TW200500368A - Process to tetrahydrotriazolopyrazines and intermediates - Google Patents

Process to tetrahydrotriazolopyrazines and intermediates

Info

Publication number
TW200500368A
TW200500368A TW093105894A TW93105894A TW200500368A TW 200500368 A TW200500368 A TW 200500368A TW 093105894 A TW093105894 A TW 093105894A TW 93105894 A TW93105894 A TW 93105894A TW 200500368 A TW200500368 A TW 200500368A
Authority
TW
Taiwan
Prior art keywords
tetrahydrotriazolopyrazines
intermediates
useful
pyrazines
triazolo
Prior art date
Application number
TW093105894A
Other languages
Chinese (zh)
Inventor
Jaume Balsells
Jin-Chu Liu
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of TW200500368A publication Critical patent/TW200500368A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles

Abstract

A novel process is provided for the preparation of substituted-5,6,7,8-tetrahydro[1,2,4]-triazolo[4,3-α]pyrazines which are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.
TW093105894A 2003-03-07 2004-03-05 Process to tetrahydrotriazolopyrazines and intermediates TW200500368A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45274803P 2003-03-07 2003-03-07

Publications (1)

Publication Number Publication Date
TW200500368A true TW200500368A (en) 2005-01-01

Family

ID=32990678

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093105894A TW200500368A (en) 2003-03-07 2004-03-05 Process to tetrahydrotriazolopyrazines and intermediates

Country Status (3)

Country Link
AR (1) AR043443A1 (en)
TW (1) TW200500368A (en)
WO (1) WO2004080958A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE553077T1 (en) 2004-07-23 2012-04-15 Nuada Llc PEPTIDATE INHIBITORS
NZ566799A (en) 2005-09-14 2011-04-29 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors for treating diabetes
CN101360723A (en) 2005-09-16 2009-02-04 武田药品工业株式会社 Process for the preparation of pyrimidinedione derivatives
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US10065960B2 (en) 2010-04-02 2018-09-04 Ogeda Sa NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
BR112012025101B1 (en) 2010-04-02 2021-08-31 Ogeda S.A. Selective nk-3 receptor antagonist compounds, pharmaceutical composition and drug comprising them
CN102372716A (en) 2010-08-09 2012-03-14 江苏恒瑞医药股份有限公司 Phthalazone derivative, its preparation method and application in medicine thereof
CN101973997B (en) * 2010-09-30 2012-06-06 浙江大学 Method for preparing sitagliptin phosphate side chain
US20150025080A1 (en) 2011-06-29 2015-01-22 Ranbaxy Laboratories Limited Solid dispersions of sitagliptin and processes for their preparation
AU2012277403A1 (en) 2011-06-30 2014-01-30 Ranbaxy Laboratories Limited Novel salts of sitagliptin
RS54833B1 (en) 2011-10-03 2016-10-31 Euroscreen Sa Novel chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, and methods for use in nk-3 receptor mediated disorders
EP2788352A1 (en) 2011-12-08 2014-10-15 Ranbaxy Laboratories Limited Amorphous form of sitagliptin salts
PL3197876T3 (en) 2014-09-25 2019-05-31 Ogeda Sa Novel chiral synthesis of n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines
ES2638266T3 (en) 2015-10-22 2017-10-19 F.I.S.- Fabbrica Italiana Sintetici S.P.A. Improved procedure for the preparation of triazole and one of its salts
US10047094B1 (en) 2017-02-10 2018-08-14 F.I.S.—Fabbrica Italiana Sintetici S.p.A. Process for the preparation of triazole and salt thereof
EP3424927B1 (en) 2017-07-04 2019-04-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
WO2019137358A1 (en) * 2018-01-09 2019-07-18 江苏恒瑞医药股份有限公司 Method for preparing parp inhibitor and intermediate thereof
EP3524605B1 (en) 2018-02-13 2019-11-27 F.I.S.- Fabbrica Italiana Sintetici S.p.A. New efficient process for the preparation of sitagliptin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3252483B2 (en) * 1992-10-20 2002-02-04 東レ株式会社 Method for producing tricyclic triazolo derivative
UA74912C2 (en) * 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
MY139563A (en) * 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues

Also Published As

Publication number Publication date
WO2004080958A2 (en) 2004-09-23
WO2004080958A3 (en) 2004-12-23
AR043443A1 (en) 2005-07-27

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