CN1126468A - 氟烷氧基取代的苯甲酰胺类及其作为环状核苷酸磷酸二酯酶抑制剂的应用 - Google Patents
氟烷氧基取代的苯甲酰胺类及其作为环状核苷酸磷酸二酯酶抑制剂的应用 Download PDFInfo
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- CN1126468A CN1126468A CN94192659A CN94192659A CN1126468A CN 1126468 A CN1126468 A CN 1126468A CN 94192659 A CN94192659 A CN 94192659A CN 94192659 A CN94192659 A CN 94192659A CN 1126468 A CN1126468 A CN 1126468A
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- halogen
- phenyl
- alkyl
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- hydrogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (25)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1996/939 | 1993-07-02 | ||
CH199693 | 1993-07-02 | ||
CH1996/93-9 | 1993-07-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1126468A true CN1126468A (zh) | 1996-07-10 |
CN1046939C CN1046939C (zh) | 1999-12-01 |
Family
ID=4223466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN94192659A Expired - Lifetime CN1046939C (zh) | 1993-07-02 | 1994-07-02 | 氟烷氧基取代的苯甲酰胺类及其制备方法和应用 |
Country Status (28)
Country | Link |
---|---|
US (1) | US5712298A (zh) |
EP (1) | EP0706513B1 (zh) |
JP (1) | JP3093271B2 (zh) |
KR (1) | KR100331255B1 (zh) |
CN (1) | CN1046939C (zh) |
AT (1) | ATE217612T1 (zh) |
AU (1) | AU687087B2 (zh) |
CA (1) | CA2165192C (zh) |
CY (2) | CY2389B1 (zh) |
CZ (1) | CZ290266B6 (zh) |
DE (2) | DE59410119D1 (zh) |
DK (1) | DK0706513T3 (zh) |
ES (1) | ES2176252T3 (zh) |
FI (1) | FI112864B (zh) |
FR (1) | FR10C0052I2 (zh) |
HK (1) | HK1011690A1 (zh) |
HU (1) | HU220041B (zh) |
LU (1) | LU91709I2 (zh) |
LV (1) | LV13074B (zh) |
NO (2) | NO305598B1 (zh) |
NZ (1) | NZ271316A (zh) |
PL (1) | PL178314B1 (zh) |
PT (1) | PT706513E (zh) |
RU (1) | RU2137754C1 (zh) |
SG (1) | SG143011A1 (zh) |
SI (1) | SI0706513T1 (zh) |
SK (1) | SK283263B6 (zh) |
WO (1) | WO1995001338A1 (zh) |
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CN1655823B (zh) * | 2002-05-28 | 2010-05-26 | 尼科梅德有限责任公司 | 局部应用的药物制剂 |
US7906508B2 (en) | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
CN102093194A (zh) * | 2010-12-24 | 2011-06-15 | 江苏先声药物研究有限公司 | 3-环丙基甲氧基-4-二氟甲氧基苯甲酸的合成新方法 |
US8008292B2 (en) | 2004-07-15 | 2011-08-30 | Japan Tobacco Inc. | Condensed benzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity |
CN102317262A (zh) * | 2009-02-06 | 2012-01-11 | 奇斯药制品公司 | 苯甲酸(1-苯基-2-吡啶基-4-基)乙酯作为磷酸二酯酶抑制剂 |
CN102311382A (zh) * | 2010-06-29 | 2012-01-11 | 大道隆达(北京)医药科技发展有限公司 | 罗氟司特的新晶态及其制备方法 |
CN102336704A (zh) * | 2011-10-19 | 2012-02-01 | 丁克 | 一种制备罗氟司特的方法 |
CN102336703A (zh) * | 2011-07-20 | 2012-02-01 | 北京赛科药业有限责任公司 | 一种制备罗氟司特的方法 |
CN102336705A (zh) * | 2011-10-28 | 2012-02-01 | 成都苑东药业有限公司 | 一种制备n-(3,5-二氯吡啶-4-基)-3-环丙基甲氧基-4-二氟甲氧基苯甲酰胺的方法 |
CN102351787A (zh) * | 2011-08-18 | 2012-02-15 | 天津市汉康医药生物技术有限公司 | 高生物利用度的罗氟司特化合物 |
CN102617457A (zh) * | 2011-01-28 | 2012-08-01 | 天津药物研究院 | 一种制备罗氟司特的新方法 |
CN1635909B (zh) * | 2002-02-20 | 2012-09-05 | 奈科明有限责任公司 | 含有pde4抑制剂作为活性成分和聚乙烯吡咯烷酮作为赋形剂的口服剂型 |
CN102775345A (zh) * | 2011-05-13 | 2012-11-14 | 上海特化医药科技有限公司 | 制备罗氟司特的方法及中间体 |
CN103304475A (zh) * | 2013-06-13 | 2013-09-18 | 湖南千金湘江药业股份有限公司 | 苯甲酰胺化合物及其制备方法和用途 |
CN103630613A (zh) * | 2012-08-21 | 2014-03-12 | 北大方正集团有限公司 | 分离并检测罗氟司特及其中间体的方法 |
CN104130116A (zh) * | 2014-08-18 | 2014-11-05 | 王深涧 | 一种制备罗氟司特中间体的方法 |
CN104447245A (zh) * | 2014-10-29 | 2015-03-25 | 成都森科制药有限公司 | 罗氟司特中间体、中间体制备方法及罗氟司特的制备方法 |
CN104994854A (zh) * | 2013-01-28 | 2015-10-21 | 理森制药股份公司 | 通过吸入罗氟司特n-氧化物治疗自身免疫、呼吸和/或炎性病症的方法 |
CN105523954A (zh) * | 2016-02-05 | 2016-04-27 | 徐江平 | 新型3-环丙甲氧基-4-烷氧基苯甲酰胺类磷酸二酯酶4抑制剂 |
CN111777550A (zh) * | 2020-06-01 | 2020-10-16 | 山东希尔康泰药业有限公司 | 罗氟司特结晶性粉末原料药生产制备方法 |
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US5698711A (en) | 1991-01-28 | 1997-12-16 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
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US6096768A (en) * | 1992-01-28 | 2000-08-01 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
WO1997003967A1 (en) * | 1995-07-22 | 1997-02-06 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
EP0923568B9 (en) * | 1996-08-19 | 2003-08-13 | ALTANA Pharma AG | Novel benzofuran-4-carboxamides |
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US5874437A (en) * | 1996-11-01 | 1999-02-23 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
WO1998019672A1 (en) * | 1996-11-01 | 1998-05-14 | Nitromed Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
CN1123345C (zh) * | 1997-02-17 | 2003-10-08 | 奥坦纳医药公司 | 治疗ards或irds的组合物 |
US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
US6172118B1 (en) * | 1998-04-14 | 2001-01-09 | Smithkline Beecham Corporation | Compounds |
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US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
ES2228512T3 (es) * | 1999-05-04 | 2005-04-16 | Altana Pharma Ag | Combinacion sinergica que comprende roflumilast y un inhibidor de pde-3. |
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