HUP0300798A3 - Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them - Google Patents

Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them

Info

Publication number
HUP0300798A3
HUP0300798A3 HU0300798A HUP0300798A HUP0300798A3 HU P0300798 A3 HUP0300798 A3 HU P0300798A3 HU 0300798 A HU0300798 A HU 0300798A HU P0300798 A HUP0300798 A HU P0300798A HU P0300798 A3 HUP0300798 A3 HU P0300798A3
Authority
HU
Hungary
Prior art keywords
triazolopyrimidines
substituted
pharmaceutical compositions
compositions containing
anticancer agents
Prior art date
Application number
HU0300798A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of HUP0300798A2 publication Critical patent/HUP0300798A2/hu
Publication of HUP0300798A3 publication Critical patent/HUP0300798A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU0300798A 2000-06-30 2001-06-28 Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them HUP0300798A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
PCT/US2001/020672 WO2002002563A2 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents

Publications (2)

Publication Number Publication Date
HUP0300798A2 HUP0300798A2 (hu) 2003-07-28
HUP0300798A3 true HUP0300798A3 (en) 2006-02-28

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300798A HUP0300798A3 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US7329663B2 (hu)
EP (1) EP1307200A2 (hu)
JP (1) JP2004502691A (hu)
KR (1) KR20030013475A (hu)
CN (1) CN1592624A (hu)
AR (1) AR034553A1 (hu)
AU (2) AU7306201A (hu)
BG (1) BG107277A (hu)
BR (1) BR0112038A (hu)
CA (1) CA2413802A1 (hu)
CZ (1) CZ20024150A3 (hu)
EA (1) EA006483B1 (hu)
GE (1) GEP20053688B (hu)
HK (1) HK1052646A1 (hu)
HU (1) HUP0300798A3 (hu)
IL (1) IL152869A0 (hu)
IN (1) IN2003KO00001A (hu)
MX (1) MXPA02011913A (hu)
NO (1) NO20026195L (hu)
NZ (1) NZ523807A (hu)
PL (1) PL360027A1 (hu)
SK (1) SK18412002A3 (hu)
WO (1) WO2002002563A2 (hu)
ZA (1) ZA200300793B (hu)

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WO2002038565A2 (de) * 2000-11-13 2002-05-16 Basf Aktiengesellschaft 7-(r)-amino-triazolopyrimidine, deren herstellung und verwendung zur bekämpfung von pflanzenpathogenen pilzen
EP1381610B1 (en) * 2001-04-11 2004-08-25 Basf Aktiengesellschaft 6-(2-chloro-6-fluoro-phenyl)-triazolopyrimidines
ATE287405T1 (de) * 2001-04-11 2005-02-15 Wyeth Corp 5-halogen-6-phenyl-7-fluoroalkylamino- triazolopyrimidine als fungizide
DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
DE10121162A1 (de) * 2001-04-30 2002-10-31 Bayer Ag Triazolopyrimidine
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
CN1271071C (zh) * 2001-07-18 2006-08-23 巴斯福股份公司 作为杀真菌剂的取代的6－(2－甲苯基)－***并嘧啶
CN1324030C (zh) * 2002-03-21 2007-07-04 巴斯福股份公司 杀真菌的***并嘧啶、其制备方法、其在防治有害真菌中的用途和包含所述物质的试剂
WO2004011467A1 (ja) * 2002-07-29 2004-02-05 Hokko Chemical Industry Co., Ltd. トリアゾロピリミジン誘導体および農園芸用殺菌剤
UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
EA200501388A1 (ru) * 2003-03-31 2006-02-24 Басф Акциенгезельшафт 7-алкениламинотриазолопиримидины, способ их получения и их применение для борьбы с фитопатогенными грибами, а также содержащие их средства
DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
US20070275961A1 (en) * 2003-06-04 2007-11-29 Vernalis (Cambridge) Limited. Triazolo ' 1, 5-A ! Pyrimidines and Their Use in Medicine
DE10328171A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328173A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328481A1 (de) * 2003-06-25 2005-01-13 Bayer Ag Triazolopyrimidine
ATE398452T1 (de) 2003-09-24 2008-07-15 Wyeth Corp 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs
CA2539252A1 (en) 2003-09-24 2005-04-07 Wyeth Holdings Corporation 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents
US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
US20070129383A1 (en) * 2003-10-17 2007-06-07 Hiroshi Kuramochi Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
US20070149588A1 (en) * 2003-12-17 2007-06-28 Tormo I Blasco Jordi 6-(2,3,6-Trifluorophenyl)triazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
CN1890243A (zh) * 2003-12-17 2007-01-03 巴斯福股份公司 6－(2,4,6－三卤代苯基)***并嘧啶、其制备方法及其在防治病原性真菌中的用途以及包含所述物质的组合物
EP1732927A2 (de) * 2004-03-30 2006-12-20 Basf Aktiengesellschaft 6-(2-fluorphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
BRPI0510804A (pt) * 2004-05-17 2007-11-06 Basf Ag compostos, uso de um composto, agente adequado para combater fungos nocivos, e, processo para combater fungos fitopatogênicos
EP1758457A1 (de) * 2004-06-09 2007-03-07 Basf Aktiengesellschaft Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
AR049944A1 (es) * 2004-06-25 2006-09-20 Basf Ag Compuestos de triazolopirimidina y su uso en el control de hongos daninos
AU2006251989B2 (en) * 2005-05-20 2010-05-27 Alantos-Pharmaceuticals, Inc. Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
EP1963330A1 (en) * 2005-12-16 2008-09-03 Wyeth a Corporation of the State of Delaware Dimers and adducts of 6-[substituted) phenyl] triazolopyrimidines useful as anticancer agents
WO2007099092A1 (de) * 2006-02-28 2007-09-07 Basf Se Substituierte 6-phenyl-7-amino-[1,2,4]-triazolo[1,5-a]pyrimidine und deren verwendung zur bekämpfung von schadpilzen
WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
BRPI0815207A2 (pt) 2007-08-14 2017-03-28 Bayer Schering Pharma Ag pirimidinas bicíclicas fundidas
EP2624837A4 (en) * 2010-10-04 2014-03-26 Inst Hepatitis & Virus Res NEW HEMMER OF THE SECRETION OF HEPATITIS B VIRUS ANTIGENES
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种***并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020159942A1 (en) * 2019-01-29 2020-08-06 Tosk, Inc. Pyrazolopyrimidine modulators of ras gtpase
EP4136089A4 (en) * 2020-04-14 2024-05-29 The Trustees of The University of Pennsylvania SUBSTITUTED {1,2,4,} TRIAZOLO{1,5-A} PYRIMIDINE COMPOUNDS AND USE IN STABILIZATION OF MICROTUBULES
MX2022013619A (es) * 2020-05-01 2022-11-16 Gilead Sciences Inc Compuestos de 2,4-dioxopirimidina que inhiben cd73.
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
AU2022376954A1 (en) 2021-10-29 2024-05-02 Gilead Sciences, Inc. Cd73 compounds
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

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Also Published As

Publication number Publication date
PL360027A1 (en) 2004-09-06
NO20026195L (no) 2003-02-27
ZA200300793B (en) 2004-07-20
BG107277A (bg) 2004-01-30
CA2413802A1 (en) 2002-01-10
CN1592624A (zh) 2005-03-09
CZ20024150A3 (cs) 2003-09-17
WO2002002563A3 (en) 2003-01-03
SK18412002A3 (sk) 2003-06-03
GEP20053688B (en) 2005-12-12
AU7306201A (en) 2002-01-14
HK1052646A1 (zh) 2003-09-26
IL152869A0 (en) 2003-06-24
HUP0300798A2 (hu) 2003-07-28
WO2002002563A2 (en) 2002-01-10
BR0112038A (pt) 2003-04-01
IN2003KO00001A (hu) 2005-12-02
NO20026195D0 (no) 2002-12-23
EA200300091A1 (ru) 2003-08-28
KR20030013475A (ko) 2003-02-14
AR034553A1 (es) 2004-03-03
EP1307200A2 (en) 2003-05-07
JP2004502691A (ja) 2004-01-29
US7329663B2 (en) 2008-02-12
NZ523807A (en) 2004-09-24
AU2001273062B2 (en) 2005-11-24
MXPA02011913A (es) 2003-04-22
US20020068744A1 (en) 2002-06-06
EA006483B1 (ru) 2005-12-29

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees