EA200300091A1 - Замещенные триазолопиримидины в качестве противораковых средств - Google Patents

Замещенные триазолопиримидины в качестве противораковых средств

Info

Publication number
EA200300091A1
EA200300091A1 EA200300091A EA200300091A EA200300091A1 EA 200300091 A1 EA200300091 A1 EA 200300091A1 EA 200300091 A EA200300091 A EA 200300091A EA 200300091 A EA200300091 A EA 200300091A EA 200300091 A1 EA200300091 A1 EA 200300091A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mammal
cancer
facilities
inhibiting
substituted
Prior art date
Application number
EA200300091A
Other languages
English (en)
Other versions
EA006483B1 (ru
Inventor
Марк Р. Шмитт
Дональд Р. Кирш
Джейн Э. Харрис
Карл. Ф. Бейер
Клаус-Юрген Пеес
Пол Картер
Вальдемар Пфренгле
Гуидо Альберт
Original Assignee
Уайт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Уайт filed Critical Уайт
Publication of EA200300091A1 publication Critical patent/EA200300091A1/ru
Publication of EA006483B1 publication Critical patent/EA006483B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение относится к способу лечения или ингибирования роста раковых опухолевых клеток и сопутствующих заболеваний у млекопитающего, нуждающегося в этом, включающему введение указанному млекопитающему эффективного количества производного замещенного триазолопиримидина или его фармацевтически приемлемой соли, и также относится к способу лечения или ингибирования роста раковых опухолевых клеток и сопутствующих заболеваний у млекопитающего, нуждающегося в этом, путем взаимодействия с тубулином и микротрубочками и промотирования полимеризации микротрубочек, включающему введение указанному млекопитающему эффективного количества производного замещенного триазолопиримидина или его фармацевтически приемлемой соли.Отчет о международном поиске был опубликован 2003.01.03.
EA200300091A 2000-06-30 2001-06-28 Замещенные триазолопиримидины в качестве противораковых средств EA006483B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
PCT/US2001/020672 WO2002002563A2 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents

Publications (2)

Publication Number Publication Date
EA200300091A1 true EA200300091A1 (ru) 2003-08-28
EA006483B1 EA006483B1 (ru) 2005-12-29

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300091A EA006483B1 (ru) 2000-06-30 2001-06-28 Замещенные триазолопиримидины в качестве противораковых средств

Country Status (24)

Country Link
US (1) US7329663B2 (ru)
EP (1) EP1307200A2 (ru)
JP (1) JP2004502691A (ru)
KR (1) KR20030013475A (ru)
CN (1) CN1592624A (ru)
AR (1) AR034553A1 (ru)
AU (2) AU7306201A (ru)
BG (1) BG107277A (ru)
BR (1) BR0112038A (ru)
CA (1) CA2413802A1 (ru)
CZ (1) CZ20024150A3 (ru)
EA (1) EA006483B1 (ru)
GE (1) GEP20053688B (ru)
HK (1) HK1052646A1 (ru)
HU (1) HUP0300798A3 (ru)
IL (1) IL152869A0 (ru)
IN (1) IN2003KO00001A (ru)
MX (1) MXPA02011913A (ru)
NO (1) NO20026195L (ru)
NZ (1) NZ523807A (ru)
PL (1) PL360027A1 (ru)
SK (1) SK18412002A3 (ru)
WO (1) WO2002002563A2 (ru)
ZA (1) ZA200300793B (ru)

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Also Published As

Publication number Publication date
IN2003KO00001A (ru) 2005-12-02
GEP20053688B (en) 2005-12-12
AR034553A1 (es) 2004-03-03
KR20030013475A (ko) 2003-02-14
EA006483B1 (ru) 2005-12-29
AU7306201A (en) 2002-01-14
AU2001273062B2 (en) 2005-11-24
SK18412002A3 (sk) 2003-06-03
BG107277A (bg) 2004-01-30
JP2004502691A (ja) 2004-01-29
NO20026195L (no) 2003-02-27
ZA200300793B (en) 2004-07-20
CA2413802A1 (en) 2002-01-10
CN1592624A (zh) 2005-03-09
WO2002002563A2 (en) 2002-01-10
HK1052646A1 (zh) 2003-09-26
US20020068744A1 (en) 2002-06-06
NO20026195D0 (no) 2002-12-23
WO2002002563A3 (en) 2003-01-03
US7329663B2 (en) 2008-02-12
CZ20024150A3 (cs) 2003-09-17
PL360027A1 (en) 2004-09-06
BR0112038A (pt) 2003-04-01
HUP0300798A2 (hu) 2003-07-28
EP1307200A2 (en) 2003-05-07
HUP0300798A3 (en) 2006-02-28
IL152869A0 (en) 2003-06-24
MXPA02011913A (es) 2003-04-22
NZ523807A (en) 2004-09-24

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