HUP0301834A2 - Heterociklusos dihidropirimidin-származékok alkalmazása káliumcsatorna inhibitor hatású gyógyszerkészítmények elżállítására, valamint új származékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Heterociklusos dihidropirimidin-származékok alkalmazása káliumcsatorna inhibitor hatású gyógyszerkészítmények elżállítására, valamint új származékok és az ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0301834A2
HUP0301834A2 HU0301834A HUP0301834A HUP0301834A2 HU P0301834 A2 HUP0301834 A2 HU P0301834A2 HU 0301834 A HU0301834 A HU 0301834A HU P0301834 A HUP0301834 A HU P0301834A HU P0301834 A2 HUP0301834 A2 HU P0301834A2
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Hungary
Prior art keywords
group
general formula
pharmaceutical compositions
heterocyclic
nz5z6
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HU0301834A
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English (en)
Inventor
Karnail S. Atwal
Rao S. Bhandaru
Heather Finlay
John Lloyd
Wayne D. Vaccaro
Lin Yan
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Bristol-Myers Squibb Co.
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Publication of HUP0301834A2 publication Critical patent/HUP0301834A2/hu
Publication of HUP0301834A3 publication Critical patent/HUP0301834A3/hu

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Abstract

A találmány tárgyát az általános képletű, részben új vegyületek - aholX1, X2 és X3 egymástól függetlenül nitrogénatom, karbonilcsoport, -NR6-, -(CR7)q- vagy -(CHR7)q- általános képletű csoport, és ezek 5-7-tagú gyűrűt képeznek; R1-R7 azonos vagy különböző -(CH2)n-(Z1)m-(CH2)p-Z2 általános képletű csoport; vagy közülük megfelelőenkiválasztott kettő együttesen az atomokkal, amelyekhez kapcsolódnak,karbociklusos, illetve heterociklusos gyűrűt képez; Z1 -CZ3Z4-, -NZ3-,-C(O)Z3-, -C(O)NZ4- vagy -C(=NOZ3)- általános képletű csoport, oxigén-vagy kénatom, szulfinil-, szulfonil-, karbonil- vagytiokarbonilcsoport vagy kétértékű, nyílt láncú vagy ciklusosszénhidrogéncsoport vagy heterociklusos csoport; Z2 hidrogén- vagyhalogénatom, -OZ5, -OC(O)Z5, -NZ5-C(O)-Z6, NZ5-CO2-Z6, -NZ5(CO)-NZ6Z7,-NZ5Z6, -C(O)Z5, -CO2Z5, -C(S)Z5, -C(=NOZ5)Z6, -C(O)NZ5Z6, -C(S)NZ5Z6,-SZ5, -SOZ5, -SO2Z5 vagy -SO2NZ5Z6 általános képletű csoport, nitro-,ciano- vagy adott esetben szubsztituált alkil-, alkenil-,alkinilkarbociklil-, aril- vagy heterociklilcsoport; Z3-Z7 hidrogén-vagy halogénatom vagy adott esetben szubsztituált alkil-, alkenil-,alkinil-, karbocilklil-, aril- vagy heterociklilcsoport; vagy kettőegyüttesen heterociklusos, illetve karbociklusos gyűrűt képez; n és pegész 0-tól 10-ig, de ha m 0, p szintén 0; m egész szám, 0 vagy 1; ésq egész szám 1-től 3-ig - és izomerjeik, valamint sóik szelektívkáliumcsatorna-blokkolóként, így bizonyos IKur-asszociált betegségek,főként aritmiák kezelésére való alkalmazása, továbbá az új vegyületekés ezeket tartalmazó gyógyszerkészítmények képezik. Ó
HU0301834A 1999-12-06 2000-12-04 Use of heterocyclic dihydropyrimidine derivatives for the preparation of pharmaceutical compositions with potassim channel activity, novel derivatives and pharmaceutical compositions containing them HUP0301834A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16909199P 1999-12-06 1999-12-06
US23603700P 2000-09-28 2000-09-28
PCT/US2000/032785 WO2001040231A1 (en) 1999-12-06 2000-12-04 Heterocyclic dihydropyrimidines as potassium channel inhibitors

Publications (2)

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HUP0301834A2 true HUP0301834A2 (hu) 2003-09-29
HUP0301834A3 HUP0301834A3 (en) 2004-11-29

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HU0301834A HUP0301834A3 (en) 1999-12-06 2000-12-04 Use of heterocyclic dihydropyrimidine derivatives for the preparation of pharmaceutical compositions with potassim channel activity, novel derivatives and pharmaceutical compositions containing them

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US (3) US6706720B2 (hu)
EP (1) EP1237891B1 (hu)
JP (1) JP2004507442A (hu)
KR (1) KR20020060255A (hu)
CN (1) CN1407985A (hu)
AR (1) AR029457A1 (hu)
AT (1) ATE526329T1 (hu)
AU (1) AU781862B2 (hu)
BR (1) BR0016166A (hu)
CA (1) CA2393809C (hu)
CO (1) CO5570109A1 (hu)
CZ (1) CZ20021949A3 (hu)
HK (1) HK1048808A1 (hu)
HU (1) HUP0301834A3 (hu)
IL (2) IL149473A0 (hu)
MX (1) MXPA02005533A (hu)
MY (1) MY125533A (hu)
NO (1) NO323588B1 (hu)
NZ (1) NZ518663A (hu)
PE (1) PE20011029A1 (hu)
PL (1) PL364926A1 (hu)
RU (1) RU2296766C2 (hu)
TW (1) TWI291465B (hu)
UY (1) UY26472A1 (hu)
WO (1) WO2001040231A1 (hu)

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CN1407985A (zh) 2003-04-02
ATE526329T1 (de) 2011-10-15
MY125533A (en) 2006-08-30
US7541362B2 (en) 2009-06-02
US20040063687A1 (en) 2004-04-01
AU1812701A (en) 2001-06-12
IL149473A (en) 2009-05-04
NO20022649D0 (no) 2002-06-05
AU781862B2 (en) 2005-06-16
US20070099899A1 (en) 2007-05-03
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BR0016166A (pt) 2003-06-24
NO20022649L (no) 2002-06-06
CA2393809A1 (en) 2001-06-07
EP1237891B1 (en) 2011-09-28
AR029457A1 (es) 2003-07-02
WO2001040231A1 (en) 2001-06-07
US6706720B2 (en) 2004-03-16
US7157451B2 (en) 2007-01-02
CZ20021949A3 (cs) 2003-03-12
HK1048808A1 (zh) 2003-04-17
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RU2002118622A (ru) 2004-01-10
TWI291465B (en) 2007-12-21
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HUP0301834A3 (en) 2004-11-29
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CA2393809C (en) 2009-11-17
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EP1237891A1 (en) 2002-09-11
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