HK1052646A1 - 替代三氮苯(triazolopyrimidines)作為抗癌劑 - Google Patents

替代三氮苯(triazolopyrimidines)作為抗癌劑

Info

Publication number
HK1052646A1
HK1052646A1 HK03104812.5A HK03104812A HK1052646A1 HK 1052646 A1 HK1052646 A1 HK 1052646A1 HK 03104812 A HK03104812 A HK 03104812A HK 1052646 A1 HK1052646 A1 HK 1052646A1
Authority
HK
Hong Kong
Prior art keywords
triazolopyrimidines
substituted
anticancer agents
anticancer
agents
Prior art date
Application number
HK03104812.5A
Other languages
English (en)
Inventor
R Schmitt Mark
R Kirsch Donald
E Harris Jane
F Beyer Carl
Pees Klaus-Juergen
Carter Paul
Pfrengle Waldemar
Albert Guido
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of HK1052646A1 publication Critical patent/HK1052646A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK03104812.5A 2000-06-30 2003-07-07 替代三氮苯(triazolopyrimidines)作為抗癌劑 HK1052646A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
PCT/US2001/020672 WO2002002563A2 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents

Publications (1)

Publication Number Publication Date
HK1052646A1 true HK1052646A1 (zh) 2003-09-26

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03104812.5A HK1052646A1 (zh) 2000-06-30 2003-07-07 替代三氮苯(triazolopyrimidines)作為抗癌劑

Country Status (24)

Country Link
US (1) US7329663B2 (zh)
EP (1) EP1307200A2 (zh)
JP (1) JP2004502691A (zh)
KR (1) KR20030013475A (zh)
CN (1) CN1592624A (zh)
AR (1) AR034553A1 (zh)
AU (2) AU7306201A (zh)
BG (1) BG107277A (zh)
BR (1) BR0112038A (zh)
CA (1) CA2413802A1 (zh)
CZ (1) CZ20024150A3 (zh)
EA (1) EA006483B1 (zh)
GE (1) GEP20053688B (zh)
HK (1) HK1052646A1 (zh)
HU (1) HUP0300798A3 (zh)
IL (1) IL152869A0 (zh)
IN (1) IN2003KO00001A (zh)
MX (1) MXPA02011913A (zh)
NO (1) NO20026195L (zh)
NZ (1) NZ523807A (zh)
PL (1) PL360027A1 (zh)
SK (1) SK18412002A3 (zh)
WO (1) WO2002002563A2 (zh)
ZA (1) ZA200300793B (zh)

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DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
DE10121162A1 (de) * 2001-04-30 2002-10-31 Bayer Ag Triazolopyrimidine
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
CN1271071C (zh) * 2001-07-18 2006-08-23 巴斯福股份公司 作为杀真菌剂的取代的6－(2－甲苯基)－***并嘧啶
PL372978A1 (en) * 2002-03-21 2005-08-08 Basf Aktiengesellschaft Fungicidal triazolopyrimidines, methods for producing the same, use thereof for combating harmful fungi and agents containing said substances
WO2004011467A1 (ja) * 2002-07-29 2004-02-05 Hokko Chemical Industry Co., Ltd. トリアゾロピリミジン誘導体および農園芸用殺菌剤
UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
AU2004226233A1 (en) * 2003-03-31 2004-10-14 Basf Aktiengesellschaft 7-alkenylamino-triazolopyrimidines, method for the production thereof and use thereof in controlling harmful fungi and substances containing said triazolopyrimidines
DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
US20070275961A1 (en) * 2003-06-04 2007-11-29 Vernalis (Cambridge) Limited. Triazolo ' 1, 5-A ! Pyrimidines and Their Use in Medicine
DE10328173A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328171A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328481A1 (de) * 2003-06-25 2005-01-13 Bayer Ag Triazolopyrimidine
JP4695595B2 (ja) 2003-09-24 2011-06-08 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類
DE602004004295T8 (de) 2003-09-24 2007-09-20 Wyeth Holdings Corp. 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel
US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
JPWO2005037837A1 (ja) * 2003-10-17 2006-12-28 日本化薬株式会社 置換２−アミノ−［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体及びその用途
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN1894254A (zh) * 2003-12-17 2007-01-10 巴斯福股份公司 用于防治病原性真菌的6－(2,3,6－三氟苯基)***并嘧啶
JP2007514680A (ja) * 2003-12-17 2007-06-07 ビーエーエスエフ　アクチェンゲゼルシャフト ６−（２，４，６−トリハロフェニル）トリアゾロピリミジン、その製造方法、および植物病原性真菌類を防除するためのその使用、ならびにその物質を含有している農薬
WO2005095404A2 (de) * 2004-03-30 2005-10-13 Basf Aktiengesellschaft 6-(2-fluorphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
EP1751162A1 (de) * 2004-05-17 2007-02-14 Basf Aktiengesellschaft Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
US20070249634A1 (en) * 2004-06-09 2007-10-25 Carsten Blettner Triazolopyrimidine Compounds and Use Thereof for Controlling Harmful Fungi
EP1761544A1 (de) * 2004-06-25 2007-03-14 Basf Aktiengesellschaft Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
JP5463034B2 (ja) * 2005-05-20 2014-04-09 アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
CA2633962A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
WO2007099092A1 (de) * 2006-02-28 2007-09-07 Basf Se Substituierte 6-phenyl-7-amino-[1,2,4]-triazolo[1,5-a]pyrimidine und deren verwendung zur bekämpfung von schadpilzen
WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
UY31293A1 (es) 2007-08-14 2009-03-31 Pirimidinas biciclicas fusionadas
CN103889428A (zh) 2010-10-04 2014-06-25 肝炎与病毒研究所 乙型肝炎病毒抗原分泌的新型抑制剂
JP6311603B2 (ja) 2012-06-22 2018-04-18 住友化学株式会社 縮合複素環化合物
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种***并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020159942A1 (en) * 2019-01-29 2020-08-06 Tosk, Inc. Pyrazolopyrimidine modulators of ras gtpase
EP4136089A4 (en) * 2020-04-14 2024-05-29 The Trustees of The University of Pennsylvania SUBSTITUTED {1,2,4,} TRIAZOLO{1,5-A} PYRIMIDINE COMPOUNDS AND USE IN STABILIZATION OF MICROTUBULES
CN115698009A (zh) * 2020-05-01 2023-02-03 吉利德科学公司 抑制cd73的2,4-二氧代嘧啶化合物
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
CN118201941A (zh) 2021-10-29 2024-06-14 吉利德科学公司 Cd73化合物
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

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Also Published As

Publication number Publication date
IN2003KO00001A (zh) 2005-12-02
GEP20053688B (en) 2005-12-12
AR034553A1 (es) 2004-03-03
KR20030013475A (ko) 2003-02-14
EA006483B1 (ru) 2005-12-29
EA200300091A1 (ru) 2003-08-28
AU7306201A (en) 2002-01-14
AU2001273062B2 (en) 2005-11-24
SK18412002A3 (sk) 2003-06-03
BG107277A (bg) 2004-01-30
JP2004502691A (ja) 2004-01-29
NO20026195L (no) 2003-02-27
ZA200300793B (en) 2004-07-20
CA2413802A1 (en) 2002-01-10
CN1592624A (zh) 2005-03-09
WO2002002563A2 (en) 2002-01-10
US20020068744A1 (en) 2002-06-06
NO20026195D0 (no) 2002-12-23
WO2002002563A3 (en) 2003-01-03
US7329663B2 (en) 2008-02-12
CZ20024150A3 (cs) 2003-09-17
PL360027A1 (en) 2004-09-06
BR0112038A (pt) 2003-04-01
HUP0300798A2 (hu) 2003-07-28
EP1307200A2 (en) 2003-05-07
HUP0300798A3 (en) 2006-02-28
IL152869A0 (en) 2003-06-24
MXPA02011913A (es) 2003-04-22
NZ523807A (en) 2004-09-24

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