HRP20201334T1 - Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba - Google Patents
Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba Download PDFInfo
- Publication number
- HRP20201334T1 HRP20201334T1 HRP20201334TT HRP20201334T HRP20201334T1 HR P20201334 T1 HRP20201334 T1 HR P20201334T1 HR P20201334T T HRP20201334T T HR P20201334TT HR P20201334 T HRP20201334 T HR P20201334T HR P20201334 T1 HRP20201334 T1 HR P20201334T1
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- composition
- disease
- lymphoma
- ipilimumab
- Prior art date
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- 229960005386 ipilimumab Drugs 0.000 claims 3
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Claims (9)
1. Farmaceutska kompozicija koja sadrži nivolumab prema ipilimumabu u odnosu 1:3, koja sadrži 4.62 mg/ml ipilimumaba, 1.54 mg/ml nivolumaba, 18.46 mM Tris hidroklorida (HCl), 1.54 mM natrij citrat dihidrata, 96.15 mM NaCl, 1.15% m/v manitola, 93.85 µM pentetične kiseline (dietilen-triamin-pentaoctene kiseline), i 0.012 % m/v PS80.
2. Farmaceutska kompozicija iz patentnog zahtjeva 1, koja obuhvaća pH od 6.0.
3. Oprema koji sadrži kompoziciju iz patentnog zahtjeva 1 ili 2.
4. Metoda pravljenja kompozicije iz patentnog zahtjeva 1 ili 2, koja obuhvaća miješanje nivolumaba i ipilimumaba da se dobije željeni odnos.
5. Kompozicija iz patentnog zahtjeva 1 ili 2 za primjenu u modulaciji imunog odgovora kod pacijenta koji ima potrebu za istom.
6. Kompozicija iz patentnog zahtjeva 1 ili 2 za primjenu u liječenju bolesti ili stanja kod pacijenta.
7. Kompozicija za primjenu iz patentnog zahtjeva 6, gdje bolest ili stanje je infektivna bolest.
8. Kompozicija za primjenu iz patentnog zahtjeva 6, gdje bolest je rak.
9. Kompozicija za primjenu iz patentnog zahtjeva 8, gdje rak je melanomski rak, renalni rak, rak prostate, rak dojke, rak debelog crijeva, rak pluća, rak kostiju, rak pankreasa, rak kože, rak glave ili vrata, kutani ili intraokularni maligni melanom, rak materice, rak jajnika, rektalni rak, rak analne regije, rak trbuha, rak testisa, rak materice, karcinom jajovoda, karcinom endometrija, rak grlića materice, rak vagine, rak vulve, Hodgkinova bolest, Nehodgkinov limfom, rak jednjaka, rak tankog crijeva, rak endokrinog sistema, rak tiroidne žlijezde, rak paratiroidne žlijezde, rak nadbubrežne žlijezde, sarkom mekog tkiva, rak uretre, rak penisa, kronične ili akutne leukemije uključujući akutnu mijeloidnu leukemiju, kroničnu mijeloidnu leukemiju, akutnu limfoblastičnu leukemiju, kroničnu limfocitnu leukemiju, solidni tumori u djetinjstvu, limfocitni limfom, rak mokraćnog mjehura, rak bubrega ili uretera, rak bubrežne karlice, neoplazma centralnog živčanog sustava (CNS), primarni limfom CNS-a, angiogeneza tumora, tumor kičmenog stupa, gliom moždanog stabla, adenom hipofize, Kaposijev sarkom, epidermoidni rak, rak skvamoznih stanica, T-stanični limfom, karcinomi inducirani okolinom uključujući one inducirane azbestom, i bilo koje njihove kombinacije.
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EP16718835.8A EP3283107B1 (en) | 2015-04-17 | 2016-04-15 | Compositions comprising a combination of ipilimumab and nivolumab |
PCT/US2016/027913 WO2016168716A1 (en) | 2015-04-17 | 2016-04-15 | Compositions comprising a combination of an anti-pd-1 antibody and another antibody |
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Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
CA2909160C (en) | 2013-04-09 | 2021-05-25 | Lixte Biotechnology, Inc. | Formulations of oxabicycloheptanes and oxabicycloheptenes |
RS58705B1 (sr) | 2013-09-20 | 2019-06-28 | Bristol Myers Squibb Co | Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
WO2015173267A1 (en) | 2014-05-13 | 2015-11-19 | Medimmune Limited | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer |
PT3148579T (pt) | 2014-05-28 | 2021-03-11 | Ludwig Inst For Cancer Res Ltd | Anticorpos anti-gitr e métodos da sua utilização |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
WO2016023960A1 (en) | 2014-08-12 | 2016-02-18 | Alligator Bioscience Ab | Combination therapies with anti cd40 antibodies |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
AU2015314756A1 (en) | 2014-09-13 | 2017-03-16 | Novartis Ag | Combination therapies of alk inhibitors |
AR103726A1 (es) | 2015-02-27 | 2017-05-31 | Merck Sharp & Dohme | Cristales de anticuerpos monoclonales anti-pd-1 humanos |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
BR112017021688A2 (pt) | 2015-04-17 | 2018-08-14 | Bristol-Myers Squibb Company | composições compreendendo uma combinação de um anticorpo anti-pd-1 e outro anticorpo |
WO2016176504A1 (en) | 2015-04-28 | 2016-11-03 | Bristol-Myers Squibb Company | Treatment of pd-l1-positive melanoma using an anti-pd-1 antibody |
TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
MX2018000621A (es) | 2015-07-13 | 2018-05-11 | Cytomx Therapeutics Inc | Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y metodos de uso de los mismos. |
HUE053966T2 (hu) * | 2015-07-14 | 2021-08-30 | Bristol Myers Squibb Co | Eljárás rák kezelésére immunellenõrzõpont inhibitorral, antitest, amely köt programozott halál-1 receptorhoz (PD-1) vagy programozott halál ligandum 1-hez (PD-L1) |
GEP20227438B (en) | 2015-07-30 | 2022-11-10 | Macrogenics Inc | Pd-1-binding molecules and methods of use thereof |
EP3334763A4 (en) | 2015-08-11 | 2019-04-03 | Wuxi Biologics (Cayman) Inc. | NOVEL ANTI-PD-1 ANTIBODIES |
EP3355920A4 (en) | 2015-09-29 | 2019-05-15 | Celgene Corporation | PD-1 BINDING PROTEINS AND METHOD OF USE THEREOF |
CN108473585B (zh) | 2015-11-18 | 2022-04-05 | 默沙东公司 | Pd1和/或lag3结合剂 |
TW202134282A (zh) | 2015-12-02 | 2021-09-16 | 美商艾吉納斯公司 | 抗體和使用彼之方法 |
EP3389714A4 (en) | 2015-12-14 | 2019-11-13 | MacroGenics, Inc. | BISPECIFIC MOLECULES HAVING IMMUNOREACTIVITY TO PD-1 AND CTLA-4 AND METHODS OF USE |
AU2016371639A1 (en) | 2015-12-16 | 2018-06-28 | Merck Sharp & Dohme Llc | Anti-LAG3 antibodies and antigen-binding fragments |
US10392442B2 (en) | 2015-12-17 | 2019-08-27 | Bristol-Myers Squibb Company | Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment |
UA127200C2 (uk) | 2016-05-18 | 2023-06-07 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Молекула антитіла до pd1 |
FI4019019T3 (fi) | 2016-05-20 | 2024-05-14 | Biohaven Therapeutics Ltd | Rilutsolin, rilutsolin aihiolääkkeiden tai rilutsolin analogien käyttö immunoterapioiden kanssa syövän hoidossa |
EP3515943A4 (en) | 2016-09-19 | 2020-05-06 | Celgene Corporation | METHODS OF TREATING VITILIGO WITH PD-1 BINDING PROTEINS |
EA201990747A1 (ru) | 2016-09-19 | 2019-10-31 | Способы лечения иммунных нарушений с применением белков, связывающих pd–1 | |
AU2017359467A1 (en) | 2016-11-09 | 2019-05-02 | Agenus Inc. | Anti-OX40 antibodies, anti-GITR antibodies, and methods of use thereof |
DK3551629T3 (da) * | 2016-12-08 | 2024-02-12 | Lixte Biotechnology Inc | Oxabicycloheptaner til modulering af immunrespons |
MX2019008207A (es) * | 2017-01-09 | 2019-12-11 | Tesaro Inc | Métodos para tratar el cáncer con anticuerpos anti-pd-1. |
AR110755A1 (es) | 2017-01-20 | 2019-05-02 | Genzyme Corp | Anticuerpos dirigidos a hueso |
TWI787230B (zh) | 2017-01-20 | 2022-12-21 | 法商賽諾菲公司 | 抗TGF-β抗體及其用途 |
AU2018225102A1 (en) * | 2017-02-21 | 2019-09-05 | Regeneron Pharmaceuticals, Inc. | Anti-PD-1 antibodies for treatment of lung cancer |
WO2018175676A1 (en) * | 2017-03-23 | 2018-09-27 | The General Hospital Corporation | Cxcr4/cxcr7 blockade and treatment of human papilloma virus-associated disease |
EP3601338A4 (en) * | 2017-03-29 | 2020-12-16 | Celgene Corporation | FORMULATIONS INCLUDING PROTEINS BINDING PD-1 AND THEIR PREPARATION METHODS |
US11603407B2 (en) * | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
US11596696B2 (en) | 2017-04-20 | 2023-03-07 | Adc Therapeutics Sa | Combination therapy with an anti-CD25 antibody-drug conjugate |
WO2018193102A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
MX2019013034A (es) * | 2017-05-02 | 2020-02-05 | Merck Sharp & Dohme | Formulaciones estables de anticuerpos anti-ctla4 solos y en combinacion con anticuerpos contra el receptor de muerte programasa 1 (pd-1) y metodos para su uso. |
EP3618871A4 (en) | 2017-05-02 | 2021-01-06 | Merck Sharp & Dohme Corp. | ANTI-LAG3 ANTIBODIES ETCO-FORMULATIONS ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
TW201842929A (zh) * | 2017-05-03 | 2018-12-16 | 美商必治妥美雅史谷比公司 | 結合至肌肉生長抑制素以纖維連接蛋白為主之支架結構域蛋白質的穩定調配物 |
JP7274426B2 (ja) * | 2017-05-16 | 2023-05-16 | ブリストル-マイヤーズ スクイブ カンパニー | 抗gitrアゴニスト抗体での癌の処置 |
EP3631454B1 (en) | 2017-05-30 | 2023-09-13 | Bristol-Myers Squibb Company | Treatment of lag-3 positive tumors |
BR112019021847A2 (pt) | 2017-05-30 | 2020-06-02 | Bristol-Myers Squibb Company | Composições compreendendo um anticorpo anti-lag-3 ou um anticorpo anti-lag-3 e um anticorpo anti-pd-1 ou anti-pd-l1 |
JP7145891B2 (ja) | 2017-06-14 | 2022-10-03 | アーデーセー セラピューティクス ソシエテ アノニム | 抗cd19 adcを投与するための投与レジメ |
US20190135905A1 (en) * | 2017-06-16 | 2019-05-09 | Bristol-Myers Squibb Company | Compositions and methods for treating tauopathies |
CN111278858A (zh) | 2017-07-11 | 2020-06-12 | 指南针制药有限责任公司 | 结合人cd137的激动剂抗体及其用途 |
SG11201911919PA (en) * | 2017-08-18 | 2020-02-27 | Regeneron Pharma | Image capillary isoelectric focusing to analyze protein variants in a sample matrix |
CN111094352A (zh) | 2017-08-25 | 2020-05-01 | 戊瑞治疗有限公司 | B7-h4抗体及其使用方法 |
CA3074565A1 (en) * | 2017-09-05 | 2019-03-14 | Merck Sharp & Dohme Corp. | Compounds for reducing the viscosity of biological formulations |
JP2020532991A (ja) | 2017-09-07 | 2020-11-19 | オーガスタ ユニバーシティ リサーチ インスティテュート,インコーポレーテッド | プログラム細胞死タンパク質1に対する抗体 |
US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
MX2020004567A (es) * | 2017-11-06 | 2020-08-13 | Genentech Inc | Metodos diagnosticos y terapeuticos para el cancer. |
EP3713961A2 (en) | 2017-11-20 | 2020-09-30 | Compass Therapeutics LLC | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
US11384126B2 (en) * | 2017-12-01 | 2022-07-12 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for inhibiting DHHC-type palmitoyltransferases for cancer treatment |
WO2019143607A1 (en) * | 2018-01-16 | 2019-07-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
CA3091801A1 (en) | 2018-03-02 | 2019-09-06 | Five Prime Therapeutics, Inc. | B7-h4 antibodies and methods of use thereof |
CN112292399A (zh) * | 2018-04-04 | 2021-01-29 | 百时美施贵宝公司 | 抗cd27抗体及其用途 |
US20220111065A1 (en) | 2018-05-23 | 2022-04-14 | Adc Therapeutics Sa | Molecular adjuvant |
EP3843718A1 (en) * | 2018-06-15 | 2021-07-07 | The Board Of Regents Of The University Of Texas System | Methods of treating and preventing melanoma with s-equol |
EA202191086A1 (ru) * | 2018-10-19 | 2021-09-20 | Бристоль-Мейерз Сквибб Компани | Комбинированная терапия меланомы |
EP3880709A4 (en) * | 2018-11-05 | 2022-07-27 | Merck Sharp & Dohme Corp. | ANTI-LAG3 ANTIBODY AND COMBINATION THERAPY WITH ANTI-PD-1 ANTIBODY FOR THE TREATMENT OF CANCER |
CA3118964A1 (en) * | 2018-11-05 | 2020-05-14 | Merck Sharp & Dohme Corp. | Dosing regimen of anti-tigit antibody for treatment of cancer |
EP3877409A1 (en) * | 2018-11-06 | 2021-09-15 | Genmab A/S | Antibody formulation |
EP3876978A4 (en) | 2018-11-07 | 2022-09-28 | Merck Sharp & Dohme Corp. | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (MP-1) ANTIBODIES AND THEIR METHODS OF USE |
KR20210089215A (ko) * | 2018-11-07 | 2021-07-15 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항-pd-1 항체의 공동-제제 |
CN113166269A (zh) | 2018-11-13 | 2021-07-23 | 指南针制药有限责任公司 | 对抗检查点分子的多特异性结合构建体及其用途 |
US11634485B2 (en) | 2019-02-18 | 2023-04-25 | Eli Lilly And Company | Therapeutic antibody formulation |
JP6802598B1 (ja) * | 2019-07-18 | 2020-12-16 | Delta−Fly Pharma株式会社 | 抗がん剤の効果増強剤 |
GB201917254D0 (en) | 2019-11-27 | 2020-01-08 | Adc Therapeutics Sa | Combination therapy |
TW202138006A (zh) * | 2019-12-13 | 2021-10-16 | 韓商三星Bioepis股份有限公司 | 穩定之抗-pd1抗體醫藥調配物 |
US20230355757A1 (en) * | 2019-12-20 | 2023-11-09 | Formycon Ag | Formulations of anti-pd1 antibodies |
WO2021152548A1 (en) | 2020-01-30 | 2021-08-05 | Benitah Salvador Aznar | Combination therapy for treatment of cancer and cancer metastasis |
US20230118596A1 (en) * | 2020-03-05 | 2023-04-20 | Merck Sharp & Dohme Llc | Methods for treating cancer using a combination of a pd-1 antagonist, a ctla4 antagonist, and lenvatinib or a pharmaceutically accpetable salt thereof |
EP4114445A1 (en) | 2020-03-06 | 2023-01-11 | Ona Therapeutics S.L. | Anti-cd36 antibodies and their use to treat cancer |
JP2023522024A (ja) * | 2020-04-17 | 2023-05-26 | ディンフー バイオターゲット カンパニー リミテッド | Cd137と特異的に結合する製剤とその使用について |
CA3180463A1 (en) * | 2020-06-19 | 2021-12-23 | Ping Hu | Stable formulation for recombinant anti-pd-1 monoclonal antibody |
US20210403568A1 (en) * | 2020-06-29 | 2021-12-30 | Cai Gu Huang | Biopharmaceutical formulation of anti-pd-1, anti-pd-l1, and anti-vegfr therapeutic monoclonal antibodies and method for treating nsclc by inhalation |
CA3185091A1 (en) * | 2020-07-08 | 2022-01-13 | Yuan Cheng | Stabilized formulations containing anti-ctla-4 antibodies |
EP4008345A1 (en) * | 2020-12-03 | 2022-06-08 | Hexal AG | Novel formulations for antibodies |
GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
TW202308692A (zh) * | 2021-04-27 | 2023-03-01 | ***聯邦商拜奧卡德聯合股份公司 | 包含帕博利珠單抗(pembrolizumab)的藥學組成物及其用途 |
EP4355780A1 (en) * | 2021-06-18 | 2024-04-24 | Alligator Bioscience AB | Novel combination therapies and uses thereof |
AU2022294100A1 (en) * | 2021-06-18 | 2024-02-01 | Genzyme Corporation | Anti-tgf-beta antibody formulations and their use |
CA3220882A1 (en) * | 2021-07-02 | 2023-01-05 | David Scott Johnson | Anti-ctla-4 binding proteins and methods of use thereof |
KR20240042476A (ko) | 2021-07-30 | 2024-04-02 | 오엔에이 테라퓨틱스 에스.엘. | 항-cd36 항체 및 암을 치료하기 위한 이의 용도 |
WO2023235847A1 (en) * | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303121B1 (en) | 1992-07-30 | 2001-10-16 | Advanced Research And Technology | Method of using human receptor protein 4-1BB |
US6355476B1 (en) | 1988-11-07 | 2002-03-12 | Advanced Research And Technologyinc | Nucleic acid encoding MIP-1α Lymphokine |
US6362325B1 (en) | 1988-11-07 | 2002-03-26 | Advanced Research And Technology Institute, Inc. | Murine 4-1BB gene |
WO1992022653A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
PL188749B1 (pl) | 1996-10-11 | 2005-04-29 | Bristol Myers Squibb Co | Zastosowanie przeciwciała anty-4-1BB i kompozycjaleku |
EE05627B1 (et) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
DK2283866T3 (en) | 1999-06-25 | 2015-05-18 | Genentech Inc | METHODS OF TREATMENT USING ANTI-ERBB ANTIBODY-MAYTANSINOID CONJUGATES |
BR0013581A (pt) | 1999-08-23 | 2002-07-02 | Dana Faber Cancer Inst Inc | Pd-1, um receptor para b7-4, e usos para isto |
US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
MXPA02001911A (es) | 1999-08-24 | 2003-07-21 | Medarex Inc | Anticuerpos ctla-4 humanos y sus usos. |
US7034121B2 (en) | 2000-01-27 | 2006-04-25 | Genetics Institue, Llc | Antibodies against CTLA4 |
PT2206517T (pt) | 2002-07-03 | 2023-11-07 | Tasuku Honjo | Composições de imunopotenciação contendo anticorpos anti-pd-l1 |
WO2004007520A2 (en) | 2002-07-12 | 2004-01-22 | Medarex, Inc. | Methods and compositions for preventing oxidative degradation of proteins |
EP1539237A4 (en) | 2002-07-30 | 2006-05-24 | Bristol Myers Squibb Co | HUMANIZED ANTIBODIES AGAINST HUMAN 4-1BB |
ATE514713T1 (de) | 2002-12-23 | 2011-07-15 | Wyeth Llc | Antikörper gegen pd-1 und ihre verwendung |
AU2004253630B2 (en) | 2003-07-02 | 2010-11-25 | Innate Pharma S.A.S. | Methods for the production and cytotoxicity evaluation of KIR2DL NK-receptor antibodies |
AU2004258747B2 (en) | 2003-07-24 | 2009-11-19 | Innate Pharma | Methods and compositions for increasing the efficiency of therapeutic antibodies using NK cell potentiating compounds |
US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
JP5112863B2 (ja) | 2004-07-01 | 2013-01-09 | ノヴォ ノルディスク アー/エス | ヒト抗−kir抗体 |
EP3072522B1 (en) | 2005-01-06 | 2019-04-24 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
JP5295568B2 (ja) | 2005-01-06 | 2013-09-18 | ノヴォ ノルディスク アー/エス | Kir結合剤およびその使用方法 |
CA2600608A1 (en) | 2005-03-08 | 2006-09-14 | Pharmacia & Upjohn Company Llc | Composition comprising human igg2 antibody and chelating agent |
CN101193917A (zh) * | 2005-03-08 | 2008-06-04 | 法玛西雅厄普约翰有限责任公司 | 抗-MAdCAM抗体组合物 |
WO2006105021A2 (en) | 2005-03-25 | 2006-10-05 | Tolerrx, Inc. | Gitr binding molecules and uses therefor |
DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
CA3201163A1 (en) | 2005-07-01 | 2007-01-11 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
EP2322557B1 (en) | 2005-10-14 | 2017-08-30 | Innate Pharma | Compositions and methods for treating proliferative disorders |
WO2007113648A2 (en) | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
JP5478261B2 (ja) | 2007-01-11 | 2014-04-23 | ノヴォ ノルディスク アクティーゼルスカブ | 抗kir抗体、製剤、およびその使用 |
JP2008278814A (ja) | 2007-05-11 | 2008-11-20 | Igaku Seibutsugaku Kenkyusho:Kk | アゴニスティック抗ヒトgitr抗体による免疫制御の解除とその応用 |
ES2616355T3 (es) | 2007-06-18 | 2017-06-12 | Merck Sharp & Dohme B.V. | Anticuerpos para el receptor humano de muerte programada PD-1 |
AU2008275589B2 (en) | 2007-07-12 | 2013-11-21 | Gitr, Inc. | Combination therapies employing GITR binding molecules |
CA2700860C (en) | 2007-10-01 | 2016-07-19 | Jonathan A. Terrett | Human antibodies that bind mesothelin, and uses thereof |
WO2009073533A2 (en) | 2007-11-30 | 2009-06-11 | Medarex, Inc. | Anti-b7h4 monoclonal antibody-drug conjugate and methods of use |
WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
US20090311187A1 (en) * | 2008-05-29 | 2009-12-17 | Bristol-Myers Squibb Company | Methods for predicting patient response to modulation of the Co-stimulatory pathway |
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
PL2350129T3 (pl) | 2008-08-25 | 2015-12-31 | Amplimmune Inc | Kompozycje antagonistów PD-1 i sposoby stosowania |
JP2012510468A (ja) | 2008-11-28 | 2012-05-10 | アボット・ラボラトリーズ | 安定な抗体組成物およびこれを安定させるための方法 |
US8709411B2 (en) | 2008-12-05 | 2014-04-29 | Novo Nordisk A/S | Combination therapy to enhance NK cell mediated cytotoxicity |
HRP20240240T1 (hr) | 2008-12-09 | 2024-04-26 | F. Hoffmann - La Roche Ag | Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice |
AU2010289677B2 (en) | 2009-09-03 | 2014-07-31 | Merck Sharp & Dohme Llc | Anti-GITR antibodies |
JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Pd−l1/pd−l2の同時阻害 |
MX339621B (es) | 2010-04-13 | 2016-06-02 | Celldex Therapeutics Inc * | Anticuerpos que se unen a cd27 humano y uso de los mismos. |
BR112013012138B1 (pt) | 2010-11-22 | 2022-02-22 | Innate Pharma Sa | Uso de um composto que inibe um receptor inibidor de célula natural killer (nkcir) |
ES2699965T3 (es) | 2011-03-10 | 2019-02-13 | Provectus Pharmatech Inc | Una combinación de rosa de bengala y anticuerpo anti-CTLA4 para su uso en el tratamiento del cáncer |
SI2691112T1 (en) * | 2011-03-31 | 2018-07-31 | Merck Sharp & Dohme Corp. | STABILITY FORMULATION PROTITELES FOR HUMAN PROGRAMMED DEPRESSOR RECEPTOR PD-1 AND RELATED HEALTH |
RU2625034C2 (ru) | 2011-04-20 | 2017-07-11 | МЕДИММЬЮН, ЭлЭлСи | Антитела и другие молекулы, которые связывают в7-н1 и pd-1 |
KR102046666B1 (ko) | 2011-05-25 | 2019-11-19 | 이나뜨 파르마 | 염증성 장애의 치료를 위한 항-kir 항체 |
WO2013039954A1 (en) | 2011-09-14 | 2013-03-21 | Sanofi | Anti-gitr antibodies |
DK2776032T3 (en) | 2011-11-09 | 2019-02-04 | Bristol Myers Squibb Co | TREATMENT OF HEMATOLOGICAL MALIGNITIES WITH ANTI-CXCR4 ANTIBODY |
DK2785375T3 (da) | 2011-11-28 | 2020-10-12 | Merck Patent Gmbh | Anti-pd-l1-antistoffer og anvendelser deraf |
SG10201700698WA (en) | 2012-05-15 | 2017-02-27 | Bristol Myers Squibb Co | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
KR101566539B1 (ko) | 2012-06-08 | 2015-11-05 | 국립암센터 | 신규한 Th2 세포 전환용 에피토프 및 이의 용도 |
CN104024276A (zh) * | 2012-06-21 | 2014-09-03 | 卡姆普根有限公司 | Lsr抗体及其用于癌症治疗的用途 |
AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
WO2014055648A1 (en) | 2012-10-02 | 2014-04-10 | Bristol-Myers Squibb Company | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
US20160145355A1 (en) * | 2013-06-24 | 2016-05-26 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
KR101809151B1 (ko) * | 2013-07-18 | 2017-12-15 | (주)앗코스텍 | 키레놀 또는 희첨 추출물을 포함하는 골다공증 예방, 개선 또는 치료용 조성물 |
AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
HRP20221262T1 (hr) | 2013-09-13 | 2022-12-09 | Beigene Switzerland Gmbh | Protutijela anti-pd1 i njihova uporaba kao terapeutskih i dijagnostičkih sredstava |
RS58705B1 (sr) | 2013-09-20 | 2019-06-28 | Bristol Myers Squibb Co | Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora |
PT3148579T (pt) | 2014-05-28 | 2021-03-11 | Ludwig Inst For Cancer Res Ltd | Anticorpos anti-gitr e métodos da sua utilização |
EA037006B1 (ru) | 2014-06-06 | 2021-01-26 | Бристол-Майерс Сквибб Компани | Антитела к индуцируемому глюкокортикоидами рецептору фактора некроза опухолей (gitr) и их применения |
BR112017021688A2 (pt) * | 2015-04-17 | 2018-08-14 | Bristol-Myers Squibb Company | composições compreendendo uma combinação de um anticorpo anti-pd-1 e outro anticorpo |
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