HRP20020650B1 - PURIFIED hCG - Google Patents

PURIFIED hCG

Info

Publication number: HRP20020650B1
Authority: HR; Croatia
Prior art keywords: eluting; sample; chromatographic column; ion exchange; recombinant hcg
Prior art date: 2000-02-22

Application number

HR20020650A

Other languages

English (en)

Croatian (hr)

Inventor

Paradisi Gianfranco

Rossi Mara

Scaglia Laura

Original Assignee

Laboratoires Serono Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-22

Filing date

2002-08-01

Publication date

2011-02-28

2002-08-01 Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa

2004-12-31 Publication of HRP20020650A2 publication Critical patent/HRP20020650A2/hr

2011-02-28 Publication of HRP20020650B1 publication Critical patent/HRP20020650B1/xx

Links

238000005342 ion exchange Methods 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000004007 reversed phase HPLC Methods 0.000 abstract 1
239000000741 silica gel Substances 0.000 abstract 1
229910002027 silica gel Inorganic materials 0.000 abstract 1
238000001542 size-exclusion chromatography Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Reproductive Health (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Compounds Of Unknown Constitution (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Detergent Compositions (AREA)

HR20020650A 2000-02-22 2002-08-01 PURIFIED hCG HRP20020650B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00103690		2000-02-22
PCT/EP2001/000665 WO2001062773A1 (en)	2000-02-22	2001-01-22	PROCESS OF PURIFICATION OF hCG AND RECOMBINANT hCG PURIFIED BY THAT METHOD

Publications (2)

Publication Number	Publication Date
HRP20020650A2 HRP20020650A2 (en)	2004-12-31
HRP20020650B1 true HRP20020650B1 (en)	2011-02-28

Family

ID=8167925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020650A HRP20020650B1 (en)	2000-02-22	2002-08-01	PURIFIED hCG

Country Status (32)

Country	Link
US (2)	US7297777B2 (ja)
EP (2)	EP1257564B1 (ja)
JP (1)	JP4588960B2 (ja)
KR (1)	KR100806911B1 (ja)
CN (1)	CN100482679C (ja)
AT (1)	ATE406378T1 (ja)
AU (2)	AU783320B2 (ja)
BG (1)	BG65807B1 (ja)
BR (1)	BRPI0108556B8 (ja)
CA (1)	CA2399020A1 (ja)
CY (1)	CY1108460T1 (ja)
CZ (1)	CZ303144B6 (ja)
DE (1)	DE60135541D1 (ja)
DK (1)	DK1257564T3 (ja)
EA (1)	EA006605B1 (ja)
EE (1)	EE05644B1 (ja)
ES (1)	ES2307585T3 (ja)
HK (1)	HK1052016A1 (ja)
HR (1)	HRP20020650B1 (ja)
HU (2)	HU228935B1 (ja)
IL (2)	IL151308A0 (ja)
ME (1)	ME00296B (ja)
MX (1)	MXPA02007871A (ja)
NO (1)	NO328694B1 (ja)
PL (1)	PL205149B1 (ja)
PT (1)	PT1257564E (ja)
RS (1)	RS50741B (ja)
SI (1)	SI1257564T1 (ja)
SK (1)	SK287146B6 (ja)
UA (2)	UA78488C2 (ja)
WO (1)	WO2001062773A1 (ja)
ZA (1)	ZA200206109B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA006605B1 (ru) *	2000-02-22	2006-02-24	Апплайд Резеч Системз Арс Холдинг Н.В.	СПОСОБ ОЧИСТКИ РЕКОМБИНАНТНОГО чХГ
JP2007513192A (ja) *	2004-10-04	2007-05-24	ノベタイド，リミティド	ペプチド用の対イオン交換法
CN1958603B (zh) *	2005-11-04	2010-05-05	上海天伟生物制药有限公司	一种人绒毛膜促性腺素的纯化方法
WO2008007993A1 (fr) *	2006-07-11	2008-01-17	Koval, Anton Alexandrovich	Utilisation d'une hormone chorionique ou lutéinisante destinée à la prévention ou au traitement de l'hypogonadisme lié à l'âge
CN101397339B (zh) *	2008-09-24	2012-07-25	上海天伟生物制药有限公司	糖蛋白中去除/灭活病毒的方法
TWI604850B (zh) *	2009-10-05	2017-11-11	菲瑞茵國際中心股份有限公司	藥學製劑
CN101792481B (zh) *	2010-03-12	2012-05-30	丽珠医药集团股份有限公司	一种绒毛膜***的纯化方法
WO2012120535A2 (en) *	2011-02-03	2012-09-13	Sanzyme Limited	A composition comprising highly purified chorionic gonadotropin, it's formulation and uses of the same
WO2012131306A1 (en)	2011-03-31	2012-10-04	Ferring B.V.	Pharmaceutical preparation
WO2013102921A2 (en) *	2011-11-17	2013-07-11	Sanzyme Limited	Hcg - newer treatment modality for type 2 diabetes mellitus (t2dm)
CN103288950A (zh) *	2012-12-28	2013-09-11	青岛九龙生物医药有限公司	改进柱分离工序洗涤液和洗脱液配比去除杂质的方法
CN104101656A (zh) *	2013-04-01	2014-10-15	上海天伟生物制药有限公司	一种***的纯度测定方法
US20150065426A1 (en) *	2013-08-27	2015-03-05	Professional Compounding Centers Of America	Testosterone Booster Transdermal Compositions
CN105968185A (zh) *	2016-07-20	2016-09-28	宁波人健药业集团股份有限公司	一种绒促性素纯化方法
CN111233999B (zh) *	2020-03-21	2024-02-23	上海浦东明炎生物技术有限公司	一种从人尿中提取人绒毛膜***的方法
CN113398251B (zh) *	2021-07-30	2022-08-05	宁波人健药业集团股份有限公司	一种重组人绒毛膜***冻干粉针剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990009800A1 (en) *	1989-02-21	1990-09-07	Washington University	Modified forms of reproductive hormones
EP0571337A2 (en) *	1992-05-22	1993-11-24	SORIN BIOMEDICA S.p.A.	Process to purify proteins from cell systems
WO1998056808A1 (en) *	1997-06-13	1998-12-17	Genentech, Inc.	Protein recovery by chromatography followed by filtration upon a charged layer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1250075B (it) *	1991-12-18	1995-03-30	Serono Cesare Ist Ricerca	Composizioni farmaceutiche contenenti gonadotropine.
DK0814841T3 (da)	1995-03-21	2002-03-04	Applied Research Systems	Flydende hCG-formuleringer
EA002474B1 (ru) *	1996-02-20	2002-06-27	Апплайд Резеч Системз Арс Холдинг Н.В.	Гибридный белок, образующий гетеродимеры, способ его получения и использования
IT1287138B1 (it) *	1996-11-07	1998-08-04	Ibsa Inst Biochimique Sa	Procedimento per la separazione e purificazione di fsh e lh
WO1998056806A1 (en)	1997-06-12	1998-12-17	The Regents Of The University Of California	A TRANSCRIPTION FACTOR COACTIVATOR PROTEIN, p/CIP
US6583109B1 (en) *	1997-06-24	2003-06-24	Robert C. Gallo	Therapeutic polypeptides from β-hCG and derivatives
EA006605B1 (ru) *	2000-02-22	2006-02-24	Апплайд Резеч Системз Арс Холдинг Н.В.	СПОСОБ ОЧИСТКИ РЕКОМБИНАНТНОГО чХГ

2001
- 2001-01-22 EA EA200200892A patent/EA006605B1/ru not_active IP Right Cessation
- 2001-01-22 EP EP01901188A patent/EP1257564B1/en not_active Expired - Lifetime
- 2001-01-22 MX MXPA02007871A patent/MXPA02007871A/es active IP Right Grant
- 2001-01-22 RS YUP-602/02A patent/RS50741B/sr unknown
- 2001-01-22 SK SK1206-2002A patent/SK287146B6/sk not_active IP Right Cessation
- 2001-01-22 UA UA2002086890A patent/UA78488C2/uk unknown
- 2001-01-22 HU HU0204231A patent/HU228935B1/hu unknown
- 2001-01-22 WO PCT/EP2001/000665 patent/WO2001062773A1/en active IP Right Grant
- 2001-01-22 ME MEP-2008-389A patent/ME00296B/me unknown
- 2001-01-22 JP JP2001562554A patent/JP4588960B2/ja not_active Expired - Lifetime
- 2001-01-22 CZ CZ20022855A patent/CZ303144B6/cs not_active IP Right Cessation
- 2001-01-22 IL IL15130801A patent/IL151308A0/xx unknown
- 2001-01-22 HU HUP1300063 patent/HU1300063D0/hu unknown
- 2001-01-22 CA CA002399020A patent/CA2399020A1/en not_active Abandoned
- 2001-01-22 PL PL357508A patent/PL205149B1/pl unknown
- 2001-01-22 DK DK01901188T patent/DK1257564T3/da active
- 2001-01-22 CN CNB018053637A patent/CN100482679C/zh not_active Expired - Lifetime
- 2001-01-22 EE EEP200200469A patent/EE05644B1/xx unknown
- 2001-01-22 EP EP06024050A patent/EP1752466A3/en not_active Withdrawn
- 2001-01-22 US US10/204,630 patent/US7297777B2/en not_active Expired - Lifetime
- 2001-01-22 DE DE60135541T patent/DE60135541D1/de not_active Expired - Lifetime
- 2001-01-22 AT AT01901188T patent/ATE406378T1/de active
- 2001-01-22 AU AU26804/01A patent/AU783320B2/en not_active Expired
- 2001-01-22 BR BRPI0108556A patent/BRPI0108556B8/pt not_active IP Right Cessation
- 2001-01-22 PT PT01901188T patent/PT1257564E/pt unknown
- 2001-01-22 KR KR1020027010625A patent/KR100806911B1/ko active IP Right Grant
- 2001-01-22 SI SI200130858T patent/SI1257564T1/sl unknown
- 2001-01-22 ES ES01901188T patent/ES2307585T3/es not_active Expired - Lifetime
- 2001-01-22 UA UAA200511832A patent/UA86938C2/uk unknown
2002
- 2002-07-31 ZA ZA200206109A patent/ZA200206109B/en unknown
- 2002-08-01 HR HR20020650A patent/HRP20020650B1/xx not_active IP Right Cessation
- 2002-08-14 BG BG107000A patent/BG65807B1/bg unknown
- 2002-08-18 IL IL151308A patent/IL151308A/en active IP Right Grant
- 2002-08-21 NO NO20023985A patent/NO328694B1/no not_active IP Right Cessation
2003
- 2003-06-17 HK HK03104314.8A patent/HK1052016A1/xx unknown
2006
- 2006-01-06 AU AU2006200059A patent/AU2006200059A1/en not_active Abandoned
2007
- 2007-08-28 US US11/846,118 patent/US20070299001A1/en not_active Abandoned
2008
- 2008-10-27 CY CY20081101218T patent/CY1108460T1/el unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990009800A1 (en) *	1989-02-21	1990-09-07	Washington University	Modified forms of reproductive hormones
EP0571337A2 (en) *	1992-05-22	1993-11-24	SORIN BIOMEDICA S.p.A.	Process to purify proteins from cell systems
WO1998056808A1 (en) *	1997-06-13	1998-12-17	Genentech, Inc.	Protein recovery by chromatography followed by filtration upon a charged layer

Also Published As

Publication number	Publication date
DE60135541D1 (de)	2008-10-09
EA200200892A1 (ru)	2003-02-27
EA006605B1 (ru)	2006-02-24
BR0108556A (pt)	2003-01-28
US20070299001A1 (en)	2007-12-27
ATE406378T1 (de)	2008-09-15
EE200200469A (et)	2004-04-15
BG65807B1 (bg)	2009-12-31
PT1257564E (pt)	2008-09-10
CY1108460T1 (el)	2014-04-09
HUP0204231A2 (hu)	2003-03-28
IL151308A (en)	2009-11-18
CZ20022855A3 (cs)	2002-11-13
JP4588960B2 (ja)	2010-12-01
IL151308A0 (en)	2003-04-10
BRPI0108556B8 (pt)	2021-05-25
NO20023985L (no)	2002-08-21
RS50741B (sr)	2010-08-31
CA2399020A1 (en)	2001-08-30
UA78488C2 (en)	2007-04-10
SK287146B6 (sk)	2010-01-07
CN100482679C (zh)	2009-04-29
HU228935B1 (en)	2013-06-28
US7297777B2 (en)	2007-11-20
NO328694B1 (no)	2010-04-26
EP1257564B1 (en)	2008-08-27
CZ303144B6 (cs)	2012-05-02
UA86938C2 (uk)	2009-06-10
YU60202A (sh)	2005-09-19
AU2006200059A1 (en)	2006-02-02
KR20030001359A (ko)	2003-01-06
ME00296B (me)	2011-05-10
HRP20020650A2 (en)	2004-12-31
SK12062002A3 (sk)	2002-12-03
US20030104553A1 (en)	2003-06-05
WO2001062773A1 (en)	2001-08-30
NO20023985D0 (no)	2002-08-21
PL357508A1 (en)	2004-07-26
HU1300063D0 (hu)	2003-03-28
SI1257564T1 (sl)	2008-12-31
MEP38908A (en)	2011-02-10
DK1257564T3 (da)	2008-10-06
MXPA02007871A (es)	2003-02-10
BRPI0108556B1 (pt)	2015-04-14
ZA200206109B (en)	2003-07-31
KR100806911B1 (ko)	2008-02-22
PL205149B1 (pl)	2010-03-31
EP1752466A3 (en)	2012-10-10
CN1404485A (zh)	2003-03-19
JP2003524015A (ja)	2003-08-12
AU2680401A (en)	2001-09-03
AU783320B2 (en)	2005-10-13
EE05644B1 (et)	2013-04-15
BG107000A (en)	2003-04-30
HK1052016A1 (en)	2003-08-29
EP1257564A1 (en)	2002-11-20
ES2307585T3 (es)	2008-12-01
EP1752466A2 (en)	2007-02-14
HUP0204231A3 (en)	2005-09-28

Legal Events

Date	Code	Title	Description
2004-12-31	A1OB	Publication of a patent application
2005-05-17	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2007-11-28	PPPP	Transfer of rights	Owner name: LABORATOIRES SERONO SA, CH
2011-02-28	B1PR	Patent granted
2018-09-25	PNAN	Change of the applicant name, address/residence	Owner name: MERCK SERONO SA, CH
2019-01-11	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20181231 Year of fee payment: 19
2020-01-24	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20191217 Year of fee payment: 20
2021-02-01	PB20	Patent expired after termination of 20 years	Effective date: 20210122

Publication	Publication Date	Title
HRP20020650B1 (en)	2011-02-28	PURIFIED hCG
ES2112865T3 (es)	1998-04-16	Anticuerpos igg purificados.
ES2157994T3 (es)	2001-09-01	Inhibidores tetra y pentapeptidos sustituidos de la proteina farnesiltransferasa.
PT1162201E (pt)	2006-08-31	Derivados de ( imidazol-5-il ) metil-2-quinolinona como inibidores da proteina farnesil transferase
SE9603068D0 (sv)	1996-08-23	Process for purifying a protein
NO960772D0 (no)	1996-02-26	Naftylforbindelser og fremgangsmåte for fremstilling derav, mellomprodukter og preparater
TNSN01017A1 (fr)	2005-11-10	Compositions comprenant un antibiotique azalide, et procedes pour leur preparation
TR200200785T2 (tr)	2002-09-23	8-Fenil-6,9-dihidro-[1,2,4] triazolo [3,4-i] purin-5-on türevleri
HRP20020480B1 (en)	2006-11-30	Process for the purification of pharmacologically active proteins through cationic exchange chromatography
DK0457849T3 (da)	1995-09-11	Klæbemiddel til elektrotransport
MY125980A (en)	2006-09-29	Highly purified cytokine activating factor and methods of use
DE69911401D1 (en)	2003-10-23	Immunoregulator
CA2399100A1 (en)	2001-08-30	Purified lh
EP0087686A3 (en)	1985-09-18	Homogeneous human immune interferon and process therefor
PT1062244E (pt)	2002-12-31	Metodos melhorados para produzir proteinas do factor viii
MY119366A (en)	2005-05-31	A process for the preparation of factor ix from biological sources
AU6700796A (en)	1997-02-26	Method for the purification of proteins
IT1252867B (it)	1995-06-28	Composizioni farmaceutiche contenenti progesterone ad elevata biodisponibilita'
UA27099C2 (uk)	2000-02-28	Склад для протипухлиhhої терапії у формі розчиhу, спосіб його одержаhhя та лікарський засіб для протипухлиhhої терапії
UA42741C2 (uk)	2001-11-15	Пептид маститної вакцини (варіанти), пептид складного антигенного представлення (варіанти), фармацевтична композиція (варіанти)
BG100779A (en)	1997-09-30	Derivatives of 12.13-epoxytylosin and methods for their preparation
ZA966151B (en)	1997-02-04	Salt mediated size exclusion chromatography for buffer exchange and protein refolding.
DE59610098D1 (de)	2003-03-06	Protein mit anti-tumorwirkung
RO86650B1 (ro)	1985-03-03	Preparat farmaceutic pentru tratarea dermatozelor
DE69428437T2 (de)	2002-06-20	Chromatographie, die Siliziumdioxyd basierende Adsorbentien verwendet.