FI63406C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-entsoyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyr adrivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-entsoyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyr adrivat Download PDF

Info

Publication number
FI63406C
FI63406C FI772153A FI772153A FI63406C FI 63406 C FI63406 C FI 63406C FI 772153 A FI772153 A FI 772153A FI 772153 A FI772153 A FI 772153A FI 63406 C FI63406 C FI 63406C
Authority
FI
Finland
Prior art keywords
dihydro
pyrrolo
pyrrole
formula
carboxylic acid
Prior art date
Application number
FI772153A
Other languages
English (en)
Finnish (fi)
Other versions
FI63406B (fi
FI772153A (xx
Inventor
Joseph M Muchowski
Arthur F Kluge
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107410&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI63406(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/771,286 external-priority patent/US4089969A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI772153A publication Critical patent/FI772153A/fi
Publication of FI63406B publication Critical patent/FI63406B/fi
Application granted granted Critical
Publication of FI63406C publication Critical patent/FI63406C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
FI772153A 1976-07-14 1977-07-11 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-entsoyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyr adrivat FI63406C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70490976A 1976-07-14 1976-07-14
US70490976 1976-07-14
US05/771,286 US4089969A (en) 1976-07-14 1977-02-23 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US77128677 1977-02-23

Publications (3)

Publication Number Publication Date
FI772153A FI772153A (xx) 1978-01-15
FI63406B FI63406B (fi) 1983-02-28
FI63406C true FI63406C (fi) 1983-06-10

Family

ID=27107410

Family Applications (1)

Application Number Title Priority Date Filing Date
FI772153A FI63406C (fi) 1976-07-14 1977-07-11 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-entsoyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyr adrivat

Country Status (27)

Country Link
JP (1) JPS539788A (xx)
AR (1) AR224997A1 (xx)
CA (1) CA1102809A (xx)
CH (3) CH641458A5 (xx)
CS (1) CS204954B2 (xx)
DE (2) DE2731678A1 (xx)
DK (1) DK151886C (xx)
ES (2) ES460706A1 (xx)
FI (1) FI63406C (xx)
FR (2) FR2358406A1 (xx)
GB (1) GB1554075A (xx)
GR (1) GR61111B (xx)
HK (1) HK15981A (xx)
HU (1) HU174224B (xx)
IE (1) IE45253B1 (xx)
IL (2) IL52493A (xx)
IT (1) IT1117313B (xx)
MX (1) MX163202B (xx)
MY (1) MY8100357A (xx)
NL (2) NL186318C (xx)
NO (1) NO147564C (xx)
NZ (1) NZ184610A (xx)
PL (4) PL124444B1 (xx)
PT (1) PT66780B (xx)
SE (1) SE434643B (xx)
SU (1) SU695558A3 (xx)
YU (1) YU40816B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
JPS55124633A (en) * 1979-03-19 1980-09-25 Sohachi Takeuchi Manufacturing method of tubular vessel
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JPH0739418B2 (ja) * 1987-09-10 1995-05-01 久光製薬株式会社 新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
IT1250691B (it) * 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
DK0612521T3 (da) * 1991-11-11 2000-01-17 Hisamitsu Pharmaceutical Co Keterolacholdigt varmt omslag
DE4300697C1 (de) * 1993-01-13 1994-05-19 Roemmers Sa Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
JP2008210666A (ja) * 2007-02-27 2008-09-11 Okamura Corp 商品陳列棚における照明装置

Also Published As

Publication number Publication date
NO772494L (no) 1978-01-17
AU513384B2 (en) 1980-11-27
IL52493A (en) 1982-02-28
DE2731678C2 (xx) 1989-06-08
DK151886C (da) 1988-06-06
NZ184610A (en) 1979-03-28
NL186318C (nl) 1990-11-01
MY8100357A (en) 1981-12-31
GR61111B (en) 1978-09-12
ES470214A1 (es) 1979-09-16
FI63406B (fi) 1983-02-28
NL7707651A (nl) 1978-01-17
PL124444B1 (en) 1983-01-31
MX163202B (es) 1992-02-20
AR224997A1 (es) 1982-02-15
JPS539788A (en) 1978-01-28
IE45253B1 (en) 1982-07-14
DE2760330C2 (xx) 1989-06-15
IL52493A0 (en) 1977-10-31
JPS6254109B2 (xx) 1987-11-13
GB1554075A (en) 1979-10-17
CH641458A5 (en) 1984-02-29
NO147564C (no) 1983-05-18
NO147564B (no) 1983-01-24
SU695558A3 (ru) 1979-10-30
HU174224B (hu) 1979-11-28
PL124711B1 (en) 1983-02-28
YU172177A (en) 1983-09-30
DK151886B (da) 1988-01-11
CH646973A5 (en) 1984-12-28
CA1102809A (en) 1981-06-09
AU2697577A (en) 1979-01-18
FR2358406B1 (xx) 1981-04-17
YU40816B (en) 1986-06-30
SE434643B (sv) 1984-08-06
CH646972A5 (en) 1984-12-28
FR2358406A1 (fr) 1978-02-10
FI772153A (xx) 1978-01-15
CS204954B2 (en) 1981-04-30
PT66780A (fr) 1977-08-01
HK15981A (en) 1981-05-01
PL124445B1 (en) 1983-01-31
PT66780B (fr) 1978-12-18
DE2731678A1 (de) 1978-03-16
FR2375234B1 (xx) 1980-11-07
DK307577A (da) 1978-01-15
NL930021I2 (nl) 1997-03-03
NL186318B (nl) 1990-06-01
ES460706A1 (es) 1978-12-01
IL58779A0 (en) 1980-02-29
NL930021I1 (nl) 1993-05-03
FR2375234A1 (fr) 1978-07-21
IT1117313B (it) 1986-02-17
SE7708141L (sv) 1978-01-15
PL199603A1 (pl) 1978-04-24
PL109390B1 (en) 1980-05-31
IE45253L (en) 1978-01-14

Similar Documents

Publication Publication Date Title
FI63406C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-entsoyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyr adrivat
US4089969A (en) 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4178463A (en) Process for making 4-aminohex-5-enoic acid
US4560699A (en) 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
FI78084C (fi) Foerfarande foer framstaellning av nya, terapeutiskt verksamma bensopyranderivat.
FI63407C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-2-furoyl)- 5-(2-tenoyl)- 5-(3-furoyl)- och 5-(3-tenoyl)- 21,dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyraderivat
EP0284076B1 (en) Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
US4235778A (en) 2-Pyrrolidone compounds and processes for making same
AU613334B2 (en) Process for preparing (+)-1,2-dihyro-3H-pyrrolo (1,2-A) pyrrole-1,7-dicarboxylates
US4835288A (en) Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US4254284A (en) Process for preparing 4-aminohex-5-ynoic acid
DK151335B (da) Analogifremgangsmaade til fremstilling af (dl)- eller (l)-5-benzoyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyreestere eller salte
US4937368A (en) Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874872A (en) Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
EP0102602A1 (en) 1,7-Dihydro-pyrrolo(3,4-e)(1,4)Diazepin-2(3H)-one derivatives, a process for preparing them and their use as anticonvulsant and antianxiety agents
FI92488C (fi) Menetelmä 1,2-dihydro-3H-pyrrolo/1,2-a/pyrroli-1,7-dikarboksyylihapon ja sen di(alempi alkyyli)esterien valmistamiseksi
NZ235283A (en) Substituted pyrrole derivatives as synthesis intermediates
DK152653B (da) Analogifremgangsmaade til fremstilling af (dl)-eller (l)-5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- eller 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-carboxylsyreestere eller salte
GB1590903A (en) 1,2-disubstituted-1-phenyl-cyclopropane derivatives
HU213614B (en) Process for producing 5-aroyl-1,2-dihydro-3h-pyrrolo [1,2-a]pyrrole-1-carboxylic acides and their alkylesters
NO174346B (no) Fremgangsmaate for fremstilling av 5-aroyl-1,2-dihydro-3H-pyrrolo-(1,2- a)- pyrrol-1-carboxylsyrer og alkylestere og salter derav

Legal Events

Date Code Title Description
MA Patent expired
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L4

Extension date: 20020711

MA Patent expired

Owner name: SYNTEX (U.S.A.) INC.