MX2009011461A - Compuestos de aminoalcoxiarilsulfonamida y su uso como ligandos de la 5-hidroxitriptamina6. - Google Patents

Compuestos de aminoalcoxiarilsulfonamida y su uso como ligandos de la 5-hidroxitriptamina6.

Info

Publication number
MX2009011461A
MX2009011461A MX2009011461A MX2009011461A MX2009011461A MX 2009011461 A MX2009011461 A MX 2009011461A MX 2009011461 A MX2009011461 A MX 2009011461A MX 2009011461 A MX2009011461 A MX 2009011461A MX 2009011461 A MX2009011461 A MX 2009011461A
Authority
MX
Mexico
Prior art keywords
compounds
disorders
pharmaceutically acceptable
aminoalkoxy
ligands
Prior art date
Application number
MX2009011461A
Other languages
English (en)
Inventor
Rama Sastri Kambhampati
Venkateswarlu Jasti
Santosh Vishwakarma
Nagaraj Vishwottam Kandikere
Ramakrishna Nigori
Anil Karbhari Shinde
Anand Vijaykumar Daulatabad
Adi Reddy Dwarampudi
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of MX2009011461A publication Critical patent/MX2009011461A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención se relaciona con compuestos novedosos de aminoalcoxiasilsulfonamida de la fórmula (I), sus derivados, sus estereoisómeros, sus sales farmacéuticamente aceptables y las composiciones farmacéuticamente aceptables que los contienen. La presente invención también se relaciona con un proceso para la preparación de los compuestos novedosos anteriores, sus derivados, sus estereoisómeros, sus sales farmacéuticamente aceptables y las composiciones farmacéuticamente aceptables que los contienen. Estos compuestos son útiles en el tratamiento de varios trastornos que están relacionados con las funciones del receptor de 5-HT6. De manera específica, los compuestos de esta invención también son útiles en el tratamiento de varios trastornos del CNS, trastornos hematológicos, trastornos de la alimentación, enfermedades asociadas con el dolor, enfermedades respiratorias, trastornos genitourológicos, enfermedades cardiovasculares y cáncer.
MX2009011461A 2007-05-03 2008-04-15 Compuestos de aminoalcoxiarilsulfonamida y su uso como ligandos de la 5-hidroxitriptamina6. MX2009011461A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN940CH2007 2007-05-03
PCT/IN2008/000247 WO2008136017A1 (en) 2007-05-03 2008-04-15 Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands

Publications (1)

Publication Number Publication Date
MX2009011461A true MX2009011461A (es) 2009-11-10

Family

ID=39743760

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011461A MX2009011461A (es) 2007-05-03 2008-04-15 Compuestos de aminoalcoxiarilsulfonamida y su uso como ligandos de la 5-hidroxitriptamina6.

Country Status (21)

Country Link
US (1) US8003670B2 (es)
EP (1) EP2155674B1 (es)
JP (1) JP5139512B2 (es)
KR (1) KR101162482B1 (es)
CN (1) CN101675032B (es)
AT (1) ATE513810T1 (es)
AU (1) AU2008246947B2 (es)
BR (1) BRPI0809873A2 (es)
CA (1) CA2683124C (es)
CY (1) CY1111836T1 (es)
DK (1) DK2155674T3 (es)
EA (1) EA016594B1 (es)
ES (1) ES2366496T3 (es)
HK (1) HK1138264A1 (es)
HR (1) HRP20110530T1 (es)
IL (1) IL201491A (es)
MX (1) MX2009011461A (es)
NZ (1) NZ581580A (es)
SI (1) SI2155674T1 (es)
WO (1) WO2008136017A1 (es)
ZA (1) ZA200907015B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101337003B1 (ko) 2012-02-13 2013-12-04 주식회사 평산 링 압연 공법을 이용한 풍력 타워용 플랜지 제조방법
KR101338954B1 (ko) 2012-02-13 2013-12-09 주식회사 평산 링 압연 공정을 이용한 비대칭 단면을 가지는 제품의 성형 장치 및 성형 방법
RU2688161C2 (ru) 2013-07-25 2019-05-20 Университет Ягеллоньски Пирролохинолиновые производные в качестве 5-нт6 антагонистов, способ их получения и применение
JP6454346B2 (ja) 2013-12-20 2019-01-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族複素環式化合物及び医薬におけるその応用
US9974785B2 (en) 2014-07-08 2018-05-22 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
WO2019180176A1 (en) 2018-03-21 2019-09-26 Spherium Biomed, S.L. Composition for the treatment of schizophrenia and/or psychosis

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DZ2376A1 (fr) 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
EP0994862B1 (en) 1997-07-11 2005-06-01 SmithKline Beecham plc Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation
GB9801392D0 (en) 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
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Also Published As

Publication number Publication date
CN101675032B (zh) 2012-10-31
SI2155674T1 (sl) 2011-10-28
KR101162482B1 (ko) 2012-07-03
EA200971017A1 (ru) 2010-04-30
KR20100007954A (ko) 2010-01-22
CA2683124C (en) 2012-09-25
ATE513810T1 (de) 2011-07-15
EP2155674A1 (en) 2010-02-24
AU2008246947B2 (en) 2011-03-31
ES2366496T3 (es) 2011-10-20
CN101675032A (zh) 2010-03-17
HRP20110530T1 (hr) 2011-09-30
US8003670B2 (en) 2011-08-23
DK2155674T3 (da) 2011-09-26
CY1111836T1 (el) 2015-10-07
EP2155674B1 (en) 2011-06-22
ZA200907015B (en) 2010-07-28
IL201491A0 (en) 2010-05-31
NZ581580A (en) 2011-03-31
JP5139512B2 (ja) 2013-02-06
US20100087484A1 (en) 2010-04-08
CA2683124A1 (en) 2008-11-13
EA016594B1 (ru) 2012-06-29
JP2010526057A (ja) 2010-07-29
AU2008246947A1 (en) 2008-11-13
IL201491A (en) 2015-04-30
BRPI0809873A2 (pt) 2018-11-13
HK1138264A1 (en) 2010-08-20
WO2008136017A1 (en) 2008-11-13

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