FR2385722A1 - Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2385722A1
FR2385722A1 FR7809661A FR7809661A FR2385722A1 FR 2385722 A1 FR2385722 A1 FR 2385722A1 FR 7809661 A FR7809661 A FR 7809661A FR 7809661 A FR7809661 A FR 7809661A FR 2385722 A1 FR2385722 A1 FR 2385722A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic application
cephalosporin derivatives
new cephalosporin
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7809661A
Other languages
English (en)
Other versions
FR2385722B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of FR2385722A1 publication Critical patent/FR2385722A1/fr
Application granted granted Critical
Publication of FR2385722B1 publication Critical patent/FR2385722B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

L'invention concerne des dérivés de céphèmes, répondant à la formule générale I :
FR7809661A 1977-04-02 1978-03-31 Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique Expired FR2385722B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772714880 DE2714880A1 (de) 1977-04-02 1977-04-02 Cephemderivate und verfahren zu ihrer herstellung
DE19772716707 DE2716707A1 (de) 1977-04-02 1977-04-15 Cephemderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
FR2385722A1 true FR2385722A1 (fr) 1978-10-27
FR2385722B1 FR2385722B1 (fr) 1985-09-27

Family

ID=25771827

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7809661A Expired FR2385722B1 (fr) 1977-04-02 1978-03-31 Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
FR8110233A Granted FR2485017A1 (fr) 1977-04-02 1981-05-22 Nouveaux derives de cephalosporine et leur application en therapeutique
FR8110234A Granted FR2485018A1 (fr) 1977-04-02 1981-05-22 Nouveaux derives de cephalosporine et leur application en therapeutique

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR8110233A Granted FR2485017A1 (fr) 1977-04-02 1981-05-22 Nouveaux derives de cephalosporine et leur application en therapeutique
FR8110234A Granted FR2485018A1 (fr) 1977-04-02 1981-05-22 Nouveaux derives de cephalosporine et leur application en therapeutique

Country Status (28)

Country Link
US (4) US4758556A (fr)
JP (2) JPS5858354B2 (fr)
AT (1) AT367425B (fr)
AU (1) AU528277B2 (fr)
BE (1) BE865632A (fr)
CA (1) CA1259606A (fr)
CH (1) CH638810A5 (fr)
CS (1) CS208747B2 (fr)
DD (1) DD137231A5 (fr)
DE (2) DE2714880A1 (fr)
DK (1) DK165060C (fr)
ES (2) ES468475A1 (fr)
FI (1) FI70221C (fr)
FR (3) FR2385722B1 (fr)
GB (1) GB1604971A (fr)
GR (1) GR73632B (fr)
HK (1) HK39083A (fr)
IE (1) IE47211B1 (fr)
IL (1) IL54407A (fr)
IT (1) IT1093750B (fr)
LU (1) LU79350A1 (fr)
NL (1) NL7803486A (fr)
NO (1) NO160211C (fr)
NZ (1) NZ186842A (fr)
OA (1) OA05928A (fr)
PT (1) PT67856B (fr)
SE (2) SE448378B (fr)
YU (1) YU41827B (fr)

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2399418A1 (fr) * 1977-03-14 1979-03-02 Fujisawa Pharmaceutical Co Procede de preparation d'acides iminoacetiques et nouveaux produits ainsi obtenus, utilises pour la synthese d'acides cepham- ou cephem-carboxyliques
FR2453161A1 (fr) * 1978-08-31 1980-10-31 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide thiazolylacetique et nouveaux produits ainsi obtenus
FR2476647A2 (fr) * 1980-02-26 1981-08-28 Roussel Uclaf Procede de preparation de derives de l'acide 2-(2-amino protege 4-thiazolyl) 2-alkoxyimino acetique isomere syn
FR2488258A1 (fr) * 1980-08-11 1982-02-12 American Cyanamid Co Acide 7-beta-(alpha-syn-methoxyimino-alpha - (2-aminothiazol-4-yl) - acetamino)-3-((1,2,3-thiadiazol-5-ylthio) methyl)-3-cepheme-4-carboxylique et derives alkyliques en c1-c6 de celui-ci, compositions contenant ces composes et leurs applications
EP0045937A2 (fr) * 1980-08-11 1982-02-17 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédés pour leur préparation
EP0049119A2 (fr) * 1980-09-30 1982-04-07 Sankyo Company Limited Dérivés de céphalosporines, leur préparation et compositions pharmaceutiques les contenant
EP0049499A2 (fr) * 1980-10-06 1982-04-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de céphalosporine, leur préparation, compositions pharmaceutiques les contenant et intermédiaires pour leur préparation
FR2494279A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles oxacephalosporines, leur preparation et les medicaments qui les contiennent
EP0064256A2 (fr) * 1981-05-02 1982-11-10 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
FR2505338A1 (fr) * 1981-05-11 1982-11-12 Rhone Poulenc Sante Nouvelles oxacephalosporines et leur preparation
FR2505339A1 (fr) * 1981-05-11 1982-11-12 Rhone Poulenc Sante Nouvelles oxacephalosporines et leur preparation
EP0064740A2 (fr) * 1981-05-12 1982-11-17 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
FR2505840A1 (fr) * 1981-05-13 1982-11-19 Roussel Uclaf Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments
FR2508458A1 (fr) * 1981-06-29 1982-12-31 Sandoz Sa Nouveaux derives de l'acide cephalosporanique, leur preparation et leur application comme medicaments
FR2512448A1 (fr) * 1981-09-08 1983-03-11 Lilly Co Eli Isoquinoleinium-betaines de cephalosporine et son application pharmaceutique
FR2512449A1 (fr) * 1981-09-08 1983-03-11 Lilly Co Eli Quinoleinium-betaines de cephalosporine et leur application pharmacolique
EP0074268A2 (fr) * 1981-09-08 1983-03-16 Eli Lilly And Company Dérivés de céphalosporines thiéno- et furopyridinium substitués
EP0074645A2 (fr) * 1981-09-14 1983-03-23 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine, procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0075600A1 (fr) * 1981-03-16 1983-04-06 MITSUI TOATSU CHEMICALS, Inc. Derives de 2-thiazolamines, leur procede de preparation et composition medicinale les contenant
FR2514004A1 (fr) * 1981-10-02 1983-04-08 Lilly Co Eli Antibiotiques de dioximino-cephalosporines
EP0076528A2 (fr) * 1980-02-18 1983-04-13 Roussel-Uclaf Nouvelles oximes dérivées de l'acide 3-alkyloxy ou 3-alkylthiométhyl 7-amino thiazolylacétamido céphalosporanique et leur préparation
EP0078532A2 (fr) * 1981-11-03 1983-05-11 Hoechst Aktiengesellschaft Sels cristallins de céfodizim et procédé pour leur préparation
EP0081971A2 (fr) * 1981-12-08 1983-06-22 Tanabe Seiyaku Co., Ltd. Dérivé de céphalosporine et procédé pour sa préparation
EP0095329A2 (fr) * 1982-05-20 1983-11-30 Glaxo Group Limited Céphalosporines antibiotiques
FR2529555A1 (fr) * 1982-06-30 1984-01-06 Glaxo Group Ltd Cephalosporines a activite antibiotique, leur procede de preparation et leur application en therapeutique
FR2529556A1 (fr) * 1982-06-30 1984-01-06 Glaxo Group Ltd Nouvelles cephalosporines a activite antibiotique, leur procede de preparation et leur application en therapeutique
FR2532936A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 2-amino-thiazolyl-4-yl acetique comportant une fonction oxime substituee et leur procede de preparation
FR2536402A1 (fr) * 1982-11-24 1984-05-25 Glaxo Group Ltd Cephalosporines, leur procede de preparation et leur application en therapeutique
EP0111935A2 (fr) * 1982-12-23 1984-06-27 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
EP0112164A2 (fr) * 1982-12-13 1984-06-27 Yamanouchi Pharmaceutical Co. Ltd. Dérivés céphem, leur préparation et les médicaments les contenant
EP0113243A2 (fr) * 1982-12-24 1984-07-11 Kureha Kagaku Kogyo Kabushiki Kaisha Dérivés de céphalosporine
EP0097961A3 (en) * 1982-06-28 1984-10-03 Bristol-Myers Company Cephalosporin derivatives, a process for the manufacture thereof and pharmaceutical compositions containing said derivatives
EP0132501A2 (fr) * 1983-03-31 1985-02-13 Ajinomoto Co., Inc. Dérivés de céphalosporine, préparation et compositions pharmaceutiques
FR2552089A2 (fr) * 1981-05-13 1985-03-22 Roussel Uclaf Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments
EP0135142A2 (fr) * 1983-08-25 1985-03-27 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
EP0145906A2 (fr) * 1983-10-31 1985-06-26 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédés pour leur préparation
EP0150609A2 (fr) * 1983-12-30 1985-08-07 Glaxo Group Limited Antibiotiques de céphalosporine
US4603129A (en) * 1980-02-23 1986-07-29 Hoechst Aktiengesellschaft Cephalosporin derivatives
EP0193858A1 (fr) * 1985-03-01 1986-09-10 Merck & Co. Inc. Dérivés de 1-oxa-1-déthia-céphalosporine et agent antibactérien les contenant
EP0214462A2 (fr) * 1985-08-05 1987-03-18 Fujisawa Pharmaceutical Co., Ltd. Dérivés de 3-céphem 3,7-disubstitué et procédés pour leur préparation
EP0221719A2 (fr) * 1985-10-22 1987-05-13 Biogal Gyogyszergyar Dérivés de céphalosporine, leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0226093A2 (fr) * 1985-12-03 1987-06-24 Hoechst Aktiengesellschaft Procédé pour la préparation de céfodizime
EP0241901A2 (fr) * 1986-04-14 1987-10-21 Banyu Pharmaceutical Co., Ltd. Dérivés de céphalosporine, leurs procédés de préparation et agents antibactériens
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions
EP0272827A2 (fr) * 1986-12-23 1988-06-29 ZENECA Pharma S.A. 3-Hétérocycliquethiométhyl céphalosporines
EP0304155A2 (fr) * 1987-07-23 1989-02-22 ZENECA Pharma S.A. Dérivés de céphalosporine, procédé pour leur préparation et leurs compositions pharmaceutiques
EP0336705A2 (fr) * 1988-04-05 1989-10-11 Ajinomoto Co., Inc. Composés céphem et procédé pour leur préparation
EP0390066A2 (fr) * 1989-03-29 1990-10-03 Hoechst Aktiengesellschaft Dérivés de céphalosporines et procédé pour leur préparation
US5412093A (en) * 1986-12-23 1995-05-02 Ici Pharma 3-heterocyclic thiomethyl cephalosporins

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
BE878514A (fr) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
US4304770A (en) 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US4493833A (en) * 1976-04-12 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds
US4409217A (en) * 1977-03-14 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4427674A (en) 1977-03-14 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
PH17188A (en) 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US5089490A (en) * 1977-04-02 1992-02-18 Hoechst Aktiengesellschaft Cephem derivatives
JPS5444695A (en) * 1977-09-13 1979-04-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
SE7902598L (sv) * 1978-03-25 1979-10-04 Kyowa Hakko Kogyo Kk Cephalosporinanaloger
JPS5936914B2 (ja) * 1978-06-24 1984-09-06 協和醗酵工業株式会社 セフアロスポリン類縁体
NO790956L (no) * 1978-03-25 1979-09-26 Kyowa Hakko Kogyo Kk Analogifremgangsmaate til fremstilling av cefalosporinanaloge eller farmasoeytisk akseptable salter derav
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
SE448379B (sv) * 1978-03-31 1987-02-16 Roussel Uclaf O-substituerade oximderivat av 7-amino-tiazolyl-acetamidocefalosporansyra
US4374834A (en) * 1978-04-07 1983-02-22 Roussel Uclaf Novel compounds
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
AR231986A1 (es) * 1978-05-26 1985-04-30 Glaxo Group Ltd Procedimiento para preparar antibioticos de cefalosporina
EP0009548B1 (fr) * 1978-07-17 1985-01-16 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine, procédé pour leur préparation, compositions pharmaceutiques les contenant
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
US4372952A (en) 1978-07-31 1983-02-08 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
BE878637A (fr) * 1978-09-11 1980-03-06 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3,7-disubstitue et de leurs sels pharmaceutiquement acceptables, nouveaux produits ainsi obtenus et leur utilisation pour leurs activites antimicrobiennes
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE2945248A1 (de) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
ES486026A1 (es) * 1978-11-17 1980-09-01 Glaxo Group Ltd Un procedimiento para la preparacion de antibioticos de ce- falosporina
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS6058920B2 (ja) * 1978-12-26 1985-12-23 協和醗酵工業株式会社 セフアロスポリン類縁体
FR2448543A1 (fr) 1979-02-09 1980-09-05 Roussel Uclaf Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5671092A (en) * 1979-11-14 1981-06-13 Kyowa Hakko Kogyo Co Ltd Optical active cephalosporin analogous derivative
JPS5616491A (en) * 1979-07-19 1981-02-17 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS55108877A (en) * 1979-02-10 1980-08-21 Kyowa Hakko Kogyo Co Ltd Optically active cephalosporin analog
NO155547C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling.
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
IE49569B1 (en) * 1979-03-22 1985-10-30 Glaxo Group Ltd Cephalosporin antibiotics
US4339449A (en) 1979-03-27 1982-07-13 Fujisawa Pharmaceutical Company, Limited Analogous compounds of cephalosporins, and pharmaceutical composition comprising the same
US4331666A (en) * 1979-05-11 1982-05-25 Farmitalia Carlo Erba S.P.A. 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
FR2461713A1 (fr) 1979-07-19 1981-02-06 Roussel Uclaf Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE3069560D1 (en) 1979-09-03 1984-12-06 Fujisawa Pharmaceutical Co Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
US4271157A (en) 1980-02-28 1981-06-02 E. R. Squibb & Sons, Inc. Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4443443A (en) * 1979-12-17 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4405617A (en) * 1980-02-11 1983-09-20 Fujisawa Pharmaceutical Co., Ltd. 3-(Propynyltetrazol)thiomethyl-3-cephems
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS56131591A (en) * 1980-02-20 1981-10-15 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
US4252802A (en) 1980-03-13 1981-02-24 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
FR2479229B1 (fr) * 1980-03-26 1986-01-17 Clin Midy Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives
US4482551A (en) * 1980-06-26 1984-11-13 Hoffmann-La Roche Inc. Cephalosporin derivatives
US4308267A (en) 1980-07-03 1981-12-29 Smithkline Corporation 7-[2-Alkoxyimino-2-(amino-thiazole)acetamido]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins
US4416879A (en) * 1980-09-08 1983-11-22 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
US4507293A (en) * 1980-09-26 1985-03-26 Fujisawa Pharmaceutical Co., Ltd. Antimicrobial cephem compounds
US4486425A (en) 1980-09-30 1984-12-04 Sankyo Company Limited 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
US4367228A (en) 1980-10-29 1983-01-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compound and composition
FR2494275A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
FR2494280A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine et leur preparation
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
ES8303422A1 (es) * 1980-12-15 1983-02-01 Fujisawa Pharmaceutical Co Un procedimiento para preparar derivados del acido 7-acilaminocefalosporanico .
JPS6052754B2 (ja) * 1981-01-29 1985-11-21 山之内製薬株式会社 ７−アミノ−３−ハロゲノメチル−△↑３−セフェム−４−カルボン酸類およびその製法
EP0058250A3 (fr) * 1981-02-17 1983-08-17 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de céphalosporine, leur préparation et compositions pharmaceutiques les contenant
JPS57156495A (en) * 1981-03-23 1982-09-27 Kyoto Yakuhin Kogyo Kk Cephalosporin derivative and remedy for microbism used in oral administration
JPS6011917B2 (ja) * 1981-04-09 1985-03-28 山之内製薬株式会社 新規なセファロスポリン化合物
JPS57193489A (en) * 1981-05-21 1982-11-27 Fujisawa Pharmaceut Co Ltd Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation
US4577014A (en) * 1981-09-08 1986-03-18 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
US4382932A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company Isoquinolinium substituted cephalosporins
US4474954A (en) * 1981-12-07 1984-10-02 Bristol-Myers Company Intermediates for cephalosporin derivatives
US4394503A (en) * 1981-12-07 1983-07-19 Bristol-Myers Company Cephalosporin derivatives
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
JPS58167594A (ja) * 1982-03-26 1983-10-03 Sankyo Co Ltd 経口用セフアロスポリン化合物
US4457929A (en) * 1982-03-29 1984-07-03 Bristol-Myers Company 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives
US4500526A (en) * 1982-06-28 1985-02-19 Bristol-Myers Company Cephalosporin derivatives
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
JPS59193889A (ja) * 1983-04-18 1984-11-02 Asahi Chem Ind Co Ltd セフアロスポリン系化合物
JPS5910591A (ja) * 1982-07-09 1984-01-20 Meiji Seika Kaisha Ltd １−オキサデチアセフアロスポリン化合物及びそれを含む抗菌剤
JPS5951291A (ja) * 1982-09-16 1984-03-24 Meiji Seika Kaisha Ltd オキサデチアセフアロスポリン中間体およびその製造法
JPS5946287A (ja) * 1982-07-23 1984-03-15 Meiji Seika Kaisha Ltd 新規１−オキサ−１−デチア−セフアロスポリン誘導体
IL69246A (en) * 1982-08-07 1986-07-31 Tanabe Seiyaku Co 7-((2-aminothiazolyl-2-pyrrolidonyl or(piperidonyl)-oxyimino)acetamido)cephem carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
US4473577A (en) * 1982-10-22 1984-09-25 Mitsui Toatsu Chemicals, Incorporated 2-Thiazolamine derivatives, process for preparing same, and pharmaceutical compositions comprising same
DK521883A (da) * 1982-11-17 1984-05-18 Toyama Chemical Co Ltd Cephalosporinderivater, fremgangsmaade til fremstilling heraf og fremgangsmaade til fremstilling af mellemprodukter herfor
JPS59104389A (ja) * 1982-12-06 1984-06-16 Shionogi & Co Ltd オキサセファム誘導体
JPS59116291A (ja) * 1982-12-06 1984-07-05 Fujisawa Pharmaceut Co Ltd ７−置換−３−セフエム−４−カルボン酸エステルおよびその製法
JPS59161386A (ja) * 1983-03-01 1984-09-12 Kureha Chem Ind Co Ltd セフアロスポリン誘導体及び該誘導体を含有する医薬
JPS59118793A (ja) * 1982-12-24 1984-07-09 Kureha Chem Ind Co Ltd セフアロスポリン誘導体及び該誘導体を含有する医薬
US4499088A (en) * 1983-01-04 1985-02-12 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS59155391A (ja) * 1983-02-22 1984-09-04 Tanabe Seiyaku Co Ltd 新規セファロスポリン誘導体
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
US4514564A (en) * 1983-04-18 1985-04-30 Eli Lilly And Company 7β-(2'-(1",3",5"-Triazepin-4"-one)-2'-(oxime ether)-acetamido)-3-substituted cephalosporins
JPS59225193A (ja) * 1983-06-02 1984-12-18 Takeda Chem Ind Ltd セフアロスポリンエステル
JPS6041683A (ja) * 1983-07-06 1985-03-05 Asahi Chem Ind Co Ltd 経口用セフアロスボリン誘導体
US4690921A (en) * 1983-10-11 1987-09-01 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin compounds and salts thereof
US4692443A (en) * 1983-10-17 1987-09-08 Eli Lilly And Company 3-bicyclicpyridinium-methyl cephalosporins
DE3485860T2 (de) * 1983-12-29 1993-01-14 Mochida Pharm Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE3404906A1 (de) * 1984-02-11 1985-08-14 Bayer Ag, 5090 Leverkusen 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung
DE3405728A1 (de) * 1984-02-17 1985-08-22 Hoechst Ag, 6230 Frankfurt Verwendung von cephemverbindungen als immunmodulatoren
JPS60174787A (ja) * 1984-02-21 1985-09-09 Kyowa Hakko Kogyo Co Ltd ３位置換カルバセフエム化合物
JPS60178891A (ja) * 1984-02-24 1985-09-12 Kureha Chem Ind Co Ltd セファロスポリン誘導体及び該誘導体を含有する医薬
US4788185A (en) * 1984-04-23 1988-11-29 Takeda Chemical Industries, Ltd. Cephalosporin compounds
JPS60231682A (ja) * 1984-05-02 1985-11-18 Meiji Seika Kaisha Ltd 新規セフアロスポリン系抗菌性化合物及びその製造法
DE3418376A1 (de) * 1984-05-17 1985-11-21 Bayer Ag, 5090 Leverkusen Zwischenprodukte sowie verfahren zur herstellung von zwischenprodukten fuer die synthese von cephalosporinen
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds
JPS6140291A (ja) * 1984-07-31 1986-02-26 Shionogi & Co Ltd ヒドロキシアルキルチオセフアロスポリン
JPS61178991A (ja) * 1984-09-07 1986-08-11 Meiji Seika Kaisha Ltd 新規セフアロスポリン化合物
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
JPH0653739B2 (ja) * 1984-11-15 1994-07-20 協和醗酵工業株式会社 ３位置換カルバセフエム化合物
EP0182633A3 (fr) * 1984-11-20 1987-09-02 Ici Pharma Dérivés de céphalosporine
EP0187456A1 (fr) * 1984-11-29 1986-07-16 Ici Pharma Dérivés de céphalosporine
JPS61267584A (ja) * 1985-01-16 1986-11-27 Fujisawa Pharmaceut Co Ltd セフアロスポラン酸誘導体もしくはその薬理学的に許容しうる塩
JPS61267585A (ja) * 1985-01-16 1986-11-27 Fujisawa Pharmaceut Co Ltd セフアロスポラン酸誘導体もしくはその薬理学的に許容しうる塩
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
HUT40660A (en) 1985-04-30 1987-01-28 Lilly Co Eli Process for production of derivatives of 7-substituated bicyclic pirasilididone
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
AR243179A1 (es) * 1985-10-29 1993-07-30 Merrell Dow Pharma Procedimiento para preparar nuevas 5-(het)-2,4-dialquil-3h-1,2,4-triazolo-3-tionas
US4670450A (en) * 1985-11-13 1987-06-02 Merrell Dow Pharmaceuticals Inc. Cardiotonic thiazolones
IE862850L (en) * 1985-11-21 1987-05-21 Inst Animal Health Ltd Intermediates for the preparation of beta-lactam antibiotics
GB8626245D0 (en) * 1985-11-27 1986-12-03 Ici Pharma Cephalosporin compounds
EP0238060B1 (fr) 1986-03-19 1992-01-08 Banyu Pharmaceutical Co., Ltd. Dérivés de céphalosporine, procédés pour leur préparation et agents antibactériens
JP2503500B2 (ja) * 1986-04-14 1996-06-05 萬有製薬株式会社 新規セフアロスポリン誘導体及びその製造法
US5596102A (en) * 1986-05-23 1997-01-21 Zeneca Limited Biocides
CA1283404C (fr) * 1986-07-01 1991-04-23 Shigeru Sanai Composes de cephalosporine, procede de preparation et agents antibacteriens
FR2621589B1 (fr) * 1987-10-08 1990-03-02 Sanofi Sa Derives des cephalosporines a pharmacocinetique amelioree, procede pour leur preparation et compositions pharmaceutiques les contenant
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63284164A (ja) * 1987-05-15 1988-11-21 Ube Ind Ltd ２−メチル−４−アミノ−５−アミノメチルピリミジン炭酸塩及びその製造方法
DE3854804T2 (de) * 1987-07-23 1996-06-13 Zeneca Pharma Sa Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US5223496A (en) * 1987-11-10 1993-06-29 The Upjohn Company Cephalosporin antibiotics
US4937332A (en) * 1987-12-25 1990-06-26 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
DE3804841A1 (de) * 1988-02-17 1989-08-31 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
JPH01265093A (ja) * 1988-10-12 1989-10-23 Sankyo Co Ltd 経口用セフアロスポリン化合物
US5391759A (en) * 1988-12-19 1995-02-21 Dowelanco Preparation of 5-acylamino-1,2,4-triazole-3-sulfonamides
DE3911322A1 (de) * 1989-04-07 1990-10-11 Hoechst Ag Verfahren zur herstellung von cefodizim-dinatrium
DE3919259A1 (de) * 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
KR930001114B1 (ko) * 1990-07-20 1993-02-18 한국과학기술연구원 세팔로스포린 유도체 및 그의 제조방법
YU48484B (sh) * 1991-05-24 1998-09-18 Hoechst Aktiengesellschaft Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
ATE262533T1 (de) * 1991-09-07 2004-04-15 Aventis Pharma Gmbh Diastereomer des 3-cephem-4-carbonsäure-1-(- isopropoxycarbonyloxy)ethylesters und verfahren zu dessen herstellung
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
TW212181B (fr) * 1992-02-14 1993-09-01 Hoechst Ag
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
ATE164378T1 (de) * 1992-05-21 1998-04-15 Hoechst Ag Verfahren zur spaltung von cephalosporin prodrugestern zu 7-amino-3-methoxymethylceph-3-em-4-carbonsäure
KR0154901B1 (ko) * 1992-12-26 1998-11-16 성재갑 신규 세팔로스포린계 항생제(v)
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
US7427680B2 (en) * 2001-01-12 2008-09-23 The Regents Of The University Of California Fluorogenic substrates for BETA-lactamase gene expression
US6121489A (en) * 1996-03-05 2000-09-19 Trega Biosciences, Inc. Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein
EP1214292B1 (fr) 1999-09-24 2007-06-13 Genentech, Inc. Derives de tyrosine
EP1392317A4 (fr) * 2001-05-16 2005-10-19 Antexpharma Inc 1-benzazepines substituees et leurs derives
EP1740173A4 (fr) * 2004-03-23 2009-05-27 Genentech Inc Inhibiteurs azabicyclo-octane de l'iap
JP4691549B2 (ja) 2004-04-07 2011-06-01 ノバルティス アーゲー Ｉａｐの阻害剤
CN101005854A (zh) * 2004-04-16 2007-07-25 健泰科生物技术公司 用于增进b细胞消除的方法
KR100984459B1 (ko) * 2004-07-02 2010-09-29 제넨테크, 인크. Ｉａｐ의 억제제
CA2574040C (fr) 2004-07-15 2014-05-06 Tetralogic Pharmaceuticals Corporation Composes de liaison aux proteines iap
ATE477254T1 (de) 2004-12-20 2010-08-15 Genentech Inc Pyrrolidine als inhibitoren von iap
CA2598995C (fr) * 2005-02-25 2014-07-15 Stephen M. Condon Inhibiteurs iap dimeriques
US20100256046A1 (en) * 2009-04-03 2010-10-07 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
CA2632807A1 (fr) * 2005-12-19 2007-09-20 Genentech, Inc. Inhibiteurs iap (inhibiteurs de l'apoptose)
WO2008014236A1 (fr) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Inhibiteurs d'iap dimériques
WO2008014238A2 (fr) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Inhibiteurs des iap dimères
EP2049524A2 (fr) * 2006-07-24 2009-04-22 Tetralogic Pharmaceuticals Corporation Inhibiteurs des iap
US20100113326A1 (en) * 2006-07-24 2010-05-06 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
US7985735B2 (en) * 2006-07-24 2011-07-26 Tetralogic Pharmaceuticals Corporation Dimeric IAP inhibitors
PE20110224A1 (es) 2006-08-02 2011-04-05 Novartis Ag PROCEDIMIENTO PARA LA SINTESIS DE UN PEPTIDOMIMETICO DE Smac INHIBIDOR DE IAP, Y COMPUESTOS INTERMEDIARIOS PARA LA SINTESIS DEL MISMO
AU2007337104A1 (en) * 2006-12-19 2008-07-03 Genentech, Inc. Imidazopyridine inhibitors of IAP
MX2009011783A (es) * 2007-04-30 2009-12-04 Genentech Inc Inhibidores de iap.
WO2009089502A1 (fr) * 2008-01-11 2009-07-16 Genentech, Inc. Inhibiteurs de iap
JP2011529962A (ja) 2008-08-02 2011-12-15 ジェネンテック， インコーポレイテッド Ｉａｐのインヒビター
CA2730357A1 (fr) * 2008-08-16 2010-02-25 Genetech, Inc. Inhibiteurs azaindoles d'iap
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
WO2011072064A1 (fr) 2009-12-08 2011-06-16 Array Biopharma Inc. Spiro[chromane-4,4'-imidazol]ones en tant qu'inhibiteurs de bêta-sécrétase
WO2011123674A1 (fr) 2010-03-31 2011-10-06 Array Biopharma Inc. Composés pour traiter des maladies neurodégénératives
WO2011130741A1 (fr) 2010-04-16 2011-10-20 Array Biopharma Inc. Composés pour le traitement de maladies neurodégénératives
AR083953A1 (es) 2010-11-22 2013-04-10 Array Biopharma Inc Compuestos para tratar enfermedades neurodegenerativas
MX2016008624A (es) 2013-12-30 2017-01-06 Genentech Inc Inhibidores de serina/treonina cinasa.
JP6769963B2 (ja) 2014-08-29 2020-10-14 ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ α−アミノ−β−カルボキシムコン酸セミアルデヒド脱炭酸酵素の阻害剤
AU2017319500C1 (en) 2016-08-31 2022-10-20 Les Laboratoires Servier Inhibitors of cellular metabolic processes
WO2019060051A1 (fr) 2017-08-04 2019-03-28 Ardelyx, Inc. Dérivés d'acide glycyrrhétinique de traitement de l'hyperkaliémie
WO2020163642A1 (fr) 2019-02-07 2020-08-13 Ardelyx, Inc. Dérivés d'acide glycyrrhétinique destinés à être utilisés dans le traitement de l'hyperkaliémie

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2123544A1 (fr) * 1971-01-29 1972-09-08 Glaxo Lab Ltd
FR2137899A1 (fr) * 1971-05-14 1972-12-29 Glaxo Lab Ltd
FR2294690A1 (fr) * 1974-12-19 1976-07-16 Takeda Chemical Industries Ltd Composes thiazo-lylacetamido
FR2346014A1 (fr) * 1976-01-23 1977-10-28 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2348218A1 (fr) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Nouveaux derives cephalosporines ayant un nouveau groupe 7-acyle et leur procede de fabrication
FR2361893A2 (fr) * 1976-01-23 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE36041B1 (en) * 1971-01-29 1976-08-04 Glaxo Lab Ltd Improvements in or relating to antibiotics
US4091211A (en) * 1974-05-05 1978-05-23 Hoffmann-La Roche Inc. Cephalosporins
US4020058A (en) * 1974-10-03 1977-04-26 Glaxo Laboratories Limited Improvements in or relating to cephalosporin antibiotics
US4166155A (en) * 1974-10-11 1979-08-28 Gould Inc. Maintenance-free battery
JPS5167524A (ja) * 1974-12-09 1976-06-11 Hitachi Ltd Benchireeshonbarubu
JPS5760345B2 (fr) * 1974-12-19 1982-12-18 Takeda Chemical Industries Ltd
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
GB1575803A (en) * 1976-03-09 1980-10-01 Fujisawa Pharmaceutical Co 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4202893A (en) * 1976-03-25 1980-05-13 Roussel Uclaf Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
JPS597717B2 (ja) * 1976-09-08 1984-02-20 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
FR2361895A1 (fr) * 1976-08-20 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
FR2381053A1 (fr) * 1977-02-18 1978-09-15 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-thiadiazolyl thiomethyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS53103493A (en) * 1977-02-18 1978-09-08 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
FR2384782A1 (fr) * 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-acetoxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2384779A1 (fr) * 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-chloro ou 3-methoxy 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
KR0157073B1 (ko) * 1992-10-01 1998-11-16 김태훈 세팔로스포린 유도체 및 그의 제조방법

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2123544A1 (fr) * 1971-01-29 1972-09-08 Glaxo Lab Ltd
FR2137899A1 (fr) * 1971-05-14 1972-12-29 Glaxo Lab Ltd
FR2294690A1 (fr) * 1974-12-19 1976-07-16 Takeda Chemical Industries Ltd Composes thiazo-lylacetamido
FR2346014A1 (fr) * 1976-01-23 1977-10-28 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2361893A2 (fr) * 1976-01-23 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2348218A1 (fr) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Nouveaux derives cephalosporines ayant un nouveau groupe 7-acyle et leur procede de fabrication

Cited By (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2399418A1 (fr) * 1977-03-14 1979-03-02 Fujisawa Pharmaceutical Co Procede de preparation d'acides iminoacetiques et nouveaux produits ainsi obtenus, utilises pour la synthese d'acides cepham- ou cephem-carboxyliques
FR2453161A1 (fr) * 1978-08-31 1980-10-31 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide thiazolylacetique et nouveaux produits ainsi obtenus
EP0076528A2 (fr) * 1980-02-18 1983-04-13 Roussel-Uclaf Nouvelles oximes dérivées de l'acide 3-alkyloxy ou 3-alkylthiométhyl 7-amino thiazolylacétamido céphalosporanique et leur préparation
EP0104671A2 (fr) * 1980-02-18 1984-04-04 Roussel-Uclaf Nouvelles oximes dérivées de l'acide 3-alkyloxy ou 3-alkylthiométhyl-7 amino thiazolylacétamido céphalosporaniques, leur préparation, leur application comme médicaments et les compositions les renfermant
EP0104671B1 (fr) * 1980-02-18 1990-05-23 Roussel-Uclaf Nouvelles oximes dérivées de l'acide 3-alkyloxy ou 3-alkylthiométhyl-7 amino thiazolylacétamido céphalosporaniques, leur préparation, leur application comme médicaments et les compositions les renfermant
EP0076528B1 (fr) * 1980-02-18 1990-05-23 Roussel-Uclaf Nouvelles oximes dérivées de l'acide 3-alkyloxy ou 3-alkylthiométhyl 7-amino thiazolylacétamido céphalosporanique et leur préparation
US4603129A (en) * 1980-02-23 1986-07-29 Hoechst Aktiengesellschaft Cephalosporin derivatives
FR2476647A2 (fr) * 1980-02-26 1981-08-28 Roussel Uclaf Procede de preparation de derives de l'acide 2-(2-amino protege 4-thiazolyl) 2-alkoxyimino acetique isomere syn
EP0045937A3 (en) * 1980-08-11 1982-10-13 Fujisawa Pharmaceutical Co. Ltd. New cephem compounds and processes for preparation thereof
FR2488258A1 (fr) * 1980-08-11 1982-02-12 American Cyanamid Co Acide 7-beta-(alpha-syn-methoxyimino-alpha - (2-aminothiazol-4-yl) - acetamino)-3-((1,2,3-thiadiazol-5-ylthio) methyl)-3-cepheme-4-carboxylique et derives alkyliques en c1-c6 de celui-ci, compositions contenant ces composes et leurs applications
EP0045937A2 (fr) * 1980-08-11 1982-02-17 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédés pour leur préparation
EP0134420A1 (fr) * 1980-09-30 1985-03-20 Sankyo Company Limited Dérivés de céphalosporines, leur préparation et compositions pharmaceutiques
EP0049119A2 (fr) * 1980-09-30 1982-04-07 Sankyo Company Limited Dérivés de céphalosporines, leur préparation et compositions pharmaceutiques les contenant
EP0049119A3 (en) * 1980-09-30 1983-02-09 Sankyo Company Limited Cephalosporin derivatives, a process for their preparation and compositions containing them
EP0049499A3 (en) * 1980-10-06 1983-09-07 F. Hoffmann-La Roche & Co. Aktiengesellschaft Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates for their preparation
EP0049499A2 (fr) * 1980-10-06 1982-04-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de céphalosporine, leur préparation, compositions pharmaceutiques les contenant et intermédiaires pour leur préparation
FR2494279A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles oxacephalosporines, leur preparation et les medicaments qui les contiennent
EP0053072A1 (fr) * 1980-11-20 1982-06-02 Rhone-Poulenc Sante Nouvelles oxacéphalosporines et leur préparation
EP0053071A1 (fr) * 1980-11-20 1982-06-02 Rhone-Poulenc Sante Nouvelles oxacéphalosporines, leur préparation et les médicaments qui les contiennent
EP0053541A1 (fr) * 1980-11-20 1982-06-09 Rhone-Poulenc Sante Nouvelles oxacéphalosporines et leur préparation
EP0053073A1 (fr) * 1980-11-20 1982-06-02 Rhone-Poulenc Sante Nouvelles oxacéphalosporines et leur préparation
EP0075600A4 (fr) * 1981-03-16 1983-05-16 Mitsui Toatsu Chemicals Derives de 2-thiazolamines, leur procede de preparation et composition medicinale les contenant.
EP0075600A1 (fr) * 1981-03-16 1983-04-06 MITSUI TOATSU CHEMICALS, Inc. Derives de 2-thiazolamines, leur procede de preparation et composition medicinale les contenant
EP0064256A2 (fr) * 1981-05-02 1982-11-10 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
EP0064256A3 (en) * 1981-05-02 1983-11-23 Hoechst Aktiengesellschaft Cephalosporin derivatives and process for their preparation
FR2505339A1 (fr) * 1981-05-11 1982-11-12 Rhone Poulenc Sante Nouvelles oxacephalosporines et leur preparation
FR2505338A1 (fr) * 1981-05-11 1982-11-12 Rhone Poulenc Sante Nouvelles oxacephalosporines et leur preparation
FR2515654A1 (fr) * 1981-05-12 1983-05-06 Hoechst Ag Derives de cephalosporine utilisables comme produits intermediaires pour la preparation de produits a activite therapeutique
FR2511682A1 (fr) * 1981-05-12 1983-02-25 Hoechst Ag Derives de cephalosporine, leur procede de preparation et leur application therapeutique
EP0064740A3 (en) * 1981-05-12 1983-11-23 Hoechst Aktiengesellschaft Cephalosporin derivatives, and process for their preparation
EP0064740A2 (fr) * 1981-05-12 1982-11-17 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
FR2552089A2 (fr) * 1981-05-13 1985-03-22 Roussel Uclaf Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments
FR2505840A1 (fr) * 1981-05-13 1982-11-19 Roussel Uclaf Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments
US4476124A (en) * 1981-05-13 1984-10-09 Roussel Uclaf 2-Amino-4-thiazolyl-2-oxyimino-acetamido-bicyclooctene-carboxylic acids
FR2508458A1 (fr) * 1981-06-29 1982-12-31 Sandoz Sa Nouveaux derives de l'acide cephalosporanique, leur preparation et leur application comme medicaments
FR2511002A1 (fr) * 1981-06-29 1983-02-11 Sandoz Ag
EP0074268A2 (fr) * 1981-09-08 1983-03-16 Eli Lilly And Company Dérivés de céphalosporines thiéno- et furopyridinium substitués
FR2512448A1 (fr) * 1981-09-08 1983-03-11 Lilly Co Eli Isoquinoleinium-betaines de cephalosporine et son application pharmaceutique
FR2512449A1 (fr) * 1981-09-08 1983-03-11 Lilly Co Eli Quinoleinium-betaines de cephalosporine et leur application pharmacolique
EP0074268A3 (fr) * 1981-09-08 1984-05-23 Eli Lilly And Company Dérivés de céphalosporines thiéno- et furopyridinium substitués
EP0074645A3 (en) * 1981-09-14 1984-06-13 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds, processes for their preparation and pharmaceutical antibacterial composition containing them
EP0074645A2 (fr) * 1981-09-14 1983-03-23 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine, procédés pour leur préparation et compositions pharmaceutiques les contenant
FR2514004A1 (fr) * 1981-10-02 1983-04-08 Lilly Co Eli Antibiotiques de dioximino-cephalosporines
EP0078532A2 (fr) * 1981-11-03 1983-05-11 Hoechst Aktiengesellschaft Sels cristallins de céfodizim et procédé pour leur préparation
EP0078532A3 (en) * 1981-11-03 1984-09-12 Hoechst Aktiengesellschaft Crystalline salts of cephodizime, and process for their preparation
EP0081971A2 (fr) * 1981-12-08 1983-06-22 Tanabe Seiyaku Co., Ltd. Dérivé de céphalosporine et procédé pour sa préparation
US4576938A (en) * 1981-12-08 1986-03-18 Tanabe Seiyaku Co., Ltd. Cephalosporin compound and process for preparing the same
EP0081971A3 (fr) * 1981-12-08 1984-09-26 Tanabe Seiyaku Co., Ltd. Dérivé de céphalosporine et procédé pour sa préparation
EP0095329A3 (fr) * 1982-05-20 1984-11-28 Glaxo Group Limited Céphalosporines antibiotiques
EP0095329A2 (fr) * 1982-05-20 1983-11-30 Glaxo Group Limited Céphalosporines antibiotiques
EP0097961A3 (en) * 1982-06-28 1984-10-03 Bristol-Myers Company Cephalosporin derivatives, a process for the manufacture thereof and pharmaceutical compositions containing said derivatives
FR2543949A1 (fr) * 1982-06-30 1984-10-12 Glaxo Group Ltd Derives de l'acide 2-cyclopropylmethoxyimino-2-(thiazole-4-yl) acetique, leur procede de preparation et leur application a la preparation d'antibiotiques de type cephalosporine
FR2529556A1 (fr) * 1982-06-30 1984-01-06 Glaxo Group Ltd Nouvelles cephalosporines a activite antibiotique, leur procede de preparation et leur application en therapeutique
FR2529555A1 (fr) * 1982-06-30 1984-01-06 Glaxo Group Ltd Cephalosporines a activite antibiotique, leur procede de preparation et leur application en therapeutique
FR2532936A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 2-amino-thiazolyl-4-yl acetique comportant une fonction oxime substituee et leur procede de preparation
FR2536402A1 (fr) * 1982-11-24 1984-05-25 Glaxo Group Ltd Cephalosporines, leur procede de preparation et leur application en therapeutique
EP0112164A2 (fr) * 1982-12-13 1984-06-27 Yamanouchi Pharmaceutical Co. Ltd. Dérivés céphem, leur préparation et les médicaments les contenant
EP0112164A3 (fr) * 1982-12-13 1985-06-26 Yamanouchi Pharmaceutical Co. Ltd. Dérivés céphem, leur préparation et les médicaments les contenant
EP0111935A3 (en) * 1982-12-23 1985-07-03 Hoechst Aktiengesellschaft Cephalosporin derivatives and process for their preparation
EP0111935A2 (fr) * 1982-12-23 1984-06-27 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
EP0113243A2 (fr) * 1982-12-24 1984-07-11 Kureha Kagaku Kogyo Kabushiki Kaisha Dérivés de céphalosporine
EP0113243A3 (en) * 1982-12-24 1985-05-02 Kureha Kagaku Kogyo Kabushiki Kaisha Cephalosporin derivatives
EP0132501A3 (fr) * 1983-03-31 1985-09-18 Ajinomoto Co., Inc. Dérivés de céphalosporine, préparation et compositions pharmaceutiques
EP0132501A2 (fr) * 1983-03-31 1985-02-13 Ajinomoto Co., Inc. Dérivés de céphalosporine, préparation et compositions pharmaceutiques
EP0135142A3 (en) * 1983-08-25 1986-01-08 Hoechst Aktiengesellschaft Cephalosporin derivatives and process for their preparation
EP0135142A2 (fr) * 1983-08-25 1985-03-27 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
EP0145906A2 (fr) * 1983-10-31 1985-06-26 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédés pour leur préparation
EP0145906B1 (fr) * 1983-10-31 1992-03-11 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédés pour leur préparation
EP0150609A3 (fr) * 1983-12-30 1986-04-23 Glaxo Group Limited Antibiotiques de céphalosporine
EP0150609A2 (fr) * 1983-12-30 1985-08-07 Glaxo Group Limited Antibiotiques de céphalosporine
EP0193858A1 (fr) * 1985-03-01 1986-09-10 Merck & Co. Inc. Dérivés de 1-oxa-1-déthia-céphalosporine et agent antibactérien les contenant
EP0214462A2 (fr) * 1985-08-05 1987-03-18 Fujisawa Pharmaceutical Co., Ltd. Dérivés de 3-céphem 3,7-disubstitué et procédés pour leur préparation
EP0214462A3 (fr) * 1985-08-05 1987-12-09 Fujisawa Pharmaceutical Co., Ltd. Dérivés de 3-céphem 3,7-disubstitué et procédés pour leur préparation
EP0221719A2 (fr) * 1985-10-22 1987-05-13 Biogal Gyogyszergyar Dérivés de céphalosporine, leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0221719A3 (fr) * 1985-10-22 1987-12-16 Biogal Gyogyszergyar Dérivés de céphalosporine, leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0226093A2 (fr) * 1985-12-03 1987-06-24 Hoechst Aktiengesellschaft Procédé pour la préparation de céfodizime
EP0226093A3 (en) * 1985-12-03 1988-11-09 Hoechst Aktiengesellschaft Process for the preparation of cefodizime
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions
EP0241901A2 (fr) * 1986-04-14 1987-10-21 Banyu Pharmaceutical Co., Ltd. Dérivés de céphalosporine, leurs procédés de préparation et agents antibactériens
EP0241901A3 (en) * 1986-04-14 1989-06-14 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents
EP0272827A3 (fr) * 1986-12-23 1990-02-07 ZENECA Pharma S.A. 3-Hétérocycliquethiométhyl céphalosporines
EP0272827A2 (fr) * 1986-12-23 1988-06-29 ZENECA Pharma S.A. 3-Hétérocycliquethiométhyl céphalosporines
US5412093A (en) * 1986-12-23 1995-05-02 Ici Pharma 3-heterocyclic thiomethyl cephalosporins
US5057511A (en) * 1986-12-23 1991-10-15 Ici Pharma 3-heterocyclic thiomethyl cephalosporins
EP0304155A2 (fr) * 1987-07-23 1989-02-22 ZENECA Pharma S.A. Dérivés de céphalosporine, procédé pour leur préparation et leurs compositions pharmaceutiques
EP0304155B1 (fr) * 1987-07-23 1995-11-15 ZENECA Pharma S.A. Dérivés de céphalosporine, procédé pour leur préparation et leurs compositions pharmaceutiques
EP0336705A2 (fr) * 1988-04-05 1989-10-11 Ajinomoto Co., Inc. Composés céphem et procédé pour leur préparation
EP0336705A3 (fr) * 1988-04-05 1991-07-03 Ajinomoto Co., Inc. Composés céphem et procédé pour leur préparation
EP0390066A3 (fr) * 1989-03-29 1992-02-26 Hoechst Aktiengesellschaft Dérivés de céphalosporines et procédé pour leur préparation
US5306717A (en) * 1989-03-29 1994-04-26 Hoechst Aktiengesellschaft Cephalosporin derivatives
EP0390066A2 (fr) * 1989-03-29 1990-10-03 Hoechst Aktiengesellschaft Dérivés de céphalosporines et procédé pour leur préparation

Also Published As

Publication number Publication date
AT367425B (de) 1982-07-12
FI70221C (fi) 1986-09-15
DK143378A (da) 1978-10-03
YU76578A (en) 1983-04-30
SE8306994L (sv) 1983-12-16
AU528277B2 (en) 1983-04-21
CH638810A5 (de) 1983-10-14
FR2385722B1 (fr) 1985-09-27
ATA229078A (de) 1981-11-15
SE7803660L (sv) 1978-10-03
ES468475A1 (es) 1979-08-16
FI70221B (fi) 1986-02-28
JPS5858354B2 (ja) 1983-12-24
CS208747B2 (en) 1981-09-15
ES477591A1 (es) 1980-01-01
OA05928A (fr) 1981-06-30
NO781130L (no) 1978-10-03
NL7803486A (nl) 1978-10-04
SE448378B (sv) 1987-02-16
PT67856A (de) 1978-04-01
CA1259606A (fr) 1989-09-19
JPS549296A (en) 1979-01-24
US5710146A (en) 1998-01-20
DK165060C (da) 1993-02-22
DE2714880A1 (de) 1978-10-26
FR2485017A1 (fr) 1981-12-24
YU41827B (en) 1988-02-29
NZ186842A (en) 1980-11-14
GB1604971A (en) 1981-12-16
FR2485018B1 (fr) 1985-04-12
IL54407A (en) 1985-09-29
FI780966A (fi) 1978-10-03
PT67856B (de) 1979-12-19
SE8306994D0 (sv) 1983-12-16
USRE35754E (en) 1998-03-24
NO160211C (no) 1989-03-22
DE2716707A1 (de) 1978-10-19
IL54407A0 (en) 1978-06-15
FR2485018A1 (fr) 1981-12-24
JPS5716887A (en) 1982-01-28
BE865632A (fr) 1978-10-03
IT7821901A0 (it) 1978-03-31
AU3464878A (en) 1979-10-04
IE780642L (en) 1978-10-02
IT1093750B (it) 1985-07-26
IE47211B1 (en) 1984-01-25
GR73632B (fr) 1984-03-26
US4278793A (en) 1981-07-14
DK165060B (da) 1992-10-05
LU79350A1 (de) 1978-11-27
FR2485017B1 (fr) 1985-04-12
US4758556A (en) 1988-07-19
HK39083A (en) 1983-10-13
NO160211B (no) 1988-12-12
DD137231A5 (de) 1979-08-22
JPS6228153B2 (fr) 1987-06-18

Similar Documents

Publication Publication Date Title
FR2385722A1 (fr) Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
FR2387234A1 (fr) Derives de cephalosporine, leur procede de preparation et leurs applications en therapeutique
FR2392016A1 (fr) Derives de mevalonolactone, leur procede de preparation et leur application therapeutique
FR2364219A1 (fr) Derives de thiazolidine, leur procede de preparation et leur application en therapeutique
FR2384765A1 (fr) Derives amino-substitues du furanne et procede pour leur preparation
FR2378521A1 (fr) Derives du carbostyrile, utiles notamment comme stimulants des centres b- adrenorecepteurs, et leur procede de preparation
FR2375250A1 (fr) 3-de-0-methylfortimicines, leur procede de preparation et leur utilisation therapeutique comme antibiotiques
FR2366297A1 (fr) Nouvelles cephalosporines, leur procede de preparation et leur application en therapeutique
FR2405246A1 (fr) Nouveaux derives de pyrrole, leur procede de preparation et leurs applications en therapeutique
FR2400500A1 (fr) Derives d'acides cycloalcoylidenemethylphenylacetiques, leur procede de preparation et leur application en therapeutique
FR2446283A1 (fr) Phenoxyphenylpiperidines, leur preparation et leurs applications therapeutiques
FR2427337A1 (fr) Nouveaux derives acyles de la cephalosporine, leur preparation et leurs utilisations therapeutiques
FR2381753A1 (fr) Nouveaux derives de la pyrrolidine, leur procede de preparation et leur application en therapeutique
FR2387988A1 (fr) Esters de cefuroxime, leur preparation et leur application therapeutique
FR2384811A1 (fr) Derives de la neocarzinostatine, leur application therapeutique et leur procede de preparation
FR2453151A1 (fr) Derives de la vitamine d3, leur procede de preparation et leur application en therapeutique
FR2421900A1 (fr) Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
FR2355849A1 (fr) Derives de l'acide 7 b-acylamidoceph-3-eme 4-carboxyliques, leur procede de preparation et application therapeutique
FR2355020A1 (fr) Antibiotiques de b-lactames et leur procede de preparation
FR2388789A1 (fr) Derives d'acide benzoique, leur procede de preparation et leur application therapeutique
FR2355831A1 (fr) Derives de benzazocine, leur procede de preparation et leur application therapeutique
FR2358401A1 (fr) Nouveaux derives d'oxadiazine, leur procede de preparation et leur application comme insecticides
FR2361881A2 (fr) Nouveaux sulfoxydes, leur procede de preparation et leur application
FR2368489A1 (fr) Derives de la clavuline, leur procede de preparation et leur application en therapeutique
FR2446282A1 (fr) Phenylthiophenylpiperidines, leur preparation et leurs applications therapeutiques