KR101061975B1 - 약물 송달 및 다른 용도를 위한 신속 용해형 마이크로 퍼포레이터를 포함하는 어레이 - Google Patents
약물 송달 및 다른 용도를 위한 신속 용해형 마이크로 퍼포레이터를 포함하는 어레이 Download PDFInfo
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- KR101061975B1 KR101061975B1 KR1020107022923A KR20107022923A KR101061975B1 KR 101061975 B1 KR101061975 B1 KR 101061975B1 KR 1020107022923 A KR1020107022923 A KR 1020107022923A KR 20107022923 A KR20107022923 A KR 20107022923A KR 101061975 B1 KR101061975 B1 KR 101061975B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
도 2A-2G는 적합한 마이크로 퍼포레이터 예들의 투시도이다.
도 3은 마이크로 퍼포레이터 어레이와 그것을 둘러싸고 있는 RDMP 시스템의 일부인 접착식 환형 고리의 평면도이다.
도 4-9는 RDMP 피부침투에 사용될 수 있는 활성화 메카니즘을 예시한다.
도 10은 약물 저장소 시스템을 예시한다.
도 11A-11C 및 도 12A-12F는 어떤 고려된 패치 시스템의 작동을 예시한다.
15. 표피 17. 진피
31. 어레이 33. 환형 영역
41. 마이크로-퍼포레이터 42. 피부
45. 관통 개시기 51, 61, 71. 마이크로-퍼포레이터
54. 나사 101. 저장소
102. 마이크로-퍼포레이터 어레이 103. 저장소 약물 송달 시스템
Claims (18)
- 복수 개의 용해가능하며 고체인 약물 용액 송달 퍼포레이터를 포함하는 어레이로서, 상기 퍼포레이터는 피부를 뚫어서 환자 신체에 피부 틈새를 제공하도록 적합하게 된 1개 이상의 뾰족한 단부 또는 칼날을 구비한 제1 단부를 포함하고, 상기 퍼포레이터 중에서 1개 이상은 용해 가능하며 매트릭스 내에 구비된 제1의 선택된 약물을 포함하는 매트릭스 재료로 형성된 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 매트릭스 재료는 용해성 생체 재료로 구성된 것을 특징으로 하는 어레이.
- 제 2 항에 있어서, 상기 용해성 생체 재료로는 중합체를 채택한 것을 특징으로 하는 어레이.
- 제 2 항에 있어서, 상기 용해성 생체 재료로는 탄수화물 유도체를 채택한 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 매트릭스 재료로는 수용성 유리를 채택한 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 매트릭스 재료로는 비이온계 친수성 계면활성제 또는 이온계 계면활성제 또는 친유성 첨가제 중에서 어느 하나를 채택한 것을 특징으로 하는 어레이.
- 삭제
- 제 1 항에 있어서, 상기 퍼포레이터의 상기 제1 단부가 교두형 단면 모양을 갖는 바늘인 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 퍼포레이터가 10-100㎛ 범위의 상기 제 1 단부 근접 외경을 가지는 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 어레이가 1cm2 이하의 면적을 가지는 영역 내에 20개 이상의 상기 용해가능한 퍼포레이터를 포함하는 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 피부 틈새와 유체 연통되며, 상기 퍼포레이터를 용해하기 위한 용매의 선택된 양을 수용하여 보유하도록 적합하게 된 유체 용기를 구비한, 유체 저장소를 더 포함하는 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 피부 틈새와 유체 연통되며, 제2 약물의 선택된 양을 수용하여 보유하도록 적합하게 된 유체 용기를 구비한, 저장소를 더 포함하는 것을 특징으로 하는 어레이.
- 제 11 항에 있어서, 상기 저장소가 제2 약물을 수용하여 보유하는 패치 저장소를 포함하며, 상기 제1 약물과 제2 약물이 동일한 것을 특징으로 하는 어레이.
- 제 11 항에 있어서, 상기 저장소가 제2 약물을 수용하여 보유하는 패치 저장소를 포함하며, 상기 제 1 약물과 제2 약물이 서로 상이한 것을 특징으로 하는 어레이.
- 제 11 항에 있어서, 상기 저장소가 상기 환자 피부 위의 선택된 영역을 둘러싸서 접촉하는 접착제 영역을 가지는 패치 저장소를 포함하는 것을 특징으로 하는 어레이.
- 제 15 항에 있어서, 상기 접착제 영역에 항균 물질이 구비된 것을 특징으로 하는 어레이.
- 제 11 항에 있어서, 상기 저장소가 지방 알콜, 산, 에스테르, 계면활성제, 매크로시클리스, 테르펜, 인지질, 피롤리돈, 아미드 및 아미노산으로 구성된 군으로부터 선택된 화학적 증진제를 포함하는 유체를 함유하는 것을 특징으로 하는 어레이.
- 제 12 항에 있어서, 상기 제2 약물은 단백질, 펩티드, DNA 성분, 유전자, 다당류, 백신, 합성 유기 화합물 및 합성 비-유기 화합물 중 하나를 포함하는 것을 특징으로 하는 어레이.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/179,749 US6945952B2 (en) | 2002-06-25 | 2002-06-25 | Solid solution perforator for drug delivery and other applications |
US10/179,749 | 2002-06-25 | ||
US41106302P | 2002-09-16 | 2002-09-16 | |
US60/411,063 | 2002-09-16 | ||
PCT/US2003/019820 WO2004000389A2 (en) | 2002-06-25 | 2003-06-19 | Rapidly dissolving micro-perforator for drug delivery and other applications |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047021103A Division KR100993477B1 (ko) | 2002-06-25 | 2003-06-19 | 약물 송달 및 다른 용도를 위한 신속 용해형마이크로-퍼포레이터 |
Publications (2)
Publication Number | Publication Date |
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KR20100115393A KR20100115393A (ko) | 2010-10-27 |
KR101061975B1 true KR101061975B1 (ko) | 2011-09-05 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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KR1020047021103A KR100993477B1 (ko) | 2002-06-25 | 2003-06-19 | 약물 송달 및 다른 용도를 위한 신속 용해형마이크로-퍼포레이터 |
KR1020107022923A KR101061975B1 (ko) | 2002-06-25 | 2003-06-19 | 약물 송달 및 다른 용도를 위한 신속 용해형 마이크로 퍼포레이터를 포함하는 어레이 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047021103A KR100993477B1 (ko) | 2002-06-25 | 2003-06-19 | 약물 송달 및 다른 용도를 위한 신속 용해형마이크로-퍼포레이터 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1534376B1 (ko) |
JP (2) | JP4829497B2 (ko) |
KR (2) | KR100993477B1 (ko) |
CN (1) | CN100591386C (ko) |
AU (1) | AU2003243750A1 (ko) |
CA (1) | CA2490137C (ko) |
DK (1) | DK1534376T3 (ko) |
ES (1) | ES2607128T3 (ko) |
WO (1) | WO2004000389A2 (ko) |
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- 2003-06-19 CA CA2490137A patent/CA2490137C/en not_active Expired - Lifetime
- 2003-06-19 CN CN03819714A patent/CN100591386C/zh not_active Expired - Fee Related
- 2003-06-19 KR KR1020107022923A patent/KR101061975B1/ko active IP Right Review Request
- 2003-06-19 WO PCT/US2003/019820 patent/WO2004000389A2/en active Application Filing
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AU2003243750A1 (en) | 2004-01-06 |
ES2607128T3 (es) | 2017-03-29 |
CA2490137C (en) | 2012-01-03 |
EP1534376A4 (en) | 2013-10-02 |
AU2003243750A8 (en) | 2004-01-06 |
JP2010046548A (ja) | 2010-03-04 |
DK1534376T3 (en) | 2016-12-05 |
KR20100115393A (ko) | 2010-10-27 |
KR20050019789A (ko) | 2005-03-03 |
KR100993477B1 (ko) | 2010-11-11 |
EP1534376B1 (en) | 2016-08-31 |
CN1674954A (zh) | 2005-09-28 |
CA2490137A1 (en) | 2003-12-31 |
WO2004000389A9 (en) | 2004-06-10 |
WO2004000389A2 (en) | 2003-12-31 |
WO2004000389A3 (en) | 2004-03-04 |
JP5323657B2 (ja) | 2013-10-23 |
CN100591386C (zh) | 2010-02-24 |
JP4829497B2 (ja) | 2011-12-07 |
EP1534376A2 (en) | 2005-06-01 |
JP2006500973A (ja) | 2006-01-12 |
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