HK1083018A1 - Methods for synthesis of acyloxyalkyl derivatives of gaba analogs - Google Patents

Methods for synthesis of acyloxyalkyl derivatives of gaba analogs

Info

Publication number
HK1083018A1
HK1083018A1 HK06103037.3A HK06103037A HK1083018A1 HK 1083018 A1 HK1083018 A1 HK 1083018A1 HK 06103037 A HK06103037 A HK 06103037A HK 1083018 A1 HK1083018 A1 HK 1083018A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
methods
gaba analogs
acyloxyalkyl derivatives
acyloxyalkyl
Prior art date
Application number
HK06103037.3A
Other languages
English (en)
Inventor
Stephen P Raillard
Cindy X Zhou
Fenmei Yao
Suresh Kumar Manthati
Jia-Ning Xiang
Mark A Gallop
Original Assignee
Xenoport Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenoport Inc filed Critical Xenoport Inc
Publication of HK1083018A1 publication Critical patent/HK1083018A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK06103037.3A 2002-06-11 2006-03-09 Methods for synthesis of acyloxyalkyl derivatives of gaba analogs HK1083018A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/171,485 US6818787B2 (en) 2001-06-11 2002-06-11 Prodrugs of GABA analogs, compositions and uses thereof
PCT/US2003/018495 WO2003104184A1 (fr) 2002-06-11 2003-06-11 Procede pour une synthese de derives acyloxyalkyle d'analogues du gaba

Publications (1)

Publication Number Publication Date
HK1083018A1 true HK1083018A1 (en) 2006-06-23

Family

ID=29732785

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06103037.3A HK1083018A1 (en) 2002-06-11 2006-03-09 Methods for synthesis of acyloxyalkyl derivatives of gaba analogs

Country Status (10)

Country Link
US (2) US6818787B2 (fr)
EP (2) EP2275401B1 (fr)
JP (1) JP4310271B2 (fr)
CN (2) CN101613307A (fr)
AU (1) AU2003247522A1 (fr)
DK (1) DK2275401T3 (fr)
ES (1) ES2416032T3 (fr)
HK (1) HK1083018A1 (fr)
IL (1) IL165687A (fr)
WO (1) WO2003104184A1 (fr)

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US20030176398A1 (en) 2003-09-18
EP2275401A1 (fr) 2011-01-19
CN100540526C (zh) 2009-09-16
WO2003104184A1 (fr) 2003-12-18
EP2275401B1 (fr) 2013-04-03
US20040006132A1 (en) 2004-01-08
US6972341B2 (en) 2005-12-06
US6818787B2 (en) 2004-11-16
JP4310271B2 (ja) 2009-08-05
JP2005529941A (ja) 2005-10-06
CN1675165A (zh) 2005-09-28
EP1554237A4 (fr) 2006-11-02
EP1554237A1 (fr) 2005-07-20
IL165687A (en) 2011-02-28
CN101613307A (zh) 2009-12-30

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