ES2170735A1 - Metodo para la preparacion de citalopram. - Google Patents

Metodo para la preparacion de citalopram.

Info

Publication number
ES2170735A1
ES2170735A1 ES200101920A ES200101920A ES2170735A1 ES 2170735 A1 ES2170735 A1 ES 2170735A1 ES 200101920 A ES200101920 A ES 200101920A ES 200101920 A ES200101920 A ES 200101920A ES 2170735 A1 ES2170735 A1 ES 2170735A1
Authority
ES
Spain
Prior art keywords
citalopram
preparation
compound
formula
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200101920A
Other languages
English (en)
Other versions
ES2170735B2 (es
Inventor
Hans Petersen
Haleh Ahmadian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2170735A1 publication Critical patent/ES2170735A1/es
Application granted granted Critical
Publication of ES2170735B2 publication Critical patent/ES2170735B2/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Método para la preparación de citaloporam que comprende la conversión de un compuesto de Fórmula VIII **FIGURA 01** en la que Z es halógeno, en un compuesto de Fórmula IV **FIGURA 02** seguida por la conversión del compuesto de Fórmula IV en citalopram. También se describen métodos para la preparación del compuesto de Formula IV.
ES200101920A 2000-08-18 2001-08-17 Metodo para la preparacion de citalopram. Expired - Fee Related ES2170735B2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18

Publications (2)

Publication Number Publication Date
ES2170735A1 true ES2170735A1 (es) 2002-08-01
ES2170735B2 ES2170735B2 (es) 2003-09-16

Family

ID=8159660

Family Applications (4)

Application Number Title Priority Date Filing Date
ES01957785T Expired - Lifetime ES2230347T3 (es) 2000-08-18 2001-08-14 Metodo para la preparacion de citalopram.
ES01957786T Expired - Lifetime ES2228920T3 (es) 2000-08-18 2001-08-14 Metodo para la preparacion de citalopram.
ES200101919A Expired - Fee Related ES2170734B2 (es) 2000-08-18 2001-08-17 Metodo para la preparacion de citalopram.
ES200101920A Expired - Fee Related ES2170735B2 (es) 2000-08-18 2001-08-17 Metodo para la preparacion de citalopram.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES01957785T Expired - Lifetime ES2230347T3 (es) 2000-08-18 2001-08-14 Metodo para la preparacion de citalopram.
ES01957786T Expired - Lifetime ES2228920T3 (es) 2000-08-18 2001-08-14 Metodo para la preparacion de citalopram.
ES200101919A Expired - Fee Related ES2170734B2 (es) 2000-08-18 2001-08-17 Metodo para la preparacion de citalopram.

Country Status (41)

Country Link
US (2) US6426422B1 (es)
EP (2) EP1309581B1 (es)
JP (2) JP2004506729A (es)
KR (2) KR100887206B1 (es)
CN (3) CN1222517C (es)
AR (3) AR029597A1 (es)
AT (4) ATE281448T1 (es)
AU (6) AU2001279609B2 (es)
BE (2) BE1013443A6 (es)
BG (2) BG65964B1 (es)
CA (2) CA2354880C (es)
CH (2) CH691968A5 (es)
CL (2) CL2008002412A1 (es)
CZ (2) CZ295863B6 (es)
DE (4) DE60106932T2 (es)
DK (4) DK200101216A (es)
EA (2) EA005811B1 (es)
ES (4) ES2230347T3 (es)
FI (2) FI20011622A (es)
FR (2) FR2813078B1 (es)
GB (2) GB2362647B (es)
GR (1) GR1004074B (es)
HK (3) HK1044538B (es)
HR (2) HRP20030065A2 (es)
HU (2) HUP0103291A3 (es)
IE (2) IES20010761A2 (es)
IL (2) IL144816A (es)
IS (2) IS2121B (es)
ME (2) MEP2208A (es)
MX (2) MXPA03000913A (es)
NL (2) NL1018776C1 (es)
NO (2) NO326772B1 (es)
NZ (2) NZ523877A (es)
PL (2) PL359825A1 (es)
PT (2) PT1309581E (es)
RS (2) RS50287B (es)
SI (2) SI1309582T1 (es)
SK (2) SK287008B6 (es)
UA (2) UA72340C2 (es)
WO (2) WO2002016341A1 (es)
ZA (1) ZA200106683B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) * 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EA002801B1 (ru) 1999-10-25 2002-10-31 Х.Лундбекк А/С Способ получения циталопрама
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
ATE261953T1 (de) 1999-12-28 2004-04-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
TR200201688T2 (tr) 1999-12-30 2002-11-21 H. Lundbeck A/S Sitalopram hazırlama yöntemi.
EA005134B1 (ru) * 2000-01-14 2004-12-30 Х.Лундбекк А/С Способ получения 5-цианофталида
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
TR200202166T2 (tr) 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
EA200200968A1 (ru) * 2000-03-13 2003-02-27 Х.Лундбекк А/С Поэтапное алкилирование 5-замещенных 1-(4-фторфенил)-1,3-дигидроизобензофуранов
CA2402557A1 (en) 2000-03-14 2001-09-20 Hans Petersen Method for the preparation of citalopram
CA2402869A1 (en) * 2000-03-16 2001-09-20 Hans Petersen Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
KR100439329B1 (ko) 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136193A (en) * 1976-01-14 1979-01-23 Kefalas A/S Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
WO2000011926A2 (en) * 1999-06-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
WO2000013648A2 (en) * 1999-06-25 2000-03-16 H. Lundbeck A/S Method for the preparation of citalopram

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (es) 1965-03-18
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DE69714480T2 (de) 1997-11-11 2003-03-06 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
CZ300408B6 (cs) * 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
TR200101874T1 (tr) 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
KR100439329B1 (ko) 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
AU3920201A (en) 2000-12-28 2001-07-09 H. Lundbeck A/S Process for the preparation of pure citalopram

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136193A (en) * 1976-01-14 1979-01-23 Kefalas A/S Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
WO2000011926A2 (en) * 1999-06-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
WO2000013648A2 (en) * 1999-06-25 2000-03-16 H. Lundbeck A/S Method for the preparation of citalopram

Also Published As

Publication number Publication date
AU2001100278B4 (en) 2001-11-29
CA2354877A1 (en) 2002-02-18
HK1044538A1 (en) 2002-10-25
US6509483B2 (en) 2003-01-21
FR2813078A1 (fr) 2002-02-22
JP2004506729A (ja) 2004-03-04
DE10140028A1 (de) 2002-04-18
BG107583A (bg) 2004-01-30
RS50258B (sr) 2009-07-15
MEP2308A (xx) 2010-02-10
HK1047086A1 (en) 2003-02-07
EP1309581B1 (en) 2004-11-03
KR20030022385A (ko) 2003-03-15
DE10140029A1 (de) 2002-05-02
SK287236B6 (sk) 2010-04-07
PL359825A1 (en) 2004-09-06
NL1018776C1 (nl) 2001-10-24
CH691968A5 (de) 2001-12-14
KR20030022378A (ko) 2003-03-15
CN1239490C (zh) 2006-02-01
CH691969A5 (de) 2001-12-14
AU2001100271A4 (en) 2001-09-13
NO20013943L (no) 2002-02-19
MEP2208A (xx) 2010-02-10
BE1013444A6 (fr) 2002-01-15
DK200101219A (da) 2002-02-19
PT1309581E (pt) 2005-03-31
NZ523853A (en) 2004-07-30
CA2354880C (en) 2003-06-03
GB0119734D0 (en) 2001-10-03
IS2121B (is) 2006-06-15
IS2120B (is) 2006-06-15
IL144816A0 (en) 2002-06-30
NO326772B1 (no) 2009-02-16
GB0119733D0 (en) 2001-10-03
DK200101216A (da) 2002-02-19
CN1339436A (zh) 2002-03-13
AU7960901A (en) 2002-03-04
PL359969A1 (en) 2004-09-06
EA200300279A1 (ru) 2003-08-28
HUP0103291A2 (hu) 2002-05-29
DE60106932T2 (de) 2005-11-03
CA2354880A1 (en) 2002-01-22
SK3202003A3 (en) 2003-08-05
AU2001279609B2 (en) 2007-09-06
NO326570B1 (no) 2009-01-12
AU7960801A (en) 2002-03-04
IS6047A (is) 2001-10-20
FR2813078B1 (fr) 2004-04-02
CN1515564A (zh) 2004-07-28
HK1044538B (zh) 2006-07-07
US20020025982A1 (en) 2002-02-28
HRP20030064A2 (en) 2005-02-28
ATE281448T1 (de) 2004-11-15
HK1047086B (zh) 2005-04-22
FI20011621A (fi) 2002-02-19
KR100887207B1 (ko) 2009-03-06
CA2354877C (en) 2006-05-02
IES20010761A2 (en) 2002-02-20
JP2004506730A (ja) 2004-03-04
IS6048A (is) 2001-10-19
AU2001100278A4 (en) 2001-09-13
BG65964B1 (bg) 2010-07-30
HUP0103295A2 (hu) 2002-05-29
DE60106932D1 (de) 2004-12-09
EA005946B1 (ru) 2005-08-25
CL2008002673A1 (es) 2009-01-02
GB2365865A (en) 2002-02-27
NO20013943D0 (no) 2001-08-14
AR066694A2 (es) 2009-09-09
BG107584A (bg) 2004-01-30
US20020026062A1 (en) 2002-02-28
MXPA03001329A (es) 2003-06-06
GR1004074B (el) 2002-11-26
CN1339435A (zh) 2002-03-13
YU11503A (sh) 2006-05-25
GR20010100398A (el) 2002-05-24
EP1309582A1 (en) 2003-05-14
EP1309582B1 (en) 2004-11-03
US6426422B1 (en) 2002-07-30
ATE281447T1 (de) 2004-11-15
NL1018775C1 (nl) 2001-10-24
NO20013942D0 (no) 2001-08-14
NZ523877A (en) 2004-08-27
EP1309581A1 (en) 2003-05-14
HRP20030065A2 (en) 2005-02-28
AR029598A1 (es) 2003-07-10
WO2002016342A1 (en) 2002-02-28
CL2008002412A1 (es) 2009-01-02
ES2230347T3 (es) 2005-05-01
CZ294746B6 (cs) 2005-03-16
EA005811B1 (ru) 2005-06-30
AU2001100271B4 (en) 2001-11-29
AR029597A1 (es) 2003-07-10
SI1309582T1 (en) 2005-06-30
RS50287B (sr) 2009-09-08
YU6903A (sh) 2006-05-25
FR2813077B1 (fr) 2004-08-20
DE60106933D1 (de) 2004-12-09
SK3222003A3 (en) 2003-08-05
IL144816A (en) 2005-09-25
DK1309582T3 (da) 2005-03-14
PT1309582E (pt) 2005-03-31
GB2362647A (en) 2001-11-28
CZ20012958A3 (cs) 2002-04-17
ES2170734B2 (es) 2003-09-16
FR2813077A1 (fr) 2002-02-22
CZ295863B6 (cs) 2005-11-16
GB2362647B (en) 2002-09-18
ES2228920T3 (es) 2005-04-16
MXPA03000913A (es) 2003-06-24
DE60106933T2 (de) 2005-12-01
HK1068069A1 (en) 2005-04-22
CN1159307C (zh) 2004-07-28
GB2365865B (en) 2002-07-17
NO20013942L (no) 2002-02-19
SK287008B6 (sk) 2009-09-07
DK1309581T3 (da) 2005-03-14
ZA200106683B (en) 2002-08-05
EA200300277A1 (ru) 2003-08-28
HU0103291D0 (en) 2001-10-28
IES20010760A2 (en) 2002-02-20
AT4946U1 (de) 2002-01-25
FI20011622A (fi) 2002-02-19
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
ES2170734A1 (es) 2002-08-01
BG65965B1 (bg) 2010-07-30
CZ20012959A3 (cs) 2002-04-17
AT5026U1 (de) 2002-02-25
IL144817A0 (en) 2002-06-30
CN1222517C (zh) 2005-10-12
HUP0103295A3 (en) 2005-01-28
BE1013443A6 (fr) 2002-01-15
FI20011622A0 (fi) 2001-08-09
KR100887206B1 (ko) 2009-03-06
UA72340C2 (uk) 2005-02-15
HUP0103291A3 (en) 2003-02-28
WO2002016341A1 (en) 2002-02-28
UA71676C2 (en) 2004-12-15
AU2001279608B2 (en) 2006-10-05
SI1309581T1 (en) 2005-04-30

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