EP0194599A3
(en)
|
1985-03-14 |
1988-01-20 |
Nissan Chemical Industries Ltd. |
Benzamide derivatives, process for producing the same, and soil fungicides containing the same
|
GB9122590D0
(en)
|
1991-10-24 |
1991-12-04 |
Lilly Industries Ltd |
Pharmaceutical compounds
|
DE4410453A1
(de)
|
1994-03-25 |
1995-09-28 |
Hoechst Ag |
Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
|
GB9514160D0
(en)
|
1994-07-25 |
1995-09-13 |
Zeneca Ltd |
Aromatic compounds
|
PL321244A1
(en)
|
1995-01-19 |
1997-11-24 |
Ciba Geigy Ag |
Insecticide composition
|
WO1997018712A1
(en)
|
1995-11-23 |
1997-05-29 |
Novartis Ag |
Herbicidal composition
|
EP0873311A1
(en)
|
1995-12-15 |
1998-10-28 |
Merck Frosst Canada Inc. |
Tri-aryl ethane derivatives as pde iv inhibitors
|
JPH10114654A
(ja)
|
1996-10-09 |
1998-05-06 |
Fujisawa Pharmaceut Co Ltd |
新規用途
|
AU6209098A
(en)
|
1997-01-15 |
1998-08-07 |
Novartis Ag |
Herbicidal agent
|
GB9716657D0
(en)
|
1997-08-07 |
1997-10-15 |
Zeneca Ltd |
Chemical compounds
|
DE19742951A1
(de)
|
1997-09-29 |
1999-04-15 |
Hoechst Schering Agrevo Gmbh |
Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
|
DE19802697A1
(de)
|
1998-01-24 |
1999-07-29 |
Bayer Ag |
Selektive Herbizide auf Basis von N-Aryl-triazolin(thi)onen und N-Arylsulfonylamino(thio)carbonyltriazolin(thi)onen
|
CA2320217C
(en)
|
1998-02-13 |
2005-01-11 |
Kureha Kagaku Kogyo Kabushiki Kaisha |
N-(phenylsulfonyl) picolinamide derivatives, process for producing the same, and herbicide
|
BR9909440A
(pt)
|
1998-04-06 |
2000-12-26 |
Fujisawa Pharmaceutical Co |
Derivados de indol
|
IL146455A0
(en)
|
1999-06-10 |
2002-07-25 |
Warner Lambert Co |
Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives
|
DE19936438A1
(de)
|
1999-08-03 |
2001-02-08 |
Aventis Cropscience Gmbh |
Kombinationen von Herbiziden und Safenern
|
DE19940860A1
(de)
|
1999-08-27 |
2001-03-01 |
Bayer Ag |
Selektive Herbizide auf Basis eines substituierten Phenylsulfonyl aminocarbonyltriazolinons und Safenern II
|
DE19958381A1
(de)
|
1999-12-03 |
2001-06-07 |
Bayer Ag |
Herbizide auf Basis von N-Aryl-uracilen
|
AU2001286557A1
(en)
|
2000-08-23 |
2002-03-04 |
Merck Frosst Canada And Co. |
Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists
|
US20020055631A1
(en)
|
2000-09-20 |
2002-05-09 |
Augeri David J. |
N-acylsulfonamide apoptosis promoters
|
AR031130A1
(es)
|
2000-09-20 |
2003-09-10 |
Abbott Lab |
N-acilsulfonamidas promotoras de la apoptosis
|
US6720338B2
(en)
|
2000-09-20 |
2004-04-13 |
Abbott Laboratories |
N-acylsulfonamide apoptosis promoters
|
PL366068A1
(en)
|
2000-10-10 |
2005-01-24 |
Smithkline Beecham Corporation |
Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppar-gamma binding agents
|
US20100074949A1
(en)
|
2008-08-13 |
2010-03-25 |
William Rowe |
Pharmaceutical composition and administration thereof
|
DE10119721A1
(de)
|
2001-04-21 |
2002-10-31 |
Bayer Cropscience Gmbh |
Herbizide Mittel enthaltend Benzoylcyclohexandione und Safener
|
MXPA03011693A
(es)
|
2001-05-31 |
2004-12-06 |
Vicore Pharma Ab |
Compuestos triciclicos utiles como agonistas de la angiotensina ii.
|
JP4139325B2
(ja)
|
2001-06-28 |
2008-08-27 |
ファイザー・プロダクツ・インク |
ミクロソーム・トリグリセリド・トランスファータンパク質(mtp)及び/又はアポリポタンパク質b(apob)分泌の阻害剤としてのトリアミド置換インドール、ベンゾフラン及びベンゾチオフェン
|
DE10145019A1
(de)
|
2001-09-13 |
2003-04-03 |
Bayer Cropscience Gmbh |
Kombinationen aus Herbiziden und Safenern
|
DE10146873A1
(de)
|
2001-09-24 |
2003-04-17 |
Bayer Cropscience Gmbh |
Heterocyclische Amide und -Iminderivate, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
|
AU2002354056A1
(en)
|
2001-11-19 |
2003-06-10 |
Ono Pharmaceutical Co., Ltd. |
Remedies for urinary frequency
|
DE10157545A1
(de)
|
2001-11-23 |
2003-06-12 |
Bayer Cropscience Gmbh |
Herbizide Mittel enthaltend Benzoylpyrazole und Safener
|
AU2003220558A1
(en)
|
2002-03-27 |
2004-06-03 |
Smithkline Beecham Corporation |
Amide compounds and methods of using the same
|
GB0212785D0
(en)
|
2002-05-31 |
2002-07-10 |
Glaxo Group Ltd |
Compounds
|
CA2752121A1
(en)
|
2002-06-08 |
2003-12-18 |
Bayer Cropscience Ag |
Herbicidal combinations of dicamba or an agriculturally acceptable salt thereof and 4-(2-methoxybenzoylsulfamoyl)-n-cyclopropylbenzamide or an agriculturally acceptable salt thereof, as a safener
|
DE10237461A1
(de)
|
2002-08-16 |
2004-02-26 |
Bayer Cropscience Gmbh |
Herbizide Mittel enthaltend Benzoylpyrazole und Safener
|
WO2004021987A2
(en)
|
2002-09-06 |
2004-03-18 |
Merck & Co., Inc. |
Treatment of rheumatoid arthritis by inhibition of pde4
|
CA2503063A1
(en)
|
2002-10-22 |
2004-05-06 |
Merck Frosst Canada & Co./Merck Frosst Canada & Cie |
Nitric oxide releasing selective cyclooxygenase-2 inhibitors
|
GB0225548D0
(en)
|
2002-11-01 |
2002-12-11 |
Glaxo Group Ltd |
Compounds
|
WO2004046141A1
(en)
|
2002-11-21 |
2004-06-03 |
Vicore Pharma Ab |
New tricyclic angiotensin ii agonists
|
JP2006516028A
(ja)
|
2002-12-20 |
2006-06-15 |
ファイザー・プロダクツ・インク |
ミクロソームトリグリセリド輸送タンパク質阻害剤
|
MXPA05006744A
(es)
|
2002-12-20 |
2005-09-08 |
Pfizer Prod Inc |
Inhibidores de la proteina microsomal de transferencia de trigliceridos.
|
JP2006519258A
(ja)
|
2003-02-28 |
2006-08-24 |
エンサイシブ・ファーマシューティカルズ・インコーポレイテッド |
ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ii受容体拮抗薬
|
WO2004085420A1
(en)
|
2003-03-24 |
2004-10-07 |
Vicore Pharma Ab |
Bicyclic compounds useful as angiotensin ii agonists
|
DE602004022319D1
(de)
|
2003-11-14 |
2009-09-10 |
Vertex Pharma |
Thiazole udn oxazole als modulatoren von atp-bindungs-kassetten-transportern
|
GB0328024D0
(en)
|
2003-12-03 |
2004-01-07 |
Glaxo Group Ltd |
Compounds
|
CA2554716A1
(en)
|
2004-01-22 |
2005-08-04 |
Nitromed, Inc. |
Nitrosated and/or nitrosylated compounds, compositions and methods of use
|
JP4960708B2
(ja)
|
2004-01-30 |
2012-06-27 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atp結合カセットトランスポーターのモジュレーター
|
AP2006003685A0
(en)
|
2004-02-04 |
2006-08-31 |
Pfizer Prod Inc |
Substituted quinoline compounds
|
WO2005082414A2
(en)
|
2004-03-02 |
2005-09-09 |
Astellas Pharma Inc. |
Concomitant drugs of a sulfonamide and another therapeutic agent
|
DK1731512T3
(en)
|
2004-03-05 |
2015-01-05 |
Nissan Chemical Ind Ltd |
Isoxazoline-substituted benzamide AND INSTRUMENTS FOR COMBATING HARMFUL ORGANISMS
|
WO2005099705A2
(en)
|
2004-03-24 |
2005-10-27 |
Bayer Pharmaceuticals Corporation |
Preparation of imidazole derivatives and methods of use
|
GB0410121D0
(en)
|
2004-05-06 |
2004-06-09 |
Glaxo Group Ltd |
Compounds
|
US8354427B2
(en)
|
2004-06-24 |
2013-01-15 |
Vertex Pharmaceutical Incorporated |
Modulators of ATP-binding cassette transporters
|
EP2530075A3
(en)
|
2004-06-24 |
2014-12-24 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
US7550463B2
(en)
|
2004-09-15 |
2009-06-23 |
Shionogi & Co., Ltd. |
Carbamoylpyridone derivatives having inhibitory activity against HIV integrase
|
CA2581638A1
(en)
|
2004-09-29 |
2006-04-13 |
Portola Pharmaceuticals, Inc. |
Substituted 2h-1,3-benzoxazin-4(3h)-ones
|
JP2008523139A
(ja)
|
2004-12-14 |
2008-07-03 |
アストラゼネカ・アクチエボラーグ |
置換アミノピリジン類及びその使用
|
GB0428173D0
(en)
|
2004-12-23 |
2005-01-26 |
Astrazeneca Ab |
Compounds
|
CA2592442A1
(en)
|
2004-12-23 |
2006-06-29 |
Glaxo Group Limited |
Pyridine compounds for the treatment of prostaglandin mediated diseases
|
WO2007019397A2
(en)
|
2005-08-05 |
2007-02-15 |
Genelabs Technologies, Inc. |
6-membered aryl and heteroaryl derivatives for the treatment of hepatitis c virus
|
CA2618057A1
(en)
|
2005-08-11 |
2007-02-22 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
WO2007053641A2
(en)
|
2005-11-01 |
2007-05-10 |
Mars, Incorporated |
A-type procyanidins and inflammation
|
EP1974212A1
(en)
|
2005-12-27 |
2008-10-01 |
Vertex Pharmaceuticals Incorporated |
Compounds useful in cftr assays and methods therewith
|
WO2007087066A2
(en)
|
2005-12-28 |
2007-08-02 |
Vertex Pharmaceuticals Incorporated |
1-(benzo [d] [1,3] di0x0l-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
|
DK3219705T3
(da)
|
2005-12-28 |
2020-04-14 |
Vertex Pharma |
Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
|
US7671221B2
(en)
|
2005-12-28 |
2010-03-02 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
US7932283B2
(en)
|
2006-04-05 |
2011-04-26 |
Bayer Cropscience Ag |
Fungicide N-cyclopropyl-sulfonylamide derivatives
|
SI2007756T1
(sl)
|
2006-04-07 |
2015-11-30 |
Vertex Pharmaceuticals Incorporated |
Modulatorji prenašalcev z atp-vezavno kaseto
|
CA2652072A1
(en)
|
2006-05-12 |
2007-11-22 |
Vertex Pharmaceuticals Incorporated |
Compositions of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
CN101541783B
(zh)
|
2006-06-30 |
2014-10-01 |
苏尼西斯制药有限公司 |
吡啶酮基pdk1抑制剂
|
HUE034579T2
(hu)
|
2006-11-03 |
2018-02-28 |
Vertex Pharma |
Azaindol-származékok mint CFTR modulátorok
|
US20090047246A1
(en)
|
2007-02-12 |
2009-02-19 |
Intermune, Inc. |
Novel inhibitors of hepatitis c virus replication
|
WO2008141385A1
(en)
|
2007-05-21 |
2008-11-27 |
Biota Scientific Management Pty Ltd |
Viral polymerase inhibitors
|
US8058299B2
(en)
|
2007-05-22 |
2011-11-15 |
Via Pharmaceuticals, Inc. |
Diacylglycerol acyltransferase inhibitors
|
GB0716532D0
(en)
|
2007-08-24 |
2007-10-03 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
JP5272007B2
(ja)
|
2007-08-29 |
2013-08-28 |
メルク・シャープ・アンド・ドーム・コーポレーション |
ウイルス感染症を治療するための2,3−置換インドール誘導体
|
CN101918366A
(zh)
|
2007-09-14 |
2010-12-15 |
弗特克斯药品有限公司 |
N-[2,4-双(1,1-二甲基乙基)-5-羟基苯基]-1,4-二氢-4-氧代喹啉-3-甲酰胺的固体形式
|
EP2222660B1
(en)
|
2007-11-16 |
2014-03-26 |
Merck Sharp & Dohme Corp. |
3-heterocyclic substituted indole derivatives and methods of use thereof
|
GB0723794D0
(en)
|
2007-12-05 |
2008-01-16 |
Lectus Therapeutics Ltd |
Potassium ion channel modulators and uses thereof
|
SI2639222T1
(sl)
|
2007-12-07 |
2016-12-30 |
Vertex Pharmaceuticals Incorporated |
Proces za izdelavo cikloalkilkarboksiamido-piridin benzojskih kislin
|
RS55559B1
(sr)
|
2007-12-07 |
2017-05-31 |
Vertex Pharma |
Čvrste forme 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il) benzoeve kiseline
|
CN102036952A
(zh)
|
2008-04-16 |
2011-04-27 |
比奥里波克斯公司 |
用作药物的双芳基化合物
|
US20110112193A1
(en)
|
2008-05-14 |
2011-05-12 |
Peter Nilsson |
Bis-aryl compounds for use as medicaments
|
EP2145537A1
(en)
|
2008-07-09 |
2010-01-20 |
Bayer CropScience AG |
Plant growth regulator
|
UY31982A
(es)
|
2008-07-16 |
2010-02-26 |
Boehringer Ingelheim Int |
Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas
|
ME03019B
(me)
|
2008-08-13 |
2018-10-20 |
Vertex Pharma |
Farmaceutska kompozicija n-[2,4-bis(1,1- dimeтileтil)-5-hidroksifenil]- 1,4-dihidro-4-oksohinolin-3-karboksamida i njeno ordiniranje
|
JP2012500802A
(ja)
|
2008-08-21 |
2012-01-12 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
プロリルヒドロキシラーゼ阻害剤
|
MY157445A
(en)
|
2008-08-27 |
2016-06-15 |
Calcimedica Inc |
Compounds that modulate intracellular calcium.
|
MX357497B
(es)
|
2008-11-06 |
2018-07-11 |
Vertex Pharma |
Moduladores de transportadores de casete de union a atp.
|
UA104876C2
(uk)
|
2008-11-06 |
2014-03-25 |
Вертекс Фармасьютікалз Інкорпорейтед |
Модулятори atф-зв'язувальних касетних транспортерів
|
US20100160322A1
(en)
|
2008-12-04 |
2010-06-24 |
Abbott Laboratories |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
UA108193C2
(uk)
|
2008-12-04 |
2015-04-10 |
|
Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
|
EP2387560A2
(en)
|
2009-01-19 |
2011-11-23 |
Abbott Laboratories |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
MX338802B
(es)
|
2009-03-11 |
2016-05-02 |
Bayer Cropscience Ag |
Cetoenoles sustituidos con haloalquilmetilenoxi-fenilo.
|
EP3330255B1
(en)
|
2009-03-20 |
2020-12-09 |
Vertex Pharmaceuticals Incorporated |
Process for making modulators of cystic fibrosis transmembrane conductance regulator
|
US8835461B2
(en)
|
2009-03-26 |
2014-09-16 |
Shionogi & Co., Ltd. |
Substituted 3-hydroxy-4-pyridone derivative
|
CN102458122A
(zh)
*
|
2009-04-20 |
2012-05-16 |
人类健康研究所 |
含有哒嗪磺胺衍生物的化合物、组合物和方法
|
IL299019A
(en)
|
2009-05-26 |
2023-02-01 |
Abbvie Ireland Unlimited Co |
Method for preparing 2-(1H-pyrrolo[2,3-b]pyridine-5-aloxy)-4-(4-((9-(4-chlorophenyl)-3-isopropyl-3-azaspiro[5.5]-undec- 8-en-8-yl)methyl)piperazine-1 yl)benzoic acid
|
WO2011102514A1
(ja)
|
2010-02-22 |
2011-08-25 |
武田薬品工業株式会社 |
芳香環化合物
|
EP2547658A1
(en)
|
2010-03-19 |
2013-01-23 |
Vertex Pharmaceuticals Incorporated |
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
US8247436B2
(en)
*
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
EP2826776B1
(en)
|
2010-03-25 |
2020-11-25 |
Vertex Pharmaceuticals Incorporated |
Solid dispersion of amorphous form of (r)-1(2,2-difluorobenzo(d)(1,3)dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl)-cyclopropanecarboxamide
|
DK2555754T3
(en)
|
2010-04-07 |
2016-04-18 |
Vertex Pharma |
Solid forms of 3- (6- (1- (2,2-difluoro-benzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) -benzoic acid
|
SI3150198T1
(sl)
|
2010-04-07 |
2021-11-30 |
Vertex Pharmaceuticals Incorporated |
Farmacevtski sestavki 3-(6-(1-(2,2-difluorobenzo(D)(1,3)dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il)benzojske kisline in dajanje le-teh
|
US8344137B2
(en)
|
2010-04-14 |
2013-01-01 |
Hoffman-La Roche Inc. |
3,3-dimethyl tetrahydroquinoline derivatives
|
AU2011242452A1
(en)
|
2010-04-22 |
2012-11-08 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
CN103038214B
(zh)
|
2010-04-22 |
2015-09-30 |
弗特克斯药品有限公司 |
制备环烷基甲酰胺基-吲哚化合物的方法
|
TWI520960B
(zh)
|
2010-05-26 |
2016-02-11 |
艾伯維有限公司 |
用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
|
US8563593B2
(en)
|
2010-06-08 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
|
RU2013112937A
(ru)
|
2010-08-23 |
2014-09-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Фармацевтические композиции (r)-1-(2, 2-дифторбензо[d][1, 3]диоксол-5-ил)-n-(2, 3-дигидроксипропил)-6-фтор-2-(1-гидрокси-2-метилпропан-2-ил)-1н-индол-5-ил)циклопропанкарбоксамида и их применение
|
JP2013536251A
(ja)
|
2010-08-27 |
2013-09-19 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
薬学的組成物およびその投与
|
EP2630136A1
(en)
|
2010-10-21 |
2013-08-28 |
Universität des Saarlandes |
Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases
|
WO2012087938A1
(en)
|
2010-12-20 |
2012-06-28 |
Glaxosmithkline Llc |
Quinazolinone derivatives as antiviral agents
|
EP2471363A1
(de)
|
2010-12-30 |
2012-07-04 |
Bayer CropScience AG |
Verwendung von Aryl-, Heteroaryl- und Benzylsulfonamidocarbonsäuren, -carbonsäureestern, -carbonsäureamiden und -carbonitrilen oder deren Salze zur Steigerung der Stresstoleranz in Pflanzen
|
EP2669285A4
(en)
|
2011-01-26 |
2014-06-18 |
Kyorin Seiyaku Kk |
PYRAZOLOPYRIDINE DERIVATIVE OR PHARMACEUTICALLY UNINTENTIONAL SALT OF WHICH
|
US9000026B2
(en)
|
2011-02-17 |
2015-04-07 |
Bayer Intellectual Property Gmbh |
Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy
|
CN103415504B
(zh)
|
2011-03-01 |
2016-04-20 |
拜耳知识产权有限责任公司 |
2-酰氧基吡咯啉-4-酮类化合物
|
AR085585A1
(es)
|
2011-04-15 |
2013-10-09 |
Bayer Cropscience Ag |
Vinil- y alquinilciclohexanoles sustituidos como principios activos contra estres abiotico de plantas
|
US9260416B2
(en)
|
2011-05-27 |
2016-02-16 |
Amira Pharmaceuticals, Inc. |
Heterocyclic autotaxin inhibitors and uses thereof
|
CN103827095A
(zh)
|
2011-08-30 |
2014-05-28 |
Chdi基金会股份有限公司 |
犬尿氨酸-3-单加氧酶抑制剂、其药物组合物及其使用方法
|
WO2013038373A1
(en)
*
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
WO2013037955A1
(en)
|
2011-09-16 |
2013-03-21 |
Bayer Intellectual Property Gmbh |
Use of acylsulfonamides for improving plant yield
|
BR112014006940A2
(pt)
|
2011-09-23 |
2017-04-04 |
Bayer Ip Gmbh |
uso de derivados de ácido 1-fenilpirazol-3-carboxílico 4-substituído como agentes contra estresse abiótico em plantas
|
CA2852991C
(en)
|
2011-11-08 |
2019-12-31 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
US8426450B1
(en)
|
2011-11-29 |
2013-04-23 |
Helsinn Healthcare Sa |
Substituted 4-phenyl pyridines having anti-emetic effect
|
EP2806859B1
(en)
|
2012-01-25 |
2019-05-15 |
Vertex Pharmaceuticals Incorporated |
Formulations of 3-(6-(1-(2.2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
|
JP2015083542A
(ja)
|
2012-02-08 |
2015-04-30 |
大日本住友製薬株式会社 |
3位置換プロリン誘導体
|
CN109966264A
(zh)
|
2012-02-27 |
2019-07-05 |
沃泰克斯药物股份有限公司 |
药物组合物及其施用
|
US8889730B2
(en)
|
2012-04-10 |
2014-11-18 |
Pfizer Inc. |
Indole and indazole compounds that activate AMPK
|
AU2012377446A1
(en)
|
2012-04-20 |
2014-10-23 |
Vertex Pharmaceuticals Incorporated |
Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
BR112014029161A2
(pt)
|
2012-05-22 |
2017-06-27 |
Genentech Inc |
benzamidas n-substituídas e seu uso no tratamento de dor
|
AU2013270681A1
(en)
|
2012-06-08 |
2014-12-18 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions for the treatment of CFTR -mediated disorders
|
WO2013185202A1
(en)
|
2012-06-14 |
2013-12-19 |
Beta Pharma Canada Inc |
Apoptosis inducers
|
CA2878478A1
(en)
|
2012-07-06 |
2014-01-09 |
Genentech, Inc. |
N-substituted benzamides and methods of use thereof
|
WO2014014841A1
(en)
|
2012-07-16 |
2014-01-23 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
|
JP2015178458A
(ja)
|
2012-07-25 |
2015-10-08 |
杏林製薬株式会社 |
ベンゼン環縮合含窒素5員複素環式化合物、またはその薬理学的に許容される塩
|
US8883784B2
(en)
|
2012-08-13 |
2014-11-11 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
WO2014028968A1
(en)
|
2012-08-21 |
2014-02-27 |
Peter Maccallum Cancer Institute |
Perforin inhibiting benzenesulfonamide compounds, preparation and uses thereof
|
CN104981247A
(zh)
|
2012-09-06 |
2015-10-14 |
普莱希科公司 |
用于激酶调节的化合物和方法及其适应症
|
WO2014047427A2
(en)
|
2012-09-21 |
2014-03-27 |
Vanderbilt University |
Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors
|
EP2917203B1
(en)
|
2012-11-02 |
2019-04-03 |
Dana-Farber Cancer Institute, Inc. |
Method for identifying myc inhibitors
|
TW201422253A
(zh)
|
2012-11-02 |
2014-06-16 |
Vertex Pharma |
治療cftr介導疾病之醫藥組合物
|
EP2914265A4
(en)
|
2012-11-05 |
2016-04-13 |
Nant Holdings Ip Llc |
SUBSTITUTED INDOL-5-OL COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS
|
EP2928296A1
(de)
|
2012-12-05 |
2015-10-14 |
Bayer CropScience AG |
Verwendung substituierter 1-(arylethinyl)-, 1-(heteroarylethinyl)-, 1-(heterocyclylethinyl)- und 1-(cyloalkenylethinyl)-cyclohexanole als wirkstoffe gegen abiotischen pflanzenstress
|
US20150315146A1
(en)
|
2012-12-05 |
2015-11-05 |
Bayer Cropscience Ag |
Use of substituted 1-(aryl ethynyl)-, 1-(heteroaryl ethynyl)-, 1-(heterocyclyl ethynyl)- and 1-(cycloalkenylethynyl)-bicycloalkanols as active agents against abiotic plant stress
|
UA115576C2
(uk)
|
2012-12-06 |
2017-11-27 |
Байєр Фарма Акцієнгезелльшафт |
Похідні бензимідазолу як антагоністи ер4
|
GB201223265D0
(en)
|
2012-12-21 |
2013-02-06 |
Selvita Sa |
Novel benzimidazole derivatives as kinase inhibitors
|
WO2014109858A1
(en)
|
2013-01-14 |
2014-07-17 |
Amgen Inc. |
Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
|
US9637450B2
(en)
|
2013-03-14 |
2017-05-02 |
The Trustees Of Columbia University In The City Of New York |
Octahydrocyclopentapyrroles, their preparation and use
|
DK2968304T3
(en)
|
2013-03-14 |
2019-01-28 |
Univ Columbia |
4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE.
|
PT2970243T
(pt)
|
2013-03-15 |
2020-03-05 |
Cyclerion Therapeutics Inc |
Estimuladores de sgc
|
AU2014241183B2
(en)
|
2013-03-29 |
2018-08-09 |
Takeda Pharmaceutical Company Limited |
6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide derivatives and their use as PHD inhibitors
|
JP2016517895A
(ja)
|
2013-05-07 |
2016-06-20 |
ガラパゴス・ナムローゼ・フェンノートシャップGalapagos N.V. |
嚢胞性線維症を処置するための新規化合物およびこれらの医薬組成物
|
WO2014181287A1
(en)
|
2013-05-09 |
2014-11-13 |
Piramal Enterprises Limited |
Heterocyclyl compounds and uses thereof
|
US20160194299A1
(en)
|
2013-05-24 |
2016-07-07 |
The California Institute For Biomedical Research |
Compounds for treatment of drug resistant and persistent tuberculosis
|
WO2015010832A1
(en)
|
2013-07-22 |
2015-01-29 |
Syngenta Participations Ag |
Microbiocidal heterocyclic derivatives
|
US10005728B2
(en)
|
2013-08-28 |
2018-06-26 |
Vanderbilt University |
Substituted indole Mcl-1 inhibitors
|
US9663508B2
(en)
|
2013-10-01 |
2017-05-30 |
Amgen Inc. |
Biaryl acyl-sulfonamide compounds as sodium channel inhibitors
|
WO2015069287A1
(en)
|
2013-11-08 |
2015-05-14 |
Allergan, Inc. |
Compounds as tyrosine kinase modulators
|
DK3068392T5
(da)
|
2013-11-12 |
2021-09-20 |
Vertex Pharma |
Fremgangsmåde til fremstilling af farmaceutiske sammensætninger til behandlingen af cftr-medierede sygdomme
|
EP3925607B1
(en)
|
2014-04-15 |
2023-06-28 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
|
EP4159717A1
(en)
*
|
2014-10-06 |
2023-04-05 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
RU2749213C2
(ru)
|
2014-10-07 |
2021-06-07 |
Вертекс Фармасьютикалз Инкорпорейтед |
Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе
|
BR112017010406B1
(pt)
|
2014-11-18 |
2021-03-09 |
Vertex Pharmaceuticals Incorporated |
processo de realização de teste de alta produtividade de cromatografia líquida de alta eficiência
|
WO2016105484A1
(en)
|
2014-12-23 |
2016-06-30 |
Proteostasis Therapeutics, Inc. |
Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis
|
MA41253A
(fr)
|
2014-12-23 |
2017-10-31 |
Proteostasis Therapeutics Inc |
Composés, compositions et procédés pour augmenter l'activité du cftr
|
EP3259356B1
(en)
|
2015-02-20 |
2021-12-01 |
Rosalind Franklin University of Medicine and Science |
Antisense compounds targeting genes associated with cystic fibrosis
|
US20210401869A1
(en)
|
2015-02-20 |
2021-12-30 |
Rosalind Franklin University Of Medicine And Science |
Antisense Compounds Targeting Genes Associated with Cystic Fibrosis
|
CA2981495C
(en)
|
2015-03-31 |
2023-09-26 |
Vertex Pharmaceuticals (Europe) Limited |
Deuterated vx-661
|
MX2018003331A
(es)
|
2015-09-21 |
2018-08-16 |
Vertex Pharmaceuticals Europe Ltd |
Administracion de potenciadores de regulador de la conductancia transmembrana de fibrosis quistica (cftr) deuterados.
|
JP2019513714A
(ja)
|
2016-03-30 |
2019-05-30 |
ジェネンテック, インコーポレイテッド |
置換ベンズアミド及びその使用方法
|
US10738030B2
(en)
|
2016-03-31 |
2020-08-11 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
CN109563047A
(zh)
|
2016-04-07 |
2019-04-02 |
蛋白质平衡治疗股份有限公司 |
含有硅原子的依伐卡托类似物
|
EP3448842A1
(en)
|
2016-04-26 |
2019-03-06 |
AbbVie S.À.R.L. |
Modulators of cystic fibrosis transmembrane conductance regulator protein
|
US10138227B2
(en)
|
2016-06-03 |
2018-11-27 |
Abbvie S.Á.R.L. |
Heteroaryl substituted pyridines and methods of use
|
AU2017280206A1
(en)
|
2016-06-21 |
2019-01-17 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions, and methods for increasing CFTR activity
|
WO2018064632A1
(en)
|
2016-09-30 |
2018-04-05 |
Vertex Pharmaceuticals Incorporated |
Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
|
US10399940B2
(en)
|
2016-10-07 |
2019-09-03 |
Abbvie S.Á.R.L. |
Substituted pyrrolidines and methods of use
|
US9981910B2
(en)
|
2016-10-07 |
2018-05-29 |
Abbvie S.Á.R.L. |
Substituted pyrrolidines and methods of use
|
AU2017348182A1
(en)
|
2016-10-26 |
2019-05-16 |
Proteostasis Therapeutics, Inc. |
N-phenyl-2-(3-phenyl-6-oxo-1,6-dihydropyridazin-1-yl)acetamide derivatives for treating cystic fibrosis
|
AU2017348183A1
(en)
|
2016-10-26 |
2019-05-16 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions, and methods for modulating CFTR
|
AU2017348186A1
(en)
|
2016-10-26 |
2019-05-16 |
Proteostasis Therapeutics, Inc |
Pyridazine derivatives, compositions and methods for modulating CFTR
|
RU2757457C2
(ru)
|
2016-11-18 |
2021-10-18 |
Систик Файбросис Фаундейшн |
Пирролопиримидины в качестве потенциаторов мвтр
|
EA202192783A1
(ru)
|
2016-12-09 |
2022-02-24 |
Вертекс Фармасьютикалз Инкорпорейтед |
Модулятор регулятора трансмембранной проводимости при муковисцидозе, фармацевтические композиции, способы лечения и способ получения указанного модулятора
|
CN110300589B
(zh)
|
2016-12-16 |
2023-03-10 |
囊性纤维化基金会 |
作为cftr增效剂的双环异杂芳基衍生物
|
US20200123137A1
(en)
|
2016-12-20 |
2020-04-23 |
AbbVie S.à.r.l. |
Deuterated cftr modulators and methods of use
|
EP3565815B1
(en)
|
2017-01-07 |
2024-03-13 |
Fochon Pharmaceuticals, Ltd. |
Compounds as bcl-2-selective apoptosis-inducing agents
|
TW201831471A
(zh)
|
2017-02-24 |
2018-09-01 |
盧森堡商艾伯維公司 |
囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法
|
WO2018183367A1
(en)
|
2017-03-28 |
2018-10-04 |
Van Goor Fredrick F |
Methods of treating cystic fibrosis in patients with residual function mutations
|
WO2018201126A1
(en)
|
2017-04-28 |
2018-11-01 |
Proteostasis Therapeutics, Inc. |
4-sulfonylaminocarbonylquinoline derivatives for increasing cftr activity
|
MA54105A
(fr)
|
2017-06-08 |
2021-09-15 |
Vertex Pharma |
Méthodes de traitement de la fibrose kystique
|
CA3068609A1
(en)
|
2017-07-01 |
2019-01-10 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for treatment of cystic fibrosis
|
CA3069225A1
(en)
|
2017-07-17 |
2019-01-24 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
CA3069226A1
(en)
|
2017-07-17 |
2019-01-24 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
WO2019026075A1
(en)
|
2017-07-31 |
2019-02-07 |
Technion Research & Development Foundation Limited |
METHODS OF DETECTING MODIFIED AND UN-MODIFIED DNA
|
WO2019028228A1
(en)
|
2017-08-02 |
2019-02-07 |
Vertex Pharmaceuticals Incorporated |
PROCESSES FOR THE PREPARATION OF PYRROLIDINE COMPOUNDS
|
US10988454B2
(en)
|
2017-09-14 |
2021-04-27 |
Abbvie Overseas S.À.R.L. |
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
|
EP3691638A1
(en)
|
2017-10-06 |
2020-08-12 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions and methods for increasing cftr activity
|
AU2018351533B2
(en)
|
2017-10-19 |
2023-02-02 |
Vertex Pharmaceuticals Incorporated |
Crystalline forms and compositions of CFTR modulators
|
WO2019113089A1
(en)
|
2017-12-04 |
2019-06-13 |
Vertex Pharmaceuticals Incorporated |
Compositions for treating cystic fibrosis
|
EP3720849A2
(en)
|
2017-12-08 |
2020-10-14 |
Vertex Pharmaceuticals Incorporated |
Processes for making modulators of cystic fibrosis transmembrane conductance regulator
|
TWI810243B
(zh)
|
2018-02-05 |
2023-08-01 |
美商維泰克斯製藥公司 |
用於治療囊腫纖化症之醫藥組合物
|
US20210009560A1
(en)
|
2018-03-30 |
2021-01-14 |
Vertex Pharmaceuticals Incorporated |
Crystalline forms of modulators of cftr
|
US11414439B2
(en)
|
2018-04-13 |
2022-08-16 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
|