DE2731678A1 - Neue 5-aroyl-1,2-dihydro-3h-pyrrolo- eckige klammer auf 1,2-a eckige klammer zu -pyrrol-1-carbonsaeurederivate - Google Patents
Neue 5-aroyl-1,2-dihydro-3h-pyrrolo- eckige klammer auf 1,2-a eckige klammer zu -pyrrol-1-carbonsaeurederivateInfo
- Publication number
- DE2731678A1 DE2731678A1 DE19772731678 DE2731678A DE2731678A1 DE 2731678 A1 DE2731678 A1 DE 2731678A1 DE 19772731678 DE19772731678 DE 19772731678 DE 2731678 A DE2731678 A DE 2731678A DE 2731678 A1 DE2731678 A1 DE 2731678A1
- Authority
- DE
- Germany
- Prior art keywords
- pyrrolo
- dihydro
- pyrrole
- carboxylic acid
- namely
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70490976A | 1976-07-14 | 1976-07-14 | |
US05/771,286 US4089969A (en) | 1976-07-14 | 1977-02-23 | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE2731678A1 true DE2731678A1 (de) | 1978-03-16 |
DE2731678C2 DE2731678C2 (xx) | 1989-06-08 |
Family
ID=27107410
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19772731678 Granted DE2731678A1 (de) | 1976-07-14 | 1977-07-13 | Neue 5-aroyl-1,2-dihydro-3h-pyrrolo- eckige klammer auf 1,2-a eckige klammer zu -pyrrol-1-carbonsaeurederivate |
DE2760330A Expired DE2760330C2 (xx) | 1976-07-14 | 1977-07-13 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2760330A Expired DE2760330C2 (xx) | 1976-07-14 | 1977-07-13 |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS539788A (xx) |
AR (1) | AR224997A1 (xx) |
CA (1) | CA1102809A (xx) |
CH (3) | CH641458A5 (xx) |
CS (1) | CS204954B2 (xx) |
DE (2) | DE2731678A1 (xx) |
DK (1) | DK151886C (xx) |
ES (2) | ES460706A1 (xx) |
FI (1) | FI63406C (xx) |
FR (2) | FR2358406A1 (xx) |
GB (1) | GB1554075A (xx) |
GR (1) | GR61111B (xx) |
HK (1) | HK15981A (xx) |
HU (1) | HU174224B (xx) |
IE (1) | IE45253B1 (xx) |
IL (2) | IL52493A (xx) |
IT (1) | IT1117313B (xx) |
MX (1) | MX163202B (xx) |
MY (1) | MY8100357A (xx) |
NL (2) | NL186318C (xx) |
NO (1) | NO147564C (xx) |
NZ (1) | NZ184610A (xx) |
PL (4) | PL124444B1 (xx) |
PT (1) | PT66780B (xx) |
SE (1) | SE434643B (xx) |
SU (1) | SU695558A3 (xx) |
YU (1) | YU40816B (xx) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0284076A1 (en) * | 1987-03-25 | 1988-09-28 | Syntex (U.S.A.) Inc. | Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
EP0307034A1 (en) * | 1987-09-10 | 1989-03-15 | Hisamitsu Pharmaceutical Co., Inc. | Novel 3-aroyl-6,7-dihydro-5h-pyrrolo[1,2-c] imidazole-7-carboxylic acid derivatives |
EP0606657A1 (de) * | 1993-01-13 | 1994-07-20 | Roemmers S.A.I.C.F. | Ketorolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140698A (en) * | 1977-07-25 | 1979-02-20 | Syntex (Usa) Inc. | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles |
JPS55124633A (en) * | 1979-03-19 | 1980-09-25 | Sohachi Takeuchi | Manufacturing method of tubular vessel |
US4344943A (en) * | 1980-06-09 | 1982-08-17 | Syntex (U.S.A.) Inc. | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof |
US4353829A (en) * | 1980-11-21 | 1982-10-12 | Syntex (U.S.A.) Inc. | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters |
JPS5910589A (ja) * | 1982-06-10 | 1984-01-20 | メルク エンド カムパニー インコーポレーテツド | 抗炎症剤および鎮痛剤として新規な5−(ピロ−ル−2−オイル)−1,2−ジヒドロ−3H−ピロロ〔1,2−a〕ピロ−ル誘導体 |
US4511724A (en) * | 1982-06-10 | 1985-04-16 | Merck & Co., Inc. | 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents |
JP2649168B2 (ja) * | 1988-02-25 | 1997-09-03 | 久光製薬株式会社 | 新規な5,6−ジフェニル−1,2−ジヒドロ−3H−ピロロ[1,2−a]ピロール−1−カルボン酸誘導体 |
IT1250691B (it) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
DK0612521T3 (da) * | 1991-11-11 | 2000-01-17 | Hisamitsu Pharmaceutical Co | Keterolacholdigt varmt omslag |
US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
JP2008210666A (ja) * | 2007-02-27 | 2008-09-11 | Okamura Corp | 商品陳列棚における照明装置 |
-
1977
- 1977-05-17 JP JP5697777A patent/JPS539788A/ja active Granted
- 1977-07-07 DK DK307577A patent/DK151886C/da active
- 1977-07-07 AR AR268356A patent/AR224997A1/es active
- 1977-07-07 GR GR53907A patent/GR61111B/el unknown
- 1977-07-08 IL IL52493A patent/IL52493A/xx unknown
- 1977-07-08 NL NLAANVRAGE7707651,A patent/NL186318C/xx not_active IP Right Cessation
- 1977-07-08 CH CH850077A patent/CH641458A5/de not_active IP Right Cessation
- 1977-07-08 PT PT66780A patent/PT66780B/pt unknown
- 1977-07-08 IE IE1423/77A patent/IE45253B1/en not_active IP Right Cessation
- 1977-07-11 NZ NZ184610A patent/NZ184610A/xx unknown
- 1977-07-11 YU YU1721/77A patent/YU40816B/xx unknown
- 1977-07-11 FR FR7721356A patent/FR2358406A1/fr active Granted
- 1977-07-11 FI FI772153A patent/FI63406C/fi not_active IP Right Cessation
- 1977-07-11 GB GB28919/77A patent/GB1554075A/en not_active Expired
- 1977-07-12 CS CS774646A patent/CS204954B2/cs unknown
- 1977-07-12 CA CA282,599A patent/CA1102809A/en not_active Expired
- 1977-07-13 IT IT68630/77A patent/IT1117313B/it active Protection Beyond IP Right Term
- 1977-07-13 PL PL1977227290A patent/PL124444B1/pl unknown
- 1977-07-13 ES ES460706A patent/ES460706A1/es not_active Expired
- 1977-07-13 PL PL1977227291A patent/PL124445B1/pl unknown
- 1977-07-13 DE DE19772731678 patent/DE2731678A1/de active Granted
- 1977-07-13 SE SE7708141A patent/SE434643B/xx not_active IP Right Cessation
- 1977-07-13 NO NO772494A patent/NO147564C/no unknown
- 1977-07-13 SU SU772501050A patent/SU695558A3/ru active
- 1977-07-13 DE DE2760330A patent/DE2760330C2/de not_active Expired
- 1977-07-13 PL PL1977227289A patent/PL124711B1/pl unknown
- 1977-07-13 PL PL1977199603A patent/PL109390B1/pl unknown
- 1977-07-14 HU HU77SI1582A patent/HU174224B/hu unknown
- 1977-12-20 FR FR7738508A patent/FR2375234A1/fr active Granted
-
1978
- 1978-05-24 ES ES470214A patent/ES470214A1/es not_active Expired
-
1979
- 1979-11-22 IL IL58779A patent/IL58779A0/xx unknown
-
1981
- 1981-04-23 HK HK159/81A patent/HK15981A/xx unknown
- 1981-12-30 MY MY357/81A patent/MY8100357A/xx unknown
-
1984
- 1984-02-22 CH CH86684A patent/CH646973A5/de not_active IP Right Cessation
- 1984-02-22 CH CH86584A patent/CH646972A5/de not_active IP Right Cessation
-
1991
- 1991-07-05 MX MX9100104A patent/MX163202B/es unknown
-
1993
- 1993-03-23 NL NL930021C patent/NL930021I2/nl unknown
Non-Patent Citations (4)
Title |
---|
CA 37, 1943, Sp. 641·7· * |
CA 55, 1961, Sp. 1574h * |
CA 59, 1963, Sp. 7463e * |
CA 76, 1972, Ref. 25024t * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0284076A1 (en) * | 1987-03-25 | 1988-09-28 | Syntex (U.S.A.) Inc. | Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
EP0307034A1 (en) * | 1987-09-10 | 1989-03-15 | Hisamitsu Pharmaceutical Co., Inc. | Novel 3-aroyl-6,7-dihydro-5h-pyrrolo[1,2-c] imidazole-7-carboxylic acid derivatives |
US4895956A (en) * | 1987-09-10 | 1990-01-23 | Hisamitsu Pharmaceutical Co., Ltd. | 3-aroyl-6,7-dihydro-5H-pyrrolo(1,2-c)imidazole-7-carboxylic acid derivatives |
EP0606657A1 (de) * | 1993-01-13 | 1994-07-20 | Roemmers S.A.I.C.F. | Ketorolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration |
US5508301A (en) * | 1993-01-13 | 1996-04-16 | Roemmers S.A.I.C.F. | Ketorolac derivatives with considerably reduced gastro-intestinal irritation and ulceration |
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Legal Events
Date | Code | Title | Description |
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8110 | Request for examination paragraph 44 | ||
8172 | Supplementary division/partition in: |
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8364 | No opposition during term of opposition | ||
V448 | Application of spc |
Free format text: PRODUCT NAME: KETOROLAC UND DESSEN PHARMAZEUTISCH ANNEHMBARE SALZE, INSBESONDERE KETOROLAC-TROMETAMOL; REGISTRATION NO/DATE: 13753.00.00, 19911126 Spc suppl protection certif: 193 75 010 Filing date: 19930326 |
|
V472 | Application for supplementary protection certificate rejected |
Free format text: PRODUCT NAME: KETOROLAC UND DESSEN PHARMAZEUTISCH ANNEHMBARE SALZE, INSBESONDERE KETOROLAC-TROMETAMOL; REGISTRATION NO/DATE: 13753.00.00, 19911126 Spc suppl protection certif: 193 75 010 Filing date: 19930326 |