GB1554395A - Method for producing maytansinol and its derivatives - Google Patents

Method for producing maytansinol and its derivatives

Info

Publication number: GB1554395A
Authority: GB; United Kingdom
Prior art keywords: maytansinol; maytanacin; derivatives; propionate; useful
Prior art date: 1977-03-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB42821/77A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda Pharmaceutical Co Ltd

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-31

Filing date

1977-10-14

Publication date

1979-10-17

1977-10-14 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1979-10-17 Publication of GB1554395A publication Critical patent/GB1554395A/en

Status Expired legal-status Critical Current

Links

QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 title abstract 4
QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
MQYZCKOGTWYJAZ-UHFFFAOYSA-N ansamitocin P1 Natural products CN1C(=O)CC(OC(C)=O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 MQYZCKOGTWYJAZ-UHFFFAOYSA-N 0.000 abstract 3
DGBBXVWXOHSLTG-UMDRASRXSA-N ansamitocin p 2 Chemical compound C([C@@H]([C@@]1(O[C@H]1[C@@H]1C)C)OC(=O)CC)C(=O)N(C)C(C(=C(OC)C=2)Cl)=CC=2C\C(C)=C\C=C\[C@@H](OC)[C@]2(O)NC(=O)O[C@H]1C2 DGBBXVWXOHSLTG-UMDRASRXSA-N 0.000 abstract 3
241000187654 Nocardia Species 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
239000000824 cytostatic agent Substances 0.000 abstract 1
230000001085 cytostatic effect Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Public Health (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

GB42821/77A 1977-03-31 1977-10-14 Method for producing maytansinol and its derivatives Expired GB1554395A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP52037167A JPS6010718B2 (ja)	1977-03-31	1977-03-31	メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法

Publications (1)

Publication Number	Publication Date
GB1554395A true GB1554395A (en)	1979-10-17

Family

ID=12490032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB42821/77A Expired GB1554395A (en)	1977-03-31	1977-10-14	Method for producing maytansinol and its derivatives

Country Status (20)

Country	Link
JP (1)	JPS6010718B2 (fr)
AT (1)	AT362058B (fr)
AU (1)	AU507869B2 (fr)
CA (1)	CA1092999A (fr)
CH (1)	CH631740A5 (fr)
CS (1)	CS214881B2 (fr)
DE (1)	DE2746253C2 (fr)
DK (1)	DK143570C (fr)
ES (1)	ES463206A1 (fr)
FR (1)	FR2385798A1 (fr)
GB (1)	GB1554395A (fr)
HU (1)	HU177391B (fr)
IE (1)	IE45888B1 (fr)
IT (1)	IT1094003B (fr)
NL (1)	NL7711273A (fr)
PL (1)	PL108863B1 (fr)
PT (1)	PT67853B (fr)
SE (1)	SE7711543L (fr)
SU (1)	SU938746A3 (fr)
YU (1)	YU243777A (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001077360A2 (fr) *	2000-04-12	2001-10-18	Smithkline Beecham P.L.C.	Procede pour la production d'ansamitocine
CN116239607A (zh) *	2023-01-04	2023-06-09	山东大学	一种美登素新型衍生物及其生物合成方法与应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6010720B2 (ja) *	1977-11-18	1985-03-19	武田薬品工業株式会社	抗生物質ｃ―１５００３ｐ―４の製造法
JPS6016236B2 (ja) *	1977-11-18	1985-04-24	武田薬品工業株式会社	抗生物質ｃ―１５００３ｐ―３の製造法
JPS55162791A (en) *	1979-06-05	1980-12-18	Takeda Chem Ind Ltd	Antibiotic c-15003pnd and its preparation
EP0028683A1 (fr) *	1979-09-21	1981-05-20	Takeda Chemical Industries, Ltd.	Antibiotique C-15003 PHO et sa préparation
US6333410B1 (en)	2000-08-18	2001-12-25	Immunogen, Inc.	Process for the preparation and purification of thiol-containing maytansinoids
US7432088B2 (en)	2003-05-08	2008-10-07	Immunogen Inc.	Methods for the production of ansamitocins

1977
- 1977-03-31 JP JP52037167A patent/JPS6010718B2/ja not_active Expired
- 1977-09-23 AU AU29073/77A patent/AU507869B2/en not_active Expired
- 1977-10-07 SU SU772533351A patent/SU938746A3/ru active
- 1977-10-07 FR FR7730340A patent/FR2385798A1/fr active Granted
- 1977-10-10 YU YU02437/77A patent/YU243777A/xx unknown
- 1977-10-13 NL NL7711273A patent/NL7711273A/xx not_active Application Discontinuation
- 1977-10-13 SE SE7711543A patent/SE7711543L/ not_active Application Discontinuation
- 1977-10-13 CS CS776677A patent/CS214881B2/cs unknown
- 1977-10-13 HU HU77TA1458A patent/HU177391B/hu unknown
- 1977-10-14 DK DK458977A patent/DK143570C/da not_active IP Right Cessation
- 1977-10-14 ES ES463206A patent/ES463206A1/es not_active Expired
- 1977-10-14 GB GB42821/77A patent/GB1554395A/en not_active Expired
- 1977-10-14 IE IE2100/77A patent/IE45888B1/en unknown
- 1977-10-14 DE DE2746253A patent/DE2746253C2/de not_active Expired
- 1977-10-14 CA CA288,732A patent/CA1092999A/fr not_active Expired
- 1977-10-14 CH CH1260477A patent/CH631740A5/de not_active IP Right Cessation
- 1977-10-14 AT AT736377A patent/AT362058B/de not_active IP Right Cessation
- 1977-10-15 PL PL1977201539A patent/PL108863B1/pl not_active IP Right Cessation
1978
- 1978-03-30 IT IT21819/78A patent/IT1094003B/it active
- 1978-03-30 PT PT67853A patent/PT67853B/pt unknown

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001077360A2 (fr) *	2000-04-12	2001-10-18	Smithkline Beecham P.L.C.	Procede pour la production d'ansamitocine
WO2001077360A3 (fr) *	2000-04-12	2002-09-12	Smithkline Beecham Plc	Procede pour la production d'ansamitocine
US6573074B2 (en)	2000-04-12	2003-06-03	Smithkline Beecham Plc	Methods for ansamitocin production
AU2001293335B2 (en) *	2000-04-12	2005-02-24	Smithkline Beecham P.L.C.	Methods for ansamitocin production
CN116239607A (zh) *	2023-01-04	2023-06-09	山东大学	一种美登素新型衍生物及其生物合成方法与应用
CN116239607B (zh) *	2023-01-04	2024-04-09	山东大学	一种美登素衍生物及其生物合成方法与应用

Also Published As

Publication number	Publication date
NL7711273A (nl)	1978-10-03
PL201539A1 (pl)	1978-09-25
AU2907377A (en)	1979-03-29
DE2746253C2 (de)	1986-08-21
FR2385798A1 (fr)	1978-10-27
PT67853A (en)	1978-04-01
AU507869B2 (en)	1980-02-28
PT67853B (en)	1980-05-05
IT1094003B (it)	1985-07-26
IT7821819A0 (it)	1978-03-30
CS214881B2 (en)	1982-06-25
JPS53121998A (en)	1978-10-24
IE45888L (en)	1978-09-30
DK143570C (da)	1982-02-08
PL108863B1 (en)	1980-05-31
SU938746A3 (ru)	1982-06-23
DK143570B (da)	1981-09-07
AT362058B (de)	1981-04-27
ES463206A1 (es)	1978-08-16
DE2746253A1 (de)	1978-10-05
YU243777A (en)	1982-06-30
JPS6010718B2 (ja)	1985-03-19
CA1092999A (fr)	1981-01-06
SE7711543L (sv)	1978-10-01
DK458977A (da)	1978-10-01
HU177391B (en)	1981-09-28
FR2385798B1 (fr)	1980-04-25
CH631740A5 (en)	1982-08-31
ATA736377A (de)	1980-09-15
IE45888B1 (en)	1982-12-29

Legal Events

Date	Code	Title	Description
1980-01-03	PS	Patent sealed [section 19, patents act 1949]
1989-04-12	704A	Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
1997-11-05	PE20	Patent expired after termination of 20 years	Effective date: 19971013

Publication	Publication Date	Title
ATE3059T1 (de)	1983-04-15	Antibiotikum c-15003 pnd-0 und herstellung von antibiotikum c-15003 pnd.
EP0029329A3 (en)	1982-03-10	Enzyme inhibitor produced by cultivation of streptomyces microorganisms, a process for producing it and a culture of the microorganism
DK294384D0 (da)	1984-06-15	Cl-1577 antibiotisk/antitumor virkende forbindelser samt fremgangsmaade til fremstilling deraf
PT73470B (en)	1983-09-01	Process for preparing novel derivatives of c-076 compounds
DE3066026D1 (en)	1984-02-02	A method for the production of antibiotic c-15003 p-3
GB1554395A (en)	1979-10-17	Method for producing maytansinol and its derivatives
ES475178A1 (es)	1979-05-16	Un metodo mejorado para producir antibiotico c-15003 p-3.
SE7509571L (sv)	1976-03-01	Sett att framstella nya rifamyciner identifierade som rifamycin p, rifamycin q, rifamycin r och rifamycin u
ATE33148T1 (de)	1988-04-15	Sarcosin-oxidase.
ES475179A1 (es)	1979-05-16	Un metodo mejorado para producir antibiotico c-15003 p-4.
ES472318A1 (es)	1979-02-16	Un metodo para preparar el antibiotico c-14482 a.
SE8302517D0 (sv)	1983-05-03	Forfarande for framstellning av antibiotikum c-15003 p-0 (maytansinol)
ES472790A1 (es)	1980-01-16	Un procedimiento para obtener un nuevo antibiotico antitumo-ral la auromomicina
KR890014457A (ko)	1989-10-23	신규 아족시 화합물 및 그의 제조방법
ES2085770T3 (es)	1996-06-01	Actinoplanes como productor de rapamicina.
DK158083D0 (da)	1983-04-11	Fremgangsmade til fremstilling af et antibiotisk komplex, omfattende erythromycin d og estere deraf, eller dets enkelte komponenter
KR880010123A (ko)	1988-10-07	신규 시토크롬 p-450 및 그의 제조방법
DE3169901D1 (en)	1985-05-15	Antibiotic am-5344-a2 and process for the preparation thereof
AU2432488A (en)	1989-04-27	Microbiological process for making uk-61, 689 and microorganisms useful therefor
JPS5394093A (en)	1978-08-17	Novel process for preparation of 7-amino-cephalosporanic acid and their derivatives
SE7607909L (sv)	1977-01-11	Forfarande for framstellning av bioproteiner med hjelp av mikroorganismer samt mikroorganismer for detta endamal
GB1018667A (en)	1966-01-26	Production of oxytetracycline
JPS5234984A (en)	1977-03-17	Production of adenine derivatives by fermentation process
GB998195A (en)	1965-07-14	Process for the production of an antibiotic
JPS5396380A (en)	1978-08-23	Culturing of microorganism using lower alkane as carbon source