US5698711A
(en)
|
1991-01-28 |
1997-12-16 |
Rhone-Poulenc Rorer Limited |
Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
|
GB9311281D0
(en)
*
|
1993-06-01 |
1993-07-21 |
Rhone Poulenc Rorer Ltd |
Novel composition of matter
|
US6096768A
(en)
*
|
1992-01-28 |
2000-08-01 |
Rhone-Poulenc Rorer Limited |
Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
|
WO1997003967A1
(en)
*
|
1995-07-22 |
1997-02-06 |
Rhone-Poulenc Rorer Limited |
Substituted aromatic compounds and their pharmaceutical use
|
EP0923568B9
(en)
*
|
1996-08-19 |
2003-08-13 |
ALTANA Pharma AG |
Novel benzofuran-4-carboxamides
|
US6331543B1
(en)
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
US5958926A
(en)
*
|
1996-11-01 |
1999-09-28 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
|
US5874437A
(en)
*
|
1996-11-01 |
1999-02-23 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
|
USRE37234E1
(en)
*
|
1996-11-01 |
2001-06-19 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
|
WO1998019672A1
(en)
*
|
1996-11-01 |
1998-05-14 |
Nitromed Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
|
CN1123345C
(zh)
*
|
1997-02-17 |
2003-10-08 |
奥坦纳医药公司 |
治疗ards或irds的组合物
|
US6472425B1
(en)
|
1997-10-31 |
2002-10-29 |
Nitromed, Inc. |
Methods for treating female sexual dysfunctions
|
US6172118B1
(en)
*
|
1998-04-14 |
2001-01-09 |
Smithkline Beecham Corporation |
Compounds
|
CA2364258C
(en)
|
1999-03-10 |
2008-12-30 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
3-cyclopropylmethoxy-4-difluoromethoxy-n-(3,5-dichloropyrid-4-yl)benzamide in the treatment of multiple sclerosis
|
US6653309B1
(en)
|
1999-04-26 |
2003-11-25 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme technical field of the invention
|
ES2228512T3
(es)
*
|
1999-05-04 |
2005-04-16 |
Altana Pharma Ag |
Combinacion sinergica que comprende roflumilast y un inhibidor de pde-3.
|
CA2381802C
(en)
|
1999-08-21 |
2010-12-07 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Synergistic combination of roflumilast and salmeterol
|
AU2001261962B2
(en)
*
|
2000-05-25 |
2005-04-21 |
Merck Frosst Canada Ltd |
Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
|
DE10043074A1
(de)
*
|
2000-09-01 |
2002-03-14 |
Aventis Cropscience Gmbh |
Herbizid wirksame Benzoylcyclohexandione
|
EP1188438A1
(en)
*
|
2000-09-15 |
2002-03-20 |
Warner-Lambert Company |
Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
|
EP1199074A1
(en)
*
|
2000-09-15 |
2002-04-24 |
Warner-Lambert Company |
Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
|
WO2002038155A1
(en)
*
|
2000-11-07 |
2002-05-16 |
Merck & Co., Inc. |
Method of treatment with a combination of a pde4 inhibitor and a leukotriene antagonist
|
US20100310477A1
(en)
*
|
2000-11-28 |
2010-12-09 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg. |
Pharmaceutical compositions based on anticholingerics and additional active ingredients
|
US6699890B2
(en)
|
2000-12-22 |
2004-03-02 |
Memory Pharmaceuticals Corp. |
Phosphodiesterase 4 inhibitors
|
US7153871B2
(en)
|
2001-01-22 |
2006-12-26 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
|
US7205320B2
(en)
|
2001-01-22 |
2007-04-17 |
Memory Pharmaceuticals Corp. |
Phosphodiesterase 4 inhibitors
|
US6872382B1
(en)
|
2001-05-21 |
2005-03-29 |
Alcon, Inc. |
Use of selective PDE IV inhibitors to treat dry eye disorders
|
EP1397359B1
(en)
|
2001-05-24 |
2005-08-31 |
Merck Frosst Canada & Co. |
1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors
|
IL160253A0
(en)
*
|
2001-08-09 |
2004-07-25 |
Ono Pharmaceutical Co |
Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
|
MY140561A
(en)
*
|
2002-02-20 |
2009-12-31 |
Nycomed Gmbh |
Dosage form containing pde 4 inhibitor as active ingredient
|
DE10207160A1
(de)
*
|
2002-02-20 |
2003-12-18 |
Altana Pharma Ag |
Darreichungsform enthaltend PDE 4-Hemmer als Wirkstoff
|
TWI347845B
(en)
*
|
2002-03-06 |
2011-09-01 |
Nycomed Gmbh |
Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
|
PL373287A1
(en)
*
|
2002-05-07 |
2005-08-22 |
Altana Pharma Ag |
New combination of reversible proton pump inhibitors and airway therapeutics for treating airway disorders
|
WO2003094968A2
(en)
*
|
2002-05-07 |
2003-11-20 |
Altana Pharma Ag |
Combination of a proton pump inhibitor and a respiratory agent for the treatment of respiratory diseases
|
JP2005532321A
(ja)
*
|
2002-05-16 |
2005-10-27 |
ファルマシア コーポレーション |
呼吸器の疾患および状態の、選択的iNOS阻害剤とPDE阻害剤による治療方法、ならびにそのための組成物
|
NZ537308A
(en)
*
|
2002-05-28 |
2009-09-25 |
Nycomed Gmbh |
Ophthalmological use of roflumilast for the treatment of diseases of the eye
|
WO2004009552A1
(en)
|
2002-07-19 |
2004-01-29 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
|
CN101423497A
(zh)
*
|
2002-07-19 |
2009-05-06 |
记忆药物公司 |
作为磷酸二酯酶4抑制剂的6-氨基-1h-吲唑和4-氨基苯并呋喃化合物
|
WO2004022536A1
(en)
*
|
2002-09-04 |
2004-03-18 |
Glenmark Pharmaceuticals Limited |
New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
|
US20060019932A1
(en)
*
|
2002-09-06 |
2006-01-26 |
Mancini Joseph A |
Treatment of rheumatoid arthritis by inhibition of pde4
|
PL374700A1
(en)
*
|
2002-09-20 |
2005-10-31 |
Alcon, Inc. |
Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
|
US6822114B1
(en)
*
|
2002-10-08 |
2004-11-23 |
Albemarle Corporation |
Process for production of fluoroalkoxy-substituted benzamides and their intermediates
|
WO2004037805A1
(en)
|
2002-10-23 |
2004-05-06 |
Glenmark Pharmaceuticals Ltd. |
Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
|
US7087625B2
(en)
*
|
2002-11-19 |
2006-08-08 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors
|
ME00489B
(me)
*
|
2002-11-27 |
2011-10-10 |
Astrazeneca Ab |
NOVA SINERGIČKA KOMBINACIJA KOJA UKLJUČUJE ROFLUMILAST l FERMOTEROL
|
US20060083714A1
(en)
*
|
2003-01-27 |
2006-04-20 |
Warner James M |
Combination of a pde iv inhibitor and a tnf-alpha antagonist
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
EP1606261B1
(en)
|
2003-03-10 |
2009-11-04 |
Nycomed GmbH |
Novel process for the preparation of roflumilast
|
EA200501548A1
(ru)
|
2003-04-01 |
2006-02-24 |
Апплайд Резеч Системз Арс Холдинг Н.В. |
Ингибиторы фосфодиэстераз при бесплодии
|
DK1620429T3
(da)
|
2003-04-11 |
2009-05-18 |
Glenmark Pharmaceuticals Sa |
Nye heterocykliske forbindelser anvendelige til behandling af inflammatoriske og allergiske sygdomme, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger indeholdende disse
|
DE10318610A1
(de)
*
|
2003-04-24 |
2004-11-11 |
Elbion Ag |
7-Azaindole und deren Verwendung als Therapeutika
|
WO2004098598A1
(en)
*
|
2003-05-12 |
2004-11-18 |
Altana Pharma Ag |
COMPOSITION COMPRISING ROFLUMILAST AND A TNFα ANTAGONIST
|
WO2004098595A1
(en)
*
|
2003-05-12 |
2004-11-18 |
Altana Pharma Ag |
COMPOSITION COMPRISING ROFLUMILAST AND A TNFα ANTAGONIST
|
WO2004098597A1
(en)
*
|
2003-05-12 |
2004-11-18 |
Altana Pharma Ag |
Composition comprising roflumilast and shuil-1r ii
|
WO2004098596A1
(en)
*
|
2003-05-12 |
2004-11-18 |
Altana Pharma Ag |
Composition comprising roflumilast and il-1 trap
|
NZ544040A
(en)
|
2003-05-22 |
2009-03-31 |
Nycomed Gmbh |
Composition comprising a PDE4 inhibitor and a PDE5 inhibitor
|
CA2526730A1
(en)
*
|
2003-05-30 |
2004-12-09 |
Ranbaxy Laboratories Limited |
Substituted pyrrole derivatives
|
US20090274676A1
(en)
*
|
2003-07-31 |
2009-11-05 |
Robinson Cynthia B |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
|
US20050085430A1
(en)
*
|
2003-07-31 |
2005-04-21 |
Robinson Cynthia B. |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
|
US20050026883A1
(en)
*
|
2003-07-31 |
2005-02-03 |
Robinson Cynthia B. |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
|
BRPI0413330A
(pt)
*
|
2003-08-29 |
2006-10-10 |
Ranbaxy Lab Ltd |
inibidores de fosfodiesterase do tipo iv, composição farmacêutica contendo os mesmos e processo para sua preparação
|
US7776893B2
(en)
|
2003-09-05 |
2010-08-17 |
Nycomed Gmbh |
Use of PDE4 inhibitors for the treatment of diabetes mellitus
|
EP1670742A1
(en)
*
|
2003-09-12 |
2006-06-21 |
Ranbaxy Laboratories Limited |
Process for the preparation of roflumilast
|
WO2005046676A1
(en)
*
|
2003-11-12 |
2005-05-26 |
University Of South Carolina |
Treatment or prevention of cardiovascular and respiratory disorders with novel substituted cyclic amp-specific phosphodiesterase inhibitors
|
CA2544322C
(en)
*
|
2003-11-20 |
2012-05-08 |
Astellas Pharma Inc. |
Agent for treating chronic pelvic pain syndrome
|
WO2005051931A2
(en)
*
|
2003-11-26 |
2005-06-09 |
Ranbaxy Laboratories Limited |
Phosphodiesterase inhibitors
|
MY141255A
(en)
*
|
2003-12-11 |
2010-03-31 |
Memory Pharm Corp |
Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
|
PL1713473T3
(pl)
*
|
2004-02-06 |
2013-08-30 |
Meda Pharma Gmbh & Co Kg |
Kombinacja leków antycholinergicznych i glikokortykoidów do długotrwałego leczenia astmy i POChP
|
CN101518532A
(zh)
*
|
2004-02-06 |
2009-09-02 |
Meda制药有限及两合公司 |
用于呼吸道疾病治疗的抗胆碱能药和4型磷酸二酯酶抑制剂的组合
|
US7585872B2
(en)
|
2004-02-18 |
2009-09-08 |
Nycomed Gmbh |
Guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (PDE) 4 inhibitors
|
EP1720543A1
(en)
*
|
2004-02-27 |
2006-11-15 |
Altana Pharma AG |
Roflumilast and glycopryrronium combination
|
AU2005219576B2
(en)
|
2004-03-03 |
2011-06-30 |
Takeda Gmbh |
Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
|
US20060035939A1
(en)
*
|
2004-07-14 |
2006-02-16 |
Japan Tobacco Inc. |
3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
|
BRPI0513286A
(pt)
*
|
2004-07-15 |
2008-05-06 |
Japan Tobacco Inc |
compostos de benzamida condensada e inibidores de atividade de receptor vanilóide subtipo (vr1), suas composições farmacêuticas, pacote comercial, fármaco e respectivos usos
|
US20080009535A1
(en)
*
|
2004-08-30 |
2008-01-10 |
Sarala Balachandran |
Inhibitors of phosphodiesterase type-IV
|
DE102004046235A1
(de)
|
2004-09-22 |
2006-03-30 |
Altana Pharma Ag |
Arzneimittelzubereitung
|
DE102004046236A1
(de)
*
|
2004-09-22 |
2006-03-30 |
Altana Pharma Ag |
Arzneimittelzubereitung
|
CA2584169A1
(en)
*
|
2004-10-13 |
2006-04-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Remedies/preventives for chronic skin disease
|
BRPI0516341A
(pt)
|
2004-10-13 |
2008-09-02 |
Glenmark Pharmaceuticals Sa |
método para preparação de intermediários de n-(3,5-dicloropirid-4-il)-4-difluorometoxi-8-metanoss ulfonamido-dibenzo [b,d] furano-1-carboxamida, método para a preparação de compostos intermediários de n-(3,5-dicloropirid-4-il)-4-difluorometoxi-8-metanoss ulfonamido-dibenzo [b,d] furano-1-carboxamida, n-(3,5-dicloropirid-4-il)-4-difluorometoxi-8-metanoss ulfonamido-dibenzeno [b,d] furano-1-carboxamida, método para a sìntese de n-(3,5-dicloropirid-4-il)-4-difluorometoxi-8-metanoss ulfonamido-dibenzo [b,d] furano-1-carboxamida e seu sal sódico de n-(3,5-dicloropirid-4-il)-4-difluorometoxi-8-metanoss ulfonamido-dibenzo [b,d] furano-1-carboxamida
|
CA2584261A1
(en)
*
|
2004-10-13 |
2006-04-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Pharmaceutical composition
|
SI1831227T1
(sl)
|
2004-12-17 |
2013-09-30 |
Glenmark Pharmaceuticals S.A. |
Nove heterociklične spojine uporabne za zdravljenje vnetnih in alergijskih motenj
|
MX2007007345A
(es)
|
2004-12-17 |
2007-09-07 |
Glenmark Pharmaceuticals Sa |
Compuestos heterociclicos novedosos utiles para el tratamiento de trastornos inflamatorios y alergicos.
|
WO2006094640A2
(en)
*
|
2005-03-04 |
2006-09-14 |
F.Hoffmann-La Roche Ag |
Roflumilast and integrin inhibitor combination and method of treatment
|
WO2006094933A1
(en)
|
2005-03-08 |
2006-09-14 |
Nycomed Gmbh |
Roflumilast for the treatment of diabetes mellitus
|
WO2006094942A1
(en)
*
|
2005-03-08 |
2006-09-14 |
Nycomed Gmbh |
Roflumilast for the treatment of diabetes mellitus
|
EP1861074B1
(en)
|
2005-03-16 |
2013-04-24 |
Takeda GmbH |
Taste masked dosage form containing roflumilast
|
MX2007011273A
(es)
*
|
2005-03-16 |
2007-11-08 |
Meda Pharma Gmbh & Co Kg |
La combinacion de anticolinergicos y antagonistas del receptor de leucotrieno para el tratamiento de enfermedades respiratorias.
|
DK2366393T3
(da)
|
2005-04-19 |
2013-10-21 |
Takeda Gmbh |
Roflumilast til behandlingen af pulmonal hypertension
|
KR20080005601A
(ko)
*
|
2005-05-11 |
2008-01-14 |
니코메드 게엠베하 |
Pde4 억제제 로플루밀라스트와 테트라히드로비오프테린유도체의 조합
|
EP1889620A4
(en)
*
|
2005-06-09 |
2008-12-10 |
Santen Pharmaceutical Co Ltd |
EYE DROPS CONTAINING ROFLUMILAST
|
EP2258359A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation with sabcomelin
|
US7678363B2
(en)
|
2005-08-26 |
2010-03-16 |
Braincells Inc |
Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
|
EP1940389A2
(en)
|
2005-10-21 |
2008-07-09 |
Braincells, Inc. |
Modulation of neurogenesis by pde inhibition
|
US20070112017A1
(en)
|
2005-10-31 |
2007-05-17 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
SG166829A1
(en)
*
|
2005-11-08 |
2010-12-29 |
Ranbaxy Lab Ltd |
Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
|
WO2007071313A2
(en)
|
2005-12-21 |
2007-06-28 |
Meda Pharma Gmbh & Co Kg |
Combination of anticholinergics, glucocorticoids, beta2-ag0nists, pde4 inhibitor and antileukotriene for the treatment of inflammatory diseases
|
US7906508B2
(en)
|
2005-12-28 |
2011-03-15 |
Japan Tobacco Inc. |
3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
|
US7863446B2
(en)
*
|
2006-01-19 |
2011-01-04 |
Orchid Research Laboratories Limited |
Heterocycles
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
EP1991212A1
(en)
*
|
2006-03-08 |
2008-11-19 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
AR059838A1
(es)
*
|
2006-03-14 |
2008-04-30 |
Ranbaxy Lab Ltd |
Formulaciones para dosis estabilizantes de estatina
|
MX2008014320A
(es)
*
|
2006-05-09 |
2009-03-25 |
Braincells Inc |
Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
|
US20100009983A1
(en)
*
|
2006-05-09 |
2010-01-14 |
Braincells, Inc. |
5 ht receptor mediated neurogenesis
|
EP2021000A2
(en)
|
2006-05-09 |
2009-02-11 |
Braincells, Inc. |
Neurogenesis by modulating angiotensin
|
CN102764440A
(zh)
*
|
2006-07-05 |
2012-11-07 |
奈科明有限责任公司 |
用于治疗炎症性肺部疾病的HMG-CoA还原酶抑制剂与磷酸二酯酶4抑制剂的组合
|
BRPI0714361A2
(pt)
*
|
2006-07-14 |
2013-03-26 |
Ranbaxy Lab Ltd |
polimorfo cristalino, composiÇço farmacÊutica contendo o mesmo, mÉtodo para sua preparaÇço e mÉtodo de tratamento
|
US20100056791A1
(en)
|
2006-09-01 |
2010-03-04 |
Yasushi Kohno |
Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
|
EP2068872A1
(en)
*
|
2006-09-08 |
2009-06-17 |
Braincells, Inc. |
Combinations containing a 4-acylaminopyridine derivative
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
EP2066355A2
(en)
*
|
2006-09-19 |
2009-06-10 |
Braincells, Inc. |
Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
|
US20100029728A1
(en)
*
|
2006-09-22 |
2010-02-04 |
Ranbaxy Laboratories Limited |
Phosphodiesterase inhibitors
|
US20080221103A1
(en)
*
|
2007-03-09 |
2008-09-11 |
Orchid Research Laboratories Ltd. |
New heterocyclic compounds
|
KR100844125B1
(ko)
*
|
2007-03-23 |
2008-07-04 |
한국화학연구원 |
7-(3′,4′-디알콕시페닐)-[1,2,4]트리아졸로[1,5-a]피리미딘 화합물, 이의 제조방법 및 이를 포함하는 천식 및만성폐쇄성 폐질환을 포함한 염증관련 질환, 관절염,아토피 피부염, 암 및 뇌질환의 치료 및 예방을 위한약제학적 조성물
|
CN101657441B
(zh)
|
2007-05-16 |
2013-09-11 |
塔科达有限责任公司 |
作为pde4抑制剂的吡唑啉酮衍生物
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
EP2170930B3
(en)
|
2007-06-04 |
2013-10-02 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
US8426673B2
(en)
|
2008-01-11 |
2013-04-23 |
Astellas Pharma, Inc. |
Pathological animal model for pelvic pain syndrome
|
BRPI0912029A2
(pt)
|
2008-02-01 |
2020-06-30 |
Orchid Research Laboratories Limited |
novos heterociclos
|
JP2011522828A
(ja)
|
2008-06-04 |
2011-08-04 |
シナジー ファーマシューティカルズ インコーポレイテッド |
胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
|
US20100029689A1
(en)
*
|
2008-07-02 |
2010-02-04 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors
|
AU2009270833B2
(en)
|
2008-07-16 |
2015-02-19 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
EP2216327A1
(en)
*
|
2009-02-06 |
2010-08-11 |
CHIESI FARMACEUTICI S.p.A. |
Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
US8394829B2
(en)
|
2010-05-10 |
2013-03-12 |
Gilead Sciences, Inc. |
Bi-functional quinoline analogs
|
WO2011143106A1
(en)
|
2010-05-10 |
2011-11-17 |
Gilead Sciences, Inc. |
Bi - functional pyrazolopyridine compounds
|
EP2585469B1
(en)
*
|
2010-06-24 |
2016-05-25 |
Leo Pharma A/S |
Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
|
CN102311382B
(zh)
*
|
2010-06-29 |
2014-05-21 |
大道隆达(北京)医药科技发展有限公司 |
罗氟司特的晶态及其制备方法
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
CN102093194B
(zh)
*
|
2010-12-24 |
2014-01-08 |
江苏先声药物研究有限公司 |
3-环丙基甲氧基-4-二氟甲氧基苯甲酸的合成方法
|
CN102617457A
(zh)
*
|
2011-01-28 |
2012-08-01 |
天津药物研究院 |
一种制备罗氟司特的新方法
|
DK2681236T3
(en)
|
2011-03-01 |
2018-04-16 |
Synergy Pharmaceuticals Inc |
PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
|
CN102690194B
(zh)
*
|
2011-03-24 |
2014-06-25 |
上海通远生物科技有限公司 |
3-环丙基甲氧基-4-二氟甲氧基苯甲酸的制备方法
|
CN102775345A
(zh)
*
|
2011-05-13 |
2012-11-14 |
上海特化医药科技有限公司 |
制备罗氟司特的方法及中间体
|
CN102276522B
(zh)
*
|
2011-06-15 |
2013-04-17 |
无锡泓兴生物医药科技有限公司 |
一种制备罗氟司特的方法及其中间体
|
CN102336703B
(zh)
*
|
2011-07-20 |
2013-09-25 |
华润赛科药业有限责任公司 |
一种制备罗氟司特的方法
|
CN102351787B
(zh)
*
|
2011-08-18 |
2014-08-13 |
天津市汉康医药生物技术有限公司 |
高生物利用度的罗氟司特化合物
|
WO2013030789A1
(en)
|
2011-08-30 |
2013-03-07 |
Ranbaxy Laboratories Limited |
Pharmaceutical oral solid dosage form containing a poorly water soluble pde - iv inhibitor
|
CN102336704B
(zh)
*
|
2011-10-19 |
2013-04-17 |
丁克 |
一种制备罗氟司特的方法
|
RU2617401C2
(ru)
*
|
2011-10-21 |
2017-04-25 |
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. |
Производные 1-фенил 2-пиридинилалкиловых спиртов в качестве ингибиторов фосфодиэстеразы
|
CN102336705B
(zh)
*
|
2011-10-28 |
2013-03-27 |
成都苑东药业有限公司 |
一种制备n-(3,5-二氯吡啶-4-基)-3-环丙基甲氧基-4-二氟甲氧基苯甲酰胺的方法
|
CA2855021A1
(en)
*
|
2011-11-09 |
2013-05-23 |
Mylan Laboratories Ltd |
Process for the preparation of roflumilast
|
WO2013081565A1
(en)
|
2011-11-21 |
2013-06-06 |
Mahmut Bilgic |
Pharmaceutical compositions comprising roflumilast and terbutaline
|
WO2013077830A1
(en)
|
2011-11-25 |
2013-05-30 |
Mahmut Bilgic |
Synergistilly active combinations of roflumilast and carmoterol
|
WO2013084182A1
(en)
|
2011-12-08 |
2013-06-13 |
Glenmark Pharmaceuticals S.A. |
Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent
|
CN102603623A
(zh)
*
|
2011-12-26 |
2012-07-25 |
北京赛林泰医药技术有限公司 |
制备高纯度罗氟司特的方法
|
EP2804603A1
(en)
|
2012-01-10 |
2014-11-26 |
President and Fellows of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
WO2013131255A1
(en)
|
2012-03-07 |
2013-09-12 |
Scinopharm (Changshu) Pharmaceutical, Ltd. |
Preparation method of roflumilast
|
WO2014012954A1
(en)
|
2012-07-18 |
2014-01-23 |
Takeda Gmbh |
Treatment of partly controlled or uncontrolled severe asthma
|
CN103630613B
(zh)
*
|
2012-08-21 |
2015-08-05 |
北大方正集团有限公司 |
分离并检测罗氟司特及其中间体的方法
|
EP2909177B1
(en)
*
|
2012-10-17 |
2017-03-29 |
Interquim, S.A. |
Process for preparing roflumilast
|
NZ710726A
(en)
*
|
2013-01-28 |
2020-08-28 |
Incozen Therapeutics Pvt Ltd |
Methods of treating autoimmune, respiratory and inflammatory disorders by inhalation of roflumilast n-oxide
|
ES2637716T3
(es)
|
2013-02-04 |
2017-10-16 |
Grünenthal GmbH |
Nuevos compuestos de pirimidina condensados sustituidos
|
MX2015009678A
(es)
|
2013-02-04 |
2015-11-25 |
Gruenenthal Gmbh |
Compuestos de pirimidina condensada sustituida con amino en la posicion 4 como inhibidores de fosfodiesterasa 4 (pde4).
|
EP2958577A2
(en)
|
2013-02-25 |
2015-12-30 |
Synergy Pharmaceuticals Inc. |
Guanylate cyclase receptor agonists for use in colonic cleansing
|
CA2905435A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
WO2014151206A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
TW201512189A
(zh)
|
2013-04-16 |
2015-04-01 |
Gruenenthal Chemie |
新型被取代之嘧啶縮合化合物
|
EP3004138B1
(en)
|
2013-06-05 |
2024-03-13 |
Bausch Health Ireland Limited |
Ultra-pure agonists of guanylate cyclase c, method of making and using same
|
CN103304475A
(zh)
*
|
2013-06-13 |
2013-09-18 |
湖南千金湘江药业股份有限公司 |
苯甲酰胺化合物及其制备方法和用途
|
AU2014305843B2
(en)
|
2013-08-09 |
2019-08-29 |
Ardelyx, Inc. |
Compounds and methods for inhibiting phosphate transport
|
HUE035967T2
(hu)
|
2013-08-09 |
2018-06-28 |
Gruenenthal Gmbh |
Új helyettesített kondenzált pirimidinvegyületek
|
US10357486B2
(en)
|
2013-08-16 |
2019-07-23 |
Universiteit Maastricht |
Treatment of cognitive impairment with PDE4 inhibitor
|
WO2015063669A1
(en)
|
2013-10-30 |
2015-05-07 |
Wockhardt Limited |
Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof
|
US20170100385A1
(en)
|
2014-05-12 |
2017-04-13 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Pharmaceutical compositions comprising danirixin for treating infectious diseases
|
AR101197A1
(es)
|
2014-07-16 |
2016-11-30 |
Gruenenthal Gmbh |
Pirimidinas 2,5-sustituidas
|
AR101196A1
(es)
|
2014-07-16 |
2016-11-30 |
Gruenenthal Gmbh |
Compuestos de pirimidina sustituidos
|
AR101198A1
(es)
|
2014-07-16 |
2016-11-30 |
Gruenenthal Gmbh |
Pirimidinas 2,5-sustituidas como inhibidores de pde4b
|
CN104130116B
(zh)
*
|
2014-08-18 |
2015-11-11 |
朱丽平 |
一种制备罗氟司特中间体的方法
|
ES2777550T3
(es)
|
2014-10-24 |
2020-08-05 |
Hisamitsu Pharmaceutical Co |
Profármaco de roflumilast
|
CN104447245B
(zh)
*
|
2014-10-29 |
2017-06-06 |
成都森科制药有限公司 |
罗氟司特中间体、中间体制备方法及罗氟司特的制备方法
|
KR20170034707A
(ko)
|
2015-09-21 |
2017-03-29 |
한미약품 주식회사 |
로플루밀라스트 함유 경구용 고형제제 및 그 제조방법
|
EP3165224A1
(en)
|
2015-11-09 |
2017-05-10 |
Albert-Ludwigs-Universität Freiburg |
Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
|
WO2017089347A1
(en)
|
2015-11-25 |
2017-06-01 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
|
CN105523954B
(zh)
*
|
2016-02-05 |
2017-07-18 |
徐江平 |
3‑环丙甲氧基‑4‑烷氧基苯甲酰胺类磷酸二酯酶4抑制剂
|
US11129818B2
(en)
|
2017-06-07 |
2021-09-28 |
Arcutis Biotherapeutics, Inc. |
Topical roflumilast formulation having improved delivery and plasma half life
|
US9895359B1
(en)
|
2017-06-07 |
2018-02-20 |
Arcutis, Inc. |
Inhibition of crystal growth of roflumilast
|
US11534493B2
(en)
|
2017-09-22 |
2022-12-27 |
Arcutis Biotherapeutics, Inc. |
Pharmaceutical compositions of roflumilast in aqueous blends of water-miscible, pharmaceutically acceptable solvents
|
EP3700529A1
(en)
|
2017-10-23 |
2020-09-02 |
Boehringer Ingelheim International GmbH |
New combination of active agents for the treatment of progressive fibrosing interstitial lung diseases (pf-ild)
|
BR112020024768A8
(pt)
|
2018-06-04 |
2022-12-13 |
Arcutis Inc |
Método para reduzir o intervalo de penetração cutânea de roflumilaste em um paciente, composição farmacêutica compreendendo roflumilaste e uma mistura emulsificante e composição farmacêutica compreendendo roflumilaste e pelo menos um emulsificante
|
US20200155524A1
(en)
|
2018-11-16 |
2020-05-21 |
Arcutis, Inc. |
Method for reducing side effects from administration of phosphodiesterase-4 inhibitors
|
US20200368223A1
(en)
|
2019-05-21 |
2020-11-26 |
Ardelyx, Inc. |
Methods for inhibiting phosphate transport
|
IL295172A
(en)
|
2020-01-31 |
2022-09-01 |
Arcutis Biotherapeutics Inc |
Composition of topical roflumilest with improved administration and half-life in plasma
|
EP4140480A1
(en)
|
2020-04-23 |
2023-03-01 |
Natural Medicine Institute Of Zhejiang Yangshengtang Co., Ltd. |
Drug combination and use thereof
|
CN111777550A
(zh)
*
|
2020-06-01 |
2020-10-16 |
山东希尔康泰药业有限公司 |
罗氟司特结晶性粉末原料药生产制备方法
|
IL303379A
(en)
|
2020-12-04 |
2023-08-01 |
Arcutis Biotherapeutics Inc |
A topical formulation of ROFLUMILAST with antifungal activity
|
CN116963773A
(zh)
|
2021-01-21 |
2023-10-27 |
浙江养生堂天然药物研究所有限公司 |
***的组合物及方法
|
WO2022169615A1
(en)
|
2021-02-05 |
2022-08-11 |
Arcutis Biotherapeutics, Inc. |
Roflumilast formulations with an improved pharmacokinetic profile
|
WO2023129892A1
(en)
|
2021-12-28 |
2023-07-06 |
Arcutis Biotherapeutics, Inc. |
Topical aerosol foams
|
US20230201177A1
(en)
|
2021-12-28 |
2023-06-29 |
Arcutis Biotherapeutics, Inc. |
Topical Roflumilast Aerosol Foams
|
US20240108609A1
(en)
|
2022-09-15 |
2024-04-04 |
Arcutis Biotherapeutics, Inc. |
Pharmaceutical compositions of roflumilast and solvents capable of dissolving high amounts of the drug
|