HK1040516B - 帕羅西汀的製備方法 - Google Patents

帕羅西汀的製備方法

Info

Publication number
HK1040516B
HK1040516B HK02101971.9A HK02101971A HK1040516B HK 1040516 B HK1040516 B HK 1040516B HK 02101971 A HK02101971 A HK 02101971A HK 1040516 B HK1040516 B HK 1040516B
Authority
HK
Hong Kong
Prior art keywords
paroxetine
production
sesamol
derivatisation
dealkylation
Prior art date
Application number
HK02101971.9A
Other languages
English (en)
Other versions
HK1040516A1 (en
Inventor
R‧羅希
S‧特查塔
M‧唐納魯瑪
Original Assignee
裡科達蒂化學藥物公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 裡科達蒂化學藥物公司 filed Critical 裡科達蒂化學藥物公司
Publication of HK1040516A1 publication Critical patent/HK1040516A1/xx
Publication of HK1040516B publication Critical patent/HK1040516B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
HK02101971.9A 1999-02-23 2002-03-14 帕羅西汀的製備方法 HK1040516B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000364A IT1308629B1 (it) 1999-02-23 1999-02-23 Processo per la produzione di paroxetina.
PCT/EP2000/001430 WO2000050422A1 (en) 1999-02-23 2000-02-22 Process for the production of paroxetine

Publications (2)

Publication Number Publication Date
HK1040516A1 HK1040516A1 (en) 2002-06-14
HK1040516B true HK1040516B (zh) 2003-10-31

Family

ID=11382007

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02101971.9A HK1040516B (zh) 1999-02-23 2002-03-14 帕羅西汀的製備方法

Country Status (28)

Country Link
US (1) US6583287B1 (zh)
EP (1) EP1153023B1 (zh)
JP (1) JP2002537394A (zh)
KR (1) KR20010102366A (zh)
CN (1) CN1161353C (zh)
AT (1) ATE238295T1 (zh)
AU (1) AU759441B2 (zh)
BR (1) BR0008220A (zh)
CA (1) CA2361758A1 (zh)
CZ (1) CZ20012997A3 (zh)
DE (1) DE60002303T2 (zh)
DK (1) DK1153023T3 (zh)
ES (1) ES2195876T3 (zh)
HK (1) HK1040516B (zh)
HR (1) HRP20010608A2 (zh)
HU (1) HUP0105482A3 (zh)
IL (1) IL144883A (zh)
IT (1) IT1308629B1 (zh)
MX (1) MXPA01008502A (zh)
NO (1) NO319724B1 (zh)
PL (1) PL349358A1 (zh)
PT (1) PT1153023E (zh)
RU (1) RU2242473C2 (zh)
SK (1) SK12042001A3 (zh)
TR (1) TR200102441T2 (zh)
TW (1) TWI221473B (zh)
WO (1) WO2000050422A1 (zh)
YU (1) YU60801A (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2289650T3 (es) * 2004-03-03 2008-02-01 Chemi S.P.A. Sal monosodica del acido 3-piridil-1-hidroxietiliden-1,1-bifosfonico amorfa y procedimiento para la preparacion de la misma.
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
AU2013216123B2 (en) * 2012-01-31 2016-10-20 Eisai R&D Management Co., Ltd. Paroxetine derivative
CN106831736A (zh) * 2017-02-15 2017-06-13 浙江华海药业股份有限公司 一种制备帕罗西汀杂质的方法
CN112521377A (zh) * 2020-11-26 2021-03-19 北京福元医药股份有限公司 一种盐酸帕罗西汀的连续化制备方法
CN115260153B (zh) * 2022-07-21 2023-10-27 威尚（上海）生物医药有限公司 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0757758B2 (ja) 1988-10-24 1995-06-21 高砂香料工業株式会社 ルテニウム―ホスフィン錯体
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5233084A (en) * 1989-06-22 1993-08-03 Monsanto Company Method for preparing α-arylpropionic acids
FR2651152B1 (fr) * 1989-08-23 1991-11-29 Elf Aquitaine Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore.
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
DE4422672A1 (de) * 1994-06-30 1996-01-04 Hoechst Ag Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung
HUP9900318A3 (en) * 1995-05-17 2001-09-28 Novo Nordisk As Process for preparing 4-aryl-piperidine derivatives
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
EP0983239A1 (en) * 1997-05-06 2000-03-08 Novo Nordisk A/S Novel heterocyclic compounds
EP0920354B1 (en) * 1997-05-20 2003-12-03 Firmenich Sa Ruthenium catalysts and their use in the asymmetric hydrogenation of weakly coordinating substrates

Also Published As

Publication number Publication date
SK12042001A3 (sk) 2001-12-03
DE60002303D1 (de) 2003-05-28
WO2000050422A1 (en) 2000-08-31
YU60801A (sh) 2005-07-19
BR0008220A (pt) 2001-11-06
IL144883A (en) 2004-12-15
EP1153023A1 (en) 2001-11-14
HK1040516A1 (en) 2002-06-14
US6583287B1 (en) 2003-06-24
DE60002303T2 (de) 2004-04-01
NO20014078L (no) 2001-10-18
MXPA01008502A (es) 2003-06-06
ATE238295T1 (de) 2003-05-15
CN1161353C (zh) 2004-08-11
TR200102441T2 (tr) 2002-01-21
JP2002537394A (ja) 2002-11-05
IL144883A0 (en) 2002-06-30
PT1153023E (pt) 2003-09-30
NO20014078D0 (no) 2001-08-22
AU3158300A (en) 2000-09-14
NO319724B1 (no) 2005-09-05
TWI221473B (en) 2004-10-01
AU759441B2 (en) 2003-04-17
KR20010102366A (ko) 2001-11-15
EP1153023B1 (en) 2003-04-23
HUP0105482A3 (en) 2002-11-28
IT1308629B1 (it) 2002-01-09
ITMI990364A1 (it) 2000-08-23
HRP20010608A2 (en) 2002-08-31
HUP0105482A2 (en) 2002-08-28
CN1341113A (zh) 2002-03-20
PL349358A1 (en) 2002-07-15
CA2361758A1 (en) 2000-08-31
DK1153023T3 (da) 2003-08-11
CZ20012997A3 (cs) 2001-11-14
RU2242473C2 (ru) 2004-12-20
ES2195876T3 (es) 2003-12-16

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070222