HRP20190742T1 - Nova anti-cd38 protutijela za liječenje raka - Google Patents
Nova anti-cd38 protutijela za liječenje raka Download PDFInfo
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- HRP20190742T1 HRP20190742T1 HRP20190742TT HRP20190742T HRP20190742T1 HR P20190742 T1 HRP20190742 T1 HR P20190742T1 HR P20190742T T HRP20190742T T HR P20190742TT HR P20190742 T HRP20190742 T HR P20190742T HR P20190742 T1 HRP20190742 T1 HR P20190742T1
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- Prior art keywords
- bis
- benzodiazepine
- tetrahydro
- antibody
- pyrrolo
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Classifications
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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Claims (23)
1. Protutijelo koje specifično veže CD38, naznačeno time što:
i. je navedeno protutijelo sposobno ubiti CD38+ stanicu apoptozom, stanično-posredovanom citotoksičnošću ovisnom o protutijelu (ADCC), i komplementarno ovisnom citotoksičnošću (CDC);
ii. navedeno protutijelo sadrži barem jedan teški lanac, barem jedan laki lanac i barem jednu ljudsku konstantnu regiju;
iii. navedeni teški lanac sadrži varijabilnu regiju koja ima sekvencu aminokiseline prema SEQ ID No.66; i
iv. navedeni laki lanac sadrži varijabilnu regiju koja ima sekvencu aminokiseline prema SEQ ID No.62.
2. Protutijelo prema zahtjevu 1, naznačeno time što je navedeno protutijelo sposobno ubiti navedenu CD38+ stanicu apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome.
3. Protutijelo prema zahtjevu 1 ili 2, naznačeno time što navedena CD38+ stanica je stanica limfoma, stanica leukemije, ili stanica multiplog mijeloma.
4. Protutijelo prema zahtjevu 3, naznačeno time što navedena CD38+ stanica je stanica ne-Hodgkinovog limfoma (NHL), stanica Burkittovog limfoma (BL), stanica multiplog mijeloma (MM), stanica B kronične limfocitne leukemije (B-CLL), stanica B i T akutne limfocitne leukemije (ALL), stanica T-staničnog limfoma (TCL), stanica akutne mijeloične leukemije (AML), stanica leukemije vlasastih stanica (HCL), stanica Hodgkinovog limfoma (HL), ili stanica kronične mijeloične leukemije (CML).
5. Protutijelo prema zahtjevu 1, naznačeno time što:
• navedeno protutijelo je sposobno ubiti barem 24 % Daudijevih stanica limfoma apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome; i/ili
• navedeno protutijelo je sposobno ubiti više od 7 % Ramosovih stanica limfoma apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome; i/ili
• navedeno protutijelo je sposobno ubiti više od 11 % MOLP-8 stanica multiplog mijeloma apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome; i/ili
• navedeno protutijelo je sposobno ubiti više od 36 % SU-DHL-8 stanica limfoma apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome; i/ili
• navedeno protutijelo je sposobno ubiti više od 62 % DND-41 stanica leukemije apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome; i/ili
• navedeno protutijelo je sposobno ubiti više od 27 % NU-DUL-1 stanica limfoma apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome; i/ili
• navedeno protutijelo je sposobno ubiti više od 9 % JVM-13 stanica leukemije apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome; i/ili
• navedeno protutijelo je sposobno ubiti više od 4 % HC-1 stanica leukemije apoptozom u odsutnosti stromalnih stanica ili citokina izvedenih iz strome.
6. Protutijelo prema bilo kojem od prethodnih zahtjeva, naznačeno time što navedeno protutijelo veže CD38 s kD od 3 x 10-9 M ili nižim.
7. Protutijelo prema bilo kojem od zahtjeva 1 do 6, naznačeno time što navedeno protutijelo je humanizirano ili presvučeno protutijelo.
8. Protutijelo prema bilo kojem od zahtjeva 1 do 7, naznačeno time što navedena ljudska konstantna regija je ljudska IgG1/Kapa konstantna regija.
9. Konjugat koji sadrži protutijelo prema bilo kojem od zahtjeva 1 do 8 vezano na citotoksično sredstvo.
10. Konjugat prema zahtjevu 9, naznačen time što je navedeno citotoksično sredstvo odabrano iz skupine koja sadrži majtanzinoid, mali lijek, derivat tomajmicina, derivat leptomicina, predlijek, taksoid, CC-1065 i analog CC-1065.
11. Konjugat prema zahtjevu 10, naznačen time što:
• navedeno citotoksično sredstvo je majtanzin DM1 s formulom:
ili
• navedeno citotoksično sredstvo je majtanzin DM4 s formulom :
ili
• navedeno citotoksično sredstvo je derivat tomajmicina odabran iz skupine koja sadrži:
∘ 8,8'-[1,3-benzendiilbis(metilenoksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[5-metoksi-1,3-benzendiilbis(metilenoksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[1,5-pentandiilbis(oksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-piroio[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[1,4-butanediilbis(oksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[3-metil-1,5-pentandiilbis(oksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[2,6-piridinediilbis(oksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[4-(3-tert-butoksikarbonilaminopropiloksi)-2,6-piridinediilbis-(metilenoksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[5-(3-aminopropiloksi)-1,3-benzendiilbis(metilenoksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[5-(N-metil-3-tert-butoksikarbonilaminopropil)-1,3-benzendiilbis-(metilenoksi)]-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-{5-[3-(4-metil-4-metildisulfanil-pentanoilamino)propiloksi]-1,3-benzendiilbis(metilenoksi)}-bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[5-acetiltiometil-1,3-benzendiilbis(metilenoksi)]-bis[(S)-2-metilen-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ tert-butil ester bis-[2-[(S)-2-metilen-7-metoksi-5-okso-1,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-8-iloksi]-etil}-karbaminske kiseline
∘ 8,8'-[3-(2-acetiltioetil)-1,5-pentandiilbis(oksi)]-bis[(S)-2-metilen-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[5-(N-4-merkapto-4,4-dimetilbutanoil)amino-1,3-benzendiilbis(metilenoksi)]-bis[7-metoksi-2-metilen-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[5-(N-4-metilditio-4,4-dimetilbutanoil)-amino-1,3-benzendiilbis(metilenoksi)]-bis[7-metoksi-2-metilen-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[5-(N-metil-N-(2-merkapto-2,2-dimetiletil)amino-1,3-benzendiil(metilenoksi)]-bis[7-metoksi-2-metilen-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[5-(N-metil-N-(2-metilditio-2,2-dimetiletil)amino-1,3-benzendiil(metilenoksi)]-bis[7-metoksi-2-metilen-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(4-(2-(4-merkapto-4-metil)-pentanamido-etoksi)-piridin-2,6-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(1-(2-(4-metil-4-metildisulfanil)-pentanamido-etoksi)-benzen-3,5-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(4-(3-(4-metil-4-metildisulfanil)-pentanamido-propoksi)-piridin-2,6-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(4-(4-(4-metil-4-metildisulfanil)-pentanamido-butoksi)-piridin-2,6-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(4-(3-[4-(4-metil-4-metildisulfanil-pentanoil)-piperazin-1-il]-propil)-piridin-2,6-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(1-(3-[4-(4-metil-4-metildisulfanil-pentanoil)-piperazin-1-il]-propil)-benzen-3,5-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(4-(2-{2-[2-(4-metil-4-metildisulfanil-pentanoilamino)-etoksi]-etoksi}-etoksi)-piridin-2,6-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(1-(2-{2-[2-(2-{2-[2-(4-metil-4-metildisulfanil-pentanoilamino)-etoksi]-etoksi}-etoksi)-etoksi]-etoksi}-etoksi)-benzen-3,5-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(1-(2-f2-[2-(4-metil-4-metildisulfanil-pentanoilamino)-etoksi]-etoksi}-etoksi)-benzen-3,5-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(4-(2-{2-[2-(2-{2-[2-(4-metil-4-metildisulfanil-pentanoilamino)-etoksi]-etoksi}-etoksi)-etoksi]-etoksi}-etoksi)-piridin-2,6-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(1-(2-[metil-(2-metil-2-metildisulfanil-propil)-amino]-etoksi)-benzen-3,5-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(4-(3-[metil-(4-metil-4-metildisulfanil-pentanoil)-amino]-propil)-piridin-2,6-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(4-(3-[metil-(2-metil-2-metildisulfanil-propil)-amino]-propil)-piridin-2,6-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on]
∘ 8,8'-[(1-(4-metil-4-metildisulfanil)-pentanamido)-benzen-3,5-dimetil)-dioksi]-bis[(S)-2-et-(E)-iliden-7-dimetoksi-1,2,3,11a-tetrahidro-pirolo[2,1-c][1,4]benzodiazepin-5-on], ili
• navedeno citotoksično sredstvo je derivat leptomicina odabran iz skupine koju čine:
∘ (2-Metilsulfanil-etil)-amid (2E,10E,12E,16Z,18E)-(R)-6-Hidroksi-3,5, 7,9,11,15,17-heptametil-19-((2S,3S)-3-metil-6-okso-3,6-dihidro-2H-piran-2-il)-8-okso-nonadeka-2,10,12,16,18-pentaenske kiseline
∘ Bis-[(2-merkaptoetil)-amid (2E,10E,12E,16Z,18E)-(R)-6-hidroksi-3,5,7,9, 11,15,17-heptametil-19-((2S,3S)-3-metil-6-okso-3,6-dihidro-2H-piran-2-il)-8-okso-nonadeka-2,10,12,16,18-pentaenske kiseline]
∘ (2-Merkapto-etil)-amid (2E,10E,12E,16Z,18E)-(R)-6-hidroksi-3,5,7,9,11, 15,17-heptametil-19-((2S,3S)-3-metil-6-okso-3,6-dihidro-2H-piran-2-il)-8-okso-nonadeka-2,10,12,16,18-pentaenske kiseline
∘ (2-Metildisulfanil-etil)-amid (2E,10E,12E,16Z,18E)-(R)-6-hidroksi-3,5,7,9,11,15,17-heptametil-19-((2S,3S)-3-metil-6-okso-3,6-dihidro-2H-piran-2-il)-8-okso-nonadeka-2,10,12,16,18-pentaenske kiseline
∘ (2-Metil-2-metildisulfanil-propil)-amid (2E,10E,12E,16Z,18E)-(R)-6-hidroksi-3,5,7,9,11,15,17-heptametil-19-((2S,3S)-3-metil-6-okso-3,6-dihidro-2H-piran-2-il)-8-okso-nonadeka-2,10,12,16,18-pentaenske kiseline
∘ (2-Merkapto-2-metil-propil)-amid (2E,10E,12E,16Z,18E)-(R)-6-hidroksi-3,5,7,9,11,15,17-heptametil-19-((2S,3S)-3-metil-6-okso-3,6-dihidro-2H-piran-2-il)-8-okso-nonadeka-2,10,12,16,18-pentaenske kiseline.
12. Protutijelo prema bilo kojem od zahtjeva 1-8, ili konjugat prema bilo kojem od zahtjeva 9-11, naznačeno time što je za uporabu kao lijek.
13. Farmaceutski pripravak naznačen time što sadrži protutijelo prema bilo kojem od zahtjeva 1-8, ili konjugat prema bilo kojem od zahtjeva 9-11, te farmaceutski prihvatljiv nosač ili pomoćne tvari.
14. Farmaceutski pripravak prema zahtjevu 13, naznačen time što navedeni pripravak sadrži daljnje terapijsko sredstvo.
15. Farmaceutski pripravak prema zahtjevu 14, naznačen time što daljnje terapijsko sredstvo je antagonist epidermalnog faktora rasta (EGF), faktora rasta fibroblasta (FGF), faktora rasta hepatocita (HGF), tkivnog faktora (TF), proteina C, proteina S, faktora rasta izvedenog iz trombocita (PDGF), heregulina, makrofag stimulirajućeg proteina (MSP) ili vaskularnog endotelnog faktora rasta (VEGF), ili antagonist receptora za epidermalni faktor rasta (EGF), faktora rasta fibroblasta (FGF), faktora rasta hepatocita (HGF), tkivnog faktora (TF), proteina C, proteina S, faktora rasta izvedenog iz trombocita (PDGF), heregulina, makrofag stimulirajućeg proteina (MSP), ili vaskularnog endotelnog faktora rasta (VEGF), uključujući receptor HER2, receptor HER3, c-MET, i druge receptore tirozin kinaza; ili navedeno daljnje terapeutsko sredstvo je protutijelo usmjereno protiv klastera diferencijacijskog antigena odabranog iz skupine koja sadrži CD3, CD14, CD19, CD20, CD22, CD25, CD28, CD30, CD33, CD36, CD40, CD44, CD52, CD55, CD59, CD56, CD70, CD79, CD80, CD103, CD134, CD137, CD138, i CD152.
16. Protutijelo prema bilo kojem od zahtjeva 1-8, ili konjugat prema bilo kojem od zahtjeva 9-11, naznačeno time što je za uporabu za liječenje raka ili autoimune bolesti.
17. Protutijelo ili konjugat za uporabu prema zahtjevu 16, naznačeno time što navedeni rak je multipli mijelom.
18. Protutijelo ili konjugat za uporabu prema zahtjevu 16 naznačeno time što navedeni rak je limfom B-stanica.
19. Protutijelo ili konjugat za uporabu prema bilo kojem od zahtjeva 16 do 18, naznačeno time što liječenje nadalje obuhvaća uporabu daljnjeg terapeutskog sredstva u istom ili u drugom pripravku.
20. Protutijelo ili konjugat za uporabu prema zahtjevu 19, naznačeno time što daljnje terapijsko sredstvo je antagonist faktora rasta fibroblasta (FGF), faktora rasta hepatocita (HGF), tkivnog faktora (TF), proteina C, proteina S, faktora rasta izvedenog iz trombocita (PDGF), heregulina, makrofag stimulirajućeg proteina (MSP) ili vaskularnog endotelnog faktora rasta (VEGF), ili antagonist receptora za epidermalni faktor rasta (EGF), faktora rasta fibroblasta (FGF), faktora rasta hepatocita (HGF), tkivnog faktora (TF), proteina C, proteina S, faktora rasta izvedenog iz trombocita (PDGF), heregulina, makrofag stimulirajućeg proteina (MSP), ili vaskularnog endotelnog faktora rasta (VEGF), uključujući receptor HER2, receptor HER3, c-MET, i druge receptore tirozin kinaza; ili navedeno daljnje terapeutsko sredstvo je protutijelo usmjereno protiv klastera diferencijacijskog antigena odabranog iz skupine koja sadrži CD3, CD14, CD19, CD20, CD22, CD25, CD28, CD30, CD33, CD36, CD40, CD44, CD52, CD55, CD59, CD56, CD70, CD79, CD80, CD103, CD134, CD137, CD138, i CD152.
21. Polinukleotid naznačen time što:
• navedeni polinukleotid kodira protutijelo kako je definirano u bilo kojem od patentnih zahtjeva 1-8; ili
• navedeni polinukleotid kodira teški lanac i laki lanac protutijela tijela kako je definirano u bilo kojem od patentnih zahtjeva 1-8.
22. Rekombinantni vektor naznačen time što sadrži polinukleotid prema zahtjevu 21.
23. Stanica domaćin naznačena time što sadrži vektor prema zahtjevu 22.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP06291628A EP1914242A1 (en) | 2006-10-19 | 2006-10-19 | Novel anti-CD38 antibodies for the treatment of cancer |
EP07859236.7A EP2076540B1 (en) | 2006-10-19 | 2007-10-16 | Novel anti-cd38 antibodies for the treatment of cancer |
PCT/IB2007/004172 WO2008047242A2 (en) | 2006-10-19 | 2007-10-16 | Novel anti-cd38 antibodies for the treatment of cancer |
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Country Status (43)
Families Citing this family (308)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9200061B2 (en) * | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
AU2005235811B2 (en) | 2004-02-06 | 2011-11-03 | Morphosys Ag | Anti-CD38 human antibodies and uses therefor |
WO2006122355A1 (en) * | 2005-05-16 | 2006-11-23 | Qrsciences Pty Ltd | A system and method for improving the analysis of chemical substances using nqr |
CA2621982C (en) | 2005-09-07 | 2017-11-28 | Jennerex Biotherapeutics Ulc | Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses |
TWI428444B (zh) | 2005-10-12 | 2014-03-01 | Morphosys Ag | 由全長人類HuCAL GOLD-衍生之對人類CD38有特異性之治療抗體之產生及鑑定 |
EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
US7259237B1 (en) | 2006-12-29 | 2007-08-21 | Miller Kent D | Pan-antiviral peptides |
SI2019104T1 (sl) | 2007-07-19 | 2013-12-31 | Sanofi | Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba |
PA8849001A1 (es) * | 2008-11-21 | 2010-06-28 | Lilly Co Eli | Anticuerpos de c-met |
EP2191842A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
EP2191841A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
EP2191843A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide |
EP2191840A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
FR2947269B1 (fr) | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
FR2949469A1 (fr) * | 2009-08-25 | 2011-03-04 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application en therapeutique |
ES2848650T3 (es) | 2009-09-14 | 2021-08-11 | Sillajen Biotherapeutics Inc | Terapia combinada contra el cáncer con virus vaccinia oncolítico |
AR078471A1 (es) | 2009-10-02 | 2011-11-09 | Sanofi Aventis | COMPUESTOS MAITANSINOIDES Y EL USO DE ESTOS PARA PREPARAR CONJUGADOS CON UN ANTICUERPO LOS CUALES SE UTILIZAN COMO AGENTES ANTICANCERIGENOS Y EL PROCEDIMIENTO DE PREPARACIoN DE ESTOS CONJUGADOS |
HUE029026T2 (en) | 2009-12-22 | 2017-01-30 | Roche Glycart Ag | Anti-HER3 antibodies and their applications |
MX2012007379A (es) * | 2009-12-23 | 2012-08-31 | Genentech Inc | Anticuerpos anti-bv8 y usos de los mismos. |
US9220743B2 (en) | 2010-01-22 | 2015-12-29 | Nuovo Biologics, Llc | Pan-antiviral peptides for protein kinase inhibition |
US8697688B2 (en) | 2010-04-15 | 2014-04-15 | Seattle Genetics Inc. | Pyrrolobenzodiazepines used to treat proliferative diseases |
US9242013B2 (en) | 2010-04-15 | 2016-01-26 | Seattle Genetics Inc. | Targeted pyrrolobenzodiazapine conjugates |
SI2580243T1 (sl) | 2010-06-09 | 2020-02-28 | Genmab A/S | Protitelesa proti humanemu CD38 |
FR2963007B1 (fr) | 2010-07-26 | 2013-04-05 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application therapeutique |
RU2595839C2 (ru) | 2010-09-27 | 2016-08-27 | МорфоСис АГ | Антитело к cd38 и леналидомид или бортезомиб для лечения множественной миеломы и nhl |
UA112170C2 (uk) * | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
CN103429258B (zh) * | 2011-01-04 | 2016-03-09 | 新罗杰公司 | 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性 |
MY171008A (en) | 2011-03-29 | 2019-09-23 | Immunogen Inc | Preparation of maytansinoid antibody conjugates by a one-step process |
UA116524C2 (uk) | 2011-03-29 | 2018-04-10 | Іммуноджен, Інк. | Спосіб одержання кон'югата антитіло-майтансиноїд |
CN103826661B (zh) | 2011-04-21 | 2019-03-05 | 西雅图基因公司 | 新的结合剂-药物缀合物(adc)及其用途 |
MX339239B (es) * | 2011-04-29 | 2016-05-18 | Apexigen Inc | Anticuerpos anti-cd40 y metodos de uso. |
AU2012253571A1 (en) | 2011-05-09 | 2014-01-09 | Mayo Foundation For Medical Education And Research | Cancer treatments |
US8846042B2 (en) | 2011-05-16 | 2014-09-30 | Fabion Pharmaceuticals, Inc. | Multi-specific FAB fusion proteins and methods of use |
KR101860174B1 (ko) | 2011-09-20 | 2018-05-21 | 메디뮨 리미티드 | 표적 접합체 내의 내포를 위한 비대칭 이량체 pbd 화합물로서 피롤로벤조디아제핀 |
JP6393617B2 (ja) | 2011-10-14 | 2018-09-19 | シアトル ジェネティクス,インコーポレーテッド | ピロロベンゾジアゼピンおよび標的コンジュゲート |
EP2753178B1 (en) | 2011-10-14 | 2017-12-06 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
MX341523B (es) | 2011-10-14 | 2016-08-24 | Medimmune Ltd | Pirrolobenzodiazepinas. |
AU2012322932B2 (en) | 2011-10-14 | 2016-11-10 | Medimmune Limited | Pyrrolobenzodiazepines |
KR102037541B1 (ko) | 2011-10-28 | 2019-10-29 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 폴리펩티드 구축물 및 이의 용도 |
WO2013075740A1 (en) * | 2011-11-23 | 2013-05-30 | Sanofi | Antibody purification method |
CN108324943B (zh) * | 2012-02-10 | 2024-03-08 | 思进股份有限公司 | Cd30+癌症的检测和治疗 |
AR090549A1 (es) | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
MX2014012889A (es) | 2012-05-01 | 2014-11-14 | Genentech Inc | Anticuerpos e inmunoconjugados anti-pmel17. |
IN2014DN10652A (hr) | 2012-07-09 | 2015-09-11 | Genentech Inc | |
BR112015000441A2 (pt) | 2012-07-09 | 2017-12-19 | Genentech Inc | imunoconjugados, formulação farmacêutica e método de tratamento e método para inbir a proliferação de uma célula positiva para cd22 |
BR112015002193A2 (pt) | 2012-08-02 | 2017-07-04 | Genentech Inc | anticorpos anti-etbr e imunoconjugados |
CA2885792C (en) | 2012-09-25 | 2021-09-28 | Jan Endell | Pharmaceutical combination of an anti-cd38 antibody and melphalan for treating multiple myeloma |
US10413606B2 (en) | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
RU2661083C2 (ru) | 2012-10-04 | 2018-07-11 | Иммуноджен, Инк. | Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент |
JP6270859B2 (ja) | 2012-10-12 | 2018-01-31 | エイディーシー・セラピューティクス・エス・アー・エール・エルAdc Therapeutics Sarl | ピロロベンゾジアゼピン−抗体結合体 |
RS53818B1 (en) | 2012-10-12 | 2015-06-30 | Spirogen Sàrl | PIROLOBENZODIAZEPINI I NJIHOVI conjugated |
KR101995621B1 (ko) | 2012-10-12 | 2019-07-03 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항-cd22 항체 컨주게이트 |
JP6367204B2 (ja) | 2012-10-12 | 2018-08-01 | メドイミューン・リミテッドMedImmune Limited | 結合用のピロロベンゾジアゼピン誘導体の合成および中間体 |
CA2887895C (en) | 2012-10-12 | 2019-10-29 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine-anti-cd19 antibody conjugates |
CA2885315C (en) | 2012-10-12 | 2020-06-23 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
PT2906296T (pt) | 2012-10-12 | 2018-06-01 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina-anticorpo |
WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
AR093357A1 (es) * | 2012-11-05 | 2015-06-03 | Pf Medicament | Proteinas de union al antigeno y su utilizacion como producto de direccionamiento para el tratamiento del cancer |
DK2914302T3 (en) | 2012-11-05 | 2017-04-10 | Morphosys Ag | RADIOACTIVALLY MARKED ANTIBODY AND USES OF IT |
US10342869B2 (en) | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
UA118255C2 (uk) * | 2012-12-07 | 2018-12-26 | Санофі | Композиція, яка містить антитіло до cd38 і леналідомід |
JP6340019B2 (ja) | 2013-03-13 | 2018-06-06 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
KR102057755B1 (ko) | 2013-03-13 | 2019-12-19 | 메디뮨 리미티드 | 피롤로벤조디아제핀 및 그의 컨쥬게이트 |
MY175418A (en) | 2013-03-13 | 2020-06-24 | Sanofi Sa | Compositions comprising anti-cd38 antibodies and carfilzomib |
KR20150127199A (ko) | 2013-03-14 | 2015-11-16 | 제넨테크, 인크. | 항-b7-h4 항체 및 면역접합체 |
US9562099B2 (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
EA033115B1 (ru) | 2013-04-29 | 2019-08-30 | Тева Фармасьютикалз Острэйлиа Пти Лтд. | АНТИТЕЛА ПРОТИВ CD38 И СЛИТЫЕ БЕЛКИ С ОСЛАБЛЕННЫМ ИНТЕРФЕРОНОМ АЛЬФА-2b |
HUE057119T2 (hu) * | 2013-05-06 | 2022-04-28 | Sanofi Sa | Folyamatos többlépéses eljárás antitestek tisztítására |
KR20160042080A (ko) | 2013-08-12 | 2016-04-18 | 제넨테크, 인크. | 1-(클로로메틸)-2,3-디히드로-1H-벤조[e]인돌 이량체 항체-약물 접합체 화합물, 및 사용 및 치료 방법 |
EP3046940B1 (en) | 2013-09-17 | 2019-07-03 | F.Hoffmann-La Roche Ag | Methods of using anti-lgr5 antibodies |
US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
US9956299B2 (en) | 2013-10-11 | 2018-05-01 | Medimmune Limited | Pyrrolobenzodiazepine—antibody conjugates |
EP3054983B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
CN103513040B (zh) * | 2013-10-16 | 2015-03-11 | 常晓天 | 蛋白cd38在制备类风湿性关节炎诊断标记物中的应用 |
CA2927099A1 (en) | 2013-10-31 | 2015-05-07 | Sanofi | Specific anti-cd38 antibodies for treating human cancers |
EP3176185A1 (en) | 2013-11-04 | 2017-06-07 | Glenmark Pharmaceuticals S.A. | Production of t cell retargeting hetero-dimeric immunoglobulins |
AU2014362238A1 (en) | 2013-12-13 | 2016-06-09 | Genentech, Inc. | Anti-CD33 antibodies and immunoconjugates |
WO2015095212A1 (en) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
ES2815098T3 (es) | 2013-12-23 | 2021-03-29 | Bayer Pharma AG | Conjugados de ligadores (ADCs) con inhibidores de KSP |
US10675352B2 (en) * | 2014-02-14 | 2020-06-09 | Centrose, Llc | Extracellular targeted drug conjugates |
US10836998B2 (en) | 2014-02-14 | 2020-11-17 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
KR102497443B1 (ko) * | 2014-03-28 | 2023-02-08 | 젠코어 인코포레이티드 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
CA2946662A1 (en) | 2014-05-22 | 2015-11-26 | Genentech, Inc. | Anti-gpc3 antibodies and immunoconjugates |
US10106620B2 (en) | 2014-06-16 | 2018-10-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Blocking CD38 using anti-CD38 F(ab′)2 to protect NK cells |
WO2015195555A1 (en) | 2014-06-16 | 2015-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Blocking cd38 using anti-cd38 antibody conjugated to protein g to protect nk cells |
CA2952424C (en) | 2014-06-16 | 2019-07-23 | Mayo Foundation For Medical Education And Research | Treating myelomas |
US9212225B1 (en) * | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
WO2016011210A2 (en) | 2014-07-15 | 2016-01-21 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
WO2016022589A2 (en) * | 2014-08-08 | 2016-02-11 | The Regents Of The University Of California | Methods for treating multiple myeloma |
RU2764074C2 (ru) | 2014-08-28 | 2022-01-13 | Байоатла, Ллк | Условно активные химерные антигенные рецепторы для модифицированных т-клеток |
WO2016040294A2 (en) | 2014-09-09 | 2016-03-17 | Janssen Biotech, Inc. | Combination therapies with anti-cd38 antibodies |
CN106804108B (zh) | 2014-09-12 | 2021-08-10 | 基因泰克公司 | 抗-b7-h4抗体及免疫缀合物 |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
KR20170052600A (ko) | 2014-09-12 | 2017-05-12 | 제넨테크, 인크. | 시스테인 가공된 항체 및 콘주게이트 |
DK3191135T3 (da) | 2014-09-12 | 2020-10-12 | Genentech Inc | Anti-HER2-antistoffer og immunokonjugater |
MA40579A (fr) | 2014-09-12 | 2016-03-17 | Genentech Inc | Anticorps anti-cll-1 et immunoconjugués |
JP6767362B2 (ja) * | 2014-09-16 | 2020-10-14 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | リンパ球における阻害経路の中和 |
JP6730261B2 (ja) | 2014-09-17 | 2020-07-29 | ジェネンテック, インコーポレイテッド | 抗her2抗体を含む免疫複合体 |
US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
IL251822B2 (en) | 2014-10-29 | 2023-03-01 | Teva Pharmaceuticals Australia Pty Ltd | Variants of interferon alpha-2-b |
MA40894A (fr) * | 2014-11-04 | 2017-09-12 | Glenmark Pharmaceuticals Sa | Immunoglobulines hétéro-dimères reciblant des lymphocytes t cd3/cd38 et leurs procédés de production |
US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
CA2966932A1 (en) | 2014-11-19 | 2016-05-26 | Immunogen, Inc. | Process for preparing cell-binding agent-cytotoxic agent conjugates |
EP3223854A1 (en) | 2014-11-25 | 2017-10-04 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
CA2967426A1 (en) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and tumor antigens |
SG11201704390PA (en) * | 2014-12-04 | 2017-06-29 | Janssen Biotech Inc | Anti-cd38 antibodies for treatment of acute myeloid leukemia |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201506389D0 (en) * | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
KR20180015650A (ko) | 2015-05-07 | 2018-02-13 | 아게누스 인코포레이티드 | 항-ox40 항체 및 이의 사용 방법 |
CA2984464C (en) | 2015-05-13 | 2023-10-10 | Morphosys Ag | Treatment for multiple myeloma (mm) |
BR112017024877A2 (pt) | 2015-05-20 | 2019-09-17 | Janssen Biotech, Inc. | anticorpo anti-cd38 e seu uso no tratamento de amiloidose de cadeia leve e outras malignidades hematológicas positivas para cd38 |
MY188049A (en) | 2015-05-29 | 2021-11-12 | Bristol Myers Squibb Co | Antibodies against ox40 and uses thereof |
KR20240038121A (ko) | 2015-05-30 | 2024-03-22 | 몰레큘러 템플레이츠, 인코퍼레이션. | 탈면역된 시가 독소 a 서브유닛 스캐폴드 및 이를 포함하는 세포-표적화 분자 |
CA2990406A1 (en) * | 2015-06-22 | 2016-12-29 | Janssen Biotech, Inc. | Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors |
CN114917361A (zh) | 2015-06-22 | 2022-08-19 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物(adc)和抗体前药缀合物(apdc) |
US20160376373A1 (en) | 2015-06-24 | 2016-12-29 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體-抗體組合物及其製造及使用方法 |
CA2998611A1 (en) * | 2015-09-14 | 2017-03-23 | Leukemia Therapeutics, LLC | Identification of novel diagnostics and therapeutics by modulating rhoh |
TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
EA202190808A2 (ru) | 2015-11-03 | 2021-12-31 | Янссен Байотек, Инк. | Составы антител к cd38 для подкожного введения и их применение |
CN105837688B (zh) * | 2015-11-20 | 2019-02-26 | 北京大学深圳研究生院 | 单域抗体及其编码基因,免疫毒素及其编码基因、制备方法、表达载体、应用,及宿主细胞 |
CA3007233A1 (en) | 2015-12-02 | 2017-06-08 | Agenus Inc. | Antibodies and methods of use thereof |
EP3399861A4 (en) | 2016-01-07 | 2019-08-07 | Mayo Foundation for Medical Education and Research | INTERFERON CANCER TREATMENT METHODS |
CN113912725B (zh) * | 2016-01-09 | 2024-03-08 | 嘉立医疗科技(广州)有限公司 | 用于癌症治疗的钙粘蛋白-17特异性抗体和细胞毒性细胞 |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
EP3411077A1 (en) | 2016-02-05 | 2018-12-12 | ImmunoGen, Inc. | Efficient process for preparing cell-binding agent-cytotoxic agent conjugates |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
CA3014531A1 (en) | 2016-02-12 | 2017-08-17 | Mayo Foundation For Medical Education And Research | Hematologic cancer treatments |
AU2017226960B2 (en) | 2016-03-04 | 2024-03-21 | Morphosys Ag | Clinical assessment of M-protein response in multiple myeloma |
JP7034489B2 (ja) | 2016-03-15 | 2022-03-14 | アイタブメッド (エイチケイ) リミテッド | 多重特異性Fab融合タンパクおよびその使用 |
US11878061B2 (en) | 2016-03-21 | 2024-01-23 | Mayo Foundation For Medical Education And Research | Methods for improving the therapeutic index for a chemotherapeutic drug |
CA3018341A1 (en) | 2016-03-21 | 2017-09-28 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
KR20180123047A (ko) | 2016-03-24 | 2018-11-14 | 바이엘 파마 악티엔게젤샤프트 | 효소적으로 절단가능한 기를 갖는 세포독성 활성제의 전구약물 |
US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
AU2017248644B2 (en) | 2016-04-15 | 2019-10-31 | Bioatla, Llc | Anti-Axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
WO2017196847A1 (en) | 2016-05-10 | 2017-11-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Variable new antigen receptor (vnar) antibodies and antibody conjugates targeting tumor and viral antigens |
SI3455261T1 (sl) | 2016-05-13 | 2023-01-31 | Bioatla, Inc. | Protitelesa proti ROR2, fragmenti protitelesa, njihovi imunokonjugati in uporabe le-teh |
US20170370906A1 (en) | 2016-05-27 | 2017-12-28 | Genentech, Inc. | Bioanalytical analysis of site-specific antibody drug conjugates |
WO2017214182A1 (en) | 2016-06-07 | 2017-12-14 | The United States Of America. As Represented By The Secretary, Department Of Health & Human Services | Fully human antibody targeting pdi for cancer immunotherapy |
EP3919518A1 (en) | 2016-06-15 | 2021-12-08 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
WO2018002181A1 (en) | 2016-06-28 | 2018-01-04 | Umc Utrecht Holding B.V. | TREATMENT OF IgE-MEDIATED DISEASES WITH ANTIBODIES THAT SPECIFICALLY BIND CD38 |
CA3030834A1 (en) * | 2016-07-15 | 2018-01-18 | Takeda Pharmaceutical Company Limited | Methods and materials for assessing response to plasmablast- and plasma cell-depleting therapies |
US11618784B2 (en) | 2016-07-19 | 2023-04-04 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-CD47 combination therapy |
WO2018015498A1 (en) | 2016-07-20 | 2018-01-25 | Hybrigenics Sa | Combinations of inecalcitol with an anti-cd38 agent and their uses for treating cancer |
AU2017305170A1 (en) | 2016-08-02 | 2019-02-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies targeting glypican-2 (GPC2) and use thereof |
CN109689111B (zh) | 2016-08-11 | 2024-04-05 | 基因泰克公司 | 吡咯并苯并二氮杂䓬前药及其抗体缀合物 |
US11160876B2 (en) | 2016-09-01 | 2021-11-02 | Mayo Foundation For Medical Education And Research | Methods and compositions for targeting t-cell cancers |
CA3035378A1 (en) | 2016-09-01 | 2018-03-08 | Mayo Foundation For Medical Education And Research | Carrier-pd-l1 binding agent compositions for treating cancers |
EP3509635A1 (en) | 2016-09-06 | 2019-07-17 | Vavotar Life Sciences LLC | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
US11311631B2 (en) | 2016-09-06 | 2022-04-26 | Mayo Foundation For Medical Education And Research | Paclitaxel-albumin-binding agent compositions and methods for using and making the same |
EP3510048A1 (en) | 2016-09-06 | 2019-07-17 | Mayo Foundation for Medical Education and Research | Methods of treating pd-l1 expressing cancer |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
TWI788307B (zh) * | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
US11697680B2 (en) | 2016-11-21 | 2023-07-11 | Cureab Gmbh | Anti-GP73 antibodies and immunoconjugates |
CN110312533B (zh) | 2016-12-21 | 2023-11-03 | 拜耳公司 | 具有酶促可裂解的基团的细胞毒性活性剂的前药 |
US11236171B2 (en) | 2016-12-21 | 2022-02-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for FLT3 and uses thereof |
PE20191235A1 (es) | 2016-12-21 | 2019-09-11 | Bayer Pharma AG | Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente |
EP3558387B1 (de) | 2016-12-21 | 2021-10-20 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
JP6827113B2 (ja) | 2017-01-21 | 2021-02-10 | 広州白雲山漢方現代薬業有限公司Guangzhou Hanfang Pharmaceutical Co.,Ltd. | シェーグレン症候群の治療におけるペオニフロリン−6’−o−ベンゼンスルホン酸の使用 |
US11160872B2 (en) | 2017-02-08 | 2021-11-02 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
CN110582505B (zh) | 2017-04-18 | 2021-04-02 | 免疫医疗有限公司 | 吡咯并苯并二氮杂*缀合物 |
CN110536703A (zh) | 2017-04-20 | 2019-12-03 | Adc治疗有限公司 | 使用抗axl抗体-药物缀合物的组合疗法 |
CA3059472A1 (en) | 2017-05-19 | 2018-11-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibody targeting tnfr2 for cancer immunotherapy |
US11318211B2 (en) | 2017-06-14 | 2022-05-03 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-CD19 ADC |
KR20200017519A (ko) * | 2017-06-20 | 2020-02-18 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Cd38 항체 약물 접합체 |
PL3538645T3 (pl) | 2017-06-20 | 2021-11-08 | Institut Curie | Komórki odpornościowe z defektem suv39h1 |
CA3066953A1 (en) | 2017-06-30 | 2019-01-03 | Lentigen Technology, Inc. | Human monoclonal antibodies specific for cd33 and methods of their use |
WO2019005208A1 (en) | 2017-06-30 | 2019-01-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | ANTIBODIES TO HUMAN MESOTHELIN AND USES IN ANTICANCER THERAPY |
EP3434692A1 (en) * | 2017-07-24 | 2019-01-30 | Encefa | Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases |
UY37757A (es) * | 2017-08-10 | 2018-11-30 | Grifols Diagnostic Solutions Inc | Composiciones, procedimientos y/o kits que comprenden un dominio extracelular de cd38 humano recombinante |
WO2019034752A1 (en) * | 2017-08-16 | 2019-02-21 | Tusk Therapeutics Ltd | CD38 MODULATOR ANTIBODY |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
CA3072296A1 (en) * | 2017-08-16 | 2019-02-21 | Black Belt Therapeutics Limited | Cd38 antibody |
SI3668874T1 (sl) | 2017-08-18 | 2022-04-29 | Medimmune Limited | Pirolobenzodiazepinski konjugati |
US20200207867A1 (en) | 2017-09-13 | 2020-07-02 | Teneobio, Inc. | Heavy chain antibodies binding to ectoenzymes |
BR112020005028A2 (pt) * | 2017-09-14 | 2020-09-15 | Glaxosmithkline Intellectual Property Development Limited | tratamento em combinação para câncer |
CN116999573A (zh) | 2017-09-29 | 2023-11-07 | 第一三共株式会社 | 抗体-药物偶联物及其制造方法、药物组合物及其在制备***的药物中的应用 |
US11945868B2 (en) * | 2017-10-02 | 2024-04-02 | Visterra, Inc. | Antibody molecules to CD138 and uses thereof |
BR112020007002A2 (pt) * | 2017-10-10 | 2020-11-17 | Sanofi | anticorpos anti-cd38 e métodos de uso |
MA50514A (fr) | 2017-10-31 | 2020-09-09 | Janssen Biotech Inc | Méthodes de traitement du myélome multiple à haut risque |
WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
CN111902159A (zh) | 2017-11-01 | 2020-11-06 | 朱诺治疗学股份有限公司 | 对b细胞成熟抗原(bcma)具有特异性的嵌合抗原受体 |
US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
US20210254000A1 (en) | 2017-11-01 | 2021-08-19 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
US11623961B2 (en) | 2017-11-01 | 2023-04-11 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for B-cell maturation antigen |
BR112020008340A2 (pt) | 2017-11-01 | 2020-11-17 | Juno Therapeutics Inc | processo para gerar composições terapêuticas de células modificadas |
EP3706785A4 (en) * | 2017-11-10 | 2021-08-04 | Actinium Pharmaceuticals, Inc. | COMBINATION THERAPY FOR TREATMENT OF A HEMATOLOGICAL DISEASE |
SG11202005272SA (en) | 2017-12-08 | 2020-07-29 | Juno Therapeutics Inc | Process for producing a composition of engineered t cells |
WO2019113556A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Serum-free media formulation for culturing cells and methods of use thereof |
US20210128616A1 (en) | 2017-12-08 | 2021-05-06 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
EP3694546A1 (en) | 2018-01-30 | 2020-08-19 | Cellectis | Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen |
CN110144008B (zh) * | 2018-02-12 | 2021-03-19 | 杭州尚健生物技术有限公司 | Cd38蛋白抗体及其应用 |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
EP3762031A4 (en) * | 2018-03-08 | 2021-12-22 | Phanes Therapeutics, Inc. | ANTI-CLAUDINE ANTIBODIES 18.2 AND THEIR USES |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
CA3100118A1 (en) | 2018-05-16 | 2019-11-21 | Janssen Biotech, Inc. | Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy |
CN108752475B (zh) * | 2018-06-14 | 2021-07-30 | 北京智仁美博生物科技有限公司 | 抗人cd38抗体及其用途 |
EP3820575A1 (en) | 2018-07-10 | 2021-05-19 | Sanofi | Combination therapies against cancer targeting cd38 and tgf-beta |
US11939377B2 (en) | 2018-07-12 | 2024-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Affinity matured CD22-specific monoclonal antibody and uses thereof |
SG11202012993SA (en) | 2018-07-13 | 2021-02-25 | Genmab As | Variants of cd38 antibody and uses thereof |
EP3820890A1 (en) | 2018-07-13 | 2021-05-19 | Genmab A/S | Trogocytosis-mediated therapy using cd38 antibodies |
WO2020033430A1 (en) | 2018-08-08 | 2020-02-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High affinity monoclonal antibodies targeting glypican-2 and uses thereof |
AU2019316647A1 (en) | 2018-08-09 | 2021-02-25 | Juno Therapeutics, Inc. | Methods for assessing integrated nucleic acids |
AU2019338999A1 (en) | 2018-09-11 | 2021-03-18 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-CD38 antibody, antigen-binding fragment thereof, and pharmaceutical use |
CN109293773B (zh) * | 2018-09-25 | 2020-09-04 | 上海邦耀生物科技有限公司 | 靶向cd38蛋白的抗体、嵌合抗原受体和药物 |
CN109265551B (zh) * | 2018-09-25 | 2020-09-15 | 华东师范大学 | Cd38抗体、嵌合抗原受体和药物 |
BR112021007227A2 (pt) | 2018-10-17 | 2021-08-10 | Janssen Biotech, Inc. | método para fornecer administração subcutânea de anticorpos anti-cd38 |
KR20210086651A (ko) | 2018-10-26 | 2021-07-08 | 테네오바이오, 인코포레이티드 | Cd38에 결합하는 중쇄 항체 |
AU2019374103A1 (en) | 2018-11-01 | 2021-05-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D) |
EP3873943A2 (en) | 2018-11-01 | 2021-09-08 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
BR112021008879A2 (pt) | 2018-11-13 | 2021-10-26 | Janssen Biotech, Inc. | Controle de oligometais durante a produção de anticorpos anti-cd38 |
SG11202104012QA (en) | 2018-12-14 | 2021-05-28 | Morphosys Ag | Antibody formulations |
CA3125484A1 (en) | 2019-01-08 | 2020-07-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cross-species single domain antibodies targeting mesothelin for treating solid tumors |
EP3883971A1 (en) | 2019-01-22 | 2021-09-29 | The United States of America, as represented by the Secretary, Department of Health and Human Services | High affinity monoclonal antibodies targeting glypican-1 and methods of use |
BR112021014699A2 (pt) | 2019-01-28 | 2021-11-23 | Sanofi Sa | Métodos de tratamento de mieloma múltiplo |
EP3917952A4 (en) * | 2019-01-28 | 2022-11-02 | Multitude Inc. | CD44-SPECIFIC ANTIBODIES |
BR112021016923A2 (pt) | 2019-02-27 | 2021-11-03 | Genentech Inc | Métodos para tratar um paciente com câncer hematológico, métodos para tratar um paciente com mm recidivante ou refratário, métodos para tratar um paciente tendo um lnh recidivante ou refratário e kits |
WO2020187718A1 (en) | 2019-03-15 | 2020-09-24 | Morphosys Ag | Anti-cd38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease |
SG11202111602YA (en) * | 2019-04-23 | 2021-11-29 | Sanofi Sa | Anti-cd38 antibodies and formulations |
KR20220016474A (ko) | 2019-05-01 | 2022-02-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 변형된 cd247 유전자 자리로부터 키메라 수용체를 발현하는 세포, 관련 폴리뉴클레오타이드 및 방법 |
AU2020265741A1 (en) | 2019-05-01 | 2021-11-25 | Editas Medicine, Inc. | Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods |
SG11202112513YA (en) | 2019-05-14 | 2021-12-30 | Sanofi Sa | Methods of administering anti-cd38 antibody to treat multiple myeloma |
US11655302B2 (en) | 2019-06-10 | 2023-05-23 | Sanofi | Anti-CD38 antibodies and formulations |
JP2022538836A (ja) | 2019-06-27 | 2022-09-06 | クリスパー セラピューティクス アクチェンゲゼルシャフト | がんを治療するためのキメラ抗原受容体t細胞及びnk細胞阻害剤の使用 |
BR112021026832A2 (pt) | 2019-07-02 | 2022-05-10 | Hutchinson Fred Cancer Res | Vetores ad35 recombinantes e aprimoramentos da terapia gênica relacionada |
WO2021013950A1 (en) | 2019-07-23 | 2021-01-28 | Mnemo Therapeutics | Immune cells defective for suv39h1 |
US20220362299A1 (en) * | 2019-10-21 | 2022-11-17 | Purdue Research Foundation | Engineered natural killer cells and methods for using the same in immunotherapy and autophagy inhibiton techniques |
CN114729041A (zh) | 2019-10-22 | 2022-07-08 | 美国政府(由卫生和人类服务部的部长所代表) | 用于治疗多种实体瘤的靶向b7h3(cd276)的高亲和力纳米抗体 |
GB201916150D0 (en) | 2019-11-06 | 2019-12-18 | Univ Of Ireland Galway | Treatment of multiple myeloma |
KR20220092580A (ko) | 2019-11-06 | 2022-07-01 | 제넨테크, 인크. | 혈액암의 치료를 위한 진단과 치료 방법 |
CN112876563B (zh) * | 2019-11-29 | 2022-08-16 | 康诺亚生物医药科技(成都)有限公司 | 药物组合物及其制备方法和应用 |
WO2021113739A1 (en) | 2019-12-05 | 2021-06-10 | Thomas Ballet | Formulations of anti-cd38 antibodies for subcutaneous administration |
EP4069740A1 (en) | 2019-12-06 | 2022-10-12 | Sanofi-Aventis U.S. LLC | Use of isatuximab for the treatment of relapsed and/or refractory multiple myeloma |
JP2023506158A (ja) | 2019-12-12 | 2023-02-15 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Cd276に特異的な抗体-薬物コンジュゲートおよびその使用 |
CN115023441A (zh) | 2019-12-18 | 2022-09-06 | 特诺福尔股份有限公司 | 与cd38结合的重链抗体 |
JP2023510397A (ja) | 2020-01-16 | 2023-03-13 | ジェンマブ エー/エス | Cd38抗体の製剤およびその使用 |
AU2021251265A1 (en) | 2020-04-10 | 2022-11-03 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting B-cell maturation antigen |
WO2021231657A1 (en) | 2020-05-13 | 2021-11-18 | Juno Therapeutics, Inc. | Methods of identifying features associated with clinical response and uses thereof |
EP4171616A1 (en) | 2020-06-26 | 2023-05-03 | Juno Therapeutics GmbH | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
WO2021260657A1 (en) | 2020-06-26 | 2021-12-30 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
CN111808193B (zh) * | 2020-06-30 | 2022-04-05 | 源道隆(苏州)医学科技有限公司 | 可结合人cd38的纳米抗体及其应用 |
EP4188395A1 (en) | 2020-07-30 | 2023-06-07 | Institut Curie | Immune cells defective for socs1 |
CN114075285B (zh) * | 2020-08-20 | 2023-05-30 | 瑞阳(苏州)生物科技有限公司 | 抗人cd38人源化单克隆抗体及其应用 |
JP2023541457A (ja) | 2020-09-14 | 2023-10-02 | ブイオーアール バイオファーマ インコーポレーテッド | Cd38修飾のための化合物および方法 |
WO2022093745A1 (en) | 2020-10-26 | 2022-05-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies targeting sars coronavirus spike protein and uses thereof |
CN112300281B (zh) * | 2020-10-29 | 2021-06-11 | 杭州爱唯生命科技有限公司 | 含有nk细胞的药物组合物及其治疗癌症的用途 |
EP4240416A1 (en) | 2020-11-03 | 2023-09-13 | Sanofi-Aventis U.S. LLC | Use of isatuximab for the treatment of multiple myeloma |
CN116802203A (zh) | 2020-11-04 | 2023-09-22 | 朱诺治疗学股份有限公司 | 从经修饰的恒定cd3免疫球蛋白超家族链基因座表达嵌合受体的细胞、相关多核苷酸和方法 |
EP4251282A1 (en) | 2020-11-27 | 2023-10-04 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for diagnosis and monitoring of toxic epidermal necrolysis |
WO2022117572A2 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | An ltbr agonist in combination therapy against cancer |
US20220202859A1 (en) | 2020-12-23 | 2022-06-30 | Crispr Therapeutics Ag | Cancer treatment using cd38 inhibitor and/or lenalidomide and t-cells expressing a chimeric antigen receptor |
AU2022208200A1 (en) | 2021-01-14 | 2023-07-20 | Morphosys Ag | Anti-cd38 antibodies and their uses |
JP2024505600A (ja) | 2021-02-03 | 2024-02-06 | モーツァルト セラピューティクス, インコーポレイテッド | 結合剤およびそれを使用する方法 |
US20220275090A1 (en) | 2021-02-22 | 2022-09-01 | Janssen Biotech, Inc. | Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors |
TW202302642A (zh) | 2021-03-01 | 2023-01-16 | 德商莫菲西斯公司 | 用於治療抗體介導移植物排斥用途之抗cd38抗體 |
JP2024509853A (ja) | 2021-03-03 | 2024-03-05 | ジュノー セラピューティクス インコーポレイテッド | T細胞療法およびdgk阻害剤の組合せ |
WO2022232612A1 (en) | 2021-04-29 | 2022-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Lassa virus-specific nanobodies and methods of their use |
CN117916256A (zh) | 2021-05-06 | 2024-04-19 | 朱诺治疗学有限公司 | 用于刺激和转导t细胞的方法 |
WO2022238386A1 (en) | 2021-05-10 | 2022-11-17 | Institut Curie | Methods for the treatment of cancer, inflammatory diseases and autoimmune diseases |
TW202310870A (zh) | 2021-05-12 | 2023-03-16 | 瑞士商Crispr治療公司 | 用於治療造血惡性腫瘤之靶向cd70的基因工程化免疫細胞 |
AR125852A1 (es) | 2021-05-12 | 2023-08-16 | Crispr Therapeutics Ag | Células inmunes modificadas genéticamente que se focalizan en cd70 para su uso en tratamiento de tumores sólidos |
CN113244175B (zh) * | 2021-05-22 | 2022-11-04 | 苏州大学 | 一种免疫囊泡美登素偶联物及其制备方法与应用 |
WO2022248602A1 (en) | 2021-05-25 | 2022-12-01 | Institut Curie | Myeloid cells overexpressing bcl2 |
WO2022261017A1 (en) | 2021-06-09 | 2022-12-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cross species single domain antibodies targeting pd-l1 for treating solid tumors |
CN113278075B (zh) * | 2021-06-18 | 2021-12-14 | 芜湖森爱驰生物科技有限公司 | 一种炎症检测试剂盒 |
WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
TW202321303A (zh) | 2021-07-19 | 2023-06-01 | 德商莫菲西斯公司 | 抗pla2r自體抗體媒介膜性腎病變之治療 |
IL310372A (en) | 2021-07-28 | 2024-03-01 | Genentech Inc | IL15/IL15R alpha heterodimeric FC-fused proteins for the treatment of blood cancer |
TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法 |
CN113896802A (zh) * | 2021-10-09 | 2022-01-07 | 宜明昂科生物医药技术(上海)有限公司 | 靶向cd47和cd38的重组融合蛋白及其制备和用途 |
WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
WO2023079494A1 (en) | 2021-11-03 | 2023-05-11 | Janssen Biotech, Inc. | Corticosteriod reduction in treatment with anti-cd38 antibodies |
CN113912727B (zh) * | 2021-11-16 | 2023-05-02 | 福州迈新生物技术开发有限公司 | 抗cd38蛋白单克隆抗体、细胞系及其制备方法和应用 |
WO2023126458A1 (en) | 2021-12-28 | 2023-07-06 | Mnemo Therapeutics | Immune cells with inactivated suv39h1 and modified tcr |
CN114457017B (zh) * | 2022-01-19 | 2023-10-17 | 四川大学华西第二医院 | 一种小鼠成纤维细胞肿瘤细胞株HXLyAF-KBM及其应用 |
WO2023147515A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Methods of manufacturing cellular compositions |
WO2023144303A1 (en) | 2022-01-31 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd38 as a biomarker and biotarget in t-cell lymphomas |
WO2023159182A1 (en) | 2022-02-18 | 2023-08-24 | Rakuten Medical, Inc. | Anti-programmed death-ligand 1 (pd-l1) antibody molecules, encoding polynucleotides, and methods of use |
WO2023172917A1 (en) | 2022-03-07 | 2023-09-14 | Sanofi-Aventis U.S. Llc | Use of isatuximab in combination with other agents for the treatment of multiple myeloma |
WO2023187024A1 (en) | 2022-03-31 | 2023-10-05 | Institut Curie | Modified rela protein for inducing interferon expression and engineered immune cells with improved interferon expression |
TW202406934A (zh) | 2022-05-03 | 2024-02-16 | 美商建南德克公司 | 抗Ly6E抗體、免疫結合物及其用途 |
WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
WO2024040151A1 (en) | 2022-08-18 | 2024-02-22 | Pfizer Inc. | Sirp alpha fusion protein and anti-cd38 antibody combination therapies |
WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
WO2024079010A1 (en) | 2022-10-10 | 2024-04-18 | F. Hoffmann-La Roche Ag | Combination therapy of a gprc5d tcb and cd38 antibodies |
Family Cites Families (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2429001A (en) | 1946-12-28 | 1947-10-14 | Axel H Stone | Artificial hand |
US2429004A (en) | 1947-02-20 | 1947-10-14 | Wachsman Michael | Fabric contacting circuit closer for knitting machines |
FR1516743A (fr) | 1966-04-01 | 1968-02-05 | Rhone Poulenc Sa | Nouvel antibiotique et son procédé de préparation par culture de streptomyces croceus |
US4307016A (en) * | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
US4256746A (en) * | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
JPS55102583A (en) * | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
JPS5645483A (en) * | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
US4444887A (en) * | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
US4313946A (en) * | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
US4716111A (en) * | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5807715A (en) * | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
IL89489A0 (en) | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
WO1989009622A1 (en) | 1988-04-15 | 1989-10-19 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
WO1989009825A1 (en) | 1988-04-16 | 1989-10-19 | Celltech Limited | Method for producing recombinant dna proteins |
JP3771253B2 (ja) | 1988-09-02 | 2006-04-26 | ダイアックス コープ. | 新規な結合タンパク質の生成と選択 |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
WO1991010737A1 (en) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
US5780225A (en) * | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
WO1991010741A1 (en) | 1990-01-12 | 1991-07-25 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
EP0580737B1 (en) * | 1991-04-10 | 2004-06-16 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
CA2110799A1 (en) | 1991-06-14 | 1992-12-23 | Arnold H. Horwitz | Microbially-produced antibody fragments and their conjugates |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
ES2227512T3 (es) | 1991-12-02 | 2005-04-01 | Medical Research Council | Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago. |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
CA2076465C (en) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
EP1069182A1 (en) * | 1992-07-16 | 2001-01-17 | Icos Corporation | Alleviation of symptoms associated with inflammatory disease states, using antibodies to CD18 |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
WO1995015982A2 (en) | 1993-12-08 | 1995-06-15 | Genzyme Corporation | Process for generating specific antibodies |
PT1231268E (pt) | 1994-01-31 | 2005-11-30 | Univ Boston | Bancos de anticorpos policlonais |
US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
GB9424449D0 (en) * | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
JP2978435B2 (ja) * | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
CN100387621C (zh) | 1997-04-14 | 2008-05-14 | 麦可麦脱股份公司 | 抗人抗原受体的新的生产方法及其用途 |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
EP1193270B1 (en) | 1998-08-27 | 2003-05-14 | Spirogen Limited | Pyrrolobenzodiazepines |
GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
US7223397B1 (en) * | 1999-01-07 | 2007-05-29 | Research Development Foundation | Potentiation of anti-CD38-Immunotoxin cytotoxicity |
ATE349438T1 (de) | 1999-11-24 | 2007-01-15 | Immunogen Inc | Cytotoxische wirkstoffe enthaltend taxane und deren therapeutische anwendung |
WO2001049698A1 (en) * | 1999-12-29 | 2001-07-12 | Immunogen, Inc. | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
JP2003534022A (ja) * | 2000-05-26 | 2003-11-18 | スミスクライン・ビーチャム・コーポレイション | Rankリガンド介在障害の治療に有用な抗−rankリガンドモノクローナル抗体 |
GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
CA2785941C (en) | 2000-10-06 | 2017-01-10 | Kyowa Hakko Kirin Co., Ltd. | Antibody composition-producing cell |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
US6716821B2 (en) * | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
WO2003074679A2 (en) | 2002-03-01 | 2003-09-12 | Xencor | Antibody optimization |
US6534660B1 (en) | 2002-04-05 | 2003-03-18 | Immunogen, Inc. | CC-1065 analog synthesis |
US6756397B2 (en) * | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
AU2003236018A1 (en) | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kirin Co., Ltd. | METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcGamma RECEPTOR IIIa |
EP1498490A4 (en) | 2002-04-09 | 2006-11-29 | Kyowa Hakko Kogyo Kk | PROCESS FOR PREPARING ANTIBODY COMPOSITION |
US6596757B1 (en) * | 2002-05-14 | 2003-07-22 | Immunogen Inc. | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
DK2345671T3 (en) | 2002-09-27 | 2016-02-15 | Xencor Inc | Optimized Fc variants and methods for their formation |
US7541440B2 (en) * | 2002-09-30 | 2009-06-02 | Immunomedics, Inc. | Chimeric, human and humanized anti-granulocyte antibodies and methods of use |
AU2003295411A1 (en) * | 2002-11-07 | 2004-06-03 | Celltech R & D | Human monoclonal antibodies to heparanase |
AU2003285878B2 (en) | 2002-11-07 | 2011-04-28 | Immunogen, Inc. | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same |
US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
WO2005014649A2 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Corporation | Method for the preparation of molecules having antibody activity |
US20050208627A1 (en) * | 2003-09-18 | 2005-09-22 | Bowdish Katherine S | Elicitation of antibodies to self peptides in mice by immunization with dendritic cells |
CA2542130A1 (en) | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Cell genomically modified to produce polypeptides with an altered glycosylation pattern |
AU2004284075A1 (en) | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
WO2005056766A2 (en) * | 2003-12-04 | 2005-06-23 | Medimmune, Inc. | TARGETED DRUG DELIVERY USING EphA2 OR Eph4 BINDING MOIETIES |
EP1720907B1 (en) * | 2004-02-06 | 2015-04-08 | MorphoSys AG | Anti-cd38 human antibodies and uses therefor |
WO2005085260A1 (en) | 2004-03-09 | 2005-09-15 | Spirogen Limited | Pyrrolobenzodiazepines |
CA2885854C (en) * | 2004-04-13 | 2017-02-21 | F. Hoffmann-La Roche Ag | Anti-p-selectin antibodies |
WO2005103081A2 (en) * | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
EP1778879A4 (en) * | 2004-06-21 | 2010-02-24 | Univ Washington | WEST NILE ANTI-VIRUS ANTIBODIES: THERAPEUTIC AND PROPHYLACTIC USES |
EP2471813B1 (en) | 2004-07-15 | 2014-12-31 | Xencor, Inc. | Optimized Fc variants |
EP1773884B1 (en) * | 2004-08-03 | 2012-03-07 | Innate Pharma | Therapeutic and diagnostic methods and compositions targeting 4ig-b7-h3 and its counterpart nk cell receptor |
US20060223147A1 (en) | 2004-08-05 | 2006-10-05 | Kyowa Hakko Kogyo Co., Ltd., | Process for producing glycoprotein composition |
WO2006047350A2 (en) | 2004-10-21 | 2006-05-04 | Xencor, Inc. | IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION |
PE20061401A1 (es) * | 2004-12-15 | 2006-12-23 | Neuralab Ltd | ANTICUERPOS Aß PARA MEJORAR LA COGNICION |
AU2006214121B9 (en) * | 2005-02-15 | 2013-02-14 | Duke University | Anti-CD19 antibodies and uses in oncology |
SG10201912554TA (en) * | 2005-03-23 | 2020-02-27 | Genmab As | Antibodies against cd38 for treatment of multiple myeloma |
AU2006230413B8 (en) | 2005-03-31 | 2011-01-20 | Xencor, Inc | Fc variants with optimized properties |
EP1888647A2 (en) * | 2005-05-24 | 2008-02-20 | MorphoSys AG | Generation and profiling of fully human hucal gold®-derived therapeutic antibodies specific for human cd38 |
DE102005030112A1 (de) | 2005-06-28 | 2007-01-18 | Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH | Lötzusatzwerkstoff |
EP1931709B1 (en) | 2005-10-03 | 2016-12-07 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
PT1813614E (pt) | 2006-01-25 | 2012-01-09 | Sanofi Sa | Agentes citotóxicos compreendendo novos derivados de tomaimicina |
EP1864682A1 (en) * | 2006-06-09 | 2007-12-12 | Sanofi-Aventis | Leptomycin derivatives |
EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
UA108735C2 (uk) * | 2008-07-21 | 2015-06-10 | Структурні варіанти антитіл для покращення терапевтичних характеристик | |
RU2595839C2 (ru) * | 2010-09-27 | 2016-08-27 | МорфоСис АГ | Антитело к cd38 и леналидомид или бортезомиб для лечения множественной миеломы и nhl |
JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
KR102037541B1 (ko) * | 2011-10-28 | 2019-10-29 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 폴리펩티드 구축물 및 이의 용도 |
CN109934744B (zh) | 2012-02-20 | 2023-09-05 | 株式会社诺瑞韩国 | 基于知识单元提供教育服务的方法、***和计算机可读记录介质 |
US10342869B2 (en) * | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
WO2016040294A2 (en) * | 2014-09-09 | 2016-03-17 | Janssen Biotech, Inc. | Combination therapies with anti-cd38 antibodies |
SG11201704390PA (en) * | 2014-12-04 | 2017-06-29 | Janssen Biotech Inc | Anti-cd38 antibodies for treatment of acute myeloid leukemia |
WO2016111677A1 (en) * | 2015-01-06 | 2016-07-14 | Hewlett-Packard Development Company, L.P. | Adapter to concatenate connectors |
BR112017024877A2 (pt) * | 2015-05-20 | 2019-09-17 | Janssen Biotech, Inc. | anticorpo anti-cd38 e seu uso no tratamento de amiloidose de cadeia leve e outras malignidades hematológicas positivas para cd38 |
CA2990406A1 (en) * | 2015-06-22 | 2016-12-29 | Janssen Biotech, Inc. | Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors |
US20170044265A1 (en) * | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
EA202190808A2 (ru) * | 2015-11-03 | 2021-12-31 | Янссен Байотек, Инк. | Составы антител к cd38 для подкожного введения и их применение |
US10781261B2 (en) * | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
BR112020007002A2 (pt) * | 2017-10-10 | 2020-11-17 | Sanofi | anticorpos anti-cd38 e métodos de uso |
US11605302B2 (en) | 2020-11-10 | 2023-03-14 | Rockwell Collins, Inc. | Time-critical obstacle avoidance path planning in uncertain environments |
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