FI114475B - Menetelmä uusien terapeuttisesti käyttökelpoisten kinuklidiinijohdannaisten valmistamiseksi - Google Patents
Menetelmä uusien terapeuttisesti käyttökelpoisten kinuklidiinijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI114475B FI114475B FI935297A FI935297A FI114475B FI 114475 B FI114475 B FI 114475B FI 935297 A FI935297 A FI 935297A FI 935297 A FI935297 A FI 935297A FI 114475 B FI114475 B FI 114475B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- methyl
- azabicyclo
- diphenylmethyl
- methoxyphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70840491A | 1991-05-31 | 1991-05-31 | |
US70840491 | 1991-05-31 | ||
US9203317 | 1992-04-28 | ||
PCT/US1992/003317 WO1992021677A1 (en) | 1991-05-31 | 1992-04-28 | bibNUCLIDINE DERIVATIVES |
Publications (3)
Publication Number | Publication Date |
---|---|
FI935297A FI935297A (fi) | 1993-11-29 |
FI935297A0 FI935297A0 (fi) | 1993-11-29 |
FI114475B true FI114475B (fi) | 2004-10-29 |
Family
ID=24845673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI935297A FI114475B (fi) | 1991-05-31 | 1993-11-29 | Menetelmä uusien terapeuttisesti käyttökelpoisten kinuklidiinijohdannaisten valmistamiseksi |
Country Status (41)
Country | Link |
---|---|
US (3) | US5807867A (pl) |
EP (1) | EP0587723B1 (pl) |
JP (2) | JPH0733386B2 (pl) |
KR (1) | KR100214905B1 (pl) |
CN (1) | CN1048492C (pl) |
AP (1) | AP299A (pl) |
AT (1) | ATE135006T1 (pl) |
AU (1) | AU657552B2 (pl) |
BG (1) | BG61694B1 (pl) |
BR (1) | BR9206073A (pl) |
CA (1) | CA2102179C (pl) |
CZ (1) | CZ281403B6 (pl) |
DE (4) | DE122006000066I2 (pl) |
DK (1) | DK0587723T3 (pl) |
EG (1) | EG19944A (pl) |
ES (1) | ES2084361T3 (pl) |
FI (1) | FI114475B (pl) |
GR (1) | GR3019687T3 (pl) |
GT (1) | GT199200028A (pl) |
HU (1) | HU217548B (pl) |
IE (1) | IE72473B1 (pl) |
IL (1) | IL102008A (pl) |
IS (1) | IS1611B (pl) |
LU (1) | LU91293I2 (pl) |
MA (1) | MA22539A1 (pl) |
MX (1) | MX9202554A (pl) |
NL (1) | NL300250I2 (pl) |
NO (2) | NO302701B1 (pl) |
NZ (2) | NZ242956A (pl) |
OA (1) | OA09867A (pl) |
PL (1) | PL171379B1 (pl) |
PT (1) | PT100546B (pl) |
RO (1) | RO110499B1 (pl) |
RU (1) | RU2103269C1 (pl) |
SK (1) | SK390692A3 (pl) |
TW (1) | TW204349B (pl) |
UA (1) | UA27776C2 (pl) |
UY (1) | UY23422A1 (pl) |
WO (1) | WO1992021677A1 (pl) |
YU (1) | YU48995B (pl) |
ZA (1) | ZA923942B (pl) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
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PL171379B1 (en) * | 1991-05-31 | 1997-04-30 | Pfizer | Method of obtaining novel derivatives of quinuclidine |
UA39168C2 (uk) * | 1991-06-20 | 2001-06-15 | Пфайзер, Інк. | Фторалкоксифенільні похідні піперидину або хінуклідину, що є антагоністами речовини p і фармацевтична композиція на їх основі |
DE69331103T2 (de) * | 1992-08-19 | 2002-03-14 | Pfizer Inc., New York | Substituierte benzylamin-stickstoff enthaltende nichtaromatische heterocyclen |
KR950704311A (ko) * | 1992-11-12 | 1995-11-17 | 알렌 제이. 스피겔 | 물질 p 길항체로서의 퀴누클리딘 유도체(quinuclidine derivative as substance p antagonist) |
US5344830A (en) * | 1992-12-10 | 1994-09-06 | Merck & Co., Inc. | N,N-diacylpiperazine tachykinin antagonists |
IL109646A0 (en) * | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
JP2822274B2 (ja) * | 1993-05-19 | 1998-11-11 | ファイザー製薬株式会社 | P物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類 |
US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
EP0653208A3 (en) * | 1993-11-17 | 1995-10-11 | Pfizer | Substance P antagonists for the treatment or prevention of sunburn. |
EP0659409A3 (en) * | 1993-11-23 | 1995-08-09 | Pfizer | Substance P antagonists for the inhibition of angiogenesis. |
EP0655246A1 (en) * | 1993-11-30 | 1995-05-31 | Pfizer Inc. | Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria |
IL116249A (en) * | 1994-12-12 | 2003-07-06 | Pfizer | Nk-1 receptor antagonists for the treatment of neuronal damage and stroke |
PE8798A1 (es) * | 1995-07-17 | 1998-03-02 | Pfizer | Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil] |
TW458774B (en) | 1995-10-20 | 2001-10-11 | Pfizer | Antiemetic pharmaceutical compositions |
IL123740A0 (en) * | 1997-03-28 | 1998-10-30 | Pfizer | NK-1 receptor antagonists for the treatment of delayed emesis |
NZ329807A (en) * | 1997-04-23 | 2000-07-28 | Pfizer | NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome |
KR20010041991A (ko) * | 1998-03-19 | 2001-05-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 복소환식 화합물, 그의 제조법 및 타키키닌 수용체길항약으로서의 용도 |
US6387925B1 (en) * | 1999-06-01 | 2002-05-14 | Pfizer Inc. | Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions |
US6255320B1 (en) * | 1999-06-01 | 2001-07-03 | Pfizer Inc. | Polymorphs of a crystalline azo-bicyclo (2,2,2) octan-3-amine citrate and their pharmaceutical compositions |
US6262067B1 (en) * | 1999-06-22 | 2001-07-17 | Pfizer Inc. | Polymorphs of a crystalline azo-bicyclo 2,2,2 OCT-3-yl amine dihydrochloride and their pharmaceutical compositions |
JP2001172178A (ja) * | 1999-10-25 | 2001-06-26 | Pfizer Prod Inc | 偏頭痛治療用のnk−1レセプターアンタゴニスト及びエレトリプタン |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
MXPA02004330A (es) | 1999-11-03 | 2004-07-30 | Albany Molecular Res Inc | Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina.. |
IL142810A0 (en) * | 2000-05-03 | 2002-03-10 | Pfizer Prod Inc | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles |
WO2002004455A2 (en) | 2000-07-11 | 2002-01-17 | Albany Molecular Research, Inc | 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
US20020049211A1 (en) * | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
EP1192952A3 (en) * | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist |
PL367944A1 (pl) * | 2001-07-20 | 2005-03-07 | Pfizer Products Inc. | Zastosowanie antagonistów receptora NK-1 do modyfikowania niepożądanego zachowania psów, kotów i koni |
US6686507B2 (en) | 2002-03-06 | 2004-02-03 | Pfizer Inc | Purification of 2-methoxy-5-trifluoromethoxybenzaldehyde |
US6861526B2 (en) * | 2002-10-16 | 2005-03-01 | Pfizer Inc. | Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine |
US20050136487A1 (en) * | 2003-10-27 | 2005-06-23 | Meyer Donald W. | Transmissible spongiform encephalopathy detection in cervids, sheep and goats |
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RU2337685C2 (ru) * | 2004-01-30 | 2008-11-10 | Пфайзер Продактс Инк. | Антагонисты нейрокининового рецептора nk-1 для выхода из наркоза |
KR100834232B1 (ko) * | 2004-01-30 | 2008-05-30 | 화이자 프로덕츠 인크. | 액체 투여형용 베타-시클로덱스트린을 사용하는 다수회투여 제형을 얻기 위한 항균 방부제 |
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RU2388751C2 (ru) | 2004-07-15 | 2010-05-10 | Амр Текнолоджи, Инк. | Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина |
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JP5501227B2 (ja) | 2007-06-27 | 2014-05-21 | メルク・シャープ・アンド・ドーム・コーポレーション | ヒストンデアセチラーゼ阻害剤としての4−カルボキシベンジルアミノ誘導体 |
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EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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1992
- 1992-04-28 PL PL92301472A patent/PL171379B1/pl unknown
- 1992-04-28 DK DK92912601.9T patent/DK0587723T3/da active
- 1992-04-28 ES ES92912601T patent/ES2084361T3/es not_active Expired - Lifetime
- 1992-04-28 DE DE200612000066 patent/DE122006000066I2/de active Active
- 1992-04-28 AT AT92912601T patent/ATE135006T1/de active
- 1992-04-28 AU AU19901/92A patent/AU657552B2/en not_active Expired
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- 1992-04-28 CA CA002102179A patent/CA2102179C/en not_active Expired - Lifetime
- 1992-04-28 DE DE69208877T patent/DE69208877T2/de not_active Expired - Lifetime
- 1992-04-28 CZ CS923906A patent/CZ281403B6/cs not_active IP Right Cessation
- 1992-04-28 DE DE1992608877 patent/DE122006000066I1/de active Pending
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- 1992-04-28 RU RU93058555A patent/RU2103269C1/ru active Protection Beyond IP Right Term
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- 1992-04-28 BR BR9206073A patent/BR9206073A/pt not_active Application Discontinuation
- 1992-04-28 RO RO93-01581A patent/RO110499B1/ro unknown
- 1992-04-28 WO PCT/US1992/003317 patent/WO1992021677A1/en active IP Right Grant
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- 1992-04-28 UA UA93004096A patent/UA27776C2/uk unknown
- 1992-04-28 HU HU9303393A patent/HU217548B/hu active Protection Beyond IP Right Term
- 1992-05-05 TW TW081103509A patent/TW204349B/zh not_active IP Right Cessation
- 1992-05-11 AP APAP/P/1992/000384A patent/AP299A/en active
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- 1992-05-29 NZ NZ242956A patent/NZ242956A/en not_active IP Right Cessation
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- 1992-05-29 MA MA22826A patent/MA22539A1/fr unknown
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- 1992-05-30 EG EG28492A patent/EG19944A/xx active
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1993
- 1993-11-26 BG BG98248A patent/BG61694B1/bg unknown
- 1993-11-29 FI FI935297A patent/FI114475B/fi not_active IP Right Cessation
- 1993-11-29 NO NO934312A patent/NO302701B1/no not_active IP Right Cessation
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1994
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1995
- 1995-01-24 US US08/377,552 patent/US6222038B1/en not_active Expired - Lifetime
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1996
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1997
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2006
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2007
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