HRP20050089B1 - Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti - Google Patents

Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti

Info

Publication number
HRP20050089B1
HRP20050089B1 HRP20050089AA HRP20050089A HRP20050089B1 HR P20050089 B1 HRP20050089 B1 HR P20050089B1 HR P20050089A A HRP20050089A A HR P20050089AA HR P20050089 A HRP20050089 A HR P20050089A HR P20050089 B1 HRP20050089 B1 HR P20050089B1
Authority
HR
Croatia
Prior art keywords
treating
autoimmune diseases
methods
pyrimidinediamine compounds
preventing autoimmune
Prior art date
Application number
HRP20050089AA
Other languages
English (en)
Inventor
Rajinder Singh
Ankush Argade
Donald G. Payan
Jeffrey Clough
Holger Keim
Catherine Sylvain
Hui Li
Somasekhar Bhamidipati
Original Assignee
Rigel Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31721742&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20050089(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rigel Pharmaceuticals filed Critical Rigel Pharmaceuticals
Publication of HRP20050089A2 publication Critical patent/HRP20050089A2/hr
Publication of HRP20050089B1 publication Critical patent/HRP20050089B1/hr

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

Ovaj izum omogućuje metode tretiranja ili prevenciju autoimunih bolesti sa 2,4-pirimidindiamin spojevima, kao i metode tretiranja, prevencije ili poboljšanja simptoma povezanih s takvim bolestima. Specifičan primjer autoimmunih bolesti koje mogu biti tretirane ili preventirane sa takvim spojevima uključuju reumatoidni artritis i/ili njegovim povezanim simptomima, sistemski lupus eritematosus i/ili njegovim povezanim simptomima i multiplu sklerozu i/ili njenim povezanim simptomima.
HRP20050089AA 2002-07-29 2005-01-26 Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti HRP20050089B1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39967302P 2002-07-29 2002-07-29
US44394903P 2003-01-31 2003-01-31
US45233903P 2003-03-06 2003-03-06
US10/631,029 US7517886B2 (en) 2002-07-29 2003-07-29 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
PCT/US2003/024087 WO2004014382A1 (en) 2002-07-29 2003-07-29 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds

Publications (2)

Publication Number Publication Date
HRP20050089A2 HRP20050089A2 (hr) 2007-08-31
HRP20050089B1 true HRP20050089B1 (hr) 2015-06-19

Family

ID=31721742

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050089AA HRP20050089B1 (hr) 2002-07-29 2005-01-26 Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti

Country Status (25)

Country Link
US (5) US7517886B2 (hr)
EP (1) EP1534286B1 (hr)
JP (2) JP2006514989A (hr)
CN (2) CN1678321A (hr)
AT (1) ATE451104T1 (hr)
AU (1) AU2003265336B8 (hr)
BR (1) BR0313059B8 (hr)
CA (1) CA2492325C (hr)
CY (1) CY1110292T1 (hr)
DE (1) DE60330466D1 (hr)
DK (1) DK1534286T3 (hr)
ES (2) ES2445208T3 (hr)
HK (2) HK1079978A1 (hr)
HR (1) HRP20050089B1 (hr)
IL (3) IL166241A0 (hr)
IS (1) IS2923B (hr)
MX (1) MXPA05001096A (hr)
NO (1) NO332550B1 (hr)
NZ (1) NZ537752A (hr)
PL (1) PL216744B1 (hr)
RS (1) RS51752B (hr)
RU (1) RU2659777C9 (hr)
SE (1) SE0500203L (hr)
SG (1) SG176311A1 (hr)
WO (1) WO2004014382A1 (hr)

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UA80767C2 (en) * 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
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