HUP0303811A2 - Eljárás 1,3-helyettesített indének és aril-kondenzált azapoliciklusos vegyületek előállítására - Google Patents
Eljárás 1,3-helyettesített indének és aril-kondenzált azapoliciklusos vegyületek előállításáraInfo
- Publication number
- HUP0303811A2 HUP0303811A2 HU0303811A HUP0303811A HUP0303811A2 HU P0303811 A2 HUP0303811 A2 HU P0303811A2 HU 0303811 A HU0303811 A HU 0303811A HU P0303811 A HUP0303811 A HU P0303811A HU P0303811 A2 HUP0303811 A2 HU P0303811A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- aryl
- group
- general formula
- carbon atoms
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000002469 indenes Chemical class 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052792 caesium Inorganic materials 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- -1 cesium cations Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000003454 indenyl group Chemical class C1(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
A találmány eljárást nyújt az (Ia), (Ib) és (Ic) általános képletű1,3-szubsztituált indéneknek vagy ezek keverékeinek az előállítására.Az (Ia), (Ib) és (Ic) általános képletű vegyületek vagy ezek keverékeköztesanyagként használható fel a (II) általános képletű vegyületekelőállításánál. Az (Ia), (Ib) és (Ic) általános képletekben R2 és R3jelentése egymástól függetlenül hidrogén-, fluor-, klóratom, -SOq(1-6szénatomos akil) általános képletű csoport, melyen belül q jelentése0, 1 vagy 2; (1-6 szénatomos alkil)2-amino-, -CO2R7, -CONR8R9, -SO2NR10R11, aril-(0-3 szénatomos alkil)- vagy aril-(0-3 szénatomosalkil)-O- általános képletű csoport, melyen belül az arilcsoportjelentése fenil- vagy naftilcsoport; heteroaril-(0-3 szénatomosalkil)- vagy heteroaril-(0-3 szénatomos alkil)-O- általános képletűcsoport, melyen belül a nevezett heteroarilcsoport 1-4 heteroatomot,ami lehet oxigén-, nitrogén- vagy kénatom, tartalmazó, 5-7 tagú aromásgyűrű; X2(0-6 szénatomos) R5 jelentése 1-6 szénatomos alkilcsoportvagy Si(R12)3 általános képletű csoport; R1 jelentése elektronvonzócsoport, az alábbiakból kiválasztva: ciano-, alkoxi-karbonil-, alkil-karbonil-, aril-karbonil-, aril-, nitro-, trifluor-metil- vagyszulfonilcsoport; R4 jelentése egymástól függetlenül hidrogénatom, 1-6szénatomos alkilcsoport, H(L)3N+ általános képletű vagy fémkation,beleértve az alkálifémeket, mint amilyen a nátrium-, kálium-, lítium-vagy céziumkation; vagy a két R4 csoport egy 2-3 szénatomosalkilénhidat képez. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28513101P | 2001-04-20 | 2001-04-20 | |
| PCT/IB2002/000660 WO2002085843A2 (en) | 2001-04-20 | 2002-03-04 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0303811A2 true HUP0303811A2 (hu) | 2004-03-01 |
| HUP0303811A3 HUP0303811A3 (en) | 2008-05-28 |
Family
ID=23092860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303811A HUP0303811A3 (en) | 2001-04-20 | 2002-03-04 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7091372B2 (hu) |
| EP (1) | EP1383733B1 (hu) |
| JP (1) | JP2004527545A (hu) |
| KR (1) | KR100551183B1 (hu) |
| CN (1) | CN1321107C (hu) |
| AR (2) | AR035957A1 (hu) |
| AT (1) | ATE388135T1 (hu) |
| AU (1) | AU2002234836B2 (hu) |
| BR (1) | BR0208992A (hu) |
| CA (1) | CA2443946A1 (hu) |
| CZ (1) | CZ20032814A3 (hu) |
| DE (1) | DE60225433T2 (hu) |
| DK (1) | DK1383733T3 (hu) |
| ES (1) | ES2300430T3 (hu) |
| HK (1) | HK1062170A1 (hu) |
| HU (1) | HUP0303811A3 (hu) |
| IL (1) | IL157881A0 (hu) |
| MX (1) | MXPA03009527A (hu) |
| PL (1) | PL366657A1 (hu) |
| PT (1) | PT1383733E (hu) |
| RU (1) | RU2282619C9 (hu) |
| TW (1) | TWI244472B (hu) |
| WO (1) | WO2002085843A2 (hu) |
| YU (1) | YU78303A (hu) |
| ZA (1) | ZA200307205B (hu) |
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|---|---|---|---|---|
| DE60234268D1 (de) * | 2001-11-16 | 2009-12-17 | Cdt Oxford Ltd | Leuchtdiode und verwendete verbindungen |
| MXPA05005517A (es) * | 2002-11-25 | 2005-07-25 | Pfizer Prod Inc | Procedimiento mejorado para la preparacion de indenos 1,3-disustituidos. |
| RU2291862C2 (ru) * | 2003-01-15 | 2007-01-20 | Пфайзер Продактс Инк. | Способ получения арилконденсированных полициклических лактамов |
| MXPA05013084A (es) * | 2003-06-04 | 2006-03-02 | Pfizer Prod Inc | Preparacion de quinoxalinas sustituidas a partir de la dianilina con 2,3-dihidroxi-1,4-dioxano. |
| CA2533100A1 (en) * | 2003-07-21 | 2005-01-27 | Pfizer Products Inc. | Aryl fused azapolycyclic compounds |
| DE602006013688D1 (de) * | 2005-11-16 | 2010-05-27 | Hoffmann La Roche | Neues verfahren zur herstellung von thoc |
| DE102006024903A1 (de) * | 2006-05-24 | 2007-11-29 | Basf Ag | Verfahren zur Vermeidung von Fumarsäureablagerungen bei der Herstellung von Maleinsäureanhydrid |
| RS52074B (en) * | 2007-05-16 | 2012-06-30 | Nycomed Gmbh | PIRAZOLONE DERIVATED AS PDE4 INHIBITORS |
| EP2019107A1 (en) | 2007-07-26 | 2009-01-28 | Dynamit Nobel GmbH Explosivstoff- und Systemtechnik | Use of phosphonium salts in coupling reactions and process for their manufacture |
| WO2009065872A2 (en) * | 2007-11-20 | 2009-05-28 | Medichem, S.A. | Improved processes for the synthesis of varenicline l-tartrate |
| WO2009101185A2 (en) * | 2008-02-15 | 2009-08-20 | Medichem, S.A. | A NEW POLYMORPHIC FORM OF A PYRAZINO[2,3-h][3] BENZAZEPINE DERIVATIVE |
| WO2009143347A2 (en) * | 2008-05-22 | 2009-11-26 | Teva Pharmaceutical Industries Ltd. | Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate |
| US20090318695A1 (en) * | 2008-06-19 | 2009-12-24 | Vinod Kumar Kansal | Processes for the preparation of varenicline and intermediates thereof |
| WO2010005643A1 (en) * | 2008-07-10 | 2010-01-14 | Teva Pharmaceutical Industries Ltd. | Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt |
| WO2010151524A1 (en) | 2009-06-22 | 2010-12-29 | Teva Pharmaceutical Industries Ltd | Solid states forms of varenicline salts and processes for preparation thereof |
| US20120004239A1 (en) | 2010-06-11 | 2012-01-05 | Medichem, S.A. | Process for Preparing Quinoxaline Derivatives |
| KR101603427B1 (ko) * | 2014-08-14 | 2016-03-15 | 영남대학교 산학협력단 | 케스케이드 반응을 통한 인덴 유도체의 효율적 합성방법 |
| CN104478803A (zh) * | 2014-12-19 | 2015-04-01 | 连云港恒运医药科技有限公司 | 伐尼克兰中间体及其硝基还原杂质的制备方法 |
| JP6956707B2 (ja) * | 2015-08-14 | 2021-11-02 | ボウロス アンド クーパー ファーマスーティカルズ プロプライエタリー リミテッドＢｏｕｌｏｓ ＆ Ｃｏｏｐｅｒ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｐｔｙ Ｌｔｄ | アリール化合物の合成 |
| US11084853B2 (en) | 2016-07-07 | 2021-08-10 | Howard Hughes Medical Institute | Modified ligand-gated ion channels and methods of use |
| WO2019094778A1 (en) | 2017-11-10 | 2019-05-16 | Scott Sternson | Modified ligand-gated ion channels and methods of use |
| CN111995519B (zh) * | 2020-09-26 | 2022-08-26 | 安徽金禾实业股份有限公司 | 一种3-甲氧基丙烯酸甲酯的制备方法 |
| CN115322105A (zh) * | 2021-05-11 | 2022-11-11 | 江苏润安制药有限公司 | 一种合成艾拉莫德关键中间体的方法 |
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| US6605610B1 (en) * | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
| US6151357A (en) * | 1998-01-16 | 2000-11-21 | Aspect Communications Corporation | Method and apparatus for displaying a visual indication of a transmission status |
| US6108003A (en) * | 1998-03-18 | 2000-08-22 | International Business Machines Corporation | Maintaining visibility and status indication of docked applications and application bars |
| CA2330576A1 (en) * | 1998-04-29 | 1999-11-04 | Pfizer Products Inc. | Substituted benzazocines as nicotine-binding inhibitors |
| FR2788982B1 (fr) * | 1999-02-02 | 2002-08-02 | Synthelabo | Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique |
| EP1194399A2 (en) * | 1999-07-02 | 2002-04-10 | Prescient Neuropharma Inc. | Novel aminoindanes |
| IL137937A0 (en) * | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| US20010036943A1 (en) * | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| US20010036949A1 (en) * | 2000-05-09 | 2001-11-01 | Coe Jotham Wadsworth | Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal |
| US20020010192A1 (en) * | 2000-06-02 | 2002-01-24 | Coe Jotham Wadsworth | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| US20020016334A1 (en) * | 2000-07-31 | 2002-02-07 | Coe Jotham Wadsworth | Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD) |
-
2002
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- 2002-03-04 YU YU78303A patent/YU78303A/sh unknown
- 2002-03-04 WO PCT/IB2002/000660 patent/WO2002085843A2/en active IP Right Grant
- 2002-03-04 CN CNB028085124A patent/CN1321107C/zh not_active Expired - Fee Related
- 2002-03-04 CZ CZ20032814A patent/CZ20032814A3/cs unknown
- 2002-03-04 CA CA002443946A patent/CA2443946A1/en not_active Abandoned
- 2002-03-04 AT AT02701498T patent/ATE388135T1/de not_active IP Right Cessation
- 2002-03-04 MX MXPA03009527A patent/MXPA03009527A/es active IP Right Grant
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- 2002-03-04 IL IL15788102A patent/IL157881A0/xx unknown
- 2002-03-04 AU AU2002234836A patent/AU2002234836B2/en not_active Ceased
- 2002-03-04 DK DK02701498T patent/DK1383733T3/da active
- 2002-03-04 KR KR1020037013659A patent/KR100551183B1/ko not_active IP Right Cessation
- 2002-03-04 JP JP2002583371A patent/JP2004527545A/ja active Pending
- 2002-03-04 PL PL02366657A patent/PL366657A1/xx not_active Application Discontinuation
- 2002-03-04 DE DE60225433T patent/DE60225433T2/de not_active Expired - Fee Related
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- 2002-03-04 RU RU2003130751/04A patent/RU2282619C9/ru not_active IP Right Cessation
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- 2002-04-15 TW TW091107632A patent/TWI244472B/zh not_active IP Right Cessation
- 2002-04-17 US US10/124,135 patent/US7091372B2/en not_active Expired - Fee Related
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2005
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