JP2006500973A - 薬物送達のための急速に溶解する微小穿孔器および他の適用 - Google Patents
薬物送達のための急速に溶解する微小穿孔器および他の適用 Download PDFInfo
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- JP2006500973A JP2006500973A JP2004516176A JP2004516176A JP2006500973A JP 2006500973 A JP2006500973 A JP 2006500973A JP 2004516176 A JP2004516176 A JP 2004516176A JP 2004516176 A JP2004516176 A JP 2004516176A JP 2006500973 A JP2006500973 A JP 2006500973A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- Medical Informatics (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
本発明は、薬物の経皮送達に関する。
有効な任意の薬物は、体内に、治療有効な速度および量で、1つ以上の生物学的バリアを横切って輸送されなければならない。多くの例において、薬物は、十分効果的に経口投与され得るが、多くの他の例において、その経口経路は、胃腸管内の重大な分解、腸膜内の乏しい吸収、および/または肝臓による最初の通過の分解のために、効果的ではない。これらの障害は、タンパク質成分、ペプチド成分およびDNA成分を含む多くのさらに新しい薬物に対して、特に問題である。例えば、組換えヒトインスリン、成長ホルモン、エリトロポイエチン、インターフェロンおよび他のタンパク質は全て、現在において、経口以外の幾つかの様式で投与されなければならない。
図1は、角質層13、表皮層または表皮15および真皮層または真皮17を含む、皮膚11の上層の断面図である。皮膚の最外層、角質層13は、通常10ミクロン(μm)厚と20ミクロン(μm)厚との間の、死んだ細胞層である。この角質13は、脂質の疎水性細胞外マトリクス、主にセラミドによって囲まれた親水性ケラチノサイトを含む。構造的特徴および組成的特徴のために、角質13は、体内への薬物または他の分子の経皮流れならびに体外への体液および他の分析物の経皮流れ、に対する最大のバリアを提供する。角質13は、2〜3週の平均回転時間で、角質細胞の脱離によって連続的に再生される。
α−インターフェロン 11〜100μgm
多発性硬化症のためのβ−インターフェロン 22〜44μgm
貧血症に対するエリスロポイエチン 10〜30μgm
卵胞刺激ホルモン(FSH) 5〜30μgm
G−CSF 9〜15μgm
GM−CSF 250μgm
ヒト絨毛性性腺刺激ホルモン 30〜300μgm
黄体形成(leutinizing)ホルモン 2〜30μgm
サケカルシトニン 25〜50μgm
グルカゴン 1mgm
GNRHアンタゴニスト 2mgm
インスリン 0.75〜1.5mgm
ヒト成長ホルモン(GHD) 0.25〜1.5mgm
ヒト成長ホルモン(AIDS) 6mgm
テストステロン 5〜10mgm
リドカイン 2〜5%
ジクロフェナクナトリウム 100 200mgm
オキシブチニン 5〜15mgm
ケトプロフェン 75〜200mgm
アレンドロネート(Alemdronate) 10mgm
マレイン酸エナラプリル(enalpril) 10〜40mgm
フェニルプロパノールアミンHCl 75mgm
クロモリンナトリウム 3.2〜10mgm
イソトレチノイン 0.5〜2mgm/kgm
オキシトシン 1〜2単位/分/iv
パロキセチンHCl 20mgm
フルルビプロフェン 100mgm
セルタリン(sertaline) 50mgm
ベンラファキシン(venlafaxine) 75mgm
ロイプロリド 0.125〜0.25mgm
リスペリドン(risperidone) 4〜6mgm
ガランタミン臭化水素酸塩 16〜24mgm
エノキサプリン、抗凝血剤
エタナーセプト(etanercept)、慢性関節リウマチ
フェンタニール、手術後および慢性の痛み
フィルグラスチン、化学療法由来の低白血球
ヘパリン、抗凝血剤
副甲状腺ホルモン(PTH)
ソマトロピン、成長ホルモン
スマトリプタン、片頭痛
モルヒネ
オピエート抗関節炎。
B型肝炎
HIVワクチン
インフルエンザ
ジフテリア
破傷風
百日咳
ライム病
狂犬病
肺炎双球菌
黄熱病
コレラ
種痘疹
結核
風疹
麻疹
おたふくかぜ
ロタウイルス
ボツリヌス
ヘルペスウイルス
他のDNAワクチン
B型肝炎
HIVワクチン
インフルエンザ
ジフテリア
破傷風
百日咳
ライム病
狂犬病
肺炎双球菌
黄熱病
コレラ
種痘疹
結核。
Claims (21)
- システムであって、以下:
溶媒の供給源、および
該溶媒との接触の際に急速に溶解する複数の微小穿孔器を有するアレイ、
を備える、システム。 - 請求項1に記載のシステムであって、前記薬物がポリマーマトリックス材料内に含まれる、システム。
- 請求項1に記載のシステムであって、前記薬物が実質的に100%の微小穿孔器を含む、システム。
- 請求項1に記載のシステムであって、前記薬物がペプチドまたは核酸を含む、システム。
- 請求項1に記載のシステムであって、前記薬物が多糖を含む、システム。
- 請求項1に記載のシステムであって、前記薬物がワクチンを含む、システム。
- 請求項1に記載のシステムであって、前記微小穿孔器が皮膚から真皮層まで貫入するのに十分に長い、システム。
- 請求項1に記載のシステムであって、前記微小穿孔器が実質的に多角形の断面を有する、システム。
- 請求項1に記載のシステムであって、前記微小穿孔器が実質的に尖った形状の断面を有する、システム。
- 請求項1に記載のシステムであって、前記微小穿孔器が実質的に刃の形状である、システム。
- 請求項1に記載のシステムであって、前記微小穿孔器が20μm以下の最小先端直径を有する、システム。
- 請求項1に記載のシステムであって、少なくとも5個の前記微小穿孔器が1cm2以下の面積を有する領域内に配置される、システム。
- 請求項1に記載のシステムであって、前記溶媒の供給源が、第2の薬物を含む流体レザバを備える、システム。
- 請求項13に記載のシステムであって、前記レザバがパッチを備える、システム。
- 請求項14に記載のシステムであって、前記微小穿孔器内に含まれる薬物が、前記パッチ内に含まれる薬物と同じである、システム。
- 請求項14に記載のシステムであって、前記微小穿孔器内に含まれる薬物と、前記パッチ内に含まれる薬物とが、互いに異なる、システム。
- 請求項14に記載のシステムであって、前記パッチが周辺領域の接着剤を有する、システム。
- 請求項1に記載のシステムであって、前記溶媒の供給源が、アルコール、アミド、アミノ酸、リン脂質、スルホン、ピロリドンおよび界面活性剤からなる群から選択された化学エンハンサーを含む、システム。
- 請求項1に記載のシステムであって、第2の薬物を含む第2のアレイの微小穿孔器をさらに備える、システム。
- 請求項1に記載のシステムであって、前記微小穿孔器を皮膚に駆動する、手動操作型圧力機構をさらに備える、システム。
- 請求項1に記載のシステムであって、前記微小穿孔器を皮膚内に10〜1000μm駆動する圧力機構をさらに備える、システム。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/179,749 US6945952B2 (en) | 2002-06-25 | 2002-06-25 | Solid solution perforator for drug delivery and other applications |
US10/179,749 | 2002-06-25 | ||
US41106302P | 2002-09-16 | 2002-09-16 | |
US60/411,063 | 2002-09-16 | ||
PCT/US2003/019820 WO2004000389A2 (en) | 2002-06-25 | 2003-06-19 | Rapidly dissolving micro-perforator for drug delivery and other applications |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2009275003A Division JP5323657B2 (ja) | 2002-06-25 | 2009-12-02 | 薬物送達のための急速に溶解する微小穿孔器および他の適用 |
Publications (3)
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JP2006500973A true JP2006500973A (ja) | 2006-01-12 |
JP2006500973A5 JP2006500973A5 (ja) | 2009-01-29 |
JP4829497B2 JP4829497B2 (ja) | 2011-12-07 |
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JP2004516176A Expired - Fee Related JP4829497B2 (ja) | 2002-06-25 | 2003-06-19 | 薬物送達のための急速に溶解する微小穿孔器および他の適用 |
JP2009275003A Expired - Fee Related JP5323657B2 (ja) | 2002-06-25 | 2009-12-02 | 薬物送達のための急速に溶解する微小穿孔器および他の適用 |
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JP2009275003A Expired - Fee Related JP5323657B2 (ja) | 2002-06-25 | 2009-12-02 | 薬物送達のための急速に溶解する微小穿孔器および他の適用 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1534376B1 (ja) |
JP (2) | JP4829497B2 (ja) |
KR (2) | KR100993477B1 (ja) |
CN (1) | CN100591386C (ja) |
AU (1) | AU2003243750A1 (ja) |
CA (1) | CA2490137C (ja) |
DK (1) | DK1534376T3 (ja) |
ES (1) | ES2607128T3 (ja) |
WO (1) | WO2004000389A2 (ja) |
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WO2008020633A1 (fr) * | 2006-08-18 | 2008-02-21 | Toppan Printing Co., Ltd. | Micro-aiguille et timbre à micro-aiguilles |
JP2008142183A (ja) * | 2006-12-07 | 2008-06-26 | Fujifilm Corp | マイクロニードルシート及びその製造方法 |
JP2008188273A (ja) * | 2007-02-06 | 2008-08-21 | Toppan Printing Co Ltd | 薬物輸送デバイス |
JP2010075485A (ja) * | 2008-09-26 | 2010-04-08 | Toppan Printing Co Ltd | マイクロニードル保持容器 |
JP2010075486A (ja) * | 2008-09-26 | 2010-04-08 | Toppan Printing Co Ltd | マイクロニードル保持容器 |
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JP2011078771A (ja) * | 2009-10-08 | 2011-04-21 | Palo Alto Research Center Inc | マイクロニードルを用いる経粘膜的薬物送達のための装置及び方法 |
WO2011053018A2 (ko) * | 2009-10-28 | 2011-05-05 | Kim Do We | 알레르겐 진단을 위한 바늘 구비형 피부 진단용 시험기 |
JPWO2009107806A1 (ja) * | 2008-02-29 | 2011-07-07 | 株式会社 メドレックス | マイクロニードルの皮膚内への挿入方法及び該方法に使用する補助器具 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE438418T1 (de) | 2001-05-01 | 2009-08-15 | Av Topchiev Inst Petrochemical | Hydrogel-zusammensetzungen |
US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8353861B2 (en) | 2003-09-18 | 2013-01-15 | Texmac, Inc. | Applicator for applying functional substances into human skin |
US8048423B2 (en) * | 2003-12-09 | 2011-11-01 | Allergan, Inc. | Botulinum toxin therapy for skin disorders |
EP1713450B1 (en) | 2004-01-30 | 2021-10-06 | Corium, Inc. | Rapidly dissolving film for delivery of an active agent |
GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
SE0400685D0 (sv) * | 2004-03-19 | 2004-03-19 | Pfizer Health Ab | Means for transdermal administration of nicotine |
US20060100584A1 (en) * | 2004-08-10 | 2006-05-11 | Orest Olejnik | Needleless microprotrusion elastoplast system |
AU2012201016B2 (en) * | 2004-11-18 | 2012-10-11 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
EP1833547A1 (en) * | 2004-11-18 | 2007-09-19 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
WO2006077742A1 (ja) * | 2004-12-28 | 2006-07-27 | Nabtesco Corporation | 皮膚用針製造装置および皮膚用針製造方法 |
JP2006335754A (ja) * | 2005-06-01 | 2006-12-14 | Technofarm Axesz Kk | 経皮投与剤担持薄膜とその製造法 |
JP2007014588A (ja) * | 2005-07-08 | 2007-01-25 | Nano Device & System Research Inc | 経皮投与装置,経皮投与装置製造用金型 |
JP4804827B2 (ja) * | 2005-08-05 | 2011-11-02 | 尚哉 宮野 | 経皮性薬剤配送装置及び経皮性薬剤配送装置用針装置の製造方法 |
JP2007089792A (ja) * | 2005-09-28 | 2007-04-12 | Nano Device & System Research Inc | 経皮投与装置 |
JP2007130417A (ja) * | 2005-11-08 | 2007-05-31 | Nano Device & System Research Inc | 経皮投与装置 |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
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KR100886633B1 (ko) * | 2006-07-14 | 2009-03-04 | 호남석유화학 주식회사 | 전면부에 피부를 통해 체내로 전달하고자 하는 물질의 수용공간을 갖는 피부 침투용 미세 돌기 장치 |
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US10588694B1 (en) | 2007-01-19 | 2020-03-17 | Joseph Neev | Devices and methods for generation of subsurface micro-disruptions for biomedical applications |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
WO2008130587A2 (en) | 2007-04-16 | 2008-10-30 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
AU2008327083B2 (en) | 2007-11-21 | 2014-01-16 | Bioserentach Co., Ltd. | Preparation for application to body surface and preparation holding sheet for application to body surface |
US9220678B2 (en) | 2007-12-24 | 2015-12-29 | The University Of Queensland | Coating method |
CN102007066B (zh) | 2008-02-07 | 2013-06-26 | 昆士兰大学 | 贴片制造 |
US10543123B2 (en) | 2008-04-28 | 2020-01-28 | Joseph Neev | Devices and methods for generation of subsurface micro-disruptions for opthalmic surgery and opthalmic applications |
EP2294415A4 (en) | 2008-05-23 | 2011-10-05 | Univ Queensland | ANALYTIC DETECTION BY MEANS OF MICRONADELPFLASTER WITH ANALYTICAL REAGENT |
US9320878B2 (en) * | 2008-10-07 | 2016-04-26 | Tuo Jin | Phase-transition polymeric microneedles |
EP2387394B1 (en) | 2009-01-14 | 2018-05-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
JP5408592B2 (ja) * | 2010-03-19 | 2014-02-05 | コスメディ製薬株式会社 | マイクロニードルの迅速溶解法 |
US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US9943673B2 (en) | 2010-07-14 | 2018-04-17 | Vaxxas Pty Limited | Patch applying apparatus |
EP2629836B1 (en) * | 2010-10-19 | 2018-09-12 | Trustees Of Tufts College | Silk fibroin-based microneedles and methods of making the same |
US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9283179B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
FR2973237A1 (fr) | 2011-03-31 | 2012-10-05 | Oreal | Procede de traitement cosmetique fractionne utilisant un laser ou des micro-aiguilles |
DK2726091T3 (da) * | 2011-06-29 | 2020-03-09 | Rani Therapeutics Llc | Præparater med terapeutisk middel til fremføring i et lumen i tarmkanalen ved hjælp af en synkbar anordning til lægemiddelfremføring |
JP6121674B2 (ja) * | 2011-09-12 | 2017-04-26 | コスメディ製薬株式会社 | マイクロニードル迅速溶解法 |
JP6265740B2 (ja) | 2011-10-06 | 2018-01-24 | 久光製薬株式会社 | アプリケータ |
EP4233839A3 (en) | 2011-10-12 | 2023-09-27 | Vaxxas Pty Limited | Delivery device |
KR101392947B1 (ko) * | 2011-12-13 | 2014-05-12 | 주식회사 스몰랩 | 섬유를 포함하는 미세돌기 마사지 패치 및 그 제조 방법 |
CA2867158A1 (en) * | 2012-04-03 | 2013-10-10 | Theraject, Inc. | Soluble microneedle arrays for buccal delivery of vaccines |
JP5746101B2 (ja) * | 2012-06-18 | 2015-07-08 | コスメディ製薬株式会社 | マイクロニードルの迅速溶解法 |
MX2015008157A (es) | 2012-12-21 | 2016-02-22 | Corium Int Inc | Microarreglo para la entrega de agente terapeutico y metodos de uso. |
BR112015022253B1 (pt) | 2013-03-12 | 2022-03-15 | Corium, Inc | Aplicador de microprojeções |
CA2903459C (en) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
ES2761580T3 (es) | 2013-03-15 | 2020-05-20 | Corium Inc | Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación |
BR112015022625B1 (pt) * | 2013-03-15 | 2023-01-31 | Corium, Inc | Aparelho de microestrutura para entrega de agente terapêutico |
AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
CN110302004B (zh) | 2013-05-03 | 2023-04-28 | 科尼尔赛德生物医学公司 | 用于眼部注射的设备和方法 |
WO2015005143A1 (ja) * | 2013-07-11 | 2015-01-15 | 凸版印刷株式会社 | マイクロニードルユニット |
EP2839853A1 (de) * | 2013-08-23 | 2015-02-25 | LTS LOHMANN Therapie-Systeme AG | Transdermales therapeutisches System mit Druckerzeugungsvorrichtung |
KR101724654B1 (ko) * | 2014-06-02 | 2017-04-12 | 주식회사 아모라이프사이언스 | 마이크로 니들 패치 및 그의 제조 방법 |
WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
KR102313520B1 (ko) * | 2014-09-11 | 2021-10-14 | 주식회사 엘지생활건강 | 흡수 속도를 개선한 마이크로니들 시스템 |
EP4218892A1 (en) | 2015-02-02 | 2023-08-02 | Vaxxas Pty Limited | Microprojection array applicator |
US10441768B2 (en) | 2015-03-18 | 2019-10-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
JP2015134288A (ja) * | 2015-05-07 | 2015-07-27 | コスメディ製薬株式会社 | マイクロニードルの迅速溶解法 |
WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
US11684763B2 (en) | 2015-10-16 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices |
US11160963B2 (en) * | 2015-12-04 | 2021-11-02 | Ascilion Ab | Microneedle and a chip |
WO2017120322A1 (en) | 2016-01-05 | 2017-07-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
JP6726512B2 (ja) * | 2016-03-31 | 2020-07-22 | コスメディ製薬株式会社 | マイクロニードルアプリケータ |
KR101942169B1 (ko) * | 2017-01-02 | 2019-01-24 | 가천대학교 산학협력단 | 마이크로 니들 장치 |
EP3606760B1 (en) | 2017-03-31 | 2023-09-27 | Vaxxas Pty Limited | Device and method for coating surfaces |
DE102017112573A1 (de) | 2017-06-07 | 2018-12-13 | Lts Lohmann Therapie-Systeme Ag | Mikronadelsystem zur Applikation von Glukagon-ähnlichen-Peptid Analoga |
AU2018285954A1 (en) | 2017-06-13 | 2019-12-19 | Vaxxas Pty Limited | Quality control of substrate coatings |
WO2019023757A1 (en) | 2017-08-04 | 2019-02-07 | Vaxxas Pty Limited | COMPACT MECHANICAL HIGH ENERGY STORAGE ACTUATOR WITH LOW TRIGGER STRENGTH FOR ADMINISTRATION OF MICROPROJECTION NETWORK (PRM) PATCHES |
US11318292B2 (en) * | 2018-05-28 | 2022-05-03 | Microneedles Inc. | Microneedle patch for transdermal injections |
EP3698841A1 (en) * | 2019-02-19 | 2020-08-26 | L'oreal | Injection device |
CN112957607B (zh) * | 2021-01-30 | 2023-08-04 | 上海应用技术大学 | 一种微针透皮贴及其制备方法 |
US12036300B2 (en) | 2021-03-31 | 2024-07-16 | L'oreal | Methods and compositions for improving skin |
FR3122826A1 (fr) | 2021-05-12 | 2022-11-18 | L'oreal | Procedes et compositions pour l’amelioration de la peau |
WO2023276090A1 (ja) * | 2021-06-30 | 2023-01-05 | シンクランド株式会社 | 経皮投与装置及び経皮投与システム |
FR3124952A1 (fr) | 2021-07-09 | 2023-01-13 | L'oreal | Procédés et compositions pour l’amélioration de la peau |
CN114558241B (zh) * | 2021-12-31 | 2024-01-12 | 北京化工大学 | 一种基于聚合物可溶性微针的给药式内窥镜装置 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002005889A1 (en) * | 2000-07-17 | 2002-01-24 | Becton, Dickinson And Company | Delivery device with microneedles for the transdermal administration of a substance |
WO2002005890A2 (en) * | 2000-07-14 | 2002-01-24 | Becton, Dickinson And Company | Microdevice and method of manufacturing a microdevice |
JP2002517300A (ja) * | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5749376A (en) | 1993-10-18 | 1998-05-12 | Wilk; Peter J. | Medical treatment and waste disposal method |
US5542920A (en) * | 1994-09-12 | 1996-08-06 | Delab | Needle-less parenteral introduction device |
DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
AU739616B2 (en) * | 1997-12-11 | 2001-10-18 | Alza Corporation | Device for enhancing transdermal agent flux |
KR100561892B1 (ko) * | 1997-12-11 | 2006-03-16 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
WO2002064193A2 (en) * | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
-
2003
- 2003-06-19 KR KR1020047021103A patent/KR100993477B1/ko active IP Right Grant
- 2003-06-19 DK DK03761282.7T patent/DK1534376T3/en active
- 2003-06-19 CA CA2490137A patent/CA2490137C/en not_active Expired - Lifetime
- 2003-06-19 CN CN03819714A patent/CN100591386C/zh not_active Expired - Fee Related
- 2003-06-19 KR KR1020107022923A patent/KR101061975B1/ko active IP Right Review Request
- 2003-06-19 WO PCT/US2003/019820 patent/WO2004000389A2/en active Application Filing
- 2003-06-19 JP JP2004516176A patent/JP4829497B2/ja not_active Expired - Fee Related
- 2003-06-19 ES ES03761282.7T patent/ES2607128T3/es not_active Expired - Lifetime
- 2003-06-19 AU AU2003243750A patent/AU2003243750A1/en not_active Abandoned
- 2003-06-19 EP EP03761282.7A patent/EP1534376B1/en not_active Expired - Lifetime
-
2009
- 2009-12-02 JP JP2009275003A patent/JP5323657B2/ja not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002517300A (ja) * | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
WO2002005890A2 (en) * | 2000-07-14 | 2002-01-24 | Becton, Dickinson And Company | Microdevice and method of manufacturing a microdevice |
WO2002005889A1 (en) * | 2000-07-17 | 2002-01-24 | Becton, Dickinson And Company | Delivery device with microneedles for the transdermal administration of a substance |
JP2004503341A (ja) * | 2000-07-17 | 2004-02-05 | ベクトン ディキンソン アンド カンパニー | 物質を経皮的に投与する投与器具 |
Cited By (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6445933A (en) * | 1987-08-12 | 1989-02-20 | Nissan Motor | Control device in internal combustion engine with automatic gear |
JP4913030B2 (ja) | 2005-01-31 | 2012-04-11 | 株式会社バイオセレンタック | 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具 |
JP2012110726A (ja) * | 2005-09-06 | 2012-06-14 | Theraject Inc | 薬物粒子および/または薬物を吸着した粒子を含む、固溶体穿孔器 |
JP2013027742A (ja) * | 2005-09-06 | 2013-02-07 | Theraject Inc | 薬物粒子および/または薬物を吸着した粒子を含む、固溶体穿孔器 |
WO2008020633A1 (fr) * | 2006-08-18 | 2008-02-21 | Toppan Printing Co., Ltd. | Micro-aiguille et timbre à micro-aiguilles |
WO2008020632A1 (fr) * | 2006-08-18 | 2008-02-21 | Toppan Printing Co., Ltd. | Micro-aiguille et timbre à micro-aiguilles |
JP2008142183A (ja) * | 2006-12-07 | 2008-06-26 | Fujifilm Corp | マイクロニードルシート及びその製造方法 |
JP2008188273A (ja) * | 2007-02-06 | 2008-08-21 | Toppan Printing Co Ltd | 薬物輸送デバイス |
JPWO2009107806A1 (ja) * | 2008-02-29 | 2011-07-07 | 株式会社 メドレックス | マイクロニードルの皮膚内への挿入方法及び該方法に使用する補助器具 |
JP5448097B2 (ja) * | 2008-02-29 | 2014-03-19 | 株式会社 メドレックス | マイクロニードルの皮膚内への挿入方法及び該方法に使用する補助器具 |
JP2013226427A (ja) * | 2008-02-29 | 2013-11-07 | Medorekkusu:Kk | マイクロニードルの皮膚内への挿入方法及び該方法に使用する補助器具 |
JP2011520550A (ja) * | 2008-05-21 | 2011-07-21 | セラジェクト, インコーポレイテッド | 固溶体穿孔器パッチの製造方法及びその使用 |
JP2010075486A (ja) * | 2008-09-26 | 2010-04-08 | Toppan Printing Co Ltd | マイクロニードル保持容器 |
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JPWO2010074239A1 (ja) * | 2008-12-26 | 2012-06-21 | 久光製薬株式会社 | マイクロニードルデバイス |
JP2011078771A (ja) * | 2009-10-08 | 2011-04-21 | Palo Alto Research Center Inc | マイクロニードルを用いる経粘膜的薬物送達のための装置及び方法 |
KR101018406B1 (ko) * | 2009-10-28 | 2011-02-28 | 김도위 | 알레르겐 진단을 위한 바늘 일체형 피부 진단용 시험기 |
WO2011053018A3 (ko) * | 2009-10-28 | 2011-11-03 | Kim Do We | 알레르겐 진단을 위한 바늘 구비형 피부 진단용 시험기 |
WO2011053019A3 (ko) * | 2009-10-28 | 2011-10-20 | Kim Do We | 알레르겐 진단을 위한 바늘 일체형 피부 진단용 시험기 |
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WO2011053018A2 (ko) * | 2009-10-28 | 2011-05-05 | Kim Do We | 알레르겐 진단을 위한 바늘 구비형 피부 진단용 시험기 |
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US11338118B2 (en) | 2009-12-24 | 2022-05-24 | Rani Therapeutics, Llc | Swallowable drug delivery device and methods of drug delivery |
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JPWO2013129028A1 (ja) * | 2012-02-29 | 2015-07-30 | 凸版印刷株式会社 | 針状体および針状体の製造方法 |
US9849271B2 (en) | 2012-02-29 | 2017-12-26 | Toppan Printing Co., Ltd. | Needle-like material and method for manufacturing needle-like material |
KR102064628B1 (ko) | 2012-04-05 | 2020-01-08 | 히사미쓰 세이야꾸 가부시키가이샤 | 천자 장치 및 그 제조 방법 |
WO2013151044A1 (ja) * | 2012-04-05 | 2013-10-10 | 久光製薬株式会社 | 穿刺装置及びその製造方法 |
JPWO2013151044A1 (ja) * | 2012-04-05 | 2015-12-17 | 久光製薬株式会社 | 穿刺装置及びその製造方法 |
KR20140143416A (ko) * | 2012-04-05 | 2014-12-16 | 히사미쓰 세이야꾸 가부시키가이샤 | 천자 장치 및 그 제조 방법 |
JP2015521910A (ja) * | 2012-06-29 | 2015-08-03 | イーエルシー マネージメント エルエルシー | 1つ以上の封入された化粧品成分を含む可溶性マイクロニードル |
JP2015522342A (ja) * | 2012-06-29 | 2015-08-06 | イーエルシー マネージメント エルエルシー | 1つ以上の化粧品成分を含むマイクロニードル |
JP2012196547A (ja) * | 2012-07-23 | 2012-10-18 | Toppan Printing Co Ltd | 針状体および針状体製造方法 |
WO2014097837A1 (ja) * | 2012-12-21 | 2014-06-26 | 久光製薬株式会社 | アプリケータ |
US9913970B2 (en) | 2012-12-21 | 2018-03-13 | Hisamitsu Pharmaceutical Co., Ltd. | Applicator |
JPWO2014097837A1 (ja) * | 2012-12-21 | 2017-01-12 | 久光製薬株式会社 | アプリケータ |
US10232158B2 (en) | 2013-09-18 | 2019-03-19 | Cosmed Pharmaceutical Co., Ltd. | Microneedle patch application device and patch holder |
WO2015040697A1 (ja) | 2013-09-18 | 2015-03-26 | コスメディ製薬株式会社 | マイクロニードルパッチ適用装置及びパッチホルダー |
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US10086183B2 (en) | 2013-11-05 | 2018-10-02 | Hisamitsu Pharmaceutical Co., Inc. | Applicator |
WO2017014091A1 (ja) * | 2015-07-22 | 2017-01-26 | 日本写真印刷株式会社 | マイクロニードルパッチ用インパクト付加型アプリケータ及び先端部材 |
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US11633580B2 (en) | 2017-03-28 | 2023-04-25 | Cosmed Pharmaceutical Co., Ltd. | Applicator for water-soluble sheet-shaped preparation |
KR20190128628A (ko) | 2017-03-28 | 2019-11-18 | 코스메드 파마소티컬 씨오 쩜 엘티디 | 수용성 시트상 제제의 애플리케이터 |
WO2018181466A1 (ja) | 2017-03-28 | 2018-10-04 | コスメディ製薬株式会社 | 水溶性シート状製剤のアプリケータ |
KR20200111179A (ko) | 2018-01-24 | 2020-09-28 | 코스메드 파마소티컬 씨오 쩜 엘티디 | 마이크로니들용 긴박 기구 |
WO2019146618A1 (ja) | 2018-01-24 | 2019-08-01 | コスメディ製薬株式会社 | マイクロニードル用緊迫器具 |
KR20220002303A (ko) | 2019-04-25 | 2022-01-06 | 코스메드 파마소티컬 씨오 쩜 엘티디 | 수용성 시트상 제제의 애플리케이터 2 |
WO2020218486A1 (ja) | 2019-04-25 | 2020-10-29 | コスメディ製薬株式会社 | 水溶性シート状製剤のアプリケータ2 |
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AU2003243750A1 (en) | 2004-01-06 |
ES2607128T3 (es) | 2017-03-29 |
CA2490137C (en) | 2012-01-03 |
EP1534376A4 (en) | 2013-10-02 |
AU2003243750A8 (en) | 2004-01-06 |
JP2010046548A (ja) | 2010-03-04 |
DK1534376T3 (en) | 2016-12-05 |
KR101061975B1 (ko) | 2011-09-05 |
KR20100115393A (ko) | 2010-10-27 |
KR20050019789A (ko) | 2005-03-03 |
KR100993477B1 (ko) | 2010-11-11 |
EP1534376B1 (en) | 2016-08-31 |
CN1674954A (zh) | 2005-09-28 |
CA2490137A1 (en) | 2003-12-31 |
WO2004000389A9 (en) | 2004-06-10 |
WO2004000389A2 (en) | 2003-12-31 |
WO2004000389A3 (en) | 2004-03-04 |
JP5323657B2 (ja) | 2013-10-23 |
CN100591386C (zh) | 2010-02-24 |
JP4829497B2 (ja) | 2011-12-07 |
EP1534376A2 (en) | 2005-06-01 |
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