KR20100115393A - 약물 송달 및 다른 용도를 위한 신속 용해형 마이크로 퍼포레이터를 포함하는 어레이 - Google Patents
약물 송달 및 다른 용도를 위한 신속 용해형 마이크로 퍼포레이터를 포함하는 어레이 Download PDFInfo
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- KR20100115393A KR20100115393A KR1020107022923A KR20107022923A KR20100115393A KR 20100115393 A KR20100115393 A KR 20100115393A KR 1020107022923 A KR1020107022923 A KR 1020107022923A KR 20107022923 A KR20107022923 A KR 20107022923A KR 20100115393 A KR20100115393 A KR 20100115393A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
도 2A-2G는 적합한 마이크로 퍼포레이터 예들의 투시도이다.
도 3은 마이크로 퍼포레이터 어레이와 그것을 둘러싸고 있는 RDMP 시스템의 일부인 접착식 환형 고리의 평면도이다.
도 4-9는 RDMP 피부침투에 사용될 수 있는 활성화 메카니즘을 예시한다.
도 10은 약물 저장소 시스템을 예시한다.
도 11A-11C 및 도 12A-12F는 어떤 고려된 패치 시스템의 작동을 예시한다.
15. 표피 17. 진피
31. 어레이 33. 환형 영역
41. 마이크로-퍼포레이터 42. 피부
45. 관통 개시기 51, 61, 71. 마이크로-퍼포레이터
54. 나사 101. 저장소
102. 마이크로-퍼포레이터 어레이 103. 저장소 약물 송달 시스템
Claims (17)
- 복수 개의 용해가능하며 실질적으로 고체인 약물 용액 송달 퍼포레이터를 포함하는 어레이로서, 상기 퍼포레이터는 피부를 뚫어서 환자 신체에 피부 틈새를 제공하도록 적합하게 된 적어도 1개의 뾰족한 단부 또는 칼날을 구비한 제1 단부를 포함하고, 상기 퍼포레이터 중에서 적어도 1개는 용해 가능하며 매트릭스 내에 구비된 제1의 선택된 약물을 포함하는 매트릭스 재료로 형성된 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 매트릭스 재료는 용해성 생체 재료로 구성된 것을 특징으로 하는 어레이.
- 제 2 항에 있어서, 상기 용해성 생체 재료로는 중합체를 채택한 것을 특징으로 하는 어레이.
- 제 2 항에 있어서, 상기 용해성 생체 재료로는 탄수화물 유도체를 채택한 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 매트릭스 재료로는 수용성 유리를 채택한 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 매트릭스 재료로는 비이온계 친수성 계면활성제 또는 이온계 계면활성제 또는 친유성 첨가제 중에서 어느 하나를 채택한 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 제2 약물은 단백질, 펩티드, DNA 성분, 유전자, 다당류, 백신, 합성 유기 화합물 및 합성 비-유기 화합물 중 적어도 하나인 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 퍼포레이터의 상기 제1 단부가 교두형 단면 모양을 갖는 바늘인 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 퍼포레이터가 10-100㎛ 범위의 상기 제 1 단부 근접 외경을 가지는 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 어레이가 1cm2 이하의 면적을 가지는 영역 내에 적어도 20개의 상기 용해가능한 퍼포레이터를 포함하는 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 피부 틈새와 유체 연통되며, 상기 퍼포레이터를 용해하기 위한 용매의 선택된 양을 수용하여 보유하도록 적합하게 된 유체 용기를 구비한, 유체 저장소를 더 포함하는 것을 특징으로 하는 어레이.
- 제 1 항에 있어서, 상기 피부 틈새와 유체 연통되며, 제2의 선택된 약물의 선택된 양을 수용하여 보유하도록 적합하게 된 유체 용기를 구비한, 저장소를 더 포함하는 것을 특징으로 하는 어레이.
- 제 11 항에 있어서, 상기 저장소가 상기 제2 약물을 수용하여 보유하는 패치 저장소를 포함하며, 상기 제2 약물과 제2 약물이 실질적으로 동일한 것을 특징으로 하는 어레이.
- 제 11 항에 있어서, 상기 저장소가 상기 제2 약물을 수용하여 보유하는 패치 저장소를 포함하며, 상기 제 1 약물과 제2 약물이 서로 상이한 것을 특징으로 하는 어레이.
- 제 11 항에 있어서, 상기 저장소가 상기 환자 피부 위의 선택된 영역을 둘러싸서 접촉하는 접착제 영역을 가지는 패치 저장소를 포함하는 것을 특징으로 하는 어레이.
- 제 14 항에 있어서, 상기 접착제가 항균 물질을 포함하는 것을 특징으로 하는 어레이.
- 제 11 항에 있어서, 상기 저장소가 지방 알콜, 산, 에스테르, 계면활성제, 매크로시클리스, 테르펜, 인지질, 피롤리돈, 아미드 및 아미노산으로 구성된 군으로부터 선택된 화학적 증진제를 포함하는 유체를 함유하는 것을 특징으로 하는 어레이.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/179,749 US6945952B2 (en) | 2002-06-25 | 2002-06-25 | Solid solution perforator for drug delivery and other applications |
US10/179,749 | 2002-06-25 | ||
US41106302P | 2002-09-16 | 2002-09-16 | |
US60/411,063 | 2002-09-16 | ||
PCT/US2003/019820 WO2004000389A2 (en) | 2002-06-25 | 2003-06-19 | Rapidly dissolving micro-perforator for drug delivery and other applications |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047021103A Division KR100993477B1 (ko) | 2002-06-25 | 2003-06-19 | 약물 송달 및 다른 용도를 위한 신속 용해형마이크로-퍼포레이터 |
Publications (2)
Publication Number | Publication Date |
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KR20100115393A true KR20100115393A (ko) | 2010-10-27 |
KR101061975B1 KR101061975B1 (ko) | 2011-09-05 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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KR1020047021103A KR100993477B1 (ko) | 2002-06-25 | 2003-06-19 | 약물 송달 및 다른 용도를 위한 신속 용해형마이크로-퍼포레이터 |
KR1020107022923A KR101061975B1 (ko) | 2002-06-25 | 2003-06-19 | 약물 송달 및 다른 용도를 위한 신속 용해형 마이크로 퍼포레이터를 포함하는 어레이 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047021103A KR100993477B1 (ko) | 2002-06-25 | 2003-06-19 | 약물 송달 및 다른 용도를 위한 신속 용해형마이크로-퍼포레이터 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1534376B1 (ko) |
JP (2) | JP4829497B2 (ko) |
KR (2) | KR100993477B1 (ko) |
CN (1) | CN100591386C (ko) |
AU (1) | AU2003243750A1 (ko) |
CA (1) | CA2490137C (ko) |
DK (1) | DK1534376T3 (ko) |
ES (1) | ES2607128T3 (ko) |
WO (1) | WO2004000389A2 (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150130391A (ko) * | 2013-03-15 | 2015-11-23 | 코리움 인터네셔널, 인크. | 치료제를 전달하기 위한 마이크로어레이 및 사용 방법 |
KR20180079728A (ko) * | 2017-01-02 | 2018-07-11 | 가천대학교 산학협력단 | 마이크로 니들 장치 |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6445933A (en) * | 1987-08-12 | 1989-02-20 | Nissan Motor | Control device in internal combustion engine with automatic gear |
ATE438418T1 (de) | 2001-05-01 | 2009-08-15 | Av Topchiev Inst Petrochemical | Hydrogel-zusammensetzungen |
US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8353861B2 (en) | 2003-09-18 | 2013-01-15 | Texmac, Inc. | Applicator for applying functional substances into human skin |
US8048423B2 (en) * | 2003-12-09 | 2011-11-01 | Allergan, Inc. | Botulinum toxin therapy for skin disorders |
EP1713450B1 (en) | 2004-01-30 | 2021-10-06 | Corium, Inc. | Rapidly dissolving film for delivery of an active agent |
GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
SE0400685D0 (sv) * | 2004-03-19 | 2004-03-19 | Pfizer Health Ab | Means for transdermal administration of nicotine |
US20060100584A1 (en) * | 2004-08-10 | 2006-05-11 | Orest Olejnik | Needleless microprotrusion elastoplast system |
AU2012201016B2 (en) * | 2004-11-18 | 2012-10-11 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
EP1833547A1 (en) * | 2004-11-18 | 2007-09-19 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
WO2006077742A1 (ja) * | 2004-12-28 | 2006-07-27 | Nabtesco Corporation | 皮膚用針製造装置および皮膚用針製造方法 |
EP1844763B2 (en) | 2005-01-31 | 2022-09-07 | BioSerenTach Co., Ltd. | Percutaneously absorbable preparation, percutaneously absorbable preparation holding sheet, and percutaneously absorbable preparation holding equipment |
JP2006335754A (ja) * | 2005-06-01 | 2006-12-14 | Technofarm Axesz Kk | 経皮投与剤担持薄膜とその製造法 |
JP2007014588A (ja) * | 2005-07-08 | 2007-01-25 | Nano Device & System Research Inc | 経皮投与装置,経皮投与装置製造用金型 |
JP4804827B2 (ja) * | 2005-08-05 | 2011-11-02 | 尚哉 宮野 | 経皮性薬剤配送装置及び経皮性薬剤配送装置用針装置の製造方法 |
AU2006287603B2 (en) * | 2005-09-06 | 2012-05-10 | Theraject, Inc. | Solid solution perforator containing drug particle and/or drug-adsorbed particles |
JP2007089792A (ja) * | 2005-09-28 | 2007-04-12 | Nano Device & System Research Inc | 経皮投与装置 |
JP2007130417A (ja) * | 2005-11-08 | 2007-05-31 | Nano Device & System Research Inc | 経皮投与装置 |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US8197435B2 (en) * | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
KR100886633B1 (ko) * | 2006-07-14 | 2009-03-04 | 호남석유화학 주식회사 | 전면부에 피부를 통해 체내로 전달하고자 하는 물질의 수용공간을 갖는 피부 침투용 미세 돌기 장치 |
EP2062612A4 (en) * | 2006-08-18 | 2010-01-06 | Toppan Printing Co Ltd | MICRO NEEDLE AND MICRO NEEDLE STAMP |
JP2008142183A (ja) * | 2006-12-07 | 2008-06-26 | Fujifilm Corp | マイクロニードルシート及びその製造方法 |
WO2008089344A2 (en) * | 2007-01-19 | 2008-07-24 | Joseph Neev | Devices and methods for generation of subsurface micro-disruptions for biomedical applications |
US10588694B1 (en) | 2007-01-19 | 2020-03-17 | Joseph Neev | Devices and methods for generation of subsurface micro-disruptions for biomedical applications |
JP4935391B2 (ja) * | 2007-02-06 | 2012-05-23 | 凸版印刷株式会社 | 薬物輸送デバイス |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
WO2008130587A2 (en) | 2007-04-16 | 2008-10-30 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
AU2008327083B2 (en) | 2007-11-21 | 2014-01-16 | Bioserentach Co., Ltd. | Preparation for application to body surface and preparation holding sheet for application to body surface |
US9220678B2 (en) | 2007-12-24 | 2015-12-29 | The University Of Queensland | Coating method |
CN102007066B (zh) | 2008-02-07 | 2013-06-26 | 昆士兰大学 | 贴片制造 |
JP5448097B2 (ja) * | 2008-02-29 | 2014-03-19 | 株式会社 メドレックス | マイクロニードルの皮膚内への挿入方法及び該方法に使用する補助器具 |
US10543123B2 (en) | 2008-04-28 | 2020-01-28 | Joseph Neev | Devices and methods for generation of subsurface micro-disruptions for opthalmic surgery and opthalmic applications |
US9381680B2 (en) | 2008-05-21 | 2016-07-05 | Theraject, Inc. | Method of manufacturing solid solution perforator patches and uses thereof |
EP2294415A4 (en) | 2008-05-23 | 2011-10-05 | Univ Queensland | ANALYTIC DETECTION BY MEANS OF MICRONADELPFLASTER WITH ANALYTICAL REAGENT |
JP5503859B2 (ja) * | 2008-09-26 | 2014-05-28 | 凸版印刷株式会社 | マイクロニードル保持容器 |
JP5572301B2 (ja) * | 2008-09-26 | 2014-08-13 | 凸版印刷株式会社 | マイクロニードル保持容器 |
US9320878B2 (en) * | 2008-10-07 | 2016-04-26 | Tuo Jin | Phase-transition polymeric microneedles |
KR101634836B1 (ko) * | 2008-12-26 | 2016-06-29 | 히사미쓰 세이야꾸 가부시키가이샤 | 마이크로 니들 디바이스 |
EP2387394B1 (en) | 2009-01-14 | 2018-05-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
US9017310B2 (en) | 2009-10-08 | 2015-04-28 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including microneedles |
KR101018406B1 (ko) * | 2009-10-28 | 2011-02-28 | 김도위 | 알레르겐 진단을 위한 바늘 일체형 피부 진단용 시험기 |
KR20110046205A (ko) * | 2009-10-28 | 2011-05-04 | 김도위 | 알레르겐 진단을 위한 바늘 구비형 피부 진단용 시험기 |
AU2010336330B2 (en) * | 2009-12-24 | 2016-04-28 | Rani Therapeutics, Llc | Swallowable drug delivery device and methods of drug delivery |
US8562589B2 (en) | 2009-12-24 | 2013-10-22 | Rani Therapeutics, Llc | Swallowable drug delivery device and method of delivery |
JP5408592B2 (ja) * | 2010-03-19 | 2014-02-05 | コスメディ製薬株式会社 | マイクロニードルの迅速溶解法 |
US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US9943673B2 (en) | 2010-07-14 | 2018-04-17 | Vaxxas Pty Limited | Patch applying apparatus |
JP5672554B2 (ja) * | 2010-08-19 | 2015-02-18 | Jcrファーマ株式会社 | 皮下又は経皮吸収用組成物 |
JP5473996B2 (ja) * | 2010-09-09 | 2014-04-16 | 株式会社バイオセレンタック | 経皮吸収製剤包装投与器具 |
EP2629836B1 (en) * | 2010-10-19 | 2018-09-12 | Trustees Of Tufts College | Silk fibroin-based microneedles and methods of making the same |
US9402806B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9629799B2 (en) | 2010-12-23 | 2017-04-25 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8734429B2 (en) | 2010-12-23 | 2014-05-27 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
US10639272B2 (en) | 2010-12-23 | 2020-05-05 | Rani Therapeutics, Llc | Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device |
US9402807B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8809269B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9283179B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9861683B2 (en) | 2010-12-23 | 2018-01-09 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9284367B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9415004B2 (en) | 2010-12-23 | 2016-08-16 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
FR2973237A1 (fr) | 2011-03-31 | 2012-10-05 | Oreal | Procede de traitement cosmetique fractionne utilisant un laser ou des micro-aiguilles |
DK2726091T3 (da) * | 2011-06-29 | 2020-03-09 | Rani Therapeutics Llc | Præparater med terapeutisk middel til fremføring i et lumen i tarmkanalen ved hjælp af en synkbar anordning til lægemiddelfremføring |
JP6121674B2 (ja) * | 2011-09-12 | 2017-04-26 | コスメディ製薬株式会社 | マイクロニードル迅速溶解法 |
JP6265740B2 (ja) | 2011-10-06 | 2018-01-24 | 久光製薬株式会社 | アプリケータ |
EP4233839A3 (en) | 2011-10-12 | 2023-09-27 | Vaxxas Pty Limited | Delivery device |
KR101392947B1 (ko) * | 2011-12-13 | 2014-05-12 | 주식회사 스몰랩 | 섬유를 포함하는 미세돌기 마사지 패치 및 그 제조 방법 |
KR102088651B1 (ko) | 2012-02-29 | 2020-03-16 | 도판 인사츠 가부시키가이샤 | 침상체 및 침상체의 제조 방법 |
CA2867158A1 (en) * | 2012-04-03 | 2013-10-10 | Theraject, Inc. | Soluble microneedle arrays for buccal delivery of vaccines |
WO2013151044A1 (ja) * | 2012-04-05 | 2013-10-10 | 久光製薬株式会社 | 穿刺装置及びその製造方法 |
JP5746101B2 (ja) * | 2012-06-18 | 2015-07-08 | コスメディ製薬株式会社 | マイクロニードルの迅速溶解法 |
US20140200509A1 (en) * | 2012-06-29 | 2014-07-17 | Issac David Cohen | Dissolvable Microneedles Comprising One Or More Encapsulated Cosmetic Ingredients |
CN104379020A (zh) * | 2012-06-29 | 2015-02-25 | Elc管理有限责任公司 | 包含一种或多种化妆品成分的微针 |
JP5593355B2 (ja) * | 2012-07-23 | 2014-09-24 | 凸版印刷株式会社 | 針状体および針状体製造方法 |
MX2015008157A (es) | 2012-12-21 | 2016-02-22 | Corium Int Inc | Microarreglo para la entrega de agente terapeutico y metodos de uso. |
US9913970B2 (en) | 2012-12-21 | 2018-03-13 | Hisamitsu Pharmaceutical Co., Ltd. | Applicator |
BR112015022253B1 (pt) | 2013-03-12 | 2022-03-15 | Corium, Inc | Aplicador de microprojeções |
CA2903459C (en) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
ES2761580T3 (es) | 2013-03-15 | 2020-05-20 | Corium Inc | Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación |
AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
CN110302004B (zh) | 2013-05-03 | 2023-04-28 | 科尼尔赛德生物医学公司 | 用于眼部注射的设备和方法 |
WO2015005143A1 (ja) * | 2013-07-11 | 2015-01-15 | 凸版印刷株式会社 | マイクロニードルユニット |
EP2839853A1 (de) * | 2013-08-23 | 2015-02-25 | LTS LOHMANN Therapie-Systeme AG | Transdermales therapeutisches System mit Druckerzeugungsvorrichtung |
AU2013400841B2 (en) | 2013-09-18 | 2018-12-13 | Cosmed Pharmaceutical Co., Ltd. | Microneedle patch application device and patch holder |
JP6215343B2 (ja) | 2013-11-05 | 2017-10-18 | 久光製薬株式会社 | アプリケータ |
KR101724654B1 (ko) * | 2014-06-02 | 2017-04-12 | 주식회사 아모라이프사이언스 | 마이크로 니들 패치 및 그의 제조 방법 |
WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
KR102313520B1 (ko) * | 2014-09-11 | 2021-10-14 | 주식회사 엘지생활건강 | 흡수 속도를 개선한 마이크로니들 시스템 |
EP4218892A1 (en) | 2015-02-02 | 2023-08-02 | Vaxxas Pty Limited | Microprojection array applicator |
US10441768B2 (en) | 2015-03-18 | 2019-10-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
JP2015134288A (ja) * | 2015-05-07 | 2015-07-27 | コスメディ製薬株式会社 | マイクロニードルの迅速溶解法 |
JP2017023404A (ja) | 2015-07-22 | 2017-02-02 | 日本写真印刷株式会社 | マイクロニードルパッチ用インパクト付加型アプリケータ及び先端部材 |
JP6676644B2 (ja) | 2015-09-02 | 2020-04-08 | 久光製薬株式会社 | アプリケータ |
WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
US11684763B2 (en) | 2015-10-16 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices |
US11160963B2 (en) * | 2015-12-04 | 2021-11-02 | Ascilion Ab | Microneedle and a chip |
WO2017120322A1 (en) | 2016-01-05 | 2017-07-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
JP6726512B2 (ja) * | 2016-03-31 | 2020-07-22 | コスメディ製薬株式会社 | マイクロニードルアプリケータ |
JP6931217B2 (ja) | 2017-03-28 | 2021-09-01 | コスメディ製薬株式会社 | 水溶性シート状製剤のアプリケータ |
EP3606760B1 (en) | 2017-03-31 | 2023-09-27 | Vaxxas Pty Limited | Device and method for coating surfaces |
DE102017112573A1 (de) | 2017-06-07 | 2018-12-13 | Lts Lohmann Therapie-Systeme Ag | Mikronadelsystem zur Applikation von Glukagon-ähnlichen-Peptid Analoga |
AU2018285954A1 (en) | 2017-06-13 | 2019-12-19 | Vaxxas Pty Limited | Quality control of substrate coatings |
WO2019023757A1 (en) | 2017-08-04 | 2019-02-07 | Vaxxas Pty Limited | COMPACT MECHANICAL HIGH ENERGY STORAGE ACTUATOR WITH LOW TRIGGER STRENGTH FOR ADMINISTRATION OF MICROPROJECTION NETWORK (PRM) PATCHES |
EP3744374A4 (en) | 2018-01-24 | 2021-11-03 | Cosmed Pharmaceutical Co., Ltd. | FASTENING DEVICE FOR MICRON NEEDLE |
US11318292B2 (en) * | 2018-05-28 | 2022-05-03 | Microneedles Inc. | Microneedle patch for transdermal injections |
EP3698841A1 (en) * | 2019-02-19 | 2020-08-26 | L'oreal | Injection device |
JP7491551B2 (ja) | 2019-04-25 | 2024-05-28 | コスメディ製薬株式会社 | 水溶性シート状製剤のアプリケータ2 |
CN112957607B (zh) * | 2021-01-30 | 2023-08-04 | 上海应用技术大学 | 一种微针透皮贴及其制备方法 |
US12036300B2 (en) | 2021-03-31 | 2024-07-16 | L'oreal | Methods and compositions for improving skin |
FR3122826A1 (fr) | 2021-05-12 | 2022-11-18 | L'oreal | Procedes et compositions pour l’amelioration de la peau |
WO2023276090A1 (ja) * | 2021-06-30 | 2023-01-05 | シンクランド株式会社 | 経皮投与装置及び経皮投与システム |
FR3124952A1 (fr) | 2021-07-09 | 2023-01-13 | L'oreal | Procédés et compositions pour l’amélioration de la peau |
CN114558241B (zh) * | 2021-12-31 | 2024-01-12 | 北京化工大学 | 一种基于聚合物可溶性微针的给药式内窥镜装置 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5749376A (en) | 1993-10-18 | 1998-05-12 | Wilk; Peter J. | Medical treatment and waste disposal method |
US5542920A (en) * | 1994-09-12 | 1996-08-06 | Delab | Needle-less parenteral introduction device |
DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
AU739616B2 (en) * | 1997-12-11 | 2001-10-18 | Alza Corporation | Device for enhancing transdermal agent flux |
KR100561892B1 (ko) * | 1997-12-11 | 2006-03-16 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
CA2330207C (en) * | 1998-06-10 | 2005-08-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6440096B1 (en) * | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
US6656147B1 (en) * | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
WO2002064193A2 (en) * | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
-
2003
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- 2003-06-19 DK DK03761282.7T patent/DK1534376T3/en active
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150130391A (ko) * | 2013-03-15 | 2015-11-23 | 코리움 인터네셔널, 인크. | 치료제를 전달하기 위한 마이크로어레이 및 사용 방법 |
KR20180079728A (ko) * | 2017-01-02 | 2018-07-11 | 가천대학교 산학협력단 | 마이크로 니들 장치 |
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EP1534376B1 (en) | 2016-08-31 |
CN1674954A (zh) | 2005-09-28 |
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WO2004000389A3 (en) | 2004-03-04 |
JP5323657B2 (ja) | 2013-10-23 |
CN100591386C (zh) | 2010-02-24 |
JP4829497B2 (ja) | 2011-12-07 |
EP1534376A2 (en) | 2005-06-01 |
JP2006500973A (ja) | 2006-01-12 |
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