HRP20040690B1 - Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals - Google Patents

Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals

Info

Publication number: HRP20040690B1
Authority: HR; Croatia
Prior art keywords: same; pharmaceuticals; production; methods; carboxylic acid
Prior art date: 2002-01-31

Application number

HRP20040690AA

Other languages

English (en)

Croatian (hr)

Inventor

Germeyer Sabine

Meissner Helmut

Morschh�user Gerd

Pastel Sabine

Pieper Michael

Pohl Gerald

Reichl Richard

Speck Georg

Original Assignee

Boehringer Ingelheim Pharma Gmbh & Co.Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-31

Filing date

2004-07-29

Publication date

2012-09-30

2004-07-29 Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg

2005-10-31 Publication of HRP20040690A2 publication Critical patent/HRP20040690A2/hr

2012-09-30 Publication of HRP20040690B1 publication Critical patent/HRP20040690B1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. ***e

HRP20040690AA 2002-01-31 2004-07-29 Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals HRP20040690B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10203741A DE10203741A1 (de)	2002-01-31	2002-01-31	Neue Fluorencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP2003/000534 WO2003064419A1 (de)	2002-01-31	2003-01-21	Neue fluorencarbonsäureester, verfahren zu deren herstellung sowie deren verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
HRP20040690A2 HRP20040690A2 (en)	2005-10-31
HRP20040690B1 true HRP20040690B1 (en)	2012-09-30

Family

ID=27588159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP20040690AA HRP20040690B1 (en)	2002-01-31	2004-07-29	Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals

Country Status (29)

Country	Link
EP (2)	EP1561751A1 (xx)
JP (1)	JP4484522B2 (xx)
KR (1)	KR100950869B1 (xx)
CN (1)	CN100348598C (xx)
AR (1)	AR038379A1 (xx)
AT (1)	ATE299880T1 (xx)
AU (1)	AU2003210172C1 (xx)
BR (1)	BR0307294A (xx)
CA (1)	CA2472149C (xx)
DE (2)	DE10203741A1 (xx)
EA (1)	EA006966B1 (xx)
EC (1)	ECSP045209A (xx)
ES (1)	ES2245443T3 (xx)
HK (1)	HK1082376A1 (xx)
HR (1)	HRP20040690B1 (xx)
IL (1)	IL162527A0 (xx)
ME (1)	MEP43408A (xx)
MX (1)	MXPA04007245A (xx)
MY (1)	MY134582A (xx)
NO (1)	NO328929B1 (xx)
NZ (1)	NZ534784A (xx)
PE (1)	PE20031029A1 (xx)
PL (1)	PL209037B1 (xx)
PT (1)	PT1472251E (xx)
RS (1)	RS50918B (xx)
TW (1)	TWI352077B (xx)
UA (1)	UA78544C2 (xx)
UY (1)	UY27633A1 (xx)
WO (1)	WO2003064419A1 (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2316996T3 (es) *	2003-07-28	2009-04-16	Boehringer Ingelheim International Gmbh	Medicamentos para inhalacion, comprendiendo betamimeticos y un agente anticolinergico.
WO2005013967A1 (en) *	2003-07-28	2005-02-17	Boehringer Ingelheim International Gmbh	Medicaments comprising pde iv inhibitors and a novel anticholinergic and their use for treating respiratory disorders
ES2326320T3 (es) *	2003-07-28	2009-10-07	Boehringer Ingelheim International Gmbh	Medicamentos para inhalacion que comprenden esteroides y nuevo ester del acido fluorencarboxilico.
CA2534120C (en) *	2003-07-31	2012-09-11	Boehringer Ingelheim International Gmbh	Medicaments for inhalation comprising anticholinergics and a betamimetic
DE102004001607A1 (de) *	2004-01-09	2005-08-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen auf der Basis von Scopin- oder Tropensäureestern mit EGFR-Kinase-Hemmern
US7507745B2 (en) *	2004-02-20	2009-03-24	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins
CA2552903A1 (en) *	2004-02-20	2005-09-01	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions based on anticholinergics and pegsunercept
DE102004016179A1 (de) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Verbindungen zur Behandlung von proliferativen Prozessen
US20060034776A1 (en) *	2004-08-10	2006-02-16	Boehringer Ingelheim International Gmbh	Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics
DE102004038885A1 (de) *	2004-08-10	2006-02-23	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
ES2322148T3 (es) *	2004-08-11	2009-06-17	BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG	Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias.
DE102005001297A1 (de) *	2005-01-12	2006-07-20	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
JP2008530177A (ja) *	2005-02-16	2008-08-07	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	抗コリン作用薬及びエチプレドノールを含有する医薬組成物
WO2006094924A2 (en) *	2005-03-09	2006-09-14	Boehringer Ingelheim International Gmbh	New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
WO2006128847A2 (en) *	2005-05-31	2006-12-07	Boehringer Ingelheim International Gmbh	Medicament containing a betamimetic in conjunction with an anticholinergic and a pde iv inhibitor
DE102005030733A1 (de)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
US20090324510A1 (en)	2006-08-07	2009-12-31	Boehringer Ingelheim International Gmbh	Drug combinations for the treatment of respiratory tract diseases
UY30550A1 (es)	2006-08-22	2008-03-31	Boehringer Ingelheim Int	Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos
EP1925296A1 (de) *	2006-11-22	2008-05-28	Boehringer Ingelheim Pharma GmbH & Co. KG	Stabile Pulverformulierung enthaltend ein neues Anticholinergikum
EP1997819A1 (de) *	2007-05-25	2008-12-03	Boehringer Ingelheim Pharma GmbH & Co. KG	Verfahren zur Herstellung von Scopinestern
ES2569359T3 (es)	2007-07-06	2016-05-10	Vectura Delivery Devices Limited	Inhalador
US20100234411A1 (en) *	2007-07-18	2010-09-16	Boehringer Ingelheim Intermational Gmbh	New Combination for the Treatment of Respiratory Diseases
EP2082771A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Inhaler
EP2082767A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Inhaler
EP2082766A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Blister Strip Coil Forming
EP2082772A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Inhaler
EP2082768A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Inhaler
EP2093219A1 (de)	2008-02-22	2009-08-26	Boehringer Ingelheim International Gmbh	Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
GB0918450D0 (en)	2009-10-21	2009-12-09	Innovata Ltd	Composition
CN102876318B (zh) *	2012-09-28	2014-07-16	宁波大学	一种芴羧酸酯荧光材料及其制备方法
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CA3128468A1 (en)	2017-10-05	2019-04-11	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992016528A1 (de) *	1991-03-15	1992-10-01	Boehringer Ingelheim Kg	Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2221828A (en) *	1936-04-25	1940-11-19	Merck & Co Inc	Esters of amino alcohols with 9-hydroxyfluorene-9-carboxylic acid and processes for their production

2002
- 2002-01-31 DE DE10203741A patent/DE10203741A1/de not_active Withdrawn
2003
- 2003-01-21 EP EP05004525A patent/EP1561751A1/de not_active Withdrawn
- 2003-01-21 NZ NZ534784A patent/NZ534784A/en not_active IP Right Cessation
- 2003-01-21 AU AU2003210172A patent/AU2003210172C1/en not_active Ceased
- 2003-01-21 WO PCT/EP2003/000534 patent/WO2003064419A1/de active IP Right Grant
- 2003-01-21 RS YUP-656/04A patent/RS50918B/sr unknown
- 2003-01-21 JP JP2003564042A patent/JP4484522B2/ja not_active Expired - Lifetime
- 2003-01-21 CA CA2472149A patent/CA2472149C/en not_active Expired - Fee Related
- 2003-01-21 EA EA200400878A patent/EA006966B1/ru not_active IP Right Cessation
- 2003-01-21 DE DE50300813T patent/DE50300813D1/de not_active Expired - Lifetime
- 2003-01-21 KR KR1020047011881A patent/KR100950869B1/ko not_active IP Right Cessation
- 2003-01-21 PL PL369396A patent/PL209037B1/pl unknown
- 2003-01-21 PT PT03734600T patent/PT1472251E/pt unknown
- 2003-01-21 EP EP03734600A patent/EP1472251B1/de not_active Expired - Lifetime
- 2003-01-21 BR BR0307294-0A patent/BR0307294A/pt active Pending
- 2003-01-21 ES ES03734600T patent/ES2245443T3/es not_active Expired - Lifetime
- 2003-01-21 CN CNB038030004A patent/CN100348598C/zh not_active Expired - Fee Related
- 2003-01-21 AT AT03734600T patent/ATE299880T1/de active
- 2003-01-21 IL IL16252703A patent/IL162527A0/xx not_active IP Right Cessation
- 2003-01-21 UA UA20040807067A patent/UA78544C2/uk unknown
- 2003-01-21 MX MXPA04007245A patent/MXPA04007245A/es active IP Right Grant
- 2003-01-21 ME MEP-434/08A patent/MEP43408A/xx unknown
- 2003-01-29 PE PE2003000092A patent/PE20031029A1/es not_active Application Discontinuation
- 2003-01-29 TW TW092101968A patent/TWI352077B/zh active
- 2003-01-29 MY MYPI20030303A patent/MY134582A/en unknown
- 2003-01-30 UY UY27633A patent/UY27633A1/es not_active Application Discontinuation
- 2003-01-31 AR ARP030100288A patent/AR038379A1/es active Pending
2004
- 2004-07-28 EC EC2004005209A patent/ECSP045209A/es unknown
- 2004-07-29 HR HRP20040690AA patent/HRP20040690B1/xx not_active IP Right Cessation
- 2004-08-30 NO NO20043612A patent/NO328929B1/no not_active IP Right Cessation
2005
- 2005-11-02 HK HK05109744A patent/HK1082376A1/xx not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992016528A1 (de) *	1991-03-15	1992-10-01	Boehringer Ingelheim Kg	Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number	Publication date
AR038379A1 (es)	2005-01-12
DE50300813D1 (de)	2005-08-25
MY134582A (en)	2007-12-31
UA78544C2 (uk)	2007-04-10
MXPA04007245A (es)	2004-10-29
JP4484522B2 (ja)	2010-06-16
JP2005516067A (ja)	2005-06-02
TWI352077B (en)	2011-11-11
NZ534784A (en)	2005-08-26
KR20040081166A (ko)	2004-09-20
UY27633A1 (es)	2003-08-29
HK1082376A1 (en)	2006-05-04
IL162527A0 (en)	2005-11-20
TW200302817A (en)	2003-08-16
ATE299880T1 (de)	2005-08-15
CN100348598C (zh)	2007-11-14
CA2472149C (en)	2011-01-11
AU2003210172C1 (en)	2009-09-24
EP1561751A1 (de)	2005-08-10
CN1625557A (zh)	2005-06-08
EP1472251B1 (de)	2005-07-20
NO20043612L (no)	2004-08-30
PL209037B1 (pl)	2011-07-29
AU2003210172B2 (en)	2009-04-02
RS65604A (xx)	2006-12-15
PT1472251E (pt)	2005-10-31
RS50918B (sr)	2010-08-31
CA2472149A1 (en)	2003-08-07
EA200400878A1 (ru)	2005-02-24
DE10203741A1 (de)	2003-08-14
HRP20040690A2 (en)	2005-10-31
ECSP045209A (es)	2004-09-28
EA006966B1 (ru)	2006-06-30
WO2003064419A1 (de)	2003-08-07
PE20031029A1 (es)	2004-01-27
PL369396A1 (en)	2005-04-18
KR100950869B1 (ko)	2010-04-06
BR0307294A (pt)	2004-12-21
EP1472251A1 (de)	2004-11-03
MEP43408A (en)	2011-02-10
ES2245443T3 (es)	2006-01-01
NO328929B1 (no)	2010-06-21

Legal Events

Date	Code	Title	Description
2005-10-31	A1OB	Publication of a patent application
2006-04-27	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2012-09-30	B1PR	Patent granted
2015-01-12	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20150112 Year of fee payment: 13
2016-08-12	PBON	Lapse due to non-payment of renewal fee	Effective date: 20160121

Publication	Publication Date	Title
HRP20040690B1 (en)	2012-09-30	Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals
RS53061B (en)	2014-04-30	INHIBITORI PROTEIN KINAZE
RS50537B (sr)	2010-05-07	Derivati benzimidazola i njihovo korišćenje kao antagonista receptora a ii
HRP20030278B1 (en)	2006-02-28	Novel anticholinergic agents that can be used as medicaments and method for the production thereof
DE60310554D1 (de)	2007-02-01	Verfahren zur herstellung von chinolinderivaten
RS51471B (en)	2011-04-30	BIPHYNYLOXYXIC ACID DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES
NO20072605L (no)	2007-09-05	Nytt antranilinsyrederivat eller et salt derav
NO20050870L (no)	2005-03-31	Fosfodiesterase 4-inhibitorer, inkludert N-substituerte anilin- og difenylaminanaloger
RS52319B (en)	2012-12-31	FUNGICIDE COMPOSITION CONTAINING ACID AMID DERIVATIVES
AR041816A1 (es)	2005-06-01	Compuesto de acil-pirrolidina, su uso para preparar una composicion farmaceutica, composicion farmaceutica que lo comprende y procedimiento para prepararlo
YU57603A (sh)	2006-08-17	Inhibitori fosfodiesteraze 4
RS50980B (sr)	2010-10-31	Derivati n-hidroksiamida i njihova upotreba
EA200500201A1 (ru)	2005-08-25	Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина
RS52881B (en)	2014-02-28	BENZAMIDINE COMPOUNDS USED AS HISTONAL DEACETYLASE INHIBITORS
CO5601030A2 (es)	2006-01-31	Derivados de quinolinona/benzoxazinona y usos de los mismos
HRP20070286T3 (en)	2007-08-31	Substituted diketopiperazines and their use as oxytocyn antagonists
IS7841A (is)	2005-05-12	Efnafræðilegt milliefni
RS51193B (sr)	2010-10-31	Hidantoinski derivati korisni kao inhibitori metaloproteinaza
BRPI0408160B1 (pt)	2013-10-08	Processo para o preparo de ésteres do ácido nicotínico substituído e intermediários de enamina para uso nesse processo
RS52789B (en)	2013-10-31	PYRIDYL-TRIAZOLOPYRIMIDINE DERIVATIVES OR ITS SALTS, CONTAINING THE PESTICIDES AND THE PRODUCTION PROCEDURE
NO20050871L (no)	2005-02-18	6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
ATE495158T1 (de)	2011-01-15	Substituierte tetrahydroisochinoline als mmp- inhibitoren, verfahren zu ihrer herstellung und ihre verwendung als medikament
AU2003294082A1 (en)	2004-06-23	Composition comprising a carbamic acid derivative, its use as cosmetic and medicine
NO20082226L (no)	2008-07-01	6-heteroarylpyridoindolonderivater, deres fremstilling og terapeutisk anvendelse derav
EA200600878A1 (ru)	2006-10-27	Производные феноксиуксусных кислот, применимые в качестве двойных агонистов активируемого пероксисомным пролифератором рецептора ( ppar )