valsartanom | |
| GEP20125636B (en) | Slow-release formulation based on glycogen and alginate association | |
| WO2011141791A3 (en) | Extended release formulations of desvenlafaxine base | |
| IL179859A0 (en) | Oral sustained release formulation of tedisamil with gastric retention properties | |
| WO2007016350A3 (en) | Modified release tablet formulations with enhanced mechanical properties | |
| WO2010023690A3 (en) | Prolonged release formulation of amisulpride | |
| WO2005115346A3 (en) | Pharmaceutical composition containing risperidone | |
| WO2008092219A3 (en) | Pharmaceutical composition comprising tramadol and ketoprofen |