HRP20010113A2 - Process for purifying human papillomavirus virus-like particles - Google Patents

Process for purifying human papillomavirus virus-like particles Download PDF

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Publication number
HRP20010113A2
HRP20010113A2 HR20010113A HRP20010113A HRP20010113A2 HR P20010113 A2 HRP20010113 A2 HR P20010113A2 HR 20010113 A HR20010113 A HR 20010113A HR P20010113 A HRP20010113 A HR P20010113A HR P20010113 A2 HRP20010113 A2 HR P20010113A2
Authority
HR
Croatia
Prior art keywords
vlps
hpv
protein
vlp
hpv type
Prior art date
Application number
HR20010113A
Other languages
English (en)
Croatian (hr)
Inventor
James C Cook
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HRP20010113A2 publication Critical patent/HRP20010113A2/hr

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02Recovery or purification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20023Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20051Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HR20010113A 1998-08-14 2001-02-14 Process for purifying human papillomavirus virus-like particles HRP20010113A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9656898P 1998-08-14 1998-08-14
PCT/US1999/017930 WO2000009671A1 (en) 1998-08-14 1999-08-10 Process for purifying human papillomavirus virus-like particles

Publications (1)

Publication Number Publication Date
HRP20010113A2 true HRP20010113A2 (en) 2002-02-28

Family

ID=22257989

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010113A HRP20010113A2 (en) 1998-08-14 2001-02-14 Process for purifying human papillomavirus virus-like particles

Country Status (24)

Country Link
US (1) US6602697B1 (zh)
EP (1) EP1105466B1 (zh)
JP (1) JP4440471B2 (zh)
KR (1) KR20010072470A (zh)
CN (1) CN1354787A (zh)
AT (1) ATE324436T1 (zh)
AU (1) AU760633B2 (zh)
BR (1) BR9913026A (zh)
CA (1) CA2339034C (zh)
CY (1) CY1105084T1 (zh)
CZ (1) CZ2001570A3 (zh)
DE (1) DE69931053T2 (zh)
DK (1) DK1105466T3 (zh)
EA (1) EA200100236A1 (zh)
ES (1) ES2262333T3 (zh)
HR (1) HRP20010113A2 (zh)
HU (1) HUP0103091A3 (zh)
IL (1) IL141130A0 (zh)
NZ (1) NZ509610A (zh)
PL (1) PL347472A1 (zh)
PT (1) PT1105466E (zh)
SI (1) SI1105466T1 (zh)
SK (1) SK2232001A3 (zh)
WO (1) WO2000009671A1 (zh)

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JP2000262280A (ja) * 1999-03-18 2000-09-26 Asahi Optical Co Ltd ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
MY139500A (en) * 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
SG150501A1 (en) * 2004-02-05 2009-03-30 Millipore Corp Porous adsorptive or chromatographic media
PT1730175E (pt) * 2004-03-24 2010-06-25 Merck Sharp & Dohme Expressão optimizada de hpv 52 l1 em levedura
DE602005022458D1 (de) 2004-09-10 2010-09-02 Asahi Glass Co Ltd Impfstoff gegen humanes papillomavirus zur oralen verabreichung
EP1736538A1 (en) * 2005-06-21 2006-12-27 Cytos Biotechnology AG Process for the preparative purification of virus-like-particles (VLPs)
WO2008027861A1 (en) * 2006-08-30 2008-03-06 Ge Healthcare Bio-Sciences Corp. System and method for characterizing membranes and membrane filtration devices
SG174845A1 (en) 2006-09-29 2011-10-28 Ligocyte Pharmaceuticals Inc Norovirus vaccine formulations
CA2677023C (en) * 2007-02-22 2016-08-30 Baxter International Inc. Method of purification of hydrophobic proteins
KR20150098681A (ko) 2007-03-14 2015-08-28 다케다 백신즈 인코포레이티드 바이러스 유사 입자 정제
DK2147926T3 (en) 2007-04-29 2016-11-28 Beijing Wantai Biological Pharmacy Entpr Co Ltd Truncated human papillomavirus type 18 L1 protein
BRPI0811016B1 (pt) 2007-04-29 2021-09-21 Xiamen Innovax Biotech Co., Ltd. Proteína li truncada do papiloma vírus humano tipo 16
BRPI0810951B8 (pt) * 2007-05-29 2021-05-25 Beijing Wantai Biological Pharmacy Entpr Co Ltd proteína l1 do hpv6, polinucleotídeo, vetor, célula, partícula semelhante ao vírus (vlp) hpv6, método para produzir a proteína hpv6 l1 truncada, vacina para prevenção de condiloma acuminado ou de infecções por hpv, uso da proteína hpv6 l1 truncada, método para prevenção de condiloma acuminado ou infecções por hpv, método para obter uma vlp de uma proteína l1 do hpv6 e método para produzir uma vacina para a prevenção de condiloma acuminado ou de infecções por hpv
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
JP2010539192A (ja) * 2007-09-18 2010-12-16 リゴサイト ファーマスーティカルズ,インコーポレイテッド ノロウイルスに対して防御免疫応答を付与する方法
DE602007007927D1 (de) * 2007-11-05 2010-09-02 Agilent Technologies Inc Einfrierung eines mikrofluidischen Chips
US20090130738A1 (en) * 2007-11-19 2009-05-21 Mikhail Kozlov Media for membrane ion exchange chromatography
KR101793161B1 (ko) * 2008-08-08 2017-11-03 다케다 백신즈 인코포레이티드 강화된 교차 반응성을 가진 복합체 캡시드 아미노산 서열들을 포함하는 바이러스-유사 입자들
EP2524215B1 (en) * 2010-01-15 2018-12-26 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
CN102985536B (zh) 2010-04-14 2017-12-05 Emd密理博公司 生产高效价、高纯度的病毒母液的方法及使用其的方法
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
JP5881744B2 (ja) 2011-02-02 2016-03-09 バイオ−ラッド ラボラトリーズ インコーポレーティッド アルカリ溶液でのアパタイトの表面中和方法
ES2656527T3 (es) 2011-07-11 2018-02-27 Takeda Vaccines, Inc. Formulaciones parenterales de vacunas de norovirus
MY184076A (en) * 2011-12-01 2021-03-17 Univ Cape Town Hpv chimaeric particle
WO2013180933A1 (en) 2012-05-30 2013-12-05 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
KR101559622B1 (ko) 2012-07-30 2015-10-13 중앙대학교 산학협력단 인유두종바이러스 바이러스 유사입자의 고효율 정제방법
JP6479305B2 (ja) * 2013-07-12 2019-03-06 株式会社Umnファーマ ウイルス様粒子の精製方法
EP3157689B1 (en) 2014-06-23 2021-04-28 Bio-Rad Laboratories, Inc. Apatite pretreatment
EP3157863B1 (en) 2014-06-23 2023-06-21 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN105907729B (zh) * 2015-05-05 2019-08-16 广东东阳光药业有限公司 一种制备人***瘤病毒l1蛋白类病毒样颗粒的方法
CN108524929B (zh) * 2017-03-06 2019-05-07 广州瑞贝斯药业有限公司 一种狂犬病疫苗的生产方法

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JPS6078999A (ja) 1983-10-05 1985-05-04 Chemo Sero Therapeut Res Inst HBs抗原の精製方法
SE9000650L (sv) 1989-02-28 1990-08-29 Asahi Optical Co Ltd Separation av celler eller virus
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SK35897A3 (en) * 1994-09-22 1998-02-04 Merck & Co Inc Isolated and purified dna molecule, encoding human papillomavirus type 6a, method of expression, pharmaceutical composition, a vaccine and use
AR004464A1 (es) * 1994-11-14 1998-12-16 Merck Sharp & Dohme Un metodo para producir una proteina de capside de papilomavirus
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Also Published As

Publication number Publication date
HUP0103091A3 (en) 2002-03-28
US6602697B1 (en) 2003-08-05
DE69931053T2 (de) 2006-11-23
CA2339034A1 (en) 2000-02-24
CY1105084T1 (el) 2009-11-04
SK2232001A3 (en) 2001-08-06
SI1105466T1 (sl) 2006-08-31
PT1105466E (pt) 2006-07-31
CA2339034C (en) 2010-10-12
EP1105466B1 (en) 2006-04-26
HUP0103091A2 (hu) 2001-12-28
NZ509610A (en) 2002-10-25
AU760633B2 (en) 2003-05-22
PL347472A1 (en) 2002-04-08
EP1105466A1 (en) 2001-06-13
JP2003520188A (ja) 2003-07-02
JP4440471B2 (ja) 2010-03-24
EA200100236A1 (ru) 2001-08-27
EP1105466A4 (en) 2002-05-15
DE69931053D1 (de) 2006-06-01
WO2000009671A1 (en) 2000-02-24
CZ2001570A3 (cs) 2001-09-12
CN1354787A (zh) 2002-06-19
ES2262333T3 (es) 2006-11-16
ATE324436T1 (de) 2006-05-15
IL141130A0 (en) 2002-02-10
DK1105466T3 (da) 2006-08-14
KR20010072470A (ko) 2001-07-31
BR9913026A (pt) 2001-09-25
AU5469899A (en) 2000-03-06

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