MXPA05013084A - Preparacion de quinoxalinas sustituidas a partir de la dianilina con 2,3-dihidroxi-1,4-dioxano. - Google Patents

Preparacion de quinoxalinas sustituidas a partir de la dianilina con 2,3-dihidroxi-1,4-dioxano.

Info

Publication number
MXPA05013084A
MXPA05013084A MXPA05013084A MXPA05013084A MXPA05013084A MX PA05013084 A MXPA05013084 A MX PA05013084A MX PA05013084 A MXPA05013084 A MX PA05013084A MX PA05013084 A MXPA05013084 A MX PA05013084A MX PA05013084 A MXPA05013084 A MX PA05013084A
Authority
MX
Mexico
Prior art keywords
preparation
dihydroxy
dioxane
compounds
dianline
Prior art date
Application number
MXPA05013084A
Other languages
English (en)
Inventor
Joseph Philip Rainville
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33511699&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA05013084(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MXPA05013084A publication Critical patent/MXPA05013084A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere a un nuevo procedimiento para preparar quinoxalinas sustituidas (I) por ciclacion de la dianilina correspondiente con 2,3-dihidroxi-1,4-dioxano; en una modalidad preferida, la invencion proporciona un procedimiento para preparar compuestos que tienen la formula (ver formula III): en la que Q es un grupo protector de nitrogeno; los compuestos de formula III y sus derivados son precursores de ciertos compuestos azapoliciclicos condensados con arilo que presentan actividad como agentes para le tratamiento de trastornos neurologicos y psicologicos.
MXPA05013084A 2003-06-04 2004-05-24 Preparacion de quinoxalinas sustituidas a partir de la dianilina con 2,3-dihidroxi-1,4-dioxano. MXPA05013084A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47558903P 2003-06-04 2003-06-04
PCT/IB2004/001787 WO2004108725A1 (en) 2003-06-04 2004-05-24 Preparation of substituted quinoxalines from the dianline with 2,3-dihydroxy-1,4-dioxane

Publications (1)

Publication Number Publication Date
MXPA05013084A true MXPA05013084A (es) 2006-03-02

Family

ID=33511699

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013084A MXPA05013084A (es) 2003-06-04 2004-05-24 Preparacion de quinoxalinas sustituidas a partir de la dianilina con 2,3-dihidroxi-1,4-dioxano.

Country Status (17)

Country Link
US (1) US20070185327A1 (es)
EP (1) EP1638971B1 (es)
JP (1) JP2006526607A (es)
AR (1) AR044472A1 (es)
AT (1) ATE405566T1 (es)
BR (1) BRPI0410613A (es)
CA (1) CA2527337A1 (es)
CL (1) CL2004001271A1 (es)
DE (1) DE602004015986D1 (es)
DK (1) DK1638971T3 (es)
ES (1) ES2310730T3 (es)
MX (1) MXPA05013084A (es)
PL (2) PL1638971T3 (es)
PT (1) PT1638971E (es)
SI (1) SI1638971T1 (es)
TW (1) TWI251594B (es)
WO (1) WO2004108725A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080275051A1 (en) * 2005-02-24 2008-11-06 Busch Frank R Preparation of High Purity Substituted Quinoxalines
WO2009143347A2 (en) 2008-05-22 2009-11-26 Teva Pharmaceutical Industries Ltd. Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate
US20090318695A1 (en) * 2008-06-19 2009-12-24 Vinod Kumar Kansal Processes for the preparation of varenicline and intermediates thereof
US8314235B2 (en) 2008-09-01 2012-11-20 Actavis Group Ptc Ehf Process for preparing varenicline, varenicline intermediates, pharmaceutically acceptable salts thereof
WO2010151524A1 (en) 2009-06-22 2010-12-29 Teva Pharmaceutical Industries Ltd Solid states forms of varenicline salts and processes for preparation thereof
EP2545054A1 (en) 2010-03-09 2013-01-16 Actavis Group Ptc Ehf Highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity
US20120004239A1 (en) 2010-06-11 2012-01-05 Medichem, S.A. Process for Preparing Quinoxaline Derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605610B1 (en) * 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
CN1324013C (zh) * 1997-12-31 2007-07-04 辉瑞产品公司 芳基稠合氮杂多环化合物
HUP0303811A3 (en) * 2001-04-20 2008-05-28 Pfizer Prod Inc Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds

Also Published As

Publication number Publication date
ES2310730T3 (es) 2009-01-16
PL1638971T3 (pl) 2009-01-30
SI1638971T1 (sl) 2008-12-31
EP1638971A1 (en) 2006-03-29
EP1638971B1 (en) 2008-08-20
DE602004015986D1 (de) 2008-10-02
US20070185327A1 (en) 2007-08-09
CA2527337A1 (en) 2004-12-16
AR044472A1 (es) 2005-09-14
ATE405566T1 (de) 2008-09-15
CL2004001271A1 (es) 2005-04-22
PT1638971E (pt) 2008-10-23
BRPI0410613A (pt) 2006-06-20
WO2004108725A1 (en) 2004-12-16
TW200500365A (en) 2005-01-01
DK1638971T3 (da) 2008-10-27
JP2006526607A (ja) 2006-11-24
TWI251594B (en) 2006-03-21
PL378491A1 (pl) 2006-05-02

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