HRP20100194T8 - Peri condensed tricyclic compounds useful as antibacterial agents - Google Patents

Peri condensed tricyclic compounds useful as antibacterial agents

Info

Publication number: HRP20100194T8
Authority: HR; Croatia
Prior art keywords: alkyl; cr4r8; aromatic ring; hydroxy; hydrogen
Prior art date: 2005-10-21

Application number

HR20100194T

Other languages

English (en)

Croatian (hr)

Inventor

Cailleau Nathalie

Thomas Davies David

Michael Esken Joel

Joseph Hennessy Alan

Kumar Kusalakumari Sukumar Senthil

Edward Markwell Roger

James Miles Timothy

David Pearson Neil

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-21

Filing date

2010-04-07

Publication date

2010-06-30

2010-04-07 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2010-05-31 Publication of HRP20100194T1 publication Critical patent/HRP20100194T1/hr

2010-06-30 Publication of HRP20100194T8 publication Critical patent/HRP20100194T8/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
125000006574 non-aromatic ring group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
101000585507 Solanum tuberosum Cytochrome b-c1 complex subunit 7 Proteins 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
101150020251 NR13 gene Proteins 0.000 abstract 3
125000004414 alkyl thio group Chemical group 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000005647 linker group Chemical group 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
125000002527 bicyclic carbocyclic group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HR20100194T 2005-10-21 2010-04-07 Peri condensed tricyclic compounds useful as antibacterial agents HRP20100194T8 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US72897505P	2005-10-21	2005-10-21
US82659006P	2006-09-22	2006-09-22
PCT/US2006/060023 WO2007081597A2 (fr)	2005-10-21	2006-10-17	Composés

Publications (2)

Publication Number	Publication Date
HRP20100194T1 HRP20100194T1 (hr)	2010-05-31
HRP20100194T8 true HRP20100194T8 (en)	2010-06-30

Family

ID=38256822

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20100194T HRP20100194T8 (en)	2005-10-21	2010-04-07	Peri condensed tricyclic compounds useful as antibacterial agents

Country Status (27)

Country	Link
US (2)	US20080280892A1 (fr)
EP (1)	EP1954697B1 (fr)
JP (1)	JP2009512695A (fr)
KR (1)	KR20080064173A (fr)
AR (1)	AR057981A1 (fr)
AT (1)	ATE458737T1 (fr)
AU (1)	AU2006335042A1 (fr)
BR (1)	BRPI0617467A2 (fr)
CA (1)	CA2626641A1 (fr)
CR (1)	CR9930A (fr)
CY (1)	CY1110137T1 (fr)
DE (1)	DE602006012535D1 (fr)
DK (1)	DK1954697T3 (fr)
EA (1)	EA200801128A1 (fr)
ES (1)	ES2340531T3 (fr)
HK (1)	HK1118546A1 (fr)
HR (1)	HRP20100194T8 (fr)
IL (1)	IL190803A0 (fr)
MA (1)	MA29873B1 (fr)
NO (1)	NO20082191L (fr)
NZ (1)	NZ567315A (fr)
PE (1)	PE20070793A1 (fr)
PL (1)	PL1954697T3 (fr)
PT (1)	PT1954697E (fr)
SI (1)	SI1954697T1 (fr)
TW (1)	TW200736263A (fr)
WO (1)	WO2007081597A2 (fr)

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US20080280892A1 (en) *	2005-10-21	2008-11-13	Nathalie Cailleau	Compounds
US7732460B2 (en)	2005-12-22	2010-06-08	Glaxo Group Limited	Heterocyclic compounds, their preparation and their use as antibacterials
DE602007009205D1 (de)	2006-04-06	2010-10-28	Glaxo Group Ltd	Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0608263D0 (en)	2006-04-26	2006-06-07	Glaxo Group Ltd	Compounds
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EP2080761A1 (fr)	2008-01-18	2009-07-22	Glaxo Group Limited	Composés
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US8012961B2 (en)	2008-04-15	2011-09-06	Actelion Pharmaceutical Ltd.	Tricyclic antibiotics
US8466168B2 (en)	2008-08-04	2013-06-18	Actellon Pharmaceuticals Ltd.	Tricyclic alkylaminomethyloxazolidinone derivatives
MX2011003370A (es) *	2008-10-07	2011-04-28	Actelion Pharmaceuticals Ltd	Compuestos antibioticos de oxazolidinona triciclicos.
EP2352734A1 (fr)	2008-10-17	2011-08-10	Glaxo Group Limited	Composés azotés tricycliques utilisés comme agents antibactériens
EP2376497B1 (fr)	2008-12-12	2013-09-18	Actelion Pharmaceuticals Ltd.	Dérivés de 5-amino-2-(1-hydroxyéthyl)tétrahydropyrane
EP2379554B1 (fr)	2009-01-15	2015-11-11	Glaxo Group Limited	Composés naphthyridine-2(1h)-one utiles comme antibactériens
WO2013038374A1 (fr)	2011-09-16	2013-03-21	Actelion Pharmaceuticals Ltd	Procédé de préparation d'un intermédiaire de synthèse
TW201326180A (zh)	2011-11-30	2013-07-01	Actelion Pharmaceuticals Ltd	３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素
CA2958800C (fr)	2014-08-22	2020-10-27	Glaxosmithkline Intellectual Property Development Limited	Composes contenant de l'azote tricyclique pour le traitement de l'infection a neisseria gonorrhoeae
US11185076B2 (en)	2017-02-28	2021-11-30	Mitsui Chemicals Agro, Inc.	Composition for controlling plant diseases and method for controlling plant diseases applying the same
CA3063037A1 (fr) *	2017-05-10	2018-11-15	Albajuna Therapeutics, S.L.	Derives de proteine de fusion fc presentant une double activite elevee immunomodulatrice et antivirale contre le vih
BR112022010561A2 (pt)	2019-12-02	2022-11-16	Storm Therapeutics Ltd	Compostos poli-heterocíclicos como inibidores de mettl3
PE20230300A1 (es)	2019-12-06	2023-02-13	Vertex Pharma	Tetrahidrofuranos sustituidos como moduladores de canales de sodio

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AR042486A1 (es)	2002-12-18	2005-06-22	Glaxo Group Ltd	Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
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EP1796466A4 (fr) *	2004-06-15	2009-09-02	Glaxo Group Ltd	Agents antibacteriens
US20070254872A1 (en) *	2004-07-08	2007-11-01	Glaxo Group Limited	Antibacterial Agents
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MY150958A (en) *	2005-06-16	2014-03-31	Astrazeneca Ab	Compounds for the treatment of multi-drug resistant bacterial infections
EP1900732A4 (fr) *	2005-06-24	2009-11-18	Toyama Chemical Co Ltd	Nouveau composé hétérocyclique azoté et sel de celui-ci
US20080280892A1 (en) *	2005-10-21	2008-11-13	Nathalie Cailleau	Compounds
DE102005050892A1 (de) *	2005-10-21	2007-04-26	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
GB0521563D0 (en) *	2005-10-21	2005-11-30	Glaxo Group Ltd	Novel compounds
US7732460B2 (en) *	2005-12-22	2010-06-08	Glaxo Group Limited	Heterocyclic compounds, their preparation and their use as antibacterials
DE602007009205D1 (de) *	2006-04-06	2010-10-28	Glaxo Group Ltd	Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0608263D0 (en) *	2006-04-26	2006-06-07	Glaxo Group Ltd	Compounds
SG164384A1 (en) *	2006-05-26	2010-09-29	Toyama Chemical Co Ltd	Novel heterocyclic compound or salt thereof and intermediate thereof
GB0613208D0 (en) *	2006-07-03	2006-08-09	Glaxo Group Ltd	Compounds
EP1992628A1 (fr) *	2007-05-18	2008-11-19	Glaxo Group Limited	Dérivés et analogues de N-éthylquinolones et N-éthylazaquinolones
GB0705672D0 (en) *	2007-03-23	2007-05-02	Glaxo Group Ltd	Compounds
EP1980251A1 (fr) *	2007-04-13	2008-10-15	Glaxo Group Limited	Derivées de pyrrolo[3,2,1-ij]quinoline-4-one pour traiter la tuberculose
GB0707706D0 (en) *	2007-04-20	2007-05-30	Glaxo Group Ltd	Compounds
GB0707708D0 (en) *	2007-04-20	2007-05-30	Glaxo Group Ltd	Compounds
SI2137196T1 (sl) *	2007-04-20	2011-01-31	Glaxo Group Ltd Glaxo Welcome House	Tricikliäśne spojine, ki vsebujejo duĺ ik, uporabne kot antibakterijska sredstva

2006
- 2006-10-17 US US12/090,947 patent/US20080280892A1/en not_active Abandoned
- 2006-10-17 KR KR1020087012082A patent/KR20080064173A/ko not_active Application Discontinuation
- 2006-10-17 NZ NZ567315A patent/NZ567315A/en unknown
- 2006-10-17 US US11/550,005 patent/US20080221110A1/en not_active Abandoned
- 2006-10-17 AU AU2006335042A patent/AU2006335042A1/en not_active Abandoned
- 2006-10-17 ES ES06849235T patent/ES2340531T3/es active Active
- 2006-10-17 WO PCT/US2006/060023 patent/WO2007081597A2/fr active Application Filing
- 2006-10-17 PL PL06849235T patent/PL1954697T3/pl unknown
- 2006-10-17 PT PT06849235T patent/PT1954697E/pt unknown
- 2006-10-17 CA CA002626641A patent/CA2626641A1/fr not_active Abandoned
- 2006-10-17 BR BRPI0617467-1A patent/BRPI0617467A2/pt not_active IP Right Cessation
- 2006-10-17 DE DE602006012535T patent/DE602006012535D1/de active Active
- 2006-10-17 JP JP2008536625A patent/JP2009512695A/ja active Pending
- 2006-10-17 AT AT06849235T patent/ATE458737T1/de active
- 2006-10-17 SI SI200630624T patent/SI1954697T1/sl unknown
- 2006-10-17 EA EA200801128A patent/EA200801128A1/xx unknown
- 2006-10-17 EP EP06849235A patent/EP1954697B1/fr active Active
- 2006-10-17 DK DK06849235.4T patent/DK1954697T3/da active
- 2006-10-19 TW TW095138495A patent/TW200736263A/zh unknown
- 2006-10-19 PE PE2006001266A patent/PE20070793A1/es not_active Application Discontinuation
- 2006-10-19 AR ARP060104571A patent/AR057981A1/es not_active Application Discontinuation
2008
- 2008-04-10 IL IL190803A patent/IL190803A0/en unknown
- 2008-04-15 MA MA30851A patent/MA29873B1/fr unknown
- 2008-04-25 CR CR9930A patent/CR9930A/es not_active Application Discontinuation
- 2008-05-13 NO NO20082191A patent/NO20082191L/no not_active Application Discontinuation
- 2008-09-10 HK HK08110046.5A patent/HK1118546A1/xx not_active IP Right Cessation
2010
- 2010-04-07 HR HR20100194T patent/HRP20100194T8/xx unknown
- 2010-05-10 CY CY20101100405T patent/CY1110137T1/el unknown

Also Published As

Publication number	Publication date
AR057981A1 (es)	2008-01-09
CR9930A (es)	2008-07-29
PE20070793A1 (es)	2007-08-23
JP2009512695A (ja)	2009-03-26
EP1954697B1 (fr)	2010-02-24
EA200801128A1 (ru)	2008-10-30
PT1954697E (pt)	2010-05-17
CY1110137T1 (el)	2015-01-14
TW200736263A (en)	2007-10-01
HRP20100194T1 (hr)	2010-05-31
NZ567315A (en)	2011-01-28
KR20080064173A (ko)	2008-07-08
DE602006012535D1 (de)	2010-04-08
EP1954697A2 (fr)	2008-08-13
PL1954697T3 (pl)	2010-07-30
ATE458737T1 (de)	2010-03-15
WO2007081597A2 (fr)	2007-07-19
IL190803A0 (en)	2008-12-29
NO20082191L (no)	2008-07-16
US20080280892A1 (en)	2008-11-13
DK1954697T3 (da)	2010-06-14
SI1954697T1 (sl)	2010-05-31
US20080221110A1 (en)	2008-09-11
WO2007081597A3 (fr)	2008-06-12
CA2626641A1 (fr)	2007-07-19
MA29873B1 (fr)	2008-10-03
ES2340531T3 (es)	2010-06-04
HK1118546A1 (en)	2009-02-13
AU2006335042A1 (en)	2007-07-19
BRPI0617467A2 (pt)	2011-07-26

Publication	Publication Date	Title
HRP20100194T8 (en)	2010-06-30	Peri condensed tricyclic compounds useful as antibacterial agents
AR066111A1 (es)	2009-07-22	Compuesto triciclico de imidazol, su uso para preparar un medicamento, composicion farmaceutica que lo comprende y compuestos intermediarios en la sintesis de dicho compuesto
AR058587A1 (es)	2008-02-13	Compuestos de pirrolo-1,5-naftiridinona,su uso como agentes antibacterianos, composiciones farmaceuticas que los contienen y compuestos intermediarios para preparar dichos compuestos
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