HRP20171788T1 - Kombinacija anti-kir antitijela i anti-pd-1 antitijela u liječenju raka - Google Patents
Kombinacija anti-kir antitijela i anti-pd-1 antitijela u liječenju raka Download PDFInfo
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- HRP20171788T1 HRP20171788T1 HRP20171788TT HRP20171788T HRP20171788T1 HR P20171788 T1 HRP20171788 T1 HR P20171788T1 HR P20171788T T HRP20171788T T HR P20171788TT HR P20171788 T HRP20171788 T HR P20171788T HR P20171788 T1 HRP20171788 T1 HR P20171788T1
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- 206010028980 Neoplasm Diseases 0.000 title claims 9
- 201000011510 cancer Diseases 0.000 title claims 6
- 208000014829 head and neck neoplasm Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000026037 malignant tumor of neck Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010066476 Haematological malignancy Diseases 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Claims (16)
1. Anti-KIR antitijelo koje sadrži CDR1, CDR2 i CDR3 domene u varijabilnoj regiji teškog lanca koja ima sekvencu prikazanu u sekvenci sa identifikacijskim brojem - SEQ ID NO:3, i CDR1, CDR2 i CDR3 domene u varijabilnoj regiji lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:5, i
anti-PD-1 antitijelo koje sadrži CDR1, CDR2 i CDR3 domene u varijabilnoj regiji teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:19, i CDR1, CDR2 i CDR3 domene u varijabilnoj regiji lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:21,
za primjenu u metodi za liječenje raka kod humanog pacijenta,
gdje metoda sadrži najmanje jedan ciklus administracije, gdje je ciklus period od osam tjedana, gdje za svaki od najmanje jednog ciklusa, dvije doze anti-KIR antitijela su administrirane u dozi od 0.1, 0.3, 1, 3, 6, ili 10 mg/kg i četiri doze anti-PD-1 antitijela su administrirane u dozi od 3 mg/kg.
2. Antitijela za primjenu iz patentnog zahtjeva 1, gdje anti-KIR antitijelo i anti-PD-1 antitijelo su za administraciju u sljedećim dozama:
(a) 0.1 mg/kg anti-KIR antitijela i 3 mg/kg anti-PD-1 antitijela;
(b) 0.3 mg/kg anti-KIR antitijela i 3 mg/kg anti-PD-1 antitijela;
(c) 1 mg/kg anti-KIR antitijela i 3 mg/kg anti-PD-1 antitijela;
(d) 3 mg/kg anti-KIR antitijela i 3 mg/kg anti-PD-1 antitijela;
(e) 6 mg/kg anti-KIR antitijela i 3 mg/kg anti-PD-1 antitijela; ili
(f) 10 mg/kg anti-KIR antitijela i 3 mg/kg anti-PD-1 antitijela.
3. Antitijela za primjenu iz patentnog zahtjeva 1 ili 2, gdje anti-PD-1 i anti-KIR antitijela su formulirana za intravensku administraciju.
4. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-3, gdje se liječenje sastoji do 12 ciklusa.
5. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-4, gdje anti-PD-1 antitijelo je za administraciju na dane 1, 15, 29, i 43 svakog ciklusa.
6. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-5, gdje anti-KIR antitijelo je za administraciju na dane 1 i 29 svakog ciklusa; po izboru
(a) gdje anti-PD-1 antitijelo je za administraciju prije administracije anti-KIR antitijela na dane 1 i 29, ili
(b) gdje anti-PD-1 antitijelo je za administraciju prije administracije anti-KIR antitijela na dane 1 i 29 i anti-KIR antitijelo je za administraciju u okviru 30 minuta anti-PD-1 antitijela.
7. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-6, gdje liječenje proizvodi najmanje jedan terapijski efekt izabran od smanjenja veličine tumora, smanjenja broja metastatskih lezija tokom vremena, potpunog odgovora, djelomičnog odgovora, i stabilne bolesti.
8. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-7, gdje rak je solidni tumor, ili naročito uznapredovali refraktorni solidni tumor, i po izboru je odabran od raka glave ili vrata, nesitnostaničnog raka pluća (NSCLC), raka bubrežnih stanica (RCC), melanoma, kolorektalnog raka, i seroznog raka jajnika.
9. Antitijela za primjenu iz patentnog zahtjeva 8, gdje rak je rak glave ili vrata.
10. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-7, gdje je rak hematološki malignitet i po izboru je odabran od multiplog mijeloma, Hodgkin limfoma, folikularnog limfoma, difuznog limfoma velikih B-stanica i limfoma T stanica.
11. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-10, gdje anti-KIR, antitijelo sadrži
(a) CDR1 varijabilne regije teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:7,
(b) CDR2 varijabilne regije teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:8,
(c) CDR3 varijabilne regije teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:9,
(d) CDR1 varijabilne regije lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:10,
(e) CDR2 varijabilne regije lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:11, i
(f) CDR3 varijabilne regije lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:12; i/ili
gdje anti-PD-1 antitijelo sadrži
(a) CDR1 varijabilne regije teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:23,
(b) CDR2 varijabilne regije teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:24,
(c) CDR3 varijabilne regije teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:25,
(d) CDR1 varijabilne regije lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:26,
(e) CDR2 varijabilne regije lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:27, i
(f) CDR3 varijabilne regije lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:28.
12. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-11, gdje anti-KIR antitijelo sadrži varijabilne regije teškog i lakog lanca koje imaju sekvence prikazane u SEQ ID NOs:3 i 5, redom; i/ili
gdje anti-PD-1 antitijelo sadrži varijabilne regije teškog i lakog lanca koje imaju sekvence prikazane u SEQ ID NOs:19 i 21, redom.
13. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-12, gdje anti-KIR antitijelo sadrži teške i lake lance koji imaju sekvence prikazane u SEQ ID NOs:1 i 2, redom; i/ili
gdje anti-PD-1 antitijelo sadrži teške i lake lance koji imaju sekvence kao što je prikazano u SEQ ID NOs:17 i 18, redom.
14. Antitijela za primjenu iz bilo kojeg od patentnih zahtjeva 1-13, gdje:
(a) anti-KIR antitijelo i anti-PD-1 antitijelo se administriraju istovremeno u pojedinačnoj formulaciji; ili
(b) anti-KIR antitijelo i anti-PD-1 antitijelo su formulirani za odvojenu administraciju; ili
(c) anti-KIR antitijelo i anti-PD-1 antitijelo se administriraju istovremeno; ili
(d) anti-KIR antitijelo i anti-PD-1 antitijelo se administriraju sekvencijalno; ili
(e) anti-PD-1 antitijelo je za administraciju prvo praćeno administracijom anti-KIR antitijela; ili
(f) anti-KIR antitijelo je za administraciju prvo praćeno administracijom anti-PD-1 antitijela.
15. Set za primjenu u metodi za liječenje raka kod humanog pacijenta, set koji sadrži:
(a) dozu anti-KIR antitijela koje sadrži CDR1, CDR2 i CDR3 domene u varijabilnoj regiji teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:3, i CDR1, CDR2 i CDR3 domene u varijabilnoj regiji lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:5;
(b) dozu anti-PD-1 antitijela koje sadrži CDR1, CDR2 i CDR3 domene u varijabilnoj regiji teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:19, i CDR1, CDR2 i CDR3 domene u varijabilnoj regiji lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:21; i
(c) instrukcije za korištenje anti-KIR antitijela i anti-PD-1 antitijela u skladu sa bilo kojim od patentnih zahtjeva 1-14.
16. Anti-KIR antitijelo koje sadrži CDR1, CDR2 i CDR3 domene u varijabilnoj regiji teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:3, i CDR1, CDR2 i CDR3 domene u varijabilnoj regiji lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:5, za primjenu u liječenju subjekta, gdje anti-KIR antitijelo je za ko-administraciju sa anti-PD-1 antitijelom koje sadrži CDR1, CDR2 i CDR3 domene u varijabilnoj regiji teškog lanca koja ima sekvencu prikazanu u SEQ ID NO:19, i CDR1, CDR2 i CDR3 domene u varijabilnoj regiji lakog lanca koja ima sekvencu prikazanu u SEQ ID NO:21, u najmanje jednom ciklusu, gdje za svaki ciklus dvije doze anti-KIR antitijela su administrirane u dozi od 0.1, 0.3, 1, 3, 6, ili 10 mg/kg i četiri doze anti-PD-1 antitijela su administrirane u dozi od 3 mg/kg.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261708784P | 2012-10-02 | 2012-10-02 | |
| EP13774596.4A EP2904011B1 (en) | 2012-10-02 | 2013-10-02 | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
| PCT/US2013/063068 WO2014055648A1 (en) | 2012-10-02 | 2013-10-02 | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171788T1 true HRP20171788T1 (hr) | 2017-12-29 |
Family
ID=49326890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171788TT HRP20171788T1 (hr) | 2012-10-02 | 2017-11-17 | Kombinacija anti-kir antitijela i anti-pd-1 antitijela u liječenju raka |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20150290316A1 (hr) |
| EP (2) | EP3263601B1 (hr) |
| JP (3) | JP6239628B2 (hr) |
| KR (1) | KR102130865B1 (hr) |
| CN (1) | CN104837868B (hr) |
| AU (1) | AU2013327116C1 (hr) |
| BR (1) | BR112015007184A2 (hr) |
| CA (1) | CA2887027C (hr) |
| CY (1) | CY1119799T1 (hr) |
| DK (1) | DK2904011T3 (hr) |
| EA (1) | EA038920B1 (hr) |
| ES (1) | ES2643887T3 (hr) |
| HK (1) | HK1210786A1 (hr) |
| HR (1) | HRP20171788T1 (hr) |
| HU (1) | HUE035503T2 (hr) |
| IL (1) | IL237960B (hr) |
| LT (1) | LT2904011T (hr) |
| MX (2) | MX367042B (hr) |
| NO (1) | NO2787245T3 (hr) |
| NZ (1) | NZ631405A (hr) |
| PL (1) | PL2904011T3 (hr) |
| PT (1) | PT2904011T (hr) |
| RS (1) | RS56624B1 (hr) |
| SG (2) | SG11201502496WA (hr) |
| SI (1) | SI2904011T1 (hr) |
| WO (1) | WO2014055648A1 (hr) |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102753195A (zh) | 2009-12-07 | 2012-10-24 | 小利兰·斯坦福大学托管委员会 | 用于增强抗肿瘤抗体疗法的方法 |
| WO2012166899A2 (en) | 2011-06-03 | 2012-12-06 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| SG11201407190TA (en) | 2012-05-15 | 2014-12-30 | Bristol Myers Squibb Co | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| SI2904011T1 (sl) * | 2012-10-02 | 2017-10-30 | Bristol-Myers Squibb Company | Kombinacija anti-kir protiteles in anti-pd-1 protiteles za zdravljenje raka |
| EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| US9457019B2 (en) * | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| ME03527B (me) | 2013-12-12 | 2020-04-20 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antitijelo, njegov fragment koji se vezuje na antigen, i njegova medicinska primjena |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| WO2015198311A1 (en) * | 2014-06-24 | 2015-12-30 | Ccam Therapeutics Ltd. | Compositions comprising antibodies to ceacam-1 and kir for cancer therapy |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| CA2957258C (en) * | 2014-08-05 | 2023-11-07 | MabQuest SA | Immunological reagents |
| LT3179992T (lt) | 2014-08-11 | 2022-06-27 | Acerta Pharma B.V. | Btk inhibitoriaus, pd-1 inhibitoriaus ir (arba) pd-l1 inhibitoriaus terapiniai deriniai |
| WO2016027764A1 (ja) * | 2014-08-19 | 2016-02-25 | 国立大学法人 岡山大学 | 免疫細胞の機能増強方法及び免疫細胞の多機能性評価方法 |
| EP4089076A1 (en) | 2014-08-28 | 2022-11-16 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
| EP3925622A1 (en) * | 2014-09-13 | 2021-12-22 | Novartis AG | Combination therapies |
| GB201419084D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-PD-1 antibodies |
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| DK2699264T3 (en) | 2011-04-20 | 2018-06-25 | Medimmune Llc | ANTIBODIES AND OTHER MOLECULES BINDING B7-H1 AND PD-1 |
| AU2012260601B2 (en) | 2011-05-25 | 2018-02-01 | Innate Pharma, S.A. | Anti-KIR antibodies for the treatment of inflammatory disorders |
| SI2904011T1 (sl) * | 2012-10-02 | 2017-10-30 | Bristol-Myers Squibb Company | Kombinacija anti-kir protiteles in anti-pd-1 protiteles za zdravljenje raka |
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2013
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- 2013-10-02 BR BR112015007184A patent/BR112015007184A2/pt not_active Application Discontinuation
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- 2013-10-02 US US14/432,376 patent/US20150290316A1/en not_active Abandoned
- 2013-10-02 AU AU2013327116A patent/AU2013327116C1/en not_active Ceased
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- 2013-10-02 ES ES13774596.4T patent/ES2643887T3/es active Active
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