DE60106932D1 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number
DE60106932D1
DE60106932D1 DE60106932T DE60106932T DE60106932D1 DE 60106932 D1 DE60106932 D1 DE 60106932D1 DE 60106932 T DE60106932 T DE 60106932T DE 60106932 T DE60106932 T DE 60106932T DE 60106932 D1 DE60106932 D1 DE 60106932D1
Authority
DE
Germany
Prior art keywords
citalopram
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60106932T
Other languages
English (en)
Other versions
DE60106932T2 (de
Inventor
Hans Petersen
Haleh Ahmadian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of DE60106932D1 publication Critical patent/DE60106932D1/de
Application granted granted Critical
Publication of DE60106932T2 publication Critical patent/DE60106932T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60106932T 2000-08-18 2001-08-14 Verfahren zur herstellung von citalopram Expired - Lifetime DE60106932T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18
DK200001231 2000-08-18
PCT/DK2001/000541 WO2002016341A1 (en) 2000-08-18 2001-08-14 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
DE60106932D1 true DE60106932D1 (de) 2004-12-09
DE60106932T2 DE60106932T2 (de) 2005-11-03

Family

ID=8159660

Family Applications (4)

Application Number Title Priority Date Filing Date
DE60106932T Expired - Lifetime DE60106932T2 (de) 2000-08-18 2001-08-14 Verfahren zur herstellung von citalopram
DE60106933T Expired - Lifetime DE60106933T2 (de) 2000-08-18 2001-08-14 Verfahren zur herstellung von citalopram
DE10140029A Withdrawn DE10140029A1 (de) 2000-08-18 2001-08-16 Vefahren zur Herstellung von Citalopram
DE10140028A Withdrawn DE10140028A1 (de) 2000-08-18 2001-08-16 Verfahren zur Herstellung von Citalopram

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE60106933T Expired - Lifetime DE60106933T2 (de) 2000-08-18 2001-08-14 Verfahren zur herstellung von citalopram
DE10140029A Withdrawn DE10140029A1 (de) 2000-08-18 2001-08-16 Vefahren zur Herstellung von Citalopram
DE10140028A Withdrawn DE10140028A1 (de) 2000-08-18 2001-08-16 Verfahren zur Herstellung von Citalopram

Country Status (41)

Country Link
US (2) US6509483B2 (de)
EP (2) EP1309582B1 (de)
JP (2) JP2004506729A (de)
KR (2) KR100887206B1 (de)
CN (3) CN1239490C (de)
AR (3) AR029597A1 (de)
AT (4) ATE281448T1 (de)
AU (6) AU7960901A (de)
BE (2) BE1013443A6 (de)
BG (2) BG65964B1 (de)
CA (2) CA2354877C (de)
CH (2) CH691969A5 (de)
CL (2) CL2008002412A1 (de)
CZ (2) CZ294746B6 (de)
DE (4) DE60106932T2 (de)
DK (4) DK1309581T3 (de)
EA (2) EA005946B1 (de)
ES (4) ES2228920T3 (de)
FI (2) FI20011622A (de)
FR (2) FR2813078B1 (de)
GB (2) GB2362647B (de)
GR (1) GR1004074B (de)
HK (3) HK1044538B (de)
HR (2) HRP20030065A2 (de)
HU (2) HUP0103291A3 (de)
IE (2) IES20010761A2 (de)
IL (2) IL144816A (de)
IS (2) IS2120B (de)
ME (2) MEP2308A (de)
MX (2) MXPA03000913A (de)
NL (2) NL1018776C1 (de)
NO (2) NO326772B1 (de)
NZ (2) NZ523853A (de)
PL (2) PL359825A1 (de)
PT (2) PT1309581E (de)
RS (2) RS50287B (de)
SI (2) SI1309581T1 (de)
SK (2) SK287236B6 (de)
UA (2) UA72340C2 (de)
WO (2) WO2002016341A1 (de)
ZA (1) ZA200106683B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
PL201056B1 (pl) 1999-10-25 2009-03-31 Lundbeck & Co As H Sposób wytwarzania citalopramu
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
WO2001047909A1 (en) 1999-12-28 2001-07-05 H. Lundbeck A/S Method for the preparation of citalopram
UA73336C2 (en) 1999-12-30 2005-07-15 Lundbeck & Co As H A method for the preparation of 5-cyano-phtalid
TR200201783T2 (tr) * 2000-01-14 2002-12-23 H. Lundbeck A/S 5-Siyanofatalid hazırlamak için yöntem
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IL151490A0 (en) * 2000-03-13 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
EP1265881A1 (de) * 2000-03-13 2002-12-18 H. Lundbeck A/S Schrittweise verlaufende alkylierung von in 5-stellung substituierten 1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
KR20020080476A (ko) 2000-03-14 2002-10-23 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
EP1274699A1 (de) * 2000-03-16 2003-01-15 H. Lundbeck A/S Verfahren zur herstellung von 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuranen
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
EA003581B1 (ru) 2000-12-22 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
PE20040991A1 (es) * 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2009111031A2 (en) * 2008-03-04 2009-09-11 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (de) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
PT1015416E (pt) * 1997-07-08 2002-03-28 Lundbeck & Co As H Metodo para a producao de citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CA2291072C (en) * 1997-11-11 2002-08-20 H. Lundbeck A/S Method for the preparation of citalopram
HU228576B1 (en) * 1998-10-20 2013-04-29 Lundbeck & Co As H Method for the preparation of citalopram
AU764161B2 (en) 1998-12-23 2003-08-14 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
SK287139B6 (sk) 1999-10-25 2010-01-07 H. Lundbeck A/S Spôsob prípravy citalopramu
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
EA003581B1 (ru) 2000-12-22 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
AU3920201A (en) 2000-12-28 2001-07-09 H. Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
WO2002016341A1 (en) 2002-02-28
CN1515564A (zh) 2004-07-28
PT1309582E (pt) 2005-03-31
US20020025982A1 (en) 2002-02-28
IS2120B (is) 2006-06-15
IL144816A0 (en) 2002-06-30
AR066694A2 (es) 2009-09-09
ES2170734A1 (es) 2002-08-01
CA2354877A1 (en) 2002-02-18
FI20011621A (fi) 2002-02-19
EA005946B1 (ru) 2005-08-25
CA2354877C (en) 2006-05-02
DK200101216A (da) 2002-02-19
BG107583A (bg) 2004-01-30
FI20011622A (fi) 2002-02-19
NL1018775C1 (nl) 2001-10-24
NL1018776C1 (nl) 2001-10-24
EP1309581B1 (de) 2004-11-03
ES2228920T3 (es) 2005-04-16
DK200101219A (da) 2002-02-19
FR2813078A1 (fr) 2002-02-22
US20020026062A1 (en) 2002-02-28
IS2121B (is) 2006-06-15
ATE281447T1 (de) 2004-11-15
CN1339436A (zh) 2002-03-13
JP2004506730A (ja) 2004-03-04
HUP0103295A2 (hu) 2002-05-29
IS6047A (is) 2001-10-20
FR2813077A1 (fr) 2002-02-22
AT4946U1 (de) 2002-01-25
ZA200106683B (en) 2002-08-05
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
DK1309582T3 (da) 2005-03-14
AR029597A1 (es) 2003-07-10
DE60106933T2 (de) 2005-12-01
AU7960901A (en) 2002-03-04
ES2170734B2 (es) 2003-09-16
AU7960801A (en) 2002-03-04
HK1047086B (zh) 2005-04-22
CA2354880C (en) 2003-06-03
HK1047086A1 (en) 2003-02-07
US6509483B2 (en) 2003-01-21
GB2362647B (en) 2002-09-18
KR100887206B1 (ko) 2009-03-06
BE1013444A6 (fr) 2002-01-15
CL2008002673A1 (es) 2009-01-02
NO326772B1 (no) 2009-02-16
HK1044538A1 (en) 2002-10-25
RS50287B (sr) 2009-09-08
YU6903A (sh) 2006-05-25
DE10140028A1 (de) 2002-04-18
EP1309582A1 (de) 2003-05-14
BG65965B1 (bg) 2010-07-30
ES2230347T3 (es) 2005-05-01
CZ20012959A3 (cs) 2002-04-17
GB2365865B (en) 2002-07-17
EA005811B1 (ru) 2005-06-30
RS50258B (sr) 2009-07-15
DE10140029A1 (de) 2002-05-02
EP1309582B1 (de) 2004-11-03
CH691969A5 (de) 2001-12-14
MXPA03000913A (es) 2003-06-24
SK3222003A3 (en) 2003-08-05
IS6048A (is) 2001-10-19
NO20013943L (no) 2002-02-19
CN1222517C (zh) 2005-10-12
GB0119733D0 (en) 2001-10-03
PT1309581E (pt) 2005-03-31
ATE281448T1 (de) 2004-11-15
EP1309581A1 (de) 2003-05-14
AU2001100278A4 (en) 2001-09-13
IL144816A (en) 2005-09-25
IES20010761A2 (en) 2002-02-20
HUP0103295A3 (en) 2005-01-28
BG65964B1 (bg) 2010-07-30
NO326570B1 (no) 2009-01-12
AU2001279608B2 (en) 2006-10-05
UA71676C2 (en) 2004-12-15
GR20010100398A (el) 2002-05-24
NZ523853A (en) 2004-07-30
CZ294746B6 (cs) 2005-03-16
HUP0103291A2 (hu) 2002-05-29
AU2001100278B4 (en) 2001-11-29
AR029598A1 (es) 2003-07-10
FR2813078B1 (fr) 2004-04-02
SI1309582T1 (en) 2005-06-30
UA72340C2 (uk) 2005-02-15
FR2813077B1 (fr) 2004-08-20
SK287008B6 (sk) 2009-09-07
CZ295863B6 (cs) 2005-11-16
NO20013943D0 (no) 2001-08-14
NO20013942D0 (no) 2001-08-14
CN1339435A (zh) 2002-03-13
HU0103291D0 (en) 2001-10-28
GR1004074B (el) 2002-11-26
CN1239490C (zh) 2006-02-01
CN1159307C (zh) 2004-07-28
CA2354880A1 (en) 2002-01-22
AU2001100271A4 (en) 2001-09-13
SK3202003A3 (en) 2003-08-05
GB0119734D0 (en) 2001-10-03
HRP20030064A2 (en) 2005-02-28
MEP2308A (xx) 2010-02-10
DK1309581T3 (da) 2005-03-14
SI1309581T1 (en) 2005-04-30
EA200300279A1 (ru) 2003-08-28
EA200300277A1 (ru) 2003-08-28
PL359969A1 (en) 2004-09-06
MEP2208A (xx) 2010-02-10
HRP20030065A2 (en) 2005-02-28
DE60106932T2 (de) 2005-11-03
YU11503A (sh) 2006-05-25
IL144817A0 (en) 2002-06-30
HK1044538B (zh) 2006-07-07
GB2365865A (en) 2002-02-27
GB2362647A (en) 2001-11-28
SK287236B6 (sk) 2010-04-07
WO2002016342A1 (en) 2002-02-28
JP2004506729A (ja) 2004-03-04
HUP0103291A3 (en) 2003-02-28
DE60106933D1 (de) 2004-12-09
CH691968A5 (de) 2001-12-14
NZ523877A (en) 2004-08-27
AT5026U1 (de) 2002-02-25
FI20011622A0 (fi) 2001-08-09
KR20030022378A (ko) 2003-03-15
ES2170735A1 (es) 2002-08-01
AU2001100271B4 (en) 2001-11-29
CL2008002412A1 (es) 2009-01-02
US6426422B1 (en) 2002-07-30
IES20010760A2 (en) 2002-02-20
AU2001279609B2 (en) 2007-09-06
HK1068069A1 (en) 2005-04-22
BE1013443A6 (fr) 2002-01-15
KR20030022385A (ko) 2003-03-15
KR100887207B1 (ko) 2009-03-06
PL359825A1 (en) 2004-09-06
CZ20012958A3 (cs) 2002-04-17
MXPA03001329A (es) 2003-06-06
BG107584A (bg) 2004-01-30
NO20013942L (no) 2002-02-19

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