EA200500201A1 - Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина - Google Patents

Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина

Info

Publication number
EA200500201A1
EA200500201A1 EA200500201A EA200500201A EA200500201A1 EA 200500201 A1 EA200500201 A1 EA 200500201A1 EA 200500201 A EA200500201 A EA 200500201A EA 200500201 A EA200500201 A EA 200500201A EA 200500201 A1 EA200500201 A1 EA 200500201A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
agomelatine
application
naftyl
acetonitrile
Prior art date
Application number
EA200500201A
Other languages
English (en)
Other versions
EA007789B1 (ru
Inventor
Жан-Клод Суви
Исаак Гонсалес-Бланко
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200500201A1 publication Critical patent/EA200500201A1/ru
Publication of EA007789B1 publication Critical patent/EA007789B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B37/00—Nuts or like thread-engaging members
    • F16B37/14—Cap nuts; Nut caps or bolt caps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Abstract

Способ промышленного синтеза соединения формулы (I)Применение при синтезе агомелатина.
EA200500201A 2004-02-13 2005-02-14 Новый способ синтеза (7- метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина EA007789B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0401438A FR2866334B1 (fr) 2004-02-13 2004-02-13 Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine

Publications (2)

Publication Number Publication Date
EA200500201A1 true EA200500201A1 (ru) 2005-08-25
EA007789B1 EA007789B1 (ru) 2007-02-27

Family

ID=34685018

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500201A EA007789B1 (ru) 2004-02-13 2005-02-14 Новый способ синтеза (7- метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина

Country Status (33)

Country Link
US (2) US7476751B2 (ru)
EP (1) EP1564203B1 (ru)
JP (1) JP4252040B2 (ru)
KR (1) KR100682697B1 (ru)
CN (1) CN1315794C (ru)
AR (1) AR047667A1 (ru)
AT (1) ATE452873T1 (ru)
AU (1) AU2005200620B8 (ru)
BR (1) BRPI0500395B8 (ru)
CA (1) CA2495960C (ru)
CY (1) CY1109737T1 (ru)
DE (1) DE602005018403D1 (ru)
DK (1) DK1564203T3 (ru)
EA (1) EA007789B1 (ru)
ES (1) ES2338664T3 (ru)
FR (1) FR2866334B1 (ru)
GE (1) GEP20063961B (ru)
HK (1) HK1079187A1 (ru)
HR (1) HRP20100103T1 (ru)
MA (1) MA27517A1 (ru)
ME (1) ME01806B (ru)
MX (1) MXPA05001634A (ru)
MY (2) MY143737A (ru)
NO (1) NO333488B1 (ru)
NZ (1) NZ538192A (ru)
PL (1) PL1564203T3 (ru)
PT (1) PT1564203E (ru)
RS (1) RS51212B (ru)
SG (1) SG114702A1 (ru)
SI (1) SI1564203T1 (ru)
UA (1) UA79479C2 (ru)
WO (1) WO2005077890A1 (ru)
ZA (1) ZA200501256B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866336B1 (fr) * 2004-02-13 2006-03-24 Servier Lab Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
CN101161638B (zh) * 2006-10-13 2010-09-29 北京德众万全药物技术开发有限公司 一种新的阿戈美拉汀重要中间体的制备方法
CN101585779B (zh) * 2009-03-10 2014-04-02 上海医药工业研究院 阿戈美拉汀的晶型vi及其制备方法和应用
CN101723855B (zh) * 2009-12-03 2012-08-08 浙江科技学院 一种(7-甲氧基-1-萘基)乙腈的合成方法
CN101792400B (zh) * 2010-03-16 2013-01-30 华东师范大学 一种阿戈美拉汀的合成方法
CN102276492B (zh) * 2010-06-08 2013-04-10 上海医药工业研究院 阿戈美拉汀中间体及其制备方法
CL2011001405A1 (es) 2010-06-10 2012-03-30 Gador S A Conicet Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina.
CN102060733B (zh) * 2010-12-06 2014-01-29 威海迪素制药有限公司 (7-甲氧基-3,4-二氢-1-萘基)乙腈的制备方法
FR2970000B1 (fr) 2011-01-05 2013-01-04 Servier Lab Nouveau procede de synthese de l'agomelatine
WO2013054273A2 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
EP2785681A1 (en) 2011-12-01 2014-10-08 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
CN103319370B (zh) * 2012-03-21 2016-08-03 黑龙江福和华星制药集团股份有限公司 一种(7-甲氧基-1-萘基)乙腈的制备方法
ITMI20121444A1 (it) 2012-08-27 2014-02-28 Procos Spa Processo per la produzione di agomelatine
CN102875408B (zh) * 2012-10-09 2014-07-16 江西同和药业有限责任公司 一种阿戈美拉汀的制备方法
CN102875415B (zh) * 2012-10-09 2014-08-20 江西同和药业有限责任公司 一种化合物及其制备方法和应用
WO2016046833A2 (en) * 2014-09-24 2016-03-31 Symed Labs Limited Improved processes for the preparation of agomelatine using novel intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327022A (en) * 1973-08-16 1982-04-27 Sterling Drug Inc. Heterocyclic alkyl naphthols
US3931188A (en) * 1974-05-06 1976-01-06 Bristol-Myers Company 3-Hydroxy-5,6-benzomorphinan derivatives
US3992403A (en) * 1975-05-30 1976-11-16 Schering Corporation 2-Imidazolines and their use as hypoglycemic agents
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866335B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2866336B1 (fr) * 2004-02-13 2006-03-24 Servier Lab Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine

Also Published As

Publication number Publication date
AU2005200620A1 (en) 2005-09-01
PL1564203T3 (pl) 2010-06-30
ES2338664T3 (es) 2010-05-11
CN1315794C (zh) 2007-05-16
ATE452873T1 (de) 2010-01-15
ZA200501256B (en) 2005-11-30
AU2005200620B2 (en) 2011-05-19
BRPI0500395A (pt) 2005-09-27
BRPI0500395B1 (pt) 2018-11-06
SG114702A1 (en) 2005-09-28
UA79479C2 (en) 2007-06-25
MXPA05001634A (es) 2005-08-19
ME01806B (me) 2010-12-31
DE602005018403D1 (de) 2010-02-04
MY143737A (en) 2011-07-04
CA2495960A1 (fr) 2005-08-13
EP1564203B1 (fr) 2009-12-23
HRP20100103T1 (hr) 2010-04-30
US7999129B2 (en) 2011-08-16
NO333488B1 (no) 2013-06-24
NZ538192A (en) 2005-12-23
US20090131719A1 (en) 2009-05-21
CY1109737T1 (el) 2014-09-10
CN1680296A (zh) 2005-10-12
DK1564203T3 (da) 2010-04-12
MY142270A (en) 2010-11-15
WO2005077890A1 (fr) 2005-08-25
NO20050740D0 (no) 2005-02-11
AR047667A1 (es) 2006-02-01
JP2005239718A (ja) 2005-09-08
JP4252040B2 (ja) 2009-04-08
NO20050740L (no) 2005-08-15
RS51212B (sr) 2010-12-31
HK1079187A1 (en) 2006-03-31
KR100682697B1 (ko) 2007-02-15
EA007789B1 (ru) 2007-02-27
FR2866334B1 (fr) 2006-05-26
KR20060041902A (ko) 2006-05-12
GEP20063961B (en) 2006-11-10
US7476751B2 (en) 2009-01-13
MA27517A1 (fr) 2005-09-01
US20050182267A1 (en) 2005-08-18
PT1564203E (pt) 2010-01-15
BRPI0500395B8 (pt) 2021-05-25
EP1564203A1 (fr) 2005-08-17
AU2005200620A8 (en) 2011-06-02
CA2495960C (fr) 2007-11-27
SI1564203T1 (sl) 2010-03-31
AU2005200620B8 (en) 2011-06-02
FR2866334A1 (fr) 2005-08-19

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