DK1105466T3 - Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler - Google Patents

Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Info

Publication number
DK1105466T3
DK1105466T3 DK99940950T DK99940950T DK1105466T3 DK 1105466 T3 DK1105466 T3 DK 1105466T3 DK 99940950 T DK99940950 T DK 99940950T DK 99940950 T DK99940950 T DK 99940950T DK 1105466 T3 DK1105466 T3 DK 1105466T3
Authority
DK
Denmark
Prior art keywords
particles
human papillomavirus
papillomavirus virus
vlps
purifying human
Prior art date
Application number
DK99940950T
Other languages
English (en)
Inventor
James C Cook Iii
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK1105466T3 publication Critical patent/DK1105466T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20051—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK99940950T 1998-08-14 1999-08-10 Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler DK1105466T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9656898P 1998-08-14 1998-08-14

Publications (1)

Publication Number Publication Date
DK1105466T3 true DK1105466T3 (da) 2006-08-14

Family

ID=22257989

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99940950T DK1105466T3 (da) 1998-08-14 1999-08-10 Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Country Status (24)

Country Link
US (1) US6602697B1 (da)
EP (1) EP1105466B1 (da)
JP (1) JP4440471B2 (da)
KR (1) KR20010072470A (da)
CN (1) CN1354787A (da)
AT (1) ATE324436T1 (da)
AU (1) AU760633B2 (da)
BR (1) BR9913026A (da)
CA (1) CA2339034C (da)
CY (1) CY1105084T1 (da)
CZ (1) CZ2001570A3 (da)
DE (1) DE69931053T2 (da)
DK (1) DK1105466T3 (da)
EA (1) EA200100236A1 (da)
ES (1) ES2262333T3 (da)
HR (1) HRP20010113A2 (da)
HU (1) HUP0103091A3 (da)
IL (1) IL141130A0 (da)
NZ (1) NZ509610A (da)
PL (1) PL347472A1 (da)
PT (1) PT1105466E (da)
SI (1) SI1105466T1 (da)
SK (1) SK2232001A3 (da)
WO (1) WO2000009671A1 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69935606T9 (de) * 1998-10-16 2021-03-11 Glaxosmithkline Biologicals S.A. Adjuvanzsysteme und impfstoffe
JP2000262280A (ja) * 1999-03-18 2000-09-26 Asahi Optical Co Ltd ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
MY139500A (en) * 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
WO2005077528A1 (en) * 2004-02-05 2005-08-25 Millipore Corporation Porous adsorptive or chromatographic media
PL1730175T3 (pl) * 2004-03-24 2010-09-30 Merck Sharp & Dohme Optymalizowana ekspresja L1 HPV 52 w drożdżach
WO2006028214A1 (ja) 2004-09-10 2006-03-16 Asahi Glass Company, Limited 経口投与ワクチン
EP1736538A1 (en) * 2005-06-21 2006-12-27 Cytos Biotechnology AG Process for the preparative purification of virus-like-particles (VLPs)
WO2008027861A1 (en) * 2006-08-30 2008-03-06 Ge Healthcare Bio-Sciences Corp. System and method for characterizing membranes and membrane filtration devices
AU2007303608B2 (en) * 2006-09-29 2013-05-02 Takeda Vaccines, Inc. Norovirus vaccine formulations
CA2677023C (en) * 2007-02-22 2016-08-30 Baxter International Inc. Method of purification of hydrophobic proteins
US8481693B2 (en) 2007-03-14 2013-07-09 Takeda Vaccines (Montana), Inc. Virus like particle purification
WO2008134934A1 (en) 2007-04-29 2008-11-13 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. A truncated l1 protein of human papillomavirus 16
US9364529B2 (en) 2007-04-29 2016-06-14 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated L1 protein of human papillomavirus type 18
EP2154149B1 (en) * 2007-05-29 2019-07-10 Xiamen University A truncated l1 protein of human papillomavirus 6
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
KR20100083150A (ko) 2007-09-18 2010-07-21 리고사이트 파머슈티컬즈 인코퍼레이티드 노로바이러스에 대한 보호면역반응을 제공하는 방법
EP2011573B1 (en) * 2007-11-05 2010-07-21 Agilent Technologies, Inc. Freezing a microfluidic chip
US20090130738A1 (en) * 2007-11-19 2009-05-21 Mikhail Kozlov Media for membrane ion exchange chromatography
AU2009279456B2 (en) * 2008-08-08 2015-02-05 Takeda Vaccines, Inc. Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
CA2787009C (en) 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
JP2013523175A (ja) 2010-04-14 2013-06-17 イーエムディー・ミリポア・コーポレーション 高力価、高純度のウイルスストックの作製方法及びその使用方法
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
US9592540B2 (en) 2011-02-02 2017-03-14 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
EA035442B1 (ru) 2011-07-11 2020-06-17 Такеда Вэксинс, Инк. Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения
SG11201401579UA (en) 2011-12-01 2014-07-30 Univ Cape Town Hpv chimaeric particle
WO2013180933A1 (en) 2012-05-30 2013-12-05 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
KR101559622B1 (ko) 2012-07-30 2015-10-13 중앙대학교 산학협력단 인유두종바이러스 바이러스 유사입자의 고효율 정제방법
JP6479305B2 (ja) * 2013-07-12 2019-03-06 株式会社Ｕｍｎファーマ ウイルス様粒子の精製方法
US9802822B2 (en) 2014-06-23 2017-10-31 Bio-Rad Laboratories, Inc. Apatite pretreatment
CN105407917B (zh) 2014-06-23 2021-07-06 生物辐射实验室股份有限公司 磷灰石原位恢复
CN105907729B (zh) * 2015-05-05 2019-08-16 广东东阳光药业有限公司 一种制备人***瘤病毒l1蛋白类病毒样颗粒的方法
CN108524929B (zh) * 2017-03-06 2019-05-07 广州瑞贝斯药业有限公司 一种狂犬病疫苗的生产方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6078999A (ja) 1983-10-05 1985-05-04 Chemo Sero Therapeut Res Inst ＨＢｓ抗原の精製方法
SE9000650L (sv) 1989-02-28 1990-08-29 Asahi Optical Co Ltd Separation av celler eller virus
MXPA96005662A (es) * 1994-05-16 2004-08-19 Merck & Co Inc Vacunas de papilomavirus.
RU2177999C2 (ru) * 1994-09-22 2002-01-10 Мерк Энд Ко., Инк. Экспрессирующий вектор (варианты)
AR004464A1 (es) * 1994-11-14 1998-12-16 Merck Sharp & Dohme Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) * 1995-03-22 2005-11-20 Merck & Co Inc Dna encoding human papillomavirus type 18
IL117591A0 (en) * 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
EP0847442A1 (en) * 1995-08-30 1998-06-17 Genzyme Corporation Chromatographic purification of adenovirus and aav

Also Published As

Publication number Publication date
JP4440471B2 (ja) 2010-03-24
CA2339034C (en) 2010-10-12
EP1105466A1 (en) 2001-06-13
HUP0103091A2 (hu) 2001-12-28
SK2232001A3 (en) 2001-08-06
JP2003520188A (ja) 2003-07-02
CN1354787A (zh) 2002-06-19
IL141130A0 (en) 2002-02-10
WO2000009671A1 (en) 2000-02-24
PL347472A1 (en) 2002-04-08
ATE324436T1 (de) 2006-05-15
CA2339034A1 (en) 2000-02-24
EA200100236A1 (ru) 2001-08-27
BR9913026A (pt) 2001-09-25
CY1105084T1 (el) 2009-11-04
PT1105466E (pt) 2006-07-31
HRP20010113A2 (en) 2002-02-28
EP1105466B1 (en) 2006-04-26
EP1105466A4 (en) 2002-05-15
CZ2001570A3 (cs) 2001-09-12
HUP0103091A3 (en) 2002-03-28
SI1105466T1 (sl) 2006-08-31
DE69931053D1 (de) 2006-06-01
ES2262333T3 (es) 2006-11-16
DE69931053T2 (de) 2006-11-23
US6602697B1 (en) 2003-08-05
AU760633B2 (en) 2003-05-22
KR20010072470A (ko) 2001-07-31
AU5469899A (en) 2000-03-06
NZ509610A (en) 2002-10-25

Similar Documents

Publication Publication Date Title
DK1105466T3 (da) Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler
DE60029195D1 (de) Verfahren zur gewinnung von purifizierter virenzuammensetzung
DK1133283T3 (da) Fremgangsmåde til fremstilling af lægemiddelpartikler
NO305033B1 (no) Fremgangsmate for fremstilling av uronsyreblokker fra alginat
ES2091069T3 (es) Procedimiento de purificacion de pentafluoroetano.
FR11C0022I1 (da)
AU2449500A (en) Preparation of iodixanol
DE3752362T2 (de) Optisch aktive Verbindungen
FI102962B1 (fi) Menetelmä ksylitolin valmistamiseksi
DE60042343D1 (de) Abtrennung von fibrinogen von plasmaproteasen
EP0816374A3 (en) A method of preparing a composition containing a high proportion of ganglioside
WO2002030983A3 (de) Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung
IT1287138B1 (it) Procedimento per la separazione e purificazione di fsh e lh
MXPA03007992A (es) Composicion farmaceutica de fragmentos f(ab)2 de anticuerpos y un proceso para su preparacion
DE59610629D1 (de) Immunogenes konstrukt, verfahren zu dessen herstellung und verwendung als vakzine
WO2001046686A3 (de) Chromatographiematerial und verfahren unter verwendung desselben
WO2004029279A3 (en) Process for recovery of daughter isotopes from a source material
DK1315757T3 (da) Fremgangsmåde til oprensning af EPI-HNE-proteiner
FI953493A0 (fi) Menetelmä molybdeenin talteen ottamiseksi lähtien epäpuhtaasta kalsiummolybdaatista, joka on saatu käsittelemällä uraanipitoisia malmeja
KR970017809A (ko) 음극선관의 튜브 재생 방법
EP0955367A3 (en) Recombinant nucleoprotein of toscana virus
AU2003222305A1 (en) Separation process of 1,1,1,2-tetrafluoro-2-chloroethane (hcfc-124) from 1,1,2,2-tetrafluoro-1-chloroethane (hcfc-124a)