HRP20110530T1 - Spojevi aminoalkoksi aril sulfonamida i njihova upotreba kao ligandi 5-ht6 - Google Patents

Spojevi aminoalkoksi aril sulfonamida i njihova upotreba kao ligandi 5-ht6 Download PDF

Info

Publication number: HRP20110530T1
Authority: HR; Croatia
Prior art keywords: benzenesulfonyl; indole; dimethylamine; propoxy; ethoxy
Prior art date: 2007-05-03

Application number

HR20110530T

Other languages

English (en)

Croatian (hr)

Inventor

Nirogi Ramakrishna

Sastri Kambhampati Rama

Karbhari Shinde Anil

Vijaykumar Daulatabad Anand

Reddy Dwarampudi Adi

Vishwottam Kandikere Nagaraj

Vishwakarma Santosh

Jasti Venkateswarlu

Original Assignee

Suven Life Sciences Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-03

Filing date

2011-07-14

Publication date

2011-09-30

2011-07-14 Application filed by Suven Life Sciences Limited filed Critical Suven Life Sciences Limited

2011-09-30 Publication of HRP20110530T1 publication Critical patent/HRP20110530T1/hr

Links

239000003446 ligand Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract 16
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 4
208000035475 disorder Diseases 0.000 claims abstract 3
238000000034 method Methods 0.000 claims abstract 3
150000003839 salts Chemical class 0.000 claims abstract 3
108091005435 5-HT6 receptors Proteins 0.000 claims abstract 2
208000024172 Cardiovascular disease Diseases 0.000 claims abstract 2
208000002193 Pain Diseases 0.000 claims abstract 2
201000011529 cardiovascular cancer Diseases 0.000 claims abstract 2
208000014951 hematologic disease Diseases 0.000 claims abstract 2
208000023504 respiratory system disease Diseases 0.000 claims abstract 2
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 45
ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 42
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 13
125000001475 halogen functional group Chemical group 0.000 claims 10
125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 9
125000003545 alkoxy group Chemical group 0.000 claims 9
125000000753 cycloalkyl group Chemical group 0.000 claims 7
229910052736 halogen Inorganic materials 0.000 claims 7
150000002367 halogens Chemical group 0.000 claims 7
229910052739 hydrogen Inorganic materials 0.000 claims 7
239000001257 hydrogen Substances 0.000 claims 7
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 7
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
241001465754 Metazoa Species 0.000 claims 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
239000005557 antagonist Substances 0.000 claims 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
239000012442 inert solvent Substances 0.000 claims 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical group [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
230000002265 prevention Effects 0.000 claims 2
125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 1
DBTNKTDUMBHCDF-UHFFFAOYSA-N 1-(5-indol-1-ylsulfonyl-2-propan-2-ylphenoxy)-n,n-dimethylpropan-2-amine Chemical compound C1=C(OCC(C)N(C)C)C(C(C)C)=CC=C1S(=O)(=O)N1C2=CC=CC=C2C=C1 DBTNKTDUMBHCDF-UHFFFAOYSA-N 0.000 claims 1
208000024827 Alzheimer disease Diseases 0.000 claims 1
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
208000018522 Gastrointestinal disease Diseases 0.000 claims 1
208000008589 Obesity Diseases 0.000 claims 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
208000018737 Parkinson disease Diseases 0.000 claims 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
125000000217 alkyl group Chemical group 0.000 claims 1
150000001412 amines Chemical class 0.000 claims 1
238000010171 animal model Methods 0.000 claims 1
208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
210000003169 central nervous system Anatomy 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
229940079593 drug Drugs 0.000 claims 1
230000000694 effects Effects 0.000 claims 1
208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
208000030212 nutrition disease Diseases 0.000 claims 1
235000020824 obesity Nutrition 0.000 claims 1
239000000825 pharmaceutical preparation Substances 0.000 claims 1
229910000027 potassium carbonate Inorganic materials 0.000 claims 1
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
201000000980 schizophrenia Diseases 0.000 claims 1
229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
235000017557 sodium bicarbonate Nutrition 0.000 claims 1
239000012312 sodium hydride Substances 0.000 claims 1
229910000104 sodium hydride Inorganic materials 0.000 claims 1
125000001424 substituent group Chemical group 0.000 claims 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
239000000203 mixture Substances 0.000 abstract 2
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
208000014001 urinary system disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)

HR20110530T 2007-05-03 2011-07-14 Spojevi aminoalkoksi aril sulfonamida i njihova upotreba kao ligandi 5-ht6 HRP20110530T1 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN940CH2007		2007-05-03
PCT/IN2008/000247 WO2008136017A1 (en)	2007-05-03	2008-04-15	Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands

Publications (1)

Publication Number	Publication Date
HRP20110530T1 true HRP20110530T1 (hr)	2011-09-30

Family

ID=39743760

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20110530T HRP20110530T1 (hr)	2007-05-03	2011-07-14	Spojevi aminoalkoksi aril sulfonamida i njihova upotreba kao ligandi 5-ht6

Country Status (21)

Country	Link
US (1)	US8003670B2 (ja)
EP (1)	EP2155674B1 (ja)
JP (1)	JP5139512B2 (ja)
KR (1)	KR101162482B1 (ja)
CN (1)	CN101675032B (ja)
AT (1)	ATE513810T1 (ja)
AU (1)	AU2008246947B2 (ja)
BR (1)	BRPI0809873A2 (ja)
CA (1)	CA2683124C (ja)
CY (1)	CY1111836T1 (ja)
DK (1)	DK2155674T3 (ja)
EA (1)	EA016594B1 (ja)
ES (1)	ES2366496T3 (ja)
HK (1)	HK1138264A1 (ja)
HR (1)	HRP20110530T1 (ja)
IL (1)	IL201491A (ja)
MX (1)	MX2009011461A (ja)
NZ (1)	NZ581580A (ja)
SI (1)	SI2155674T1 (ja)
WO (1)	WO2008136017A1 (ja)
ZA (1)	ZA200907015B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101337003B1 (ko)	2012-02-13	2013-12-04	주식회사 평산	링 압연 공법을 이용한 풍력 타워용 플랜지 제조방법
KR101338954B1 (ko)	2012-02-13	2013-12-09	주식회사 평산	링 압연 공정을 이용한 비대칭 단면을 가지는 제품의 성형 장치 및 성형 방법
EP3027613B1 (en)	2013-07-25	2018-03-28	Uniwersytet Jagiellonski	Pyrroloquinoline derivatives as 5-ht6 antagonists, preparation method and use thereof
WO2015090233A1 (en)	2013-12-20	2015-06-25	Sunshine Lake Pharma Co., Ltd.	Aromatic heterocyclic compounds and their application in pharmaceuticals
AU2015286049B2 (en)	2014-07-08	2018-03-01	Sunshine Lake Pharma Co., Ltd.	Aromatic heterocyclic derivatives and pharmaceutical applications thereof
WO2019180176A1 (en)	2018-03-21	2019-09-26	Spherium Biomed, S.L.	Composition for the treatment of schizophrenia and/or psychosis

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DZ2376A1 (fr)	1996-12-19	2002-12-28	Smithkline Beecham Plc	Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
US6316450B1 (en)	1997-07-11	2001-11-13	Smithkline Beecham P.L.C.	Compounds
GB9801392D0 (en)	1998-01-22	1998-03-18	Smithkline Beecham Plc	Novel compounds
GB9803411D0 (en)	1998-02-18	1998-04-15	Smithkline Beecham Plc	Novel compounds
MXPA01010655A (es)	1999-04-21	2002-11-04	Allelix Biopharma	Compuestos de piperidin-indol que tienen afinidad por 5-ht6.
GB9926302D0 (en)	1999-11-05	2000-01-12	Smithkline Beecham Plc	Novel compounds
CN1222511C (zh)	2000-11-02	2005-10-12	惠氏公司	作为5－羟色胺－6配体的1－芳基－或1－烷基磺酰基－杂环基吲哚
CA2433351A1 (en)	2001-01-30	2002-08-08	Eli Lilly And Company	Benzenesulfonic acid indol-5-yl esters as antagonists of the 5-ht6 receptor
US7342021B2 (en)	2001-02-08	2008-03-11	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
RU2294932C2 (ru)	2001-06-07	2007-03-10	Ф.Хоффманн-Ля Рош Аг	Новые производные индола со сродством к рецептору 5-ht6
EP1414442A1 (en)	2001-08-07	2004-05-06	Smithkline Beecham Plc	3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
WO2003065046A2 (en)	2002-02-01	2003-08-07	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor
JP2005522432A (ja)	2002-02-05	2005-07-28	グラクソ　グループ　リミテッド	ニューロン成長の促進方法
BRPI0308696B8 (pt)	2002-03-27	2021-05-25	Axovant Sciences Gmbh	composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos
AU2003285759B2 (en) *	2002-11-28	2010-01-28	Suven Life Sciences Limited	N-arylsulfonyl-3-aminoalkoxyindoles
AU2003292508A1 (en)	2002-11-28	2004-06-18	Suven Life Sciences Limited	N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands
CA2509982C (en)	2002-11-28	2011-11-08	Suven Life Sciences Limited	N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
NZ540841A (en)	2002-12-18	2008-08-29	Suven Life Sciences Ltd	Tetracyclic 3-substituted indoles having serotonin receptor affinity
BR0215986A (pt) *	2002-12-20	2005-11-01	Cancer Rec Tech Ltd	Composto, composição, uso de composto, e, método para o tratamento de uma condição proliferativa, para o tratamento de câncer e de uma condição mediada pela tioredoxina/tioredoxina reductase, para inibir a tioredoxina/tioredoxina reductase em uma célula, in vitro ou in vivo e, para regular e inibir a proliferação celular
ES2222828B1 (es)	2003-07-30	2006-04-16	Laboratorios Del Dr. Esteve, S.A.	Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.
WO2006038594A1 (ja) *	2004-10-04	2006-04-13	Ono Pharmaceutical Co., Ltd.	Ｎ型カルシウムチャネル阻害薬
MX2008002018A (es)	2005-08-12	2008-03-27	Suven Life Sciences Ltd	Derivados de aminoaril sulfonamida como ligandos funcionales del 5-ht6.

2008
- 2008-04-15 DK DK08763731.0T patent/DK2155674T3/da active
- 2008-04-15 US US12/598,616 patent/US8003670B2/en not_active Expired - Fee Related
- 2008-04-15 EP EP08763731A patent/EP2155674B1/en active Active
- 2008-04-15 JP JP2010505014A patent/JP5139512B2/ja not_active Expired - Fee Related
- 2008-04-15 WO PCT/IN2008/000247 patent/WO2008136017A1/en active Application Filing
- 2008-04-15 KR KR1020097025160A patent/KR101162482B1/ko active IP Right Grant
- 2008-04-15 ES ES08763731T patent/ES2366496T3/es active Active
- 2008-04-15 AT AT08763731T patent/ATE513810T1/de active
- 2008-04-15 AU AU2008246947A patent/AU2008246947B2/en not_active Ceased
- 2008-04-15 SI SI200830379T patent/SI2155674T1/sl unknown
- 2008-04-15 EA EA200971017A patent/EA016594B1/ru not_active IP Right Cessation
- 2008-04-15 BR BRPI0809873A patent/BRPI0809873A2/pt not_active IP Right Cessation
- 2008-04-15 CA CA2683124A patent/CA2683124C/en not_active Expired - Fee Related
- 2008-04-15 NZ NZ581580A patent/NZ581580A/en not_active IP Right Cessation
- 2008-04-15 CN CN2008800144405A patent/CN101675032B/zh not_active Expired - Fee Related
- 2008-04-15 MX MX2009011461A patent/MX2009011461A/es active IP Right Grant
2009
- 2009-10-08 ZA ZA200907015A patent/ZA200907015B/xx unknown
- 2009-10-13 IL IL201491A patent/IL201491A/en active IP Right Grant
2010
- 2010-04-07 HK HK10103434.6A patent/HK1138264A1/xx not_active IP Right Cessation
2011
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- 2011-09-14 CY CY20111100881T patent/CY1111836T1/el unknown

Also Published As

Publication number	Publication date
IL201491A0 (en)	2010-05-31
MX2009011461A (es)	2009-11-10
AU2008246947B2 (en)	2011-03-31
CN101675032A (zh)	2010-03-17
CY1111836T1 (el)	2015-10-07
ES2366496T3 (es)	2011-10-20
EA200971017A1 (ru)	2010-04-30
HK1138264A1 (en)	2010-08-20
NZ581580A (en)	2011-03-31
CA2683124A1 (en)	2008-11-13
CN101675032B (zh)	2012-10-31
JP2010526057A (ja)	2010-07-29
BRPI0809873A2 (pt)	2018-11-13
ZA200907015B (en)	2010-07-28
KR20100007954A (ko)	2010-01-22
CA2683124C (en)	2012-09-25
EA016594B1 (ru)	2012-06-29
KR101162482B1 (ko)	2012-07-03
US8003670B2 (en)	2011-08-23
WO2008136017A1 (en)	2008-11-13
US20100087484A1 (en)	2010-04-08
IL201491A (en)	2015-04-30
AU2008246947A1 (en)	2008-11-13
SI2155674T1 (sl)	2011-10-28
EP2155674A1 (en)	2010-02-24
JP5139512B2 (ja)	2013-02-06
DK2155674T3 (da)	2011-09-26
EP2155674B1 (en)	2011-06-22
ATE513810T1 (de)	2011-07-15

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