ATE398452T1 - 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs - Google Patents

6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs

Info

Publication number
ATE398452T1
ATE398452T1 AT04784454T AT04784454T ATE398452T1 AT E398452 T1 ATE398452 T1 AT E398452T1 AT 04784454 T AT04784454 T AT 04784454T AT 04784454 T AT04784454 T AT 04784454T AT E398452 T1 ATE398452 T1 AT E398452T1
Authority
AT
Austria
Prior art keywords
halo
aryl
imidazoä1
aüpyrimidine
against cancer
Prior art date
Application number
AT04784454T
Other languages
English (en)
Inventor
Nan Zhang
Semiramis Ayral-Kaloustian
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE398452T1 publication Critical patent/ATE398452T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04784454T 2003-09-24 2004-09-17 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs ATE398452T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24

Publications (1)

Publication Number Publication Date
ATE398452T1 true ATE398452T1 (de) 2008-07-15

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04784454T ATE398452T1 (de) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs

Country Status (14)

Country Link
US (2) US7285555B2 (de)
EP (1) EP1684763B1 (de)
JP (1) JP4695595B2 (de)
CN (1) CN100486580C (de)
AT (1) ATE398452T1 (de)
AU (1) AU2004275728A1 (de)
BR (1) BRPI0414778A (de)
CA (1) CA2537520A1 (de)
DE (1) DE602004014525D1 (de)
DK (1) DK1684763T3 (de)
ES (1) ES2308256T3 (de)
MX (1) MXPA06002939A (de)
PL (1) PL1684763T3 (de)
WO (1) WO2005030218A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU769569B2 (en) * 1998-12-18 2004-01-29 Alza Corporation Method of administering a compound to multi-drug resistant cells
PL1973545T3 (pl) 2005-12-23 2013-05-31 Ariad Pharma Inc Bicykliczne Związki Heteroarylowe
BRPI0807458A2 (pt) * 2007-01-08 2014-06-03 Basf Se Uso de compostos, agente, semente, método para combater fungos nocivos fitopatogênicos, e, composto
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224044B (de) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
TW258648B (de) 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
EP0984919B1 (de) 1997-03-18 2003-01-22 Basf Aktiengesellschaft Verfahren zur herstellung von arylmalonaten
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
JP3423290B2 (ja) 1998-02-11 2003-07-07 アメリカン・サイアナミド・カンパニー 殺菌剤７−アルキル−トリアゾロピリミジン
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
CA2324154C (en) 1998-03-23 2008-03-18 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
SI0988790T1 (en) 1998-09-25 2003-10-31 Basf Aktiengesellschaft Fungicidal mixtures
ES2214890T3 (es) 1998-09-25 2004-09-16 Basf Aktiengesellschaft Concentrado no acuoso para suspensiones.
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
SK18412002A3 (sk) * 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
JP2004506662A (ja) 2000-08-25 2004-03-04 ビーエーエスエフ　アクチェンゲゼルシャフト 殺菌剤
JP2004515502A (ja) 2000-12-06 2004-05-27 ビーエーエスエフ アクチェンゲゼルシャフト 殺真菌性を有する６−（トリフルオロメチル−フェニル）−トリアゾロピリミジン類
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
EE200300499A (et) 2001-04-11 2003-12-15 Basf Aktiengesellschaft 5-halogeen-6-fenüül-7-fluoroalküülaminotriasolopürimidiinid
US7211545B2 (en) * 2001-09-04 2007-05-01 Sumitomo Chemical Company, Limited Imidazo[1,2-a]pyrimidine and fungicidal compositions containing thereof
AU2003211651A1 (en) * 2002-04-19 2003-11-03 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
US7915266B2 (en) 2011-03-29
US20080255157A1 (en) 2008-10-16
EP1684763B1 (de) 2008-06-18
WO2005030218A1 (en) 2005-04-07
US7285555B2 (en) 2007-10-23
EP1684763A1 (de) 2006-08-02
CN100486580C (zh) 2009-05-13
JP2007506745A (ja) 2007-03-22
AU2004275728A1 (en) 2005-04-07
ES2308256T3 (es) 2008-12-01
DK1684763T3 (da) 2008-09-01
US20050065167A1 (en) 2005-03-24
MXPA06002939A (es) 2006-05-31
CA2537520A1 (en) 2005-04-07
PL1684763T3 (pl) 2008-11-28
JP4695595B2 (ja) 2011-06-08
BRPI0414778A (pt) 2006-11-21
CN1856311A (zh) 2006-11-01
DE602004014525D1 (de) 2008-07-31

Similar Documents

Publication Publication Date Title
TR201900306T4 (tr) Mek inhibitörlerini kullanma yöntemleri.
LTPA2016016I1 (lt) Azetinidai kaip mek inhibitoriai, skirti proliferacinių ligų gydymui
ATE440603T1 (de) 8-hydroxychinolinderivate
MX2007013624A (es) Inhibidores de proteina cinasa.
EA200801998A1 (ru) ПИРИДИН[3,4-b]ПИРАЗИНОНЫ
BRPI0510177B8 (pt) composto, composição farmacêutica e uso do mesmo
WO2006020722A3 (en) Polymer conjugates of beta-lapachone and beta-lapachone analogs for tumor targeting
MXPA05008126A (es) Inhibidores de girasa y uso de los mismos.
ATE543819T1 (de) Heteroarylverbindungen, zusammensetzungen daraus und behandlungsverfahren damit
EA200801428A1 (ru) Производные пиридиазинона для лечения опухолей
RS20090249A (en) Spiroketone acetyl-coa carboxylase inhibotors
DE602004025698D1 (de) PYRIDINOi1,2-A PYRIMIDIN-4-ONVERBINDUNGEN ALS MITTEL GEGEN KREBS
EA200870117A1 (ru) Азаиндоловые ингибиторы аурора-киназ
GEP20084551B (en) 4-phenylamino-quinazolin-6-yl-amides
BR0308243A (pt) Composto, formulação farmacêutica, e, métodos de tratar diabetes, doença de alzheimer, e de inibir gsk-3 em um mamìfero
DE60206911D1 (de) Imidazol-2-carbonsäureamid derivate als raf-kinase-inhibitoren
WO2007046867A3 (en) Piperidine derivatives and their uses as therapeutic agents
RS50720B (sr) 3,11 b-cis-dihidrotetrabenazin za lečenje proliferativne bolesti ili inflamacije
EA201001196A1 (ru) Соединения 4-пиридинона и их применение для лечения рака
MX2007002525A (es) Compuestos de difeniletileno y usos de los mismos.
EA200970936A1 (ru) СОЕДИНЕНИЯ ПИРИДО[2,3-d]ПИРИМИДИН-7-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3K-АЛЬФА ДЛЯ ЛЕЧЕНИЯ РАКА
DE602005010744D1 (de) Piperazinylpyridinderivate als mittel gegen adipositas
EA201170344A1 (ru) Азаиндольные ингибиторы iap
BRPI0607285A2 (pt) tratamento de tumores com metástases
GEP20125603B (en) Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties