FI56685B - Foerfarande foer framstaellning av farmakologiskt vaerdefulla kvaternaera skopolaminbromider - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefulla kvaternaera skopolaminbromider

Info

Publication number
FI56685B
FI56685B FI1102/73A FI110273A FI56685B FI 56685 B FI56685 B FI 56685B FI 1102/73 A FI1102/73 A FI 1102/73A FI 110273 A FI110273 A FI 110273A FI 56685 B FI56685 B FI 56685B
Authority
FI
Finland
Prior art keywords
quaternamine
bromider
scopolamine
framework
pharmacological properties
Prior art date
Application number
FI1102/73A
Other languages
English (en)
Other versions
FI56685C (fi
Inventor
Silvano Casadio
Arturo Donetti
Original Assignee
Angeli Inst Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeli Inst Spa filed Critical Angeli Inst Spa
Publication of FI56685B publication Critical patent/FI56685B/fi
Application granted granted Critical
Publication of FI56685C publication Critical patent/FI56685C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI1102/73A 1972-04-18 1973-04-09 Foerfarande foer framstaellning av farmakologiskt vaerdefulla kvaternaera skopolaminbromider FI56685C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1792072A GB1413484A (en) 1972-04-18 1972-04-18 Scopolamine derivatives
GB1792072 1972-04-18

Publications (2)

Publication Number Publication Date
FI56685B true FI56685B (fi) 1979-11-30
FI56685C FI56685C (fi) 1980-03-10

Family

ID=10103564

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1102/73A FI56685C (fi) 1972-04-18 1973-04-09 Foerfarande foer framstaellning av farmakologiskt vaerdefulla kvaternaera skopolaminbromider

Country Status (28)

Country Link
US (1) US3853886A (fi)
JP (1) JPS531808B2 (fi)
AR (1) AR197500A1 (fi)
AT (1) AT327406B (fi)
AU (1) AU466971B2 (fi)
BE (1) BE797976A (fi)
CA (1) CA1010865A (fi)
CH (1) CH576979A5 (fi)
CS (1) CS172971B2 (fi)
DD (1) DD106840A5 (fi)
DE (1) DE2316728A1 (fi)
DK (1) DK138801C (fi)
ES (1) ES413535A1 (fi)
FI (1) FI56685C (fi)
FR (1) FR2187333B1 (fi)
GB (1) GB1413484A (fi)
HK (1) HK43278A (fi)
HU (1) HU165697B (fi)
IE (1) IE38748B1 (fi)
IL (1) IL41959A (fi)
IN (1) IN137569B (fi)
NL (1) NL159667B (fi)
NO (1) NO138176C (fi)
PL (1) PL89160B1 (fi)
SE (1) SE403112B (fi)
SU (1) SU469250A3 (fi)
YU (1) YU35025B (fi)
ZA (1) ZA732637B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1164227B (it) * 1983-05-13 1987-04-08 Angeli Inst Spa Composizione farmaceutica atta alla somministrazione nasale di sali quaternari d'ammonio ed attivita' anticolinergica
IT1194343B (it) * 1983-07-26 1988-09-14 Valeas Spa Sali di endo-8,8-dialchil-8-azoniabiciclo (3.2.1) ottan-6,7-esso-epossi-3-alchilcarbossilati,processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
DE4140861C2 (de) * 1991-12-11 2003-12-11 Boehringer Ingelheim Kg Verfahren zur Gewinnung von quartären Tropasäurealkaloiden
CN101307051B (zh) * 2008-04-18 2011-08-10 重庆巨琪诺美制药有限公司 东莨菪碱衍生物的合成方法
CN103880837A (zh) * 2014-03-27 2014-06-25 张家港威胜生物医药有限公司 一种西托溴铵的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670177A1 (de) * 1966-12-28 1970-11-12 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen N-substituierten Noratropiniumsalzen

Also Published As

Publication number Publication date
NO138176B (no) 1978-04-10
IL41959A0 (en) 1973-06-29
US3853886A (en) 1974-12-10
HU165697B (fi) 1974-10-28
AT327406B (de) 1976-01-26
FI56685C (fi) 1980-03-10
NL159667B (nl) 1979-03-15
DD106840A5 (fi) 1974-07-05
FR2187333A1 (fi) 1974-01-18
YU35025B (en) 1980-06-30
DK138801C (da) 1979-04-17
AU466971B2 (en) 1975-11-13
JPS4914615A (fi) 1974-02-08
IE38748B1 (en) 1978-05-24
AU5440673A (en) 1974-10-17
IE38748L (en) 1973-10-18
CH576979A5 (fi) 1976-06-30
ATA348173A (de) 1975-04-15
ES413535A1 (es) 1976-06-16
NO138176C (no) 1978-07-26
IN137569B (fi) 1975-08-16
SE403112B (sv) 1978-07-31
ZA732637B (en) 1974-04-24
FR2187333B1 (fi) 1976-10-22
PL89160B1 (fi) 1976-10-30
IL41959A (en) 1976-01-30
JPS531808B2 (fi) 1978-01-23
SU469250A3 (ru) 1975-04-30
CS172971B2 (fi) 1977-01-28
CA1010865A (en) 1977-05-24
YU95873A (en) 1979-12-31
DK138801B (da) 1978-10-30
DE2316728A1 (de) 1973-10-25
BE797976A (fr) 1973-10-10
HK43278A (en) 1978-08-11
NL7304874A (fi) 1973-10-22
GB1413484A (en) 1975-11-12
DE2316728C2 (fi) 1988-09-08
AR197500A1 (es) 1974-04-15

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